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1. 发明公开

EP1476525A4 LED ARRAY FOR ILLUMINATING CELL WELL PLATES AND AUTOMATED RACK SYSTEM FOR HANDLING THE SAME 审中-公开
标题翻译：照明ZELLENNÄPFCHENPLATTEN作者：LED阵列和IT机架系统的自动处理
公开(公告)号：EP1476525A4
公开(公告)日：2008-05-21
申请号：EP03711099
申请日：2003-02-18
申请人： BIOLEX INC
发明人： EVERETT KEITH
IPC分类号： A01H4/00 , C10H21/00 , A01G7/04 , A01G31/06 , A01N1/00 , B01L9/00 , C12M1/00 , C12M1/20 , C12M1/22 , C12M1/34 , C12M3/00 , F21S2/00 , F21V19/00 , F21W131/40 , F21Y101/02
CPC分类号： A01G7/04 , A01G31/06 , B01L9/523 , B01L2300/0829 , C12M21/02 , C12M23/12 , C12M23/48 , C12M31/10 , Y02P60/216 , Y10S47/08
摘要： An assembly (10) for promoting the growth of plant tissues that includes a plurality of plates (12) each defining an array of wells (13) wherein each of the wells (13) contains a tissue sample. Support for the plates (12) is provided by a rack (20) having a plurality of vertically stacked shelves (23) that may include one or more register depressions (26) that urge the plates into predetermined positions. Light for the tissue samples is provided by a plurality of light-emitting diode arrays (30) each mounted on a circuit board (31). Each circuit board (31) is supported by a respective card edge connector (24) of the rack (20) so that the light-emitting diodes (30) are in proximity to the plates (12) supported on one of the shelves (23) therebelow. Preferably, the light-emitting diode array (30) corresponds to the well array supported in the registered position on the shelf (23) therebelow so that each light-emitting diode (30) is centered above a respective one of the wells (13).

2. 发明公开

EP1397676A4 USE OF DUCKWEED IN HIGH THROUGHPUT SCREENING 有权
标题翻译： VERWENDUNG DER WASSERLINSE BEIM HOCHDURCHSATZ-SCREENING
公开(公告)号：EP1397676A4
公开(公告)日：2004-06-23
申请号：EP02726945
申请日：2002-05-30
申请人： BIOLEX INC
发明人： STOMP ANNE-MARIE , DICKEY LYNN , HOUGHTELING BILLY , RAJBHANDARI NIRMALA
IPC分类号： G01N33/68 , C12N15/09 , C12N15/82 , C12Q1/02 , C12Q1/68 , G01N33/48 , G01N33/50
CPC分类号： G01N33/5097 , C12N15/8257 , C12Q1/6897
摘要： Methods for high-throughput screening in duckweed are disclosed. In one aspect, these methods are used to identify nucleotide sequences encoding polypeptides of interest. In another aspect, these methods are used to identify nucleotide sequences that modulate the expression of a target nucleotide sequence. The methods combine the predictive benefits of screening in whole plants with the speed and efficiency of a high throughput system.
摘要翻译：披露了浮萍中高通量筛选的方法。一方面，这些方法用于鉴定编码目的多肽的核苷酸序列。另一方面，这些方法用于鉴定调节靶核苷酸序列表达的核苷酸序列。这些方法将整个工厂筛选的预测效益与高通量系统的速度和效率相结合。

3. 发明公开

EP1713921A2 EXPRESSION OF PLASMINOGEN AND MICROPLASMINOGEN IN DUCKWEED 审中-公开
标题翻译：表达的MIKROPLASMINOGEN LENS纤溶酶和水
公开(公告)号：EP1713921A2
公开(公告)日：2006-10-25
申请号：EP05722918.9
申请日：2005-02-11
申请人： Biolex, Inc.
发明人： SPENCER, David , DICKEY, Lynn, F. , GASDASKA, John, R. , WANG, Xiaowei , COX, Kevin, M. , PEELE, Charles, G.
IPC分类号： C12N15/82
CPC分类号： C12N15/8257 , C12N9/6435 , C12Y304/21007
摘要： The present invention provides methods and compositions for the production of recombinant plasminogen, microplasminogen, and fragments thereof in a duckweed expression system. It is the novel finding of the present invention that a duckweed expression system may be used to produce high levels of plasminogen and microplasminogen. The duckweed-produced plasminogen and microplasminogen can be activated to produce a polypeptide having protease activity. Thus, the invention encompasses methods for the expression of plasminogen, microplasminogen, and fragments thereof in duckweed, duckweed plants that are transformed with expression cassettes for the expression of plasminogen, microplasminogen, and fragments thereof, and nucleic acids comprising nucleotide sequences encoding plasminogen, microplasminogen, and fragments thereof, where these nucleotide sequences are modified to enhance their expression in duckweed.

