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1. 发明公开

EP4075128A1 MICROELECTRODE OF GENE SEQUENCING CHIP, MANUFACTURING METHOD THEREFOR, AND GENE SEQUENCING CHIP 审中-实审
公开(公告)号：EP4075128A1
公开(公告)日：2022-10-19
申请号：EP20897831.2
申请日：2020-12-11
申请人： Geneus Technologies (Chengdu) Co., Ltd. , Dalian University of Technology
发明人： SU, Yunpeng , ZHOU, Dayu , SUN, Nana , GU, Jiaye
IPC分类号： G01N27/327
摘要： Disclosed in the embodiments of the present application are a microelectrode of a gene sequencing chip, a manufacturing method therefor, and a gene sequencing chip. The microelectrode comprises a substrate, a current collector layer formed on the substrate, and an electrode layer formed on the current collector layer; the current collector layer comprises a transition metal thin film or a nitride thin film thereof or a composite thin film of a transition metal and nitride thereof, and the electrode layer comprises a nitrogen oxide thin film of the transition metal, which is formed on the transition metal thin film or the nitride thin film thereof or the composite thin film of the transition metal and nitride thereof. The embodiments of the present application improve the per unit area voltage driving capabilities of a microelectrode in a gene sequencing chip, can meet requirements for an ultra-high number of cycles, and improve the throughput and stability of a gene sequencing chip.

2. 发明公开

EP3984998A1 FLUIDIZED REACTION METHOD FOR SYNTHESIZING PROPYLENE OXIDE BY GAS PHASE EPOXIDATION OF PROPYLENE AND HYDROGEN PEROXIDE 有权
公开(公告)号：EP3984998A1
公开(公告)日：2022-04-20
申请号：EP20822728.0
申请日：2020-04-14
申请人： Dalian University of Technology , Dalian Qiyuan Technology Co., Ltd.
发明人： GUO, Hongchen , ZHU, Quanren , MIAO, Cuilan
IPC分类号： C07D303/04 , C07D301/12 , B01J29/89 , B01J35/08 , B01J37/10
摘要： A fluidized reaction method for synthesizing propylene oxide by gas phase epoxidation of propylene and hydrogen peroxide relates to a microspherical alkali metal ion modified titanium silicalite zeolite TS-1 catalyst applicable to the reaction method, and a preparation method thereof. A gas-solid phase fluidized epoxidation method refers to a gas phase epoxidation method in which the raw materials of propylene and hydrogen peroxide are directly mixed in the gas phase under normal pressure and temperature above 100°C and the feed gas enables the titanium silicalite zeolite TS-1 catalyst to be fluidized in an epoxidation reactor. A catalyst applicable to the reaction method is a microspherical alkali metal ion modified titanium silicalite zeolite TS-1 catalyst which has the main characteristic that alkali metal cations are reserved on the titanium silicalite zeolite. The method of the present invention is beneficial to inhibit the self-decomposition side-reaction of hydrogen peroxide, beneficial to disperse the reaction heat and rapidly withdraw the heat, beneficial to improve the utilization rate of the catalyst and increase the productivity of the catalyst, and beneficial to industrial application and industrial production safety.

3. 发明授权

EP2818535B1 PROCESS FOR PRODUCING MESOPHASE PITCH BY HYDROGENATION OF HIGH-TEMPERATURE COAL TAR 有权转让
公开(公告)号：EP2818535B1
公开(公告)日：2020-10-21
申请号：EP12865271.6
申请日：2012-04-06
申请人： Eco Environmental Energy Research Institute Limited , Dalian University of Technology
发明人： ZHAO, Hongmei , QIU, Jieshan , SIU, Kam Shing, Philip , LI, Baoming , LU, Junde, Steve , XIAO, Nan
IPC分类号： C10C1/20 , C10C1/16 , C10C1/18 , C10C3/00 , C10G67/04

