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1. 发明公开

EP3943158A1 AGENT TARGETING DOUBLE-MEMBRANE ORGANELLE DNA 审中-实审转让
公开(公告)号：EP3943158A1
公开(公告)日：2022-01-26
申请号：EP20773944.2
申请日：2020-03-19
申请人： CHIBA PREFECTURE
发明人： NAGASE Hiroki , WATANABE Takayoshi , KOSHIKAWA Nobuko , YASUI Nanami
IPC分类号： A61P35/00 , A61P43/00 , C12N15/11 , C12Q1/68 , G01N33/53 , A61K31/785
摘要： The present invention provides a drug for a pathological condition including mitochondria-related disease by a conjugate of a double-membrane organelle DNA sequence recognizing compound and a double-membrane organelle localizable compound. The present invention provides a conjugate in which a double-membrane organelle localizable lipophilic cation is attached to linear PI polyamide that specifically binds to a double-membrane organelle DNA sequence, a linear PI polyamide-TPP conjugate targeting the mitochondrial DNA mutation or polymorphism, comprising the conjugate, and a pharmaceutical composition comprising the conjugate.

2. 发明公开

EP3078661A1 NOVEL ALKYLATING AGENT FOR ALKYLATING TARGET WITH DRIVER ONCOGENE MUTATION 无效转让
标题翻译：新型烷化剂为靶的烷基化与驱动器ONKOGENMUTATION
公开(公告)号：EP3078661A1
公开(公告)日：2016-10-12
申请号：EP14851833.5
申请日：2014-10-14
申请人： CHIBA PREFECTURE , Kyoto University
发明人： NAGASE, Hiroki , SUGIYAMA, Hiroshi , BANDO, Toshikazu
IPC分类号： C07D403/14 , A61K31/403 , A61K47/34 , A61K47/48 , A61P35/00 , C08L77/00 , C12N15/09
CPC分类号： A61K47/48207 , A61K47/64 , C07D403/14 , C08G73/0611 , C08G73/0616
摘要： The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.

3. 发明公开

EP2264462A1 METHOD FOR SCREENING OF THERAPEUTIC AGENT FOR CANCER 有权
标题翻译：筛选 - 维尔芬FÜREIN治疗MITTEL GEGEN KREBS
公开(公告)号：EP2264462A1
公开(公告)日：2010-12-22
申请号：EP09718200.0
申请日：2009-02-27
申请人： Hisamitsu Pharmaceutical Co., Inc. , Chiba-Prefecture
发明人： NAKAGAWARA, Akira , TAKATORI, Atsushi
IPC分类号： G01N33/574 , C07K16/28 , G01N33/15 , G01N33/50 , A61K45/00 , A61P35/00 , C12N15/09 , C12Q1/02
CPC分类号： G01N33/574 , C07K16/18 , C07K16/2863 , G01N33/5011 , G01N2333/71 , G01N2500/00
摘要： A screening method for a therapeutic agent for cancer, the method including: a step of measuring an interaction between NLRR1 and EGFR under each condition of being in the presence of a test substance and in the absence of a test substance; and a step of determining that the test substance is a therapeutic agent for cancer when the interaction between NLRR1 and EGFR in the presence of the test substance is weaker than the interaction between NLRR1 and EGFR in the absence of the test substance.
摘要翻译：一种癌症治疗剂的筛选方法，所述方法包括：在存在测试物质的情况下和在不存在测试物质的条件下测量NLRR1与EGFR之间相互作用的步骤; 在测试物质存在的情况下当NLRR1和EGFR之间的相互作用弱于NLRR1和EGFR之间的相互作用时，确定测试物质是癌症治疗剂的步骤。

4. 发明授权

EP1795597B1 Nucleic acids isolated from a neuroblastoma 有权
标题翻译：从成神经细胞瘤分离的核酸
公开(公告)号：EP1795597B1
公开(公告)日：2010-08-18
申请号：EP06017801.9
申请日：2002-05-30
申请人： Chiba-Prefecture , Hisamitsu Pharmaceutical Co., Inc.
发明人： Nakagawara, Akira
IPC分类号： C12N15/12 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/47

5. 发明公开

EP2204177A1 Cancer marker and therapeutic agent for cancer 有权
标题翻译： Krebsmarker und TherapeutikumfürKrebs
公开(公告)号：EP2204177A1
公开(公告)日：2010-07-07
申请号：EP09177321.8
申请日：2009-11-27
申请人： Hisamitsu Pharmaceutical Co., Inc. , CHIBA PREFECTURE
发明人： Tatsumi, Yasutoshi , Nakagawara, Akira
IPC分类号： A61K31/713 , C12Q1/68 , C12N15/113
CPC分类号： G01N33/57434 , A61K31/7105 , A61K31/713 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G01N33/57407 , G01N33/57423 , G01N33/57442 , G01N33/57446 , G01N2333/4707
摘要： A novel cancer marker is provided. A method for detecting cancer using a level of BMCC1 gene expression as an indication is provided, in which the cancer is selected from the group consisting of prostate cancer, lung cancer, gastric cancer, bladder cancer, and uterine cancer.
摘要翻译：提供了一种新的癌症标志物。提供了使用BMCC1基因表达水平作为指标检测癌症的方法，其中癌症选自前列腺癌，肺癌，胃癌，膀胱癌和子宫癌。