4. 发明公开

EP1631658A2 BIOREACTOR FOR GROWING BIOLOGICAL MATERIALS SUPPORTED ON A LIQUID SURFACE 审中-公开
标题翻译：生物反应器园艺BY在液体表面上承载的生物材料
公开(公告)号：EP1631658A2
公开(公告)日：2006-03-08
申请号：EP04753293.2
申请日：2004-05-25
申请人： Biolex, Inc.
发明人： BRANSON, R., Edward , EVERETT, Keith , HESTER, Bob , VICKERS, Timothy, B.
IPC分类号： C12M1/00
CPC分类号： C12M21/02 , C12M23/14 , C12M23/24 , C12M23/44 , C12M23/48 , Y10S47/06
摘要： A bioreactor assembly (10) of the present invention for holding a media and supporting growth of a plurality of plants. The assembly includes a light source (13) and a container (11)having a light transmissive wall structure and defining a reservoir. A major axis of the reservoir is substantially horizontal allowing the reservoir to be filled with media to a partial level and to define a relatively large surface area for support of the plants. The assembly may also include clamps (40) to secure and seal separate wall structure portions of the container together, and end caps to the wall portions, to define an aseptic environment. As another option, the clamps may define openings therethrough that allow passage of various devices for measuring and controlling bioreactor function such as a gas supply nozzle, a gas exit nozzle, an air temperature probe, a pH probe, a sampling drain, a gas composition probe and a media temperature probe.

5. 发明公开

EP1925660A1 Bioreactor for growing biological materials supported on a liquid surface 审中-公开
标题翻译： Bioreaktor zurZüchtung生物学家Materialien auf einerflüssigenOberfläche
公开(公告)号：EP1925660A1
公开(公告)日：2008-05-28
申请号：EP08004456.3
申请日：2004-05-25
申请人： Biolex, Inc.
发明人： Branson, Edward, R. , Everett, Keith , Hester, Bob , Vickers, Timothy, B.
IPC分类号： C12M1/00
CPC分类号： C12M23/44 , C12M21/02 , C12M23/14 , C12M23/24 , C12M23/48
摘要： A bioreactor assembly (10) of the present invention for holding a media and supporting growth of a plurality of plants. The assembly includes a light source (13) and a container (11) having a flexible light transmissive wall structure and defining a reservoir. A major axis of the reservoir is substantially horizontal allowing the reservoir to be filled with media to a partial level and to define a relatively large surface area for support of the plants. The assembly may also include clamps (40) to secure and seal separate wall structure portions of the container together, and end caps to the wall portions, to define an aseptic environment. As another option, the clamps may define openings therethrough that allow passage of various devices for measuring and controlling bioreactor function such as a gas supply nozzle, a gas exit nozzle, an air temperature probe, a pH probe, a sampling drain, a gas composition probe and a media temperature probe.
摘要翻译：本发明的生物反应器组件（10），用于保持介质并支持多个植物的生长。该组件包括光源（13）和具有柔性透光壁结构并限定储存器的容器（11）。储存器的主轴基本上是水平的，允许储存器被填充到局部水平的介质并且限定用于支撑植物的相对较大的表面积。组件还可以包括用于将容器的分离的壁结构部分固定并密封在一起的端盖（40），并将端盖封闭到壁部分以限定无菌环境。作为另一选择，夹具可以限定穿过其中的开口，其允许用于测量和控制生物反应器功能的各种装置的通过，例如气体供应喷嘴，气体出口喷嘴，空气温度探针，pH探针，取样排水管，气体组成探头和介质温度探头。

6. 发明授权

EP1427528B1 PLATE AND METHOD FOR HIGH THROUGHPUT SCREENING 有权
标题翻译： TEST DRIVE用于高通量筛选
公开(公告)号：EP1427528B1
公开(公告)日：2006-05-24
申请号：EP02731943.3
申请日：2002-05-29
申请人： Biolex, Inc.
发明人： EVERETT, Keith
IPC分类号： B01L3/00 , C12M1/20
CPC分类号： B01L3/50255 , B01L3/5025 , B01L3/5085 , B01L2200/026 , B01L2200/0642 , B01L2200/12 , B01L2300/0829 , B01L2400/049 , C12M25/04 , C12M33/06 , Y10T29/49996 , Y10T436/2575
摘要： A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir of fluid media and supports a tissue sample. The properties of the frit wick the fluid media upwards to supply the tissue sample with nutrients for growth and proliferation. Old media is aspirated from the wells by a liquid handling device which inserts a pipette tip into the aspiration holes. The pipette tip applies a suction pressure which draws the media out of the cell well, through the channel, into the aspiration hole and out through the pipette tip. New media is dispersed through the pipette tip and directly into the cell well.