4. 发明公开

EP3511122A1 HIGHLY DYNAMIC WIDE-RANGE ANY-CONTOUR-ERROR MONOCULAR SIX-DIMENSIONAL MEASUREMENT METHOD FOR NUMERICAL CONTROL MACHINE TOOL 有权
公开(公告)号：EP3511122A1
公开(公告)日：2019-07-17
申请号：EP17925531.0
申请日：2017-11-07
申请人： Dalian University of Technology
发明人： LIU, Wei , JIA, Zhenyuan , LI, Xiao , PAN, Yi , MA, Xin , MA, Jianwei
IPC分类号： B23Q17/24
摘要： A monocular vision six-dimensional measurement method for high-dynamic large-range arbitrary contouring error of a CNC machine tool of the present invention belongs to the field of dynamic error detection of machine tools, and relates to a six-dimensional measurement method for high-dynamic large-range arbitrary contouring error of a CNC machine tool using a monocular vision measurement technology with short-time stroboscopic illumination and a priori standard plate. The method designs a measurement fixture and a measurement system, and uses a monocular vision pose algorithm to improve both the visual measurable dimension and range of interpolated contour in combination with priori knowledge. In light of the principle of error distribution, a small field of view is used to enhance the measurement accuracy of the coded primitives in the images. Then, by traversing all the acquired images using the proposed method, we can obtain the six-dimensional motion contour; and the six-dimensional contouring error caused by the imperfect machine interpolation can be computed by comparing the measured contour with the nominal one. The method enhances the measurable dimension of the vision technology through the monocular vision pose algorithm in combination with a datum transformation method, and realizes the six-dimensional measurement of large-range arbitrary contouring error of the CNC machine tool under the small field of view.

5. 发明公开

EP3225171A1 ULTRASONIC DRIVING STRUCTURE WITH INTEGRATED PZT TRANSDUCER AND AMPLITUDE TRANSFORMER 有权
标题翻译：集成PZT传感器和幅频变压器的超声波驱动结构
公开(公告)号：EP3225171A1
公开(公告)日：2017-10-04
申请号：EP15863501.1
申请日：2015-09-13
申请人： Dalian University of Technology
发明人： WANG, Rui , WANG, Xuyue , WANG, Xiaoming
IPC分类号： A61B17/00
CPC分类号： A61B17/8665 , A61B17/320068 , A61B2017/00402 , A61B2017/22027 , A61B2017/320088 , B06B1/0611 , H01L41/0835
摘要： A PZT transducer-horn integrated ultrasonic driving structure consists of a nut, a bolt, a left PZT circular stack, a flange, a right PZT truncated stack and a horn. The horn, the right PZT truncated stack, the flange and the left PZT circular stack are arranged in sequence and connected via the bolt and then fastened via the nut; the right PZT transducer is a truncated cone-shaped stack formed by PZT circular plates; and the right PZT transducer and the horn are integrated to form the ultrasonic driving structure. Considering the dimension of PZT on two sides of the flange and the horn meet the requirements for ultrasonic vibration node and antinode, the dimension of round contour of the circular PZT stack and flange is reduced to increase the thickness of the truncated PZT stack and flange. With the integrated structure, the effect of reducing the contour dimension of the ultrasonic driving surgical device can be obtained, and the outer diameter is reduced to the range of 8-10 mm as compared with the range of 12-15 mm in the prior art, thereby further meeting the application requirements.
摘要翻译： PZT换能器喇叭一体化超声波驱动结构由螺母，螺栓，左侧PZT圆形叠层，法兰，右侧PZT截断叠层和喇叭组成。喇叭，右侧PZT截顶堆垛，法兰和左侧PZT圆形堆垛依次排列，通过螺栓连接，然后通过螺母紧固; 右PZT换能器是由PZT圆形板形成的截锥形堆叠; 并且右侧的PZT换能器和喇叭被集成以形成超声波驱动结构。考虑到法兰和喇叭两侧PZT的尺寸符合超声波振动节点和波腹的要求，圆形PZT叠片和凸缘的圆形轮廓尺寸减小，增加了截顶PZT叠片和凸缘的厚度。采用该一体结构，可以获得减小超声波驱动手术装置的轮廓尺寸的效果，并且与现有技术中的12-15mm的范围相比，外径减小到8-10mm的范围，从而进一步满足应用需求。

