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1. 发明公开

EP0929555A1 25-METHYLENE AND 24,25-EPOXY MARCFORTINES AND PARAHERQUAMIDES 失效
标题翻译： 25亚甲基和24,25-环氧 - 马可氟汀和-PARAHERQUAMIDE
公开(公告)号：EP0929555A1
公开(公告)日：1999-07-21
申请号：EP97938665.0
申请日：1997-09-05
申请人： PHARMACIA & UPJOHN COMPANY
发明人： LEE, Byung, H. , CLOTHIER, Michael, F.
IPC分类号： A01N43 , A61K31 , A61P33 , C07D491
CPC分类号： C07D491/22
摘要： The present invention are marcfortines and paraherquamides where the 7-member oxygenated ring has been modified to produce 25-methylene compounds (VII) and 24,25-epoxy compounds (VIII) all of which are useful as antiparasitic agents against endo and ecto parasites, particularly helminths and arthropods.

2. 发明公开

EP0893991A1 STIMULATION OF IMMUNE RESPONSE WITH LOW DOSES OF INTERLEUKIN-2 失效
标题翻译：刺激用低剂量的白介素-2的免疫应答。
公开(公告)号：EP0893991A1
公开(公告)日：1999-02-03
申请号：EP97916719.0
申请日：1997-02-26
申请人： CORNELL RESEARCH FOUNDATION, INC.
发明人： SMITH, Kendall, A.
IPC分类号： A61K38
CPC分类号： A61K38/2013 , Y10S514/885 , Y10S514/886 , Y10S514/887
摘要： A method of activating the immune system of a subject comprises the chronic administration of low doses of an agent such as IL-2, fusion proteins thereof and derivatives thereof that are pharmaceutically acceptable. The agent is provided as a dermal composition, transdermal delivery device and electrotransport device as well as in the form of a kit for self-administration.

3. 发明公开

EP0892792A1 PROCESS TO PREPARE OXAZOLIDINONES 失效
标题翻译：用于生产恶唑烷酮
公开(公告)号：EP0892792A1
公开(公告)日：1999-01-27
申请号：EP97915865.0
申请日：1997-03-28
申请人： PHARMACIA & UPJOHN COMPANY
发明人： PEARLMAN, Bruce, A. , PERRAULT, William, R. , BARBACHYN, Michael, R. , MANNINEN, Peter, R. , TOOPS, Dana, S. , HOUSER, David, J. , FLECK, Thomas, J.
IPC分类号： C07D263 , C07D413 , C07D487 , C07D521 , C07D295
CPC分类号： C07D487/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/20 , C07D263/24 , C07D413/04 , C07D413/10
摘要： The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).

4. 发明公开

EP0850303A2 KIDNEY ATP-DEPENDENT POTASSIUM CHANNELS 失效
标题翻译：肝ATPABHÄNGLICHE钾通道
公开(公告)号：EP0850303A2
公开(公告)日：1998-07-01
申请号：EP96930675.0
申请日：1996-09-09
申请人： PHARMACIA & UPJOHN COMPANY
发明人： BIENKOWSKI, Michael, Jerome
IPC分类号： C12N15 , C07K14 , C12N1 , C12N5 , C12Q1
CPC分类号： C07K14/705
摘要： The present invention comprises human DNA compositions, including cDNA clones, with full sequences, called, KIRK-2 and KIRT-3, encoding proteins that confer potassium channel activity to membranes or recipient cell lines. The DNA compositions include structural genes coding for the potassium channel proteins, expression and replication plasmids or vectors containing the structural genes and host cells expressing those genes. Methods of screening compounds for potassium channel modulating activity are also described.

5. 发明公开

EP0847402A1 AUTOANTIBODIES IN PATIENTS WITH ACQUIRED HYPOPARATHYROIDISM AND ASSAY METHOD THEREFOR 失效
标题翻译：自身抗体与用于证明收购之甲状旁腺功能减退和方法病人
公开(公告)号：EP0847402A1
公开(公告)日：1998-06-17
申请号：EP96929842.0
申请日：1996-08-27
申请人： THE UNIVERSITY OF FLORIDA
发明人： MACLAREN, Noel, K. , SONG, Yao-Huo
IPC分类号： G01N33 , A61K31 , A61K38 , A61K39 , A61P5 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/4713 , A61K38/00 , C07K16/18
摘要： Acquired hypoparathyroidism (AH) occurs frequently as a component of type I autoimmune polyglandular diseases (APS-I) or as a sporadic isolated disease in adults. Whereas autoantibodies to the parathyroid glands have been reported in AH, their very existence remains controversial. We report here the detection of autoantibodies as identified through immunoblotting using sera from AH patients. The antibodies were specific to parathyroid autoantigens obtained through differential centrifugation of fresh human hypercellular parathyroid glands, obtained shortly after their surgical removal for tertiary hyperparathyroidism in patients with renal failure. Autoantibodies were detected against several parathyroid specific proteins in the 17 AH sera tested. Twelve (70 %) reacted to a protein of 70 kDa, while 16 (94 %) reacted to a protein of 80 kDa, and 3 (18 %) reacted to a protein of 120-140 kDa, respectively. The 70 and 80 kDa proteins were localized to the cytosolic fraction of the parathyroid extract, and the 120-140 kDa protein to the membrane fraction. The autoantibodies were also detectable using a dog parathyroid gland as an antigen source. However, they could not be identified using cultured human melanocytes or in rat pituitary cells as antigen sources. Sera from 50 patients with various other autoimmune diseases as well as 22 normal controls were also tested, and none reacted with any of the above specific parathyroid proteins. It is concluded that autoantibodies to 3 major autoantigens in the human parathyroid gland extract have been detected in AH patients. Furthermore, our data indicates that the 120-140 kDa autoantigen is the calcium sensing receptor and that the reactive epitope largely resides in its extracellular domain. These data confirm the autoimmune nature of AH, and the invention provides a method for detecting AH or propensity for AH as well as a method for treating AH.