7. 发明公开

EP1639114A2 CHLOROPLAST TRANSFORMATION OF DUCKWEED 审中-公开
标题翻译：水透镜体叶绿体转化
公开(公告)号：EP1639114A2
公开(公告)日：2006-03-29
申请号：EP04756479.4
申请日：2004-06-30
申请人： Biolex, Inc.
发明人： COX, Kevin, M. , PEELE, Charles, G.
IPC分类号： C12N15/82
CPC分类号： C12N15/8214
摘要： The present invention provides methods and compositions for the transformation of duckweed plastids. The compositions and methods of the invention are useful in increasing the recombinant protein production capacity of the duckweed expression system. The compositions of the invention include transformed duckweed plastids and transplastomic duckweed cells and plants, as well as nucleic acid constructs useful for transforming duckweed plastids. The invention also provides methods for introducing one or more heterologous nucleotide sequences into a duckweed plastome.

8. 发明公开

EP1476525A1 LED ARRAY FOR ILLUMINATING CELL WELL PLATES AND AUTOMATED RACK SYSTEM FOR HANDLING THE SAME 审中-公开
标题翻译：照明ZELLENNÄPFCHENPLATTEN作者：LED阵列和IT机架系统的自动处理
公开(公告)号：EP1476525A1
公开(公告)日：2004-11-17
申请号：EP03711099.6
申请日：2003-02-18
申请人： Biolex, Inc.
发明人： EVERETT, Keith
IPC分类号： C10H21/00 , A01N1/00 , C12M1/34 , C12M1/22
CPC分类号： A01G7/04 , A01G31/06 , B01L9/523 , B01L2300/0829 , C12M21/02 , C12M23/12 , C12M23/48 , C12M31/10 , Y02P60/216 , Y10S47/08
摘要： An assembly (10) for promoting the growth of plant tissues that includes a plurality of plates (12) each defining an array of wells (13) wherein each of the wells (13) contains a tissue sample. Support for the plates (12) is provided by a rack (20) having a plurality of vertically stacked shelves (23) that may include one or more register depressions (26) that urge the plates into predetermined positions. Light for the tissue samples is provided by a plurality of light-emitting diode arrays (30) each mounted on a circuit board (31). Each circuit board (31) is supported by a respective card edge connector (24) of the rack (20) so that the light-emitting diodes (30) are in proximity to the plates (12) supported on one of the shelves (23) therebelow. Preferably, the light-emitting diode array (30) corresponds to the well array supported in the registered position on the shelf (23) therebelow so that each light-emitting diode (30) is centered above a respective one of the wells (13).

9. 发明公开

EP1427528A2 PLATE AND METHOD FOR HIGH THROUGHPUT SCREENING 有权
标题翻译： TEST DRIVE用于高通量筛选
公开(公告)号：EP1427528A2
公开(公告)日：2004-06-16
申请号：EP02731943.3
申请日：2002-05-29
申请人： Biolex, Inc.
发明人： EVERETT, Keith
IPC分类号： B01L3/00 , C12M1/20
CPC分类号： B01L3/50255 , B01L3/5025 , B01L3/5085 , B01L2200/026 , B01L2200/0642 , B01L2200/12 , B01L2300/0829 , B01L2400/049 , C12M25/04 , C12M33/06 , Y10T29/49996 , Y10T436/2575
摘要： A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir of fluid media and supports a tissue sample. The properties of the frit wick the fluid media upwards to supply the tissue sample with nutrients for growth and proliferation. Old media is aspirated from the wells by a liquid handling device which inserts a pipette tip into the aspiration holes. The pipette tip applies a suction pressure which draws the media out of the cell well, through the channel, into the aspiration hole and out through the pipette tip. New media is dispersed through the pipette tip and directly into the cell well.

10. 发明公开

EP1397676A1 USE OF DUCKWEED IN HIGH THROUGHPUT SCREENING 有权
标题翻译：水镜头的高通量筛选
公开(公告)号：EP1397676A1
公开(公告)日：2004-03-17
申请号：EP02726945.5
申请日：2002-05-30
申请人： Biolex, Inc.
发明人： STOMP, Anne-Marie , DICKEY, Lynn , HOUGHTELING, Billy , RAJBHANDARI, Nirmala
IPC分类号： G01N33/48
CPC分类号： G01N33/5097 , C12N15/8257 , C12Q1/6897
摘要： Methods for high-throughput screening in duckweed are disclosed. In one aspect, these methods are used to identify nucleotide sequences encoding polypeptides of interest. In another aspect, these methods are used to identify nucleotide sequences that modulate the expression of a target nucleotide sequence. The methods combine the predictive benefits of screening in whole plants with the speed and efficiency of a high throughput system.

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