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1. 发明授权

EP2586459B1 VEGF ANTAGONIST FORMULATIONS 有权
标题翻译： VEGF拮抗剂制剂
公开(公告)号：EP2586459B1
公开(公告)日：2017-05-24
申请号：EP13152402.7
申请日：2006-03-22
申请人： Regeneron Pharmaceuticals, Inc.
发明人： DIX, Daniel , FRYE, Kelly , KAUTZ, Susan
IPC分类号： A61K38/17 , A61K47/00
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4172 , A61K31/7012 , A61K38/16 , A61K38/179 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/22 , A61K47/26 , C07K14/71 , C07K16/22 , C07K2318/20 , C07K2319/30

2. 发明授权

EP1797172B1 CULTURING HUMAN EMBRYONIC STEM CELLS 有权
标题翻译：培养人胚胎干细胞
公开(公告)号：EP1797172B1
公开(公告)日：2017-04-19
申请号：EP05806471.8
申请日：2005-09-08
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： THOMSON, James, A. , LUDWIG, Tenneille
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N2500/12 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/40 , C12N2500/44 , C12N2500/46 , C12N2500/90 , C12N2500/98 , C12N2501/115 , C12N2501/15 , C12N2501/415 , C12N2501/845 , C12N2501/999 , C12N2533/52 , C12N2533/54

3. 发明授权

EP2455394B1 A family of pesticidal proteins and methods for their use 有权
标题翻译： Pestizidproteinfamilie und Verwendungsverfahrendafür
公开(公告)号：EP2455394B1
公开(公告)日：2017-04-12
申请号：EP11173106.3
申请日：2007-06-15
申请人： Athenix Corporation
发明人： Koziel, Michael, G , Desai, Nalini , Deter, Rebekah , Tomso, Daniel, John , Hargiss, Tracy , Duck, Nicholas, B. , Carozzi, Nadine , Guo, Rong
IPC分类号： C07K14/195 , C07K14/32 , C12N15/82
CPC分类号： C12N15/8286 , A01N37/44 , C07K14/325 , C12P21/02 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO: 13, 2, 4, 6, 7, 9, 11, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37 or 61, the nucleotide sequence set forth in SEQ ID NO: 12, 1, 3, 5, 8, 10, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 60, or the nucleotide sequence deposited in a bacterial host as Accession No. NRRL B-30961, B-30955, B-30956, B-30957, B-30958, B-30942, B-30939, B-30941, B-50047, B-30959, B-30960, B-30943, or B-50048, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀虫核酸分子。另外，包含对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO： 25,27,29,31,33,35,37或61所示的核苷酸序列，SEQ ID NO：12,3,3,5,8,10,14,16,18,20,22,24， 26,28,30,32,34,36或60个核苷酸序列，或作为保藏号NRRL B-30961，B-30955，B-30956，B-30957，B-30958，B -30942，B-30939，B-30941，B-50047，B-30959，B-30960，B-30943或B-50048，以及其变体和片段。

4. 发明公开

EP3150625A2 A FAMILY OF PESTICIDAL PROTEINS AND METHODS FOR THEIR USE 有权转让
标题翻译： VERFAHREN ZU DEREN VERWENDUNG的SCHÄDLINGSBEKÄMPFENDEPROTEINFAMILIE
公开(公告)号：EP3150625A2
公开(公告)日：2017-04-05
申请号：EP16194435.0
申请日：2007-06-15
申请人： Athenix Corporation
发明人： KOZIEL, Michael, G. , DESAI, Nalini , DETER, Rebekah , TOMSO, Daniel, John , HARGISS, Tracy , DUCK, Nicholas, B. , CAROZZI, Nadine , GUO, Rong
IPC分类号： C07K14/195 , C07K14/32 , C12N15/82
CPC分类号： C12N15/8286 , A01N37/44 , C07K14/325 , C12P21/02 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37 or 61, the nucleotide sequence set forth in SEQ ID NO: 1, 3, 5, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 60, or the nucleotide sequence deposited in a bacterial host as Accession No. NRRL B-30961, B-30955, B-30956, B-30957, B-30958, B-30942, B-30939, B-30941, B-50047, B-50047, B-30959, B-30960, B-30943, B-50048, or B-50048, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀虫核酸分子。另外，包含对应于多核苷酸的氨基酸序列。具体地说，本发明提供了分离的核酸分子，其包含编码SEQ ID NO： 25,27,29,31,33,35,37或61所示的核苷酸序列，如SEQ ID NO：1,3,5,8,10,12,14,16,18,20,22,24， 26,28,30,32,34,36或60个核苷酸序列，或作为保藏号NRRL B-30961，B-30955，B-30956，B-30957，B-30958，B -30942，B-30939，B-30941，B-50047，B-50047，B-30959，B-30960，B-30943，B-50048或B-50048，以及其变体和片段。

