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1. 发明公开

EP3021119A4 METHOD FOR DIAGNOSIS OF DISEASES USING MORPHOLOGICAL CHARACTERISTICS OF LUTERIAL 审中-公开
标题翻译：方法的疾病诊断中的应用LUTERIAL的形态特征
公开(公告)号：EP3021119A4
公开(公告)日：2017-04-19
申请号：EP14823421
申请日：2014-01-14
申请人： KWON YOUNG AH , CHOI WON CHEOL , CHOI SUK HOON , CHOI CHANG HOON
发明人： KWON YOUNG AH , CHOI WON CHEOL , CHOI SUK HOON , CHOI CHANG HOON
IPC分类号： G01N33/53 , A61K35/12 , C12N5/07 , G01N33/48 , G01N33/58
CPC分类号： G01N33/5091 , A61K35/00 , C12N5/00 , G01N2800/50 , G01N2800/52 , G01N2800/7028

2. 发明公开

EP3095875A1 LUTERIAL AND METHOD FOR ISOLATING AND CULTURING SAME 审中-公开
标题翻译： LUTERIAL UND VERFAHREN ZUR ISOLIERUNG UND KULTIVIERUNG DAVON
公开(公告)号：EP3095875A1
公开(公告)日：2016-11-23
申请号：EP14878548.8
申请日：2014-05-09
申请人： Choi, Won Cheol , Kwon, Young Ah , Choi, Chang Hoon , Choi, Suk Hoon
发明人： CHOI, Won Cheol , KWON, Young Ah , CHOI, Suk Hoon , CHOI, Chang Hoon , KWON, Sung Pil , JUN, Hyun Jung
IPC分类号： C12Q1/24 , C12N1/00
CPC分类号： A61K35/19 , A61K35/12 , C12N5/0634 , C12N13/00 , C12N2529/00
摘要： The present invention relates to blood-derived luterial and a method for isolating and culturing the same. The luterial according to the present invention is a cell or cell-like structure having the following characteristics: (1) it is present in body fluids, including blood, sperm, intestinal juices, saliva, and cellular fluids; (2) it shows a positive staining with Janus green B, Acridine Orange and Rhodamine 123 in an immunofluorescence test; (3) in an optimal environment (pH 7.2-7.4), it has the property of expressing the genes homologous to beta-proteobacteria and gamma-proteobacteria, and has a size of 30-800 nm; (4) in an acidic environment, it has the property of expressing not only the genes homologous to beta-proteobacteria and gamma-proteobacteria, but also eukaryote-derived genes (particularly Streptophyta gene), and grows to a size ranging from 400 nm or more to 2000 nm or more; (5) it is involved in ATP production under normal conditions; and (6) it differs from mitochondria, completely differs from exosomes, and has fusion characteristics corresponding to those of an intermediary between a prokaryote and an eukaryote.
摘要翻译：本发明涉及血液来源的氘化物及其分离培养方法。根据本发明的氘是具有以下特征的细胞或细胞样结构：（1）其存在于体液中，包括血液，精子，肠液，唾液和细胞液; （2）在免疫荧光试验中显示了Janus绿B，吖啶橙和罗丹明123的阳性染色; （3）在最佳环境（pH 7.2-7.4）中，具有表达与β-变形杆菌和γ-变形杆菌同源的基因的特性，其尺寸为30-800nm; （4）在酸性环境中，具有不仅表达与β-变形杆菌和γ-变形杆菌同源的基因，而且表达真核生物来源的基因（特别是链牙菌基因），并且生长至400nm或多达2000nm以上; （5）在正常条件下参与ATP生产; 和（6）它不同于线粒体，完全不同于外来体，具有与原核生物与真核生物之间的中间体相应的融合特征。

3. 发明公开

EP3096141A1 METHOD FOR SCREENING CANCER PREVENTION AGENT OR ANTICANCER AGENT USING MORPHOLOGICAL CHARACTERISTICS OF LUTERIAL 审中-公开
标题翻译：方法对癌症预防剂或抗恶性肿瘤药通过形态学特征LUTERIAL的筛选
公开(公告)号：EP3096141A1
公开(公告)日：2016-11-23
申请号：EP15737047.9
申请日：2015-01-14
申请人： Choi, Won Cheol , Kwon, Young Ah , Choi, Suk Hoon , Choi, Chang Hoon
发明人： CHOI, Won Cheol , KWON, Young Ah , CHOI, Suk Hoon , CHOI, Chang Hoon , KWON, Sung Pil , JUN, Hyun Jung
IPC分类号： G01N33/574 , G01N33/53 , G01N33/48
CPC分类号： G01N33/5026 , G01N27/26 , G01N33/5011 , G01N33/5044 , G01N33/5076 , G01N33/5097 , G01N33/5432 , G01N2500/10
摘要： The present invention relates to a method for screening an anticancer agent or a cancer preventive agent, comprising the steps of: (a) isolating mutant luterial or normal luterial from a body fluid extracted from a patient or a normal person; (b) treating the isolated mutant luterial with anticancer agent candidates or cancer preventive agent candidates; and (c) either selecting, as the anticancer agent, a candidate that reduces the size or changes the shape or increases the mobility of the mutant luterial, compared to the control mutant luterial upon treatment with the candidate, or selecting, as the cancer preventive agent, a candidate that suppresses the increase in size, minimizes the change in shape or maintains the mobility of luterial, compared to the control luterial, upon treatment with the candidate.
摘要翻译：本发明涉及一种用于抗癌剂或癌症预防剂的筛选方法，包括以下步骤：（a）分离自患者或正常人中提取的体液突变luterial或正常luterial; （b）用抗癌剂的候选人或癌症预防剂候补的分离的突变luterial; 和（c）任一选择，作为抗癌剂，候选并减小了尺寸或改变形状或增加突变luterial的流动性，相对于在与所述候选或选择治疗控制突变体luterial，作为癌症的预防剂，候选确实抑制尺寸增加，最小化形状变化或保持luterial的流动性，与对照相比luterial，在与所述候选治疗。

