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1. 发明公开

EP1087828A2 EXPANDED BED ADSORPTION SYSTEM 有权
标题翻译：膨胀床吸收系统
公开(公告)号：EP1087828A2
公开(公告)日：2001-04-04
申请号：EP99927730.4
申请日：1999-06-18
申请人： UPFRONT CHROMATOGRAPHY A/S
发明人： OEHLENSCHLAEGER,René , OLSEN, Brian, A. , ZAFIRAKOS, Elias , LIHME, Allan, Otto, Fog
IPC分类号： B01D15/02
CPC分类号： B01D15/1807 , B01F13/0818 , G01N30/02 , G01N30/60 , G01N30/6004 , G01N30/6082 , G01N2030/324 , G01N2030/484 , B01D15/26
摘要： The present application describes various improvements and further developments to the Expanded Bed Adsorption (EBA) technology. In particular, the application describes an EBA process where elution is performed in fluidised mode, i.e. in expanded bed mode, the so-called All Expanded Process. This improvement which is based on the use of controlled density particles, e.g. particles having a density of at least 1.3 g/ml, provides valuable advantages with respect to use of reduced amounts of elution buffer. The application also describes the use of magnetic stirring in EBA columns, design of an inlet ring with multiple openings, outlet at the bottom or side an EBA column for the discharge of gel, mobile pipe outlet, floating outlet, temperature regulator at inlet, the use of coloured gel, the use of sensors, processes for the regeneration of buffer in EBA systems, the introduction of baffles, and disposable columns (single use sterile columns).

2. 发明授权

EP0686218B1 METHOD FOR THE MANUFACTURE OF A SHAPED OBJECT 失效转让
标题翻译：用于生产状体
公开(公告)号：EP0686218B1
公开(公告)日：2000-05-31
申请号：EP94908292.9
申请日：1994-02-22
申请人： FULL CIRCLE PRODUCTS A/S
发明人： SKJELMOSE, Frank Ivan
IPC分类号： D21J1/00
CPC分类号： D21J1/00 , D21F1/66 , D21F1/80 , D21J3/00 , Y10S264/914
摘要： A moulded body is produced on the basis of a raw material, the main content of which is material which is left after remoulding pulp from paper and extraction of fibres from the pulp mass for remanufacturing of paper. This raw material which mainly consists of water, short fibres, and fine, mineral particles is drained by pressing in a first pressing stage between filter belts for production of a coherent body, is dried partially in a first drying stage and is pressed in a second pressing stage, and dried finally in a second drying stage. The invention concerns a similar method for separation of fibres and particles from waste water which results from repulping paper and reclaiming of fibres from the pulp mass for remanufacturing of paper, whereby an environmental problem is solved in a very suitable way. A plant for manufacturing of a moulded body on basis of the raw material mentioned comprises a largely horizontal filter unit (3, 25) for draining, a first pressing unit (7) for pressing the material between surfaces of filter belt, a first drying unit (8) for drying of the material, a second pressing unit (10) for pressing the material, and a second drying unit (11) for heat treatment of the material.

3. 发明公开

EP0876109A1 WATER DISPERSIBLE COMPOSITIONS CONTAINING NATURAL HYDROPHOBIC PIGMENT, METHOD OF PREPARING SAME AND THEIR USE 失效
标题翻译：分散于水的组合物中的天然疏水性颜料，含有生产和使用方法
公开(公告)号：EP0876109A1
公开(公告)日：1998-11-11
申请号：EP97900548.0
申请日：1997-01-14
申请人： Chr. Hansen A/S
发明人： WINNING, Marianne , ISAGER, Per Pihlmann
IPC分类号： A23G3 , A23G9 , A23L1 , A23L2 , A23P1 , A61K9 , A61K47 , C09B61 , C09D5
CPC分类号： A61K47/00 , A23G3/343 , A23G3/36 , A23G9/32 , A23G2200/00 , A23G2200/14 , A23G2210/00 , A23L2/58 , A23L5/42 , A23L5/43 , A23L5/44 , A23L7/191 , A23L19/09 , A23P20/10 , A61K9/145 , A61K9/1658 , A61K9/28 , C08K9/04 , C09B61/00 , C09C3/00 , C09C3/10
摘要： A ready-to-use water dispersible pigment composition containing at least 5 % by weight of water is provided. The composition comprises a stable dispersion of a water-insoluble and/or hydrophobic natural pigment such as a carotenoid, curcumin, a porphyrin pigment or vegetable carbon black in the form of bodies of an average size which is at the most 10 νm is provided. The pigment bodies are dispersed without the use of a surface active substance in an aqueous phase comprising a hydrocolloid. The natural pigment in compositions which are useful for colouring of food products and pharmaceuticals do not migrate in the products. The compositions are useful in coating compositions for tablets and dragees.