6. 发明授权

EP2546309B1 ANTHRAPYRIDONE SULPHONIC ACID COMPOUNDS, PREPARATION AND USE THEREOF 失效
标题翻译：噻唑烷酮磺酸化合物，其制备和用途
公开(公告)号：EP2546309B1
公开(公告)日：2016-06-01
申请号：EP11855880.8
申请日：2011-01-14
申请人： Dalian University of Technology , Ninestar Management Co., Ltd.
发明人： PENG, Xiaojun , LIU, Tao , WU, Jinhe , ZHANG, Rong , WANG, Jingyue , WANG, Feng , LI, Shaolei , ZHANG, Jianzhou , YANG, Zhengru
IPC分类号： C09B5/14 , C07D221/18 , C09B62/04 , C09D11/00 , C09B62/465 , C09B62/503
CPC分类号： C09D11/328 , C09B5/14 , C09B62/04 , C09B62/465 , C09B62/503 , C09D11/037

7. 发明授权

EP2682433B1 CARBONYLPROPYLSULFONYL ANTHRACENE PYRIDONE SULFONIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF 有权转让
标题翻译：羰基丙基磺酰基蒽基吡啶酮磺酸化合物及其制备方法和用途
公开(公告)号：EP2682433B1
公开(公告)日：2015-06-03
申请号：EP11871552.3
申请日：2011-09-01
申请人： Dalian University Of Technology , Zhuhai Ninestar Management Co., Ltd.
发明人： PENG, Xiaojun , WU, Jinhe , LONG, Zhi , ZHANG, Rong , WANG, Licheng , WANG, Feng , LI, Shaolei , FAN, Jiangli , SONG, Fengling , SUN, Shiguo
IPC分类号： C09B5/14 , C07D221/18 , C09D11/00 , C09D5/00 , C09B67/22
CPC分类号： C09D11/328 , C07D221/18 , C09B5/14 , C09B67/0034 , C09B67/0038 , C09D5/028 , C09D7/41
摘要： The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), X 1 is H or CO 2 H; X 2 is OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when X 2 is OH, X 1 is H; when X 2 is phenyl group with 0-2 sulfonic acid substituents, X 1 is H or CO 2 H; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink.

8. 发明授权

EP2778161B1 TWO-PHOTON FLUORESCENT PROBE USING NAPHTHALENE AS MATRIX AND PREPARATION METHOD AND USE THEREOF 有权转让
标题翻译：与萘双光子荧光探针矩阵法生产和使用
公开(公告)号：EP2778161B1
公开(公告)日：2015-05-06
申请号：EP12870663.7
申请日：2012-03-05
申请人： Dalian University Of Technology , Dalian Chromas Bioscience Co., Ltd.
发明人： PENG, Xiaojun , ZHANG, Hua , FAN, Jiangli , WANG, Jingyun
IPC分类号： C07D401/12 , C07D403/12 , C07D471/04 , C09K11/06 , C12Q1/02
CPC分类号： G01N21/6486 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/06 , C09B57/00 , C09B57/08 , C09K11/02 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1044 , G01N21/6458 , G01N33/582 , G01N2201/06113 , G01N2201/0697
摘要： The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X 1 , X 2 , X 3 and X 4 ; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.