4. 发明公开

EP3095875A4 LUTERIAL AND METHOD FOR ISOLATING AND CULTURING SAME 审中-公开
公开(公告)号：EP3095875A4
公开(公告)日：2018-01-03
申请号：EP14878548
申请日：2014-05-09
申请人： CHOI WON CHEOL , KWON YOUNG AH , CHOI CHANG HOON , CHOI SUK HOON
发明人： CHOI WON CHEOL , KWON YOUNG AH , CHOI SUK HOON , CHOI CHANG HOON
IPC分类号： C12Q1/24 , A61K35/12 , A61P35/00 , C12N1/00
CPC分类号： A61K35/19 , A61K35/12 , C12N5/0634 , C12N13/00 , C12N2529/00
摘要： The present invention relates to blood-derived luterial and a method for isolating and culturing the same. The luterial according to the present invention is a cell or cell-like structure having the following characteristics: (1) it is present in body fluids, including blood, sperm, intestinal juices, saliva, and cellular fluids; (2) it shows a positive staining with Janus green B, Acridine Orange and Rhodamine 123 in an immunofluorescence test; (3) in an optimal environment (pH 7.2-7.4), it has the property of expressing the genes homologous to beta-proteobacteria and gamma-proteobacteria, and has a size of 30-800 nm; (4) in an acidic environment, it has the property of expressing not only the genes homologous to beta-proteobacteria and gamma-proteobacteria, but also eukaryote-derived genes (particularly Streptophyta gene), and grows to a size ranging from 400 nm or more to 2000 nm or more; (5) it is involved in ATP production under normal conditions; and (6) it differs from mitochondria, completely differs from exosomes, and has fusion characteristics corresponding to those of an intermediary between a prokaryote and an eukaryote.

5. 发明公开

EP3096141A4 METHOD FOR SCREENING CANCER PREVENTION AGENT OR ANTICANCER AGENT USING MORPHOLOGICAL CHARACTERISTICS OF LUTERIAL 审中-公开
标题翻译： VERFAHREN ZUM筛选VON KREBSPRVVENTIONSMITTELN ODER ANTIKREBSMITTELN MITTELS MORPHOLOGISCHER EIGENSCHAFTEN VON LUTERIAL
公开(公告)号：EP3096141A4
公开(公告)日：2017-09-06
申请号：EP15737047
申请日：2015-01-14
申请人： CHOI WON CHEOL , KWON YOUNG AH , CHOI SUK HOON , CHOI CHANG HOON
发明人： CHOI WON CHEOL , KWON YOUNG AH , CHOI SUK HOON , CHOI CHANG HOON
IPC分类号： G01N33/574 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/543
CPC分类号： G01N33/5026 , G01N27/26 , G01N33/5011 , G01N33/5044 , G01N33/5076 , G01N33/5097 , G01N33/5432 , G01N2500/10

6. 发明公开

EP3021119A1 METHOD FOR DIAGNOSIS OF DISEASES USING MORPHOLOGICAL CHARACTERISTICS OF LUTERIAL 审中-公开
标题翻译： VERFAHREN ZUR DIAGNOSE VON KRANKHEITEN MITTELS MORPHOLOGISCHER EIGENSCHAFTEN VON LUTERIAL
公开(公告)号：EP3021119A1
公开(公告)日：2016-05-18
申请号：EP14823421.4
申请日：2014-01-14
申请人： Kwon, Young Ah , Choi, Won Cheol , Choi, Suk Hoon , Choi, Chang Hoon
发明人： KWON, Young Ah , CHOI, Won Cheol , CHOI, Suk Hoon , CHOI, Chang Hoon , KWON, Sung Pil , JUN, Hyun Jung
IPC分类号： G01N33/53 , G01N33/58 , G01N33/48
CPC分类号： G01N33/5091 , A61K35/00 , C12N5/00 , G01N2800/50 , G01N2800/52 , G01N2800/7028
摘要： The present invention relates to a method for diagnosis of diseases using morphological characteristics of luterial which exists in blood. According to the present invention, morphological characteristics of luterial, such as the number, size or shape, and movement (nano-tracking speed) thereof change according to the kind and progress of a disease, and thus diagnosis and prognosis of a disease (particularly, cancer) can be effectively determined by observing and measuring the characteristics of luterial in the blood.
摘要翻译：本发明涉及使用存在于血液中的氘血的形态特征来诊断疾病的方法。根据本发明，根据疾病的种类和进展，诸如数量，大小或形状以及运动（纳米跟踪速度）等特征的形态学特征因疾病的诊断和预后而变化（特别是，癌症）可以通过观察和测量血液中氘血的特征来有效地确定。

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