4. 发明授权

EP0461166B1 A METHOD FOR CONTROLLING AND/OR MONITORING BIOLOGICAL PROCESSES 有权转让
标题翻译：方法控制和/或生物过程检查。
公开(公告)号：EP0461166B1
公开(公告)日：1994-06-01
申请号：EP90904261.6
申请日：1990-02-28
申请人： AKTIESELSKABET FAXE KALKBRUD
发明人： HELMO, Kim
IPC分类号： C12Q1/04 , C02F3/00
CPC分类号： C02F3/1215 , C02F3/006 , C02F3/34 , C02F2209/02 , C02F2209/06 , C02F2209/11 , C02F2209/22 , C02F2209/36 , C02F2209/40 , C02F2209/44 , C12Q1/04 , Y02W10/15 , Y02W10/37
摘要： A method for controlling and/or optimising a process in which an aqueous system comprising biodegradable material, one or more biogenic fluorophores and optionally other soluble and/or insoluble and/or suspended substances is subjected to one or several separation processes and/or to chemical reactions and to biological treatment using mixed cultures of microorganisms so as to obtain as a final product purified water which has a substantially lower content of biodegradable matter than said aqueous system, which method comprises monitoring the microbiological activity of said biological system and/or fluctuations thereof by on-line measurement of fluorescent emission and/or variations therein for at least one characteristic biogenic fluorophore, e.g. NADH or NAD(P)H2, present in the mixed culture of microorganisms in the system when irradiated with light, and controlling one or several parameters of said process by using results from said measurement as measured variable(s) in an on-line automation system. By using the method, large fluctuations in the content of biodegradable material present in inlet waste water to the biological treatment step(s) of a waste water or sewage purification plant can be minimized, and accordingly, the overall performance of the purification plant can be improved.

5. 发明授权

EP0386072B1 METHOD FOR DETERMINING THE CONCENTRATION OF OXYGEN 失效
标题翻译：程序来确定氧含量。
公开(公告)号：EP0386072B1
公开(公告)日：1994-01-26
申请号：EP88909718.4
申请日：1988-11-03
申请人： RADIOMETER A/S
发明人： JENSEN, Niels, Henrik
IPC分类号： G01N21/64
CPC分类号： G01N21/62 , G01N2021/6482
摘要： The concentration of molecular oxygen in a sample is determined by exciting oxygen molecules of the sample from the electronic ground state to the excited 1DELTAg state (excited singlet state), measuring a 1270-nm luminescence characteristic of the excited oxygen molecules (singlet oxygen) and correlating the luminescence characteristic measured with the concentration of molecular oxygen in the sample. Normally, the 1270-nm luminescence characteristic is the 1270-nm luminescence intensity. Preferably, the oxygen molecules are excited by being subjected to diffusion contact with a sensitizer such as a porphyrin or a porphyrin-related compound, e.g. a transition metal complex of a porphyrin. The sensitizer is brought into an oxygen-exciting electronic state by absorption of electromagnetic radiation such as light, the oxygen-exciting electronic state optionally being adapted to the measuring system employed by means of a quencher such as a substituted polyene. The sensitizer may be present in an organic solvent or a polymer such as polyvinylchloride. The oxygen-containing sample is preferably a sample of biological origin such as a blood sample.

6. 发明公开

EP0561772A1 A NEW PHARMACEUTICAL USE OF FUSIDIC ACID AND DERIVATIVES THEREOF 失效
标题翻译：新使用梭链孢酸及其衍生物作为补救。
公开(公告)号：EP0561772A1
公开(公告)日：1993-09-29
申请号：EP89912408.0
申请日：1989-10-30
申请人： BENDTZEN, Klaus
发明人： BENDTZEN, Klaus
IPC分类号： A61K31 , A61P1 , A61P3 , A61P9 , A61P17 , A61P27 , A61P29 , A61P37 , C07J13 , C07J31 , C07J41
CPC分类号： C07J13/007 , A61K31/565 , C07J31/003 , C07J31/006 , C07J41/0027 , C07J41/0061
摘要： La présente invention se rapporte à l'utilisation d'acide fusidique et d'un de ses dérivés pour la fabrication d'une composition destinée à interférer avec des cytokines dans un système biologique, en particulier avec une cytokine telle qu'une lymphokine, une interleukine, une monokine, un interféron ou un facteur stimulateur de colonie. L'acide fusidique et ses dérivés servent à garantir des effets des cytokines connues pour jouer un rôle pathogène dans des conditions pathologiques. Ces conditions peuvent être: le diabète sucré dépendant de l'insuline (type 1), un état d'hyperfonction ou d'hypofonction de la glande thyroïde (par exemple une thyroïdite), la maladie d'Addison, une uvéite endogène, une chirurgie de l'oeil telle qu'une transplantation de la cornée, une chirurgie au laser et une opération de la cataracte, un rejet de greffe, une maladie due à une réaction du greffon contre l'hôte, la maladie de Crohn ou une colite ulcérative, une anémie pernicieuse, une maladie coeliaque, une dermatite de contact, une dermatite allergique/atopique, un pemphigus chronique simple ou pemphigoïde, une sclérose multiple, un lupus érythémateux systémique, une pseudopolyarthrite rhizomélique, des conditions apparentées à un phénomène d'angéite, des maladies néoplastiques telles qu'un myélome multiple, un choc septique causé par des bactéries gram-négatif, une coagulation intravasculaire disséminée, une atériosclérose, des maladies du périodonte, une arthrite, une ostéoarthropathie dégénérative ou une arthrite goutteuse.