9. 发明公开

EP2818535A1 PROCESS FOR PRODUCING MESOPHASE PITCH BY HYDROGENATION OF HIGH-TEMPERATURE COAL TAR 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG VON MESOPHASEN-PECH DURCH HYDRIERUNG VON HOCHTEMPERATURKOHLENTEER
公开(公告)号：EP2818535A1
公开(公告)日：2014-12-31
申请号：EP12865271.6
申请日：2012-04-06
申请人： Eco Environmental Energy Research Institute Limite , Dalian University of Technology
发明人： ZHAO, Hongmei , QIU, Jieshan , XIAO, Jincheng , LI, Baoming , LV, Junde , XIAO, Nan
IPC分类号： C10C3/02 , C10C3/08 , C10C3/00
摘要： A process for producing mesophase pitch from high-temperature coal tar comprises: removing salts and quinoline insoluble fraction from a high-temperature coal tar to obtain a decant oil; using the decant oil as a hydrogenation feedstock, or pre-distilling the decant oil to obtain a residue with a boiling point higher than 230°C and formulating the residue into a hydrogenation feedstock; catalytic hydrorefining the hydrogenation feedstock to obtain a hydrofined oil; distilling the hydrofined oil to obtain hydrogenated pitch; and subjecting the hydrogenated pitch to the thermal polymerization to obtain the mesophase pitch. The process has features such as an easily controllable degree of hydrogenation, complete removal of impurities, good raw material flowability, not tending to form the carbon deposition and the coking during the process, and not tending to jam the reactor. The product has a high content of mesophase pitch, a low softening point and a low impurity content.
摘要翻译：从高温煤焦油生产中间相沥青的方法包括：从高温煤焦油中除去盐和喹啉不溶部分，得到滗析油; 使用倾析油作为氢化原料，或者预先蒸馏滗析油，得到沸点高于230℃的残余物，并将残余物配制成氢化原料; 催化加氢精制加氢原料以获得加氢精制油; 蒸馏加氢精制油，得到氢化沥青; 并使氢化沥青进行热聚合以获得中间相沥青。该方法具有易于控制的氢化程度，完全除去杂质，良好的原料流动性，在生产过程中不会形成碳沉积和焦化，并且不会阻塞反应器。该产品具有高含量的中间相沥青，低软化点和低杂质含量。

10. 发明公开

EP2366701A1 ACENAPHTHO HETEROCYCLE COMPOUNDS, CYCLODEXTRIN INCLUSION COMPOUNDS AND COMPLEXES, AND USES IN THE MANUFACTURES OF BH3 PROTEIN ANALOGUE, BCL-2 FAMILY PROTEIN INHIBITORS THEREOF 审中-公开
标题翻译： ACENAPHTHOHETEROCYCLUSVERBINDUNGEN，环糊精包合和复杂的和应用的BH3蛋白类似物的生产，蛋白Bcl-2家族的抑制剂的
公开(公告)号：EP2366701A1
公开(公告)日：2011-09-21
申请号：EP09825750.4
申请日：2009-10-25
申请人： Dalian University Of Technology
发明人： ZHANG, Zhichao , WU, Guiye , SONG, Ting , XIE, Feibo
IPC分类号： C07D405/12 , C07D409/12 , C07D209/70 , A61K31/403 , A61K31/54 , A61P43/00 , C08B37/16
CPC分类号： C07D209/70 , A61K31/403 , A61K31/54 , C07D405/12 , C07D409/12 , C08B37/0015
摘要： The present invention relates to acenaphtho heterocyclic compounds, cyclodextrin inclusion compounds and complexes thereof, and their uses in manufacturing the inhibitors of BH3 analogue, Bcl-2 family proteins. The acenaphtho heterocyclic compounds are obtained by introducing oxo-, thio-, carbonyl, ester or acyl in the 3-, 4- and 6-position of 8-oxo-8 H -acenaphtho[1,2-b]pyrrole-9-carbonitrile, or further substituting 9-cyano with carboxyl, ester or amide. The compounds can simulate BH3-only protein, competitively binding and antagonizing Bcl-2, Bcl-X L and Mcl-1 proteins in vitro or intracellularly, to induce cell apoptosis. The cyclodextrin inclusion compounds and complexes can improve the effects. Therefore, they can all be used in the manufacture of anticancer compounds.
摘要翻译：本发明涉及苊并杂环化合物，环糊精包合化合物和复合物，和它们的用途在制造BH 3，Bcl-2家族蛋白的类似物抑制剂。苊并杂环化合物是通过在-8-氧代8 H -acenaphtho并[1,2-b]吡咯-9-的3-，4-和6-位上引入氧代，硫代，羰基，酯基或酰基获得腈，或另外代9-氰基用羧基，酯或酰胺。这些化合物可以模拟仅BH3蛋白竞争性结合和拮抗的Bcl-2和Bcl-X L和Mcl-1的蛋白在体外或胞外，以诱导细胞凋亡。的环糊精包合化合物和络合物可以提高效果。因此，它们都可以在抗癌化合物的制造中使用。

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