5. 发明公开

EP3147362A1 MULTIFUNCTIONAL ALLELES 有权
标题翻译： MULTIFUNKTIONS等位基因
公开(公告)号：EP3147362A1
公开(公告)日：2017-03-29
申请号：EP16196614.8
申请日：2010-10-29
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： ECONOMIDES, Aris N. , MURPHY, Andrew J. , LENGYEL, Peter Matthew , YANG, Peter H. A.
IPC分类号： C12N15/10 , C12N15/90
CPC分类号： C12N15/907 , A01K2217/15 , A01K2217/20 , C12N9/00 , C12N15/63 , C12N2800/30 , C12N2800/60 , C12N2840/44
摘要： Nucleic acid constructs and methods for rendering modifications to a genome are provided, wherein the modifications comprise null alleles, conditional alleles and null alleles comprising COINS. Multifunctional alleles (MFA) are provided, as well as methods for making them, which afford the ability in a single targeting to introduce an allele that can be used to generate a null allele, a conditional allele, or an allele that is a null allele and that further includes a COIN. MFAs comprise pairs of cognate recombinase recognition sites, an actuating sequence and/or a drug selection cassette, and a nucleotide sequence of interest, and a COIN, wherein upon action of a recombinase a conditional allele with a COIN is formed. In a further embodiment, action of a second recombinase forms an allele that contains only a COIN in sense orientation. In a further embodiment, action by a third recombinase forms an allele that contains only the actuating sequence in sense orientation.
摘要翻译：提供了核酸构建体和用于对基因组进行修饰的方法，其中所述修饰包括无效等位基因，条件等位基因和包含COINS的无效等位基因。提供多功能等位基因（MFA）以及制备它们的方法，其提供单次靶向引入可用于产生无效等位基因，条件等位基因或等位基因的等位基因的能力并且还包括一个COIN。 MFAs包括成对的同源重组酶识别位点，启动序列和/或药物选择盒，以及目的核苷酸序列和COIN，其中在重组酶的作用下，形成了具有COIN的条件等位基因。在另一个实施方案中，第二重组酶的作用形成仅包含正义取向的COIN的等位基因。在另一个实施方案中，由第三重组酶的作用形成仅含义义方向的致动序列的等位基因。

6. 发明公开

EP3135300A1 DISINTEGRATING PARTICLE COMPOSITION INCLUDING MICROFIBROUS CELLULOSE 有权
标题翻译： ZERFALLENDE PARTIKELZUSAMMENSETZUNG MIT MIKROFASRIGER CELLULOSE
公开(公告)号：EP3135300A1
公开(公告)日：2017-03-01
申请号：EP15783299.9
申请日：2015-04-07
申请人： Daicel Corporation
发明人： HIRAMURA, Takahiro , IKURA, Kiyoshi , ITAYA, Sae , OKABAYASHI, Tomohito , TAKIGAWA, Yoshihisa , SAKAGUCHI, Anan , HASHIKAWA, Naohiro
IPC分类号： A61K47/38 , A61K9/16 , A61K9/20 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36
CPC分类号： A61K9/16 , A61K9/20 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The purpose of the present invention is to provide a disintegrating tablet having excellent tablet hardness and disintegrability, which is suitable for pharmaceuticals and various kinds of foods such as supplemental foods, nutrition function foods and health foods has been desired as highly convenient forms which can safely be taken by patients who have difficulty in swallowing drugs, elderly people, children, etc., and which can easily be taken without water irrespective of places; and a disintegrative particulate composition comprised in the disintegrating tablet.
The present invention relates to a disintegrative particulate composition comprising a disintegrator component and micro-fibrillated cellulose, and a disintegrating tablet for pharmaceuticals or foods, comprising the disintegrative particulate composition, which has excellent tablet hardness and disintegrability.
摘要翻译：本发明的目的是提供一种片剂硬度和崩解性优异的崩解片，其适用于药品，作为补充食品，营养功能性食品，保健食品等各种食品，可以安全地使用由吞咽药物，老人，儿童等难以忍受的患者服用，无论身处何地，都可以轻松取水; 和包含在崩解片中的崩解性颗粒组合物。本发明涉及包含崩解剂组分和微原纤维化纤维素的崩解性颗粒组合物和包含崩解颗粒组合物的药物或食品的崩解片，其具有优异的片剂硬度和崩解性。

