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1. 发明公开

EP3185919A1 IMPROVED OSTEOINDUCTIVE SUBSTRATES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：改进的导致骨质疏松的基质及其制备方法
公开(公告)号：EP3185919A1
公开(公告)日：2017-07-05
申请号：EP15759619.8
申请日：2015-08-28
申请人： Bioventus LLC
发明人： WILSON, Christopher G. , VANDERPLOEG, Eric J. , SEEHERMAN, Howard , DECKER, Zachary , SCHMIDT, Eric , MOORE, Bethany , HEUBECK, Alexander
IPC分类号： A61L27/46 , A61L27/54 , A61L27/56
CPC分类号： A61L27/44 , A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/24
摘要： Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule is loaded with an osteoinductive material, and then placed in contact with a biocompatible matrix material.
摘要翻译：提供了用于制备成骨诱导合成骨移植物的系统和方法，其中多孔陶瓷颗粒装载有骨诱导材料，然后放置成与生物相容性基质材料接触。

2. 发明授权

EP3240563B1 SYSTEMS AND METHODS FOR IMPROVED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR 有权
公开(公告)号：EP3240563B1
公开(公告)日：2020-12-09
申请号：EP15831262.9
申请日：2015-12-29
申请人： Bioventus LLC
发明人： VANDERPLOEG, Eric, J. , SEEHERMAN, Howard , WILSON, Christopher, G. , WOZNEY, John , BROWN, Christopher , KAMBOURIS, John
IPC分类号： A61K38/18 , A61K9/14 , A61L24/02 , A61L24/10

3. 发明公开

EP3468626A1 PROTEIN DELIVERY WITH POROUS METALLIC STRUCTURE 审中-公开
公开(公告)号：EP3468626A1
公开(公告)日：2019-04-17
申请号：EP17731451.5
申请日：2017-06-12
申请人： Bioventus LLC
发明人： WELCH, Jeffrey , VANDERPLOEG, Eric , WILSON, Christopher , WOZNEY, John
IPC分类号： A61L27/04 , A61L27/06 , A61L27/30 , A61L27/56

4. 发明公开

EP3240563A1 SYSTEMS AND METHODS FOR IMPROVED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR 有权
标题翻译：用于改善骨修复中的骨传导分子的系统和方法
公开(公告)号：EP3240563A1
公开(公告)日：2017-11-08
申请号：EP15831262.9
申请日：2015-12-29
申请人： Bioventus LLC
发明人： VANDERPLOEG, Eric, J. , SEEHERMAN, Howard , WILSON, Christopher, G. , WOZNEY, John , BROWN, Christopher , KAMBOURIS, John
IPC分类号： A61K38/18 , A61K9/14 , A61L24/02 , A61L24/10
CPC分类号： A61K38/17 , A61K33/06 , A61K38/1875 , A61L24/0015 , A61L24/0036 , A61L24/0084 , A61L24/02 , A61L27/12 , A61L27/446 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2430/02 , A61L2430/38 , A61K2300/00 , C08L89/06
摘要： Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

5. 发明公开

EP4061128A2 PLACENTAL TISSUE PARTICULATE COMPOSITIONS AND METHODS OF USE 审中-实审
公开(公告)号：EP4061128A2
公开(公告)日：2022-09-28
申请号：EP20888770.3
申请日：2020-11-13
申请人： Bioventus LLC , Musculoskeletal Transplant Foundation
发明人： PAVESIO, Alessandra , FLANNERY, Carl , SEAMAN, Scott , NASERT, Michael A. , SEMLER, Eric J. , LONG, Marc
IPC分类号： A01N1/02 , A61F2/02 , A61K35/50

6. 发明公开

EP3157861A1 METHOD FOR PRODUCING POROUS CALCIUM DEFICIENT HYDROXYAPATITE GRANULES 有权
标题翻译：生产多孔钙缺陷羟基磷灰石颗粒的方法
公开(公告)号：EP3157861A1
公开(公告)日：2017-04-26
申请号：EP14741187.0
申请日：2014-06-23
申请人： Mathys AG Bettlach , Bioventus LLC
发明人： DE GASPARO, Alex , VAN GARDEREN, Noémie , BOHNER, Marc , SEEHERMAN, Howard , VANDERPLOEG Eric
IPC分类号： C01B25/32
CPC分类号： C01B25/32 , A61K47/02 , C01P2004/61 , C01P2006/16
摘要： The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO
4
3- ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO
4
3- ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO
4
3- ions present in the first and second incubation is at least as large as the amount of SO
4
2- ions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.
摘要翻译：（a）将无水硫酸钙（CSA），二水合硫酸钙（CSD）或半水合硫酸钙（CSH）的颗粒置于碱性水溶液中孵育，以形成多孔钙缺乏的羟基磷灰石颗粒具有小于10且包含PO 4 3-离子的pH值; 由此无水硫酸钙（CSA），二水合硫酸钙（CSD）或半水硫酸钙（CSH）的颗粒包含具有最小平均直径3微米的互连孔; （b）用水洗涤步骤a）的温育后获得的颗粒; （c）干燥得到的缺钙羟基磷灰石多孔颗粒; 由此（d）在步骤a）的温育中存在的PO 4 3-离子的量至少与用于步骤（a）的颗粒的SO 4 2-离子的量相同。本发明获得的多孔缺钙羟基磷灰石颗粒可有目的地用作生物活性物质的载体，特别是用于蛋白质。

