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1. 发明公开

EP3157862A1 METHOD FOR PRODUCING POROUS CALCIUM DEFICIENT HYDROXYAPATITE GRANULES 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VONPORÖSEMCALCIUMARMEM HYDROXYAPATITGRANULATE
公开(公告)号：EP3157862A1
公开(公告)日：2017-04-26
申请号：EP15733330.3
申请日：2015-06-22
申请人： Mathys AG Bettlach , Bioventus LLC
发明人： DE GASPARO, Alex , VAN GARDEREN, Noémie , BOHNER, Marc , SEEHERMAN, Howard , VANDERPLOEG, Eric
IPC分类号： C01B25/32
CPC分类号： C01B25/32 , A61K47/02 , C01P2004/61 , C01P2006/16
摘要： The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO
4
3- ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO
4
3- ions present in the incubation of step a) is at least as large as the amount of SO
4
2- ions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.
摘要翻译：该方法用于生产多孔缺钙羟基磷灰石颗粒，包括以下步骤：（a）使无水硫酸钙（CSA），硫酸钙二水合物（CSD）或半水合硫酸钙（CSH）的颗粒，包含互连孔的颗粒与最小平均直径为3微米，首先在pH值小于10的碱性水溶液中孵育并含有PO43-离子; （b）使所述颗粒在pH值大于10的碱性水溶液和任选的PO43-离子中进行第二次温育; （c）过滤并干燥得到的缺钙羟基磷灰石多孔颗粒; 并且其中（d）在第一和第二温育中存在的PO43-离子的量的总和至少与用于步骤（a）的颗粒的SO42-离子的量一样大。通过本发明获得的多孔缺钙羟基磷灰石颗粒可有目的地用作生物活性物质的载体，特别是蛋白质。

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