7. 发明授权

EP2582790B1 HUMAN BLOOD-BRAIN ENDOTHELIAL CELLS DERIVED FROM PLURIPOTENT STEM CELLS AND BLOOD-BRAIN BARRIER MODEL THEREOF 有权
标题翻译：人血脑内皮OFF多能干细胞和血 - 脑SCHRANKEMODELL THEREOF
公开(公告)号：EP2582790B1
公开(公告)日：2017-01-25
申请号：EP11743384.7
申请日：2011-06-10
申请人： Wisconsin Alumni Research Foundation
发明人： SHUSTA, Eric, V. , LIPPMANN, Ethan , AZARIN, Samira , PALECEK, Sean
IPC分类号： C12N5/071 , G01N33/50
CPC分类号： C12N5/069 , C12N5/0697 , C12N2502/086 , C12N2502/28 , C12N2506/45 , C12N2533/90
摘要： A model blood brain barrier obtained from hPSCs is disclosed.

8. 发明公开

EP3094342A1 ANTI-TUMOR THERAPY 审中-公开
标题翻译： ANTITUMORTHERAPIE
公开(公告)号：EP3094342A1
公开(公告)日：2016-11-23
申请号：EP14878697.3
申请日：2014-10-24
申请人： Khodarev, Nikolai , Weichselbaum, Ralph R. , Deng, Liufu , Fu, Yangxin
发明人： Khodarev, Nikolai , Weichselbaum, Ralph R. , Deng, Liufu , Fu, Yangxin
IPC分类号： A61K38/19
CPC分类号： C12N15/1138 , A61K31/7084 , A61K31/7088 , A61K31/713 , A61K41/0038 , A61K45/06 , A61N5/1077 , A61N2005/1021 , A61N2005/1098 , C12N2310/14 , C12N2320/30 , C12N2320/31
摘要： Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.
摘要翻译：公开了用于治疗有需要的受试者中的癌症的组合物，试剂盒和方法，其涉及抑制癌症化学敏感和/或放射敏感的一种或多种基因。

9. 发明公开

EP3080277A2 AXMI477, AXMI482, AXMI486 AND AXMI525 TOXIN GENES AND METHODS FOR THEIR USE 有权转让
标题翻译： AXMI477-，AXMI482-，AXMI486- UND AXMI525-TOXIN-GENE UND VERFAHREN ZU DEREN VERWENDUNG
公开(公告)号：EP3080277A2
公开(公告)日：2016-10-19
申请号：EP14835605.8
申请日：2014-12-08
申请人： Athenix Corp.
发明人： LEHTINEN, Duane, Alan , SAMPSON, Kimberly, S. , ROBERTS, Kira , DUNN, Ethan , CHOUGULE, Nana
IPC分类号： C12N15/82 , C07K14/325
CPC分类号： C07K14/325 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a Bacillus thuringiensis toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:5-26, or the nucleotide sequence set forth in SEQ ID NO: 1-4, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含苏云金芽孢杆菌毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：5-26所示氨基酸序列的核苷酸序列，或SEQ ID NO：1-4所示的核苷酸序列，以及变体和片段。

10. 发明授权

EP2776464B1 ANTIBODY SPECIFIC FOR TRANS-RESVERATROL AND USE THEREOF 有权
标题翻译： TRANSRESVERATROL特异性抗体及其用途
公开(公告)号：EP2776464B1
公开(公告)日：2016-09-28
申请号：EP12787064.0
申请日：2012-11-09
申请人： IP Science Limited
发明人： PETYAEV, Ivan , TSYBEZOV, Valery
IPC分类号： C07K16/14 , G01N33/53
CPC分类号： G01N33/5308 , A61K39/39583 , C07K16/14 , C07K16/44 , C07K2317/14 , C07K2317/30 , G01N33/74 , G01N33/94 , G01N2430/00

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