7. 发明公开

EP2257339A4 HARD TO REACH FRACTURE APPLICATOR STRAP 审中-公开
标题翻译：重型裂纹施加器带
公开(公告)号：EP2257339A4
公开(公告)日：2014-02-19
申请号：EP09714996
申请日：2009-02-27
申请人： BIOVENTUS LLC
发明人： CONNER CRAIG PATRICK , CORS MARK W , DARLEY JESSE CHARLES , GUSE MICHAEL JOHN , LATHAM STEPHEN ANDREW , SPLAN JASON , REBACK NICHOLAS SCOTT , WILLIAMS KEVIN ALAN
IPC分类号： A61N7/00 , A61F13/00 , A61H23/00
CPC分类号： A61H23/0245 , A61F13/00025 , A61F13/00034 , A61F2013/00187 , A61F2013/00544 , A61F2013/00919 , A61H2201/165 , A61N7/00 , A61N2007/0013

8. 发明公开

EP3368094A1 MATRIX FOR ENHANCED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR 有权
公开(公告)号：EP3368094A1
公开(公告)日：2018-09-05
申请号：EP16794490.9
申请日：2016-10-31
申请人： Bioventus LLC
发明人： VANDERPLOEG, Eric , SEEHERMAN, Howard , WILSON, Christopher, G. , WOZNEY, John , BROWN, Christopher, Todd
IPC分类号： A61L27/46 , A61L27/56 , A61L24/00 , A61L27/54
CPC分类号： A61L27/56 , A61L24/0015 , A61L24/0036 , A61L24/0073 , A61L27/10 , A61L27/24 , A61L27/46 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/02
摘要： Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

9. 发明公开

EP3365358A1 IMPROVED PURIFICATION OF TGF-BETA SUPERFAMILY PROTEINS 审中-公开
公开(公告)号：EP3365358A1
公开(公告)日：2018-08-29
申请号：EP16798850.0
申请日：2016-10-21
申请人： Bioventus, LLC
发明人： BROWN, Christopher, T. , ROBERTSON, Patrick, D. , KINGSLEY, Eugene , CARONNA, Anthony
IPC分类号： C07K14/51 , C07K1/20
CPC分类号： C07K14/51 , B01D15/327 , B01D15/3804 , B01D15/424 , C07K1/20 , C07K14/495
摘要： Methods of purifying TGF-β superfamily proteins, including osteogenic proteins such as bone morphogenetic proteins (BMPs), are disclosed.

10. 发明公开

EP3157862A1 METHOD FOR PRODUCING POROUS CALCIUM DEFICIENT HYDROXYAPATITE GRANULES 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VONPORÖSEMCALCIUMARMEM HYDROXYAPATITGRANULATE
公开(公告)号：EP3157862A1
公开(公告)日：2017-04-26
申请号：EP15733330.3
申请日：2015-06-22
申请人： Mathys AG Bettlach , Bioventus LLC
发明人： DE GASPARO, Alex , VAN GARDEREN, Noémie , BOHNER, Marc , SEEHERMAN, Howard , VANDERPLOEG, Eric
IPC分类号： C01B25/32
CPC分类号： C01B25/32 , A61K47/02 , C01P2004/61 , C01P2006/16
摘要： The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO
4
3- ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO
4
3- ions present in the incubation of step a) is at least as large as the amount of SO
4
2- ions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.
摘要翻译：该方法用于生产多孔缺钙羟基磷灰石颗粒，包括以下步骤：（a）使无水硫酸钙（CSA），硫酸钙二水合物（CSD）或半水合硫酸钙（CSH）的颗粒，包含互连孔的颗粒与最小平均直径为3微米，首先在pH值小于10的碱性水溶液中孵育并含有PO43-离子; （b）使所述颗粒在pH值大于10的碱性水溶液和任选的PO43-离子中进行第二次温育; （c）过滤并干燥得到的缺钙羟基磷灰石多孔颗粒; 并且其中（d）在第一和第二温育中存在的PO43-离子的量的总和至少与用于步骤（a）的颗粒的SO42-离子的量一样大。通过本发明获得的多孔缺钙羟基磷灰石颗粒可有目的地用作生物活性物质的载体，特别是蛋白质。

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