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1. 发明公开

EP2641609A4 THERAPEUTIC AGENT FOR MUSCULAR DYSTROPHY 审中-公开
标题翻译：治疗剂，肌
公开(公告)号：EP2641609A4
公开(公告)日：2014-07-23
申请号：EP11841477
申请日：2011-11-17
申请人： FUKUDA KEIICHI
发明人： FUKUDA KEIICHI , YUASA SHINSUKE
IPC分类号： A61K38/00 , A61P21/00
CPC分类号： A61K38/193
摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.

2. 发明公开

EP2641609A1 THERAPEUTIC AGENT FOR MUSCULAR DYSTROPHY 审中-公开
标题翻译：治疗MITTELFÜRMUSKELDYSTROPHIE
公开(公告)号：EP2641609A1
公开(公告)日：2013-09-25
申请号：EP11841477.0
申请日：2011-11-17
申请人： Fukuda, Keiichi
发明人： FUKUDA, Keiichi. , YUASA, Shinsuke.
IPC分类号： A61K38/00 , A61P21/00
CPC分类号： A61K38/193
摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.
摘要翻译：本发明提供了与骨骼肌变性相关的疾病的治疗剂，其包含粒细胞集落刺激因子（G-CSF）作为活性成分。本发明的治疗剂作为肌营养不良症的治疗剂是特别有效的。

3. 发明公开

EP1946765A1 REMEDY FOR ANGIOGENESIS-RELATED DISEASE COMPRISING CHONDROMODULIN-I AS THE ACTIVE INGREDIENT 审中-公开
标题翻译： MITTEL ZUR BEHANDLUNG VON ANGIOGENESE-BEDINGTEN ERKRANKUNGEN MIT CHONDROMODULIN-I ALS WIRKSTOFF
公开(公告)号：EP1946765A1
公开(公告)日：2008-07-23
申请号：EP06810198.9
申请日：2006-09-15
申请人： Fukuda, Keiichi , Hiraki, Yuji
发明人： Fukuda, Keiichi , Hiraki, Yuji
IPC分类号： A61K38/00 , A01K67/027 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P27/02 , A61P43/00 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , C12N15/09
CPC分类号： A61K48/005 , A01K2217/075 , A01K2267/03 , A61K31/7088 , A61K38/00 , C07K14/51 , G01N33/502 , G01N2800/32
摘要： An objective of the present invention is to analyze the function of anti-angiogenic factors in cardiac valves or such to elucidate the developmental mechanism of angiogenesis-induced diseases. A more specific objective is to provide therapeutic agents for angiogenesis-induced diseases such as valvular heart disease, and methods of efficiently screening for the therapeutic agents. The present inventors discovered that chondromodulin-I was markedly expressed in cardiac valves, and plays an important role in maintaining normal functions of the valves by preventing angiogenesis, thickening, and calcification which lead to valvular heart diseases. Chondromodulin-I proteins and substances that activate the expression or function of the proteins are expected to have therapeutic effects against angiogenesis-induced diseases.
摘要翻译：本发明的目的是分析心脏瓣膜中的抗血管生成因子的功能，以阐明血管生成诱发的疾病的发展机制。更具体的目的是提供血管生成诱导的疾病如瓣膜性心脏病的治疗剂和有效筛选治疗剂的方法。本发明人发现软骨调节蛋白-1在心脏瓣膜中显着表达，并且通过预防血管生成，增厚和钙化导致瓣膜性心脏病的维持瓣膜的正常功能起重要作用。软骨调节蛋白-1蛋白质和激活蛋白质表达或功能的物质预期具有对血管生成诱导的疾病的治疗作用。

4. 发明公开

EP2154242A1 METHOD OF INDUCING DIFFERENTIATION INTO MYOCARDIAL CELLS USING G-CSF 有权
标题翻译： VERFAHREN ZUR EINLEITUNG VON DIFFERENZIERUNG在MYKARDIALE ZELLEN MITTELS G-CSF
公开(公告)号：EP2154242A1
公开(公告)日：2010-02-17
申请号：EP08765549.4
申请日：2008-06-06
申请人： Fukuda, Keiichi
发明人： YUASA, Shinsuke , SHIMOJI, Kenichiro , FUKUDA, Keiichi
IPC分类号： C12N5/06 , A61L27/00 , C12N15/09
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
摘要： A method for inducing differentiation of ES cells into cardiomyocytes, which comprises contacting the ES cells with an agonist for G-CSF receptor.
摘要翻译：一种诱导ES细胞分化为心肌细胞的方法，其包括将ES细胞与G-CSF受体的激动剂接触。

5. 发明公开

EP1946765A4 REMEDY FOR ANGIOGENESIS-RELATED DISEASE COMPRISING CHONDROMODULIN-I AS THE ACTIVE INGREDIENT 审中-公开
标题翻译： MEANS血管生成有关的疾病与软骨调节，我积极治疗
公开(公告)号：EP1946765A4
公开(公告)日：2009-10-21
申请号：EP06810198
申请日：2006-09-15
申请人： FUKUDA KEIICHI , HIRAKI YUJI
发明人： FUKUDA KEIICHI , HIRAKI YUJI
IPC分类号： A61K38/00 , A01K67/027 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P27/02 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： A61K48/005 , A01K2217/075 , A01K2267/03 , A61K31/7088 , A61K38/00 , C07K14/51 , G01N33/502 , G01N2800/32