7. 发明授权

EP0212126B1 Polarographic measuring electrode device 有权
标题翻译：极地测量电极装置
公开(公告)号：EP0212126B1
公开(公告)日：1992-09-30
申请号：EP86108303.8
申请日：1986-06-18
申请人： RADIOMETER A/S
发明人： Christiansen, Torben Falch , Kokholm, Finn
IPC分类号： G01N27/416
CPC分类号： G01N27/404

8. 发明授权

EP0236385B1 A SUPEROXIDE DISMUTASE 失效转让
标题翻译：超氧化物歧化酶
公开(公告)号：EP0236385B1
公开(公告)日：1991-11-13
申请号：EP86905243.1
申请日：1986-09-02
申请人： SYMBICOM AB
发明人： MARKLUND, Stefan , EDLUND, Thomas
IPC分类号： C12N9/02 , C12N15/53 , A61K37/50 , C12N5/00
CPC分类号： C12N9/0089 , A61K38/446 , C07K16/40
摘要： A superoxide dismutase originally found in extracellular body fluids and therefore termed extracellular superoxide dismutase (EC-SOD) is prepared by growing a cell line, preferably of mammalian origin, producing EC-SOD and recovering the EC-SOD secreted from the cells or by inserting a DNA sequence encoding EC-SOD into a suitable vector, introducing the recombinant vector into a host cell, growing the cell and recovering the EC-SOD produced. EC-SOD may be used for the prophylaxis or treatment of diseases or disorders associated with the presence or formation of superoxide radicals.

9. 发明公开

EP0434751A1 A MALARIA ANTIGEN 失效
标题翻译：疟疾抗原。
公开(公告)号：EP0434751A1
公开(公告)日：1991-07-03
申请号：EP89911024.0
申请日：1989-09-18
申请人： STATENS SERUMINSTITUT
发明人： DZIEGIEL, Morten , BORRE, Martin , JEPSEN, Soren , VUUST, Jens , RIENECK, Klaus , WIND, Anette , JAKOBSEN, Palle, Hoy
IPC分类号： C07K14 , C07K16 , C12N15 , A61K38 , A61K39
CPC分类号： C07K16/205 , A61K38/00 , A61K39/00 , C07K14/445 , Y02A50/412
摘要： The present invention relates to a polypeptide comprising a characteristic amino acid sequence derived from the Plasmodium falciparum antigen GLURP, a polypeptide which is recognized by an antiboby raised against or reactive with a polypeptide comprising said characteristic amino acid sequence and/or an antibody reactive with native GLURP, a nucleic acid molecule (DNA-fragment) encoding said polypeptide, an expression vector carrying the nucleic acid molecule, an organism expressing said nucleic acid molecule so as to produce said polypeptide, a monoclonal antibody directed against said polypeptide, a diagnostic agent comprising said antibody or said polypeptide for use in assaying Plasmodium falciparum infection and thus diagnosing malaria, and the use of said antibody or said polypeptide for therapeutic purposes, e.g. as a component in a vaccine. The polypeptide includes 3 unique repeats AENEESSLEE..., SEKSVSEPAEHVEIV and EEILPE.DKNEK...

10. 发明公开

EP0422198A1 PHOSPHORYLATED PLASMINOGEN ACTIVATORS 失效
标题翻译：磷酸肌酸激酶
公开(公告)号：EP0422198A1
公开(公告)日：1991-04-17
申请号：EP90907178.0
申请日：1990-04-11
申请人： BLASI, Francesco , STOPPELLI, Maria, Patrizia , MASTRONICOLA, Maria, Rosaria , WELINDER, Karen, Gjersing , CORREAS, Isabel
发明人： BLASI, Francesco , STOPPELLI, Maria, Patrizia , MASTRONICOLA, Maria, Rosaria , WELINDER, Karen, Gjersing , CORREAS, Isabel
IPC分类号： A61K38 , A61P7 , C12N9
CPC分类号： C12N9/6456 , A61K38/00
摘要： Un activateur de plasminogène (PA) phosphorylé, tel que la pro-urokinase (pro-u-PA) phosphorylée, qui est sensiblement exempte d'activateur de plasminogène non phosphorylé, peut être obtenu par phosphorylation d'un activateur de plasminogène non phosphorylé au moyen d'une enzyme de phosphorylation ou par séparation d'un activateur de plasminogène phosphorylé à partir d'un mélange composé d'un activateur de plasminogène phosphorylé et d'un activateur de plasminogène non phosphorylé. Le pro-u-PA phosphorylé qui est sensiblement exempt de pro-u-PA non phosphorylé, est converti par plasmine en urokinase (u-PA) phosphorylée. De tels activateurs de plasminogène phosphorylés, comme le pro-u-PA, le u-PA et le t-TA (activateur de plasminogène tissulaire) phosphorylés, peuvent servir d'agents thrombolytiques.

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