6. 发明授权

EP1739186B1 METHOD OF SCREENING COMPOUND CAPABLE OF ACCELERATING OR INHIBITING APOPTOSIS, APOPTOSIS ACCELERATOR AND APOPTOSIS INHIBITOR 有权
标题翻译：方法筛选加速或抑制细胞凋亡功能的链接凋亡加速器和凋亡的抑制剂
公开(公告)号：EP1739186B1
公开(公告)日：2009-09-30
申请号：EP05727106.6
申请日：2005-03-23
申请人： Hisamitsu Pharmaceutical Co., Inc. , Chiba-Prefecture
发明人： NAKAGAWARA, Akira, Chiba Cancer Ctr Research Inst. , OZAKI, Toshifumi, Chiba Cancer Ctr Research Inst.
IPC分类号： C12Q1/02 , A61K38/00 , A61K48/00 , A61P35/00 , C12Q1/48 , G01N33/15 , G01N33/50 , C12N15/09
CPC分类号： G01N33/502 , A61K38/00 , C07K14/4747 , G01N33/5008 , G01N2510/00
摘要： A method of screening a compound capable of accelerating apoptosis, comprising the judging step of judging a compound capable of intensifying the interaction between p73 and IKK-alpha as a compound capable of accelerating apoptosis.

7. 发明公开

EP1939292A3 Nucleic acids isolated in neuroblastoma 有权
标题翻译：神经母细胞瘤分离的核酸
公开(公告)号：EP1939292A3
公开(公告)日：2008-10-08
申请号：EP07006078.5
申请日：2002-05-30
申请人： Chiba-Prefecture , HISAMITSU PHARMACEUTICAL CO. INC.
发明人： Nakagawara, Akira
IPC分类号： C12N15/12 , C07K14/47 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/47
摘要： There are disclosed a nucleic acid whose expression is enhanced in human neuroblastoma with unfavorable prognosis based on comparison between human neuroblastoma with favorable prognosis and human neuroblastoma with unfavorable prognosis, the nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:69 in the Sequence Listing, a nucleic acid comprising a portion of any of those base sequences, and an isolated nucleic acid capable of hybridizing to a complementary base sequence of the foregoing under stringent conditions. It discloses gene sequences relating to favorable or unfavorable prognosis of neuroblastoma and will enable the provision of their genetic information and the diagnosis of favorable or unfavorable prognosis.

8. 发明公开

EP1792990A3 Nucleid acids isolated in neuroblastoma 有权
标题翻译：神经母细胞瘤分离的核酸
公开(公告)号：EP1792990A3
公开(公告)日：2007-08-22
申请号：EP07006077.7
申请日：2002-05-30
申请人： Chiba-Prefecture , HISAMITSU PHARMACEUTICAL CO. INC.
发明人： Nakagawara, Akira
IPC分类号： C12N15/12 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/47
摘要： There are disclosed a nucleic acid whose expression is enhanced in human neuroblastoma with unfavorable prognosis based on comparison between human neuroblastoma with favorable prognosis and human neuroblastoma with unfavorable prognosis, the nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:69 in the Sequence Listing, a nucleic acid comprising a portion of any of those base sequences, and an isolated nucleic acid capable of hybridizing to a complementary base sequence of the foregoing under stringent conditions. It discloses gene sequences relating to favorable or unfavorable prognosis of neuroblastoma and will enable the provision of their genetic information and the diagnosis of favorable or unfavorable prognosis.

9. 发明公开

EP1795597A2 Nucleic acids isolated in neuroblastoma 有权
标题翻译：在神经母细胞瘤中分离的核酸
公开(公告)号：EP1795597A2
公开(公告)日：2007-06-13
申请号：EP06017801.9
申请日：2002-05-30
申请人： Chiba-Prefecture , Hisamitsu Pharmaceutical Co., Inc.
发明人： Nakagawara, Akira
IPC分类号： C12N15/12 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/47
摘要： There are disclosed a nucleic acid whose expression is enhanced in human neuroblastoma with favorable prognosis based on comparison between human neuroblastoma with favorable prognosis and human neuroblastoma with unfavorable prognosis, the nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:366 in the Sequence Listing, a nucleic acid comprising a portion of any of those base sequences, and an isolated nucleic acid capable of hybridizing to a complementary base sequence of the foregoing under stringent conditions. It discloses gene sequences relating to favorable or unfavorable prognosis of neuroblastoma and will enable the provision of their genetic information and the diagnosis of favorable or unfavorable prognosis.
摘要翻译：公开了一种核酸，其基于具有良好预后的人成神经细胞瘤和具有不良预后的人神经母细胞瘤之间的比较而在人神经母细胞瘤中表达增强并具有良好预后，所述核酸包含SEQ ID NO：1至SEQ ID NO：1中列出的碱基序列中的任一个序列表中的序列号366，包含任何那些碱基序列的一部分的核酸，以及能够在严格条件下与上述的互补碱基序列杂交的分离的核酸。它公开了与神经母细胞瘤的有利或不利预后有关的基因序列，并且将能够提供它们的遗传信息和对有利或不利预后的诊断。

10. 发明公开

EP1580265A4 NUCLEIC ACIDS ISOLATED FROM NEUROBLASTOMA AT STAGE 4S 有权
标题翻译：从A阶段，神经母细胞瘤4S分离核酸
公开(公告)号：EP1580265A4
公开(公告)日：2006-08-30
申请号：EP03770029
申请日：2003-10-30
申请人： HISAMITSU PHARMACEUTICAL CO , CHIBA PREFECTURE
发明人： NAKAGAWARA AKIRA , OHIRA MIKI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N37/00 , G01N33/50
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Prognosis (in particular, determination of the progress stage and judgment of neuroblastoma at stage 4s) of neuroblastoma is diagnosed by using a diagnostic agent for the prognosis of neuroblastoma and a diagnostic kit comprising a nucleic acid probe, a primer or a nucleic acid microarry with the use of a nucleic acid comprising a sequence selected from among the nucleic acid sequences represented by SEQ ID NOS:1 to 174, fragments thereof and combinations of the same.

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