6. 发明公开

EP0811014A1 NOVEL BACTERIOCIN PISCICOLIN 126 失效
标题翻译：新型细菌PISCICOLIN 126
公开(公告)号：EP0811014A1
公开(公告)日：1997-12-10
申请号：EP96902812.0
申请日：1996-02-22
申请人： THE UNIVERSITY OF MELBOURNE , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , DARATECH PTY. LTD.
发明人： WETTENHALL, Richard, Edward, Hugh , DAVIDSON, Barrie, Ernest , HILLIER, Alan, James , HARMARK, Kim , JACK, Ralph, Wilson - Inst. Med. Mikrobiologie , HICKEY, Malcolm, Wayne , COVENTRY, John , WAN, Jason
IPC分类号： A23C19 , A23L3 , C07K14 , C12N1 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/195 , A23L3/3571
摘要： The present invention provides a bacteriocin having a molecular weight of about 4.4 kDa and methods involving the use of this bacteriocin. The bateriocin preferably has an amino acid sequence as shown in Figure 3. The present invention also provides a DNA molecule encoding this bacteriocin.

7. 发明公开

EP0796100A1 COMBINED USE OF DICLOFENAC AND TRIBENOSIDE TO TREAT OSTEOARTHRITIS 失效
标题翻译：用于治疗骨关节炎的钠盐和双氯芬酸三苄结合使用
公开(公告)号：EP0796100A1
公开(公告)日：1997-09-24
申请号：EP95941182.0
申请日：1995-12-18
申请人： KS BIOMEDIX LTD.
发明人： CHAYEN, Joseph , BITENSKY, Lucille
IPC分类号： C07H15 , A61K31 , A61K45 , A61P19 , A61P29 , A61P43
CPC分类号： A61K31/7004 , A61K31/19 , A61K2300/00
摘要： Diclofenac sodium and tribenoside, or more generally (i) a compound that acts on the chondrocytes and (ii) a compound that reduces the water content of the chondrocyte matrix, are useful in the treatment of osteoarthritis.

8. 发明公开

EP0772444A1 USE OF THE ENANTIOMERS OF OXAZOPHOSPHORINES, E.G. IFOSFAMIDE, IN ANTI-TUMOUR THERAPY, FOR REDUCING SIDE-EFFECTS 失效
标题翻译：对映异构体OXAZOPHOSPHORINEN，e.g异环磷酰胺，抗肿瘤治疗的减少副作用USE
公开(公告)号：EP0772444A1
公开(公告)日：1997-05-14
申请号：EP95922649.0
申请日：1995-06-23
申请人： Chiroscience Limited
发明人： BAKER, Helen, Frances
IPC分类号： A61K31
CPC分类号： A61K31/675 , A61K2300/00
摘要： A product containing respective enantiomers of an oxazophosphorine, each substantially free of the other, as a combined preparation for separate, simultaneous or sequential use in anti-tumour therapy. The active component may be ifosfamide. Levoifosfamide is preferred for single drug therapy, owing to its more rapid metabolism.

9. 发明公开

EP0769080A1 CONVERSION COATING AND PROCESS AND SOLUTION FOR ITS FORMATION 有权
标题翻译：转化膜工艺与解决方案生产
公开(公告)号：EP0769080A1
公开(公告)日：1997-04-23
申请号：EP95921651.0
申请日：1995-06-09
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： NELSON, Karen Joy Hammon , TAYLOR, Russell James , HUGHES, Anthony Ewart , HINTON, Bruce Roy William , HENDERSON, Mark Julian , WILSON, Lance , NUGENT, Sally Ann
IPC分类号： C23C22
CPC分类号： C23C22/83 , C23C22/48
摘要： A process for forming a conversion coating on the surface of a metal, including: contacting the metal with an acidic solution containing an oxidant in order to initiate growth of a metal oxide cell structure on the metal surface; contacting the metal with water for a period of time sufficient to thicken the oxide and form a metal oxide containing layer of a desired thickness; and treating the metal with one or more rare earth elements in order to impregnate and substantially seal the metal oxide.

10. 发明公开

EP0760946A1 APPARATUS FOR MEASURING ANALYTES IN A FLUID SAMPLE 失效
标题翻译：设备技术分析物在样品FLUSSIGEN测定
公开(公告)号：EP0760946A1
公开(公告)日：1997-03-12
申请号：EP96910565.0
申请日：1996-03-26
申请人： Coulter International Corp.
发明人： AZARNIA, Roobik , FUENTES, Susan , RUSSEL, Thomas
IPC分类号： G01N27 , C12M1 , C12Q1
CPC分类号： C12Q1/006 , C12Q1/00 , G01N27/3271 , Y10S435/817 , Y10T436/117497
摘要： An apparatus (10) for measuring an analyte in a fluid sample (12) comprises a housing (H) defining a pair of chambers (26, 30) separated by a semipermeable membrane (28). The membrane allows the analyte of interest to pass between the chambers. The second chamber (30) contains a detector adapted to either (a) directly detect the analyte of interest or (b) to detect a reaction by product of the analyte upon reacting with a substance (14) such as an enzyme, introduced into the second chamber. Means are provided to flush the second chamber after each analyte measurement.

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