6. 发明公开

EP1734112A4 METHOD OF PROLIFERATING PLURIPOTENT STEM CELL 有权
标题翻译：法检测细胞增殖细胞的多能干作者：
公开(公告)号：EP1734112A4
公开(公告)日：2007-09-05
申请号：EP05727500
申请日：2005-03-23
申请人： DAIICHI ASUBIO PHARMA CO LTD , FUKUDA KEIICHI , AKAIKE TOSHIHIRO
发明人： AKAIKE TOSHIHIRO , FUKUDA KEIICHI , NAGAOKA MASATO , KOSHIMIZU UICHI
IPC分类号： C12N5/0789 , C07K14/47 , C12N5/071 , C12N15/09
CPC分类号： C12N5/0606 , C12N2533/50

7. 发明公开

EP1674562A1 METHOD OF INDUCING THE DIFFERENTIATION OF STEM CELLS INTO MYOCARDIAL CELLS 审中-公开
标题翻译： VERFAHREN ZUR INDUZIERUNG DER DIFFERENZIERUNG VON STAMMZELLEN ZU MYOKARDZELLEN
公开(公告)号：EP1674562A1
公开(公告)日：2006-06-28
申请号：EP04792009.5
申请日：2004-10-04
申请人： Fukuda, Keiichi
发明人： FUKUDA, Keiichi , YUASA, Shinsuke , OKANO, Hideyuki , SHIMAZAKI, Takuya , KOSHIMIZU, Uichi , TANAKA, Tomofumi , SUGIMURA, Keijiro
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0657 , C12N2501/155 , C12N2506/03
摘要： For a method of inducing differentiation of cardiomyocytes from stem cells, a method is provided to induce efficiently and selectively differentiation of cardiomyocytes by such a method in which the stem cells are cultured to induce differentiation into cardiomyocytes in the presence of a substance that inihibits BMP signaling.
摘要翻译：为了诱导心肌细胞从干细胞分化的方法，提供了一种通过这样一种方法诱导心肌细胞的有效和选择性分化的方法，其中在存在抑制BMP信号的物质的情况下培养干细胞以诱导分化成心肌细胞。

8. 发明公开

EP1611899A1 COMBINED USE OF G-CSF WITH ANGIOGENETIC FACTOR 审中-公开
标题翻译： KOMBINIERTE VERWENDUNG VON G-CSF UND ANGIOGENESEFAKTOR
公开(公告)号：EP1611899A1
公开(公告)日：2006-01-04
申请号：EP04722061.1
申请日：2004-03-19
申请人： Fukuda, Keiichi , Hisaka, Yasuyo
发明人： Fukuda, Keiichi , Hisaka, Yasuyo
IPC分类号： A61K38/16
CPC分类号： A61K38/193 , A61K48/00 , A61K2300/00
摘要： An effective remedy for ischemic disease, which contains granulocyte colony-stimulating factor (G-CSF) and hepatocyte growth factor (HGF) or fibroblast growth factor (FGF) as active ingredients, is disclosed. By administering this remedy, an effective therapy particularly for obstructive arteriosclerosis is provided which can eliminate drawbacks with conventional therapies such as kinesitherapy, pharmacotherapy, revascularization and recently proposed therapies such as gene therapy and intramuscular inoculation of bone marrow cells. Furthermore, the remedy of the present invention can become a remedy for ischemic disease such as ischemic cerebrovascular disorder or ischemic heart disease.
摘要翻译：公开了含有粒细胞集落刺激因子（G-CSF）和肝细胞生长因子（HGF）或成纤维细胞生长因子（FGF）作为活性成分的缺血性疾病的有效治疗方法。通过施用这种补救措施，提供了一种特别用于阻塞性动脉硬化的有效治疗方法，其可以消除常规治疗如运动疗法，药物治疗，血运重建和最近提出的治疗如基因治疗和肌内接种骨髓细胞的缺点。此外，本发明的治疗方法可以成为缺血性疾病如缺血性脑血管障碍或缺血性心脏病的补救措施。

9. 发明授权

EP2154242B1 METHOD OF INDUCING DIFFERENTIATION INTO MYOCARDIAL CELLS USING G-CSF 有权
标题翻译： METHOD FOR引言差分在心肌细胞中的使用的G-CSF
公开(公告)号：EP2154242B1
公开(公告)日：2016-01-06
申请号：EP08765549.4
申请日：2008-06-06
申请人： Fukuda, Keiichi
发明人： YUASA, Shinsuke , SHIMOJI, Kenichiro , FUKUDA, Keiichi
IPC分类号： A61K35/12 , C12N5/0735 , C12N5/077
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02

10. 发明公开

EP2154242A4 METHOD OF INDUCING DIFFERENTIATION INTO MYOCARDIAL CELLS USING G-CSF 有权
标题翻译： METHOD FOR引言差分在心肌细胞中的使用的G-CSF
公开(公告)号：EP2154242A4
公开(公告)日：2011-08-10
申请号：EP08765549
申请日：2008-06-06
申请人： FUKUDA KEIICHI
发明人： YUASA SHINSUKE , SHIMOJI KENICHIRO , FUKUDA KEIICHI
IPC分类号： A61L27/00 , C12N5/077 , C12N15/09 , C12N5/06
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02

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