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1. 发明授权

EP0836618B1 RADIOMETAL-BINDING ANALOGUES OF LEUTENIZING HORMONE RELEASING HORMONE 失效
标题翻译：模拟LHRH，电波金属结合
公开(公告)号：EP0836618B1
公开(公告)日：2005-08-17
申请号：EP96919063.6
申请日：1996-06-07
申请人： Immunomedics, Inc.
发明人： McBRIDE, William, J. , KARACAY, Habibe , GRIFFITHS, Gary, L.
IPC分类号： C07K7/23 , A61K51/08
CPC分类号： C07K7/23 , A61K38/00 , A61K51/088

2. 发明授权

EP1222301B1 PROTEIN PRODUCTION SYSTEM 有权
标题翻译： SYSTEM FOR蛋白生产
公开(公告)号：EP1222301B1
公开(公告)日：2005-07-20
申请号：EP00971523.6
申请日：2000-10-19
申请人： Minos Biosystems Limited
发明人： CRAIG, Roger , SAVAKIS, Charalambos
IPC分类号： C12N15/90 , C12N15/54 , C12N9/22 , A01K67/033 , C12P21/02 , C07K14/61 , C07K14/47 , C12N9/24
CPC分类号： A01K67/0339 , A01K2217/05 , C07K14/47 , C07K14/61 , C12N9/22 , C12N9/2408 , C12N15/90 , C12P21/02 , C12Y302/0102 , C12Y304/21009
摘要： The invention relates to a method for producing a protein of interest, comprising transforming an insect with a non-viral expression system capable of expressing the protein of interest in the larvae of the insect; breeding the insect to produce larvae; culturing the larvae; and isolating the protein of interest from the larvae. The transformation is advantageously performed by means of a transposon vector.

3. 发明授权

EP1224324B1 Two-hybrid screening method employing the bacterial transcriptional activator sigma-54 有权
标题翻译：使用细菌Transcriptionsaktivators双杂交筛选方法Σ-54
公开(公告)号：EP1224324B1
公开(公告)日：2005-05-11
申请号：EP00958835.1
申请日：2000-09-08
申请人： MEDICAL RESEARCH COUNCIL
发明人： HOLLIGER, Philipp , SEPP, Tiina
IPC分类号： C12Q1/68 , G01N33/50 , C12N15/10
CPC分类号： C12N15/1055 , C12Q1/6897
摘要： A genetic selection system is described based on hybrid sigma 54 RNAP activator proteins. The invention permits the detection and screening for protein:DNA and protein:protein binding events.

4. 发明授权

EP1187909B1 FABRICATION OF THREEDIMENSIONAL VASCULARIZED TISSUE USING MICROFABRICATED TWO-DIMENSIONAL MOLDS 有权
标题翻译：三维血管织物由二维MICRO制成的表格生产使用
公开(公告)号：EP1187909B1
公开(公告)日：2005-02-02
申请号：EP00930192.0
申请日：2000-04-28
申请人： MASSACHUSETTS GENERAL HOSPITAL
发明人： VACANTI, Joseph, P. , BORENSTEIN, Jeffrey T. , PIEN, Homer, Dr. , CUNNUNGHAM, Brian T.
IPC分类号： C12N5/00 , A61L27/38
CPC分类号： A61L27/3604 , A61K35/12 , A61K35/44 , A61L27/38 , B33Y70/00 , C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2535/10
摘要： A method and materials to create complex vascularized living tissue in three dimensions from a two-dimension microfabricated mold has been developed. The method involved creating a two dimensional surface having a branching structure etched into the surface. The pattern begins with one or more large channels which serially branch into a large array of channels as small as individual capillaries, then converge to one or more large channels. The etched surface serves a template within a mold formed with the etched surface for the circulation of an individual tissue or organ. Living vascular cells are then seeded onto the mold, where they form living vascular channels based on the pattern etched in the mold. Once formed and sustained by their own matrix, the top of the mold is removed. The organ or tissue specific cells are then added to the etched surface, where they attach and proliferate to form a thin, vascularized sheet of tissue. The tissue can then be gently lifted from the mold using techniques such as fluid flow and other supporting material, as necessary. The tissue can then be systematically folded and compacted into a three-dimensional vascularized structure. This structure can then be implanted into animals or paitents by directly connecting the blood vessels to flow into and out of the device. Immediate perfusion of oxygenated blood occurs, which allows survival and function of the entire living mass.
摘要翻译：的方法和材料，以在从二维微制造模具三维创建复杂的血管化活组织已经研制成功。该方法涉及产生具有蚀刻到表面上的分支结构的二维表面。该图案与一个或多个大的通道哪个串联分支成一个大的阵列的通道小到单个毛细管的开始，然后收敛到一个或多个大的通道。蚀刻表面供应以用于个体的组织或器官的循环蚀刻表面形成的模具中的模板。然后活血管细胞接种到模具中，在此它们形成基于蚀刻到模具上的图案住血管通道。一旦形成并以自己的矩阵持续，模具的顶部被去除。然后将器官或组织特异性的细胞加入到蚀刻的表面，在那里它们附着和增殖，以形成组织的薄的血管化片材。组织然后可以轻轻地从使用的技术的模具抬起：如流体流动和其他辅助材料，如必要的。组织然后可以系统地折叠并压制成三维血管结构。该结构可以随后通过直接连接血管流入和流出所述装置的被植入到动物或paitents。含氧血的灌注立即发生，这使得整个生活质量的生存和功能。

5. 发明公开

EP1499631A2 RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 审中-公开
标题翻译： TGF-β和TGF-β受体基因的表达与干扰附图核酸RNA干扰介导的抑制（新浪）
公开(公告)号：EP1499631A2
公开(公告)日：2005-01-26
申请号：EP03716430.8
申请日：2003-02-11
申请人： Sirna Therapeutics, Inc.
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid
IPC分类号： C07H21/04 , A61K48/00 , C12N15/85 , C12N15/86
CPC分类号： C12N15/1138 , C12N15/1136 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating transforming growth factor beta (TGF-beta) and transforming growth factor beta receptor (TGF-betaR) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against transforming growth factor beta (TGF-beta) and transforming growth factor beta receptor (TGF-betaR) gene expression and/or activity. The siNA molecules are useful in the treatment and diagnosis of conditions that respond to the modulation of TGF-beta and/or TGF-betaR expression or activity.

6. 发明公开

EP1496120A2 In vitro sorting method 失效
标题翻译： Ein in vitro Sortierverfahren
公开(公告)号：EP1496120A2
公开(公告)日：2005-01-12
申请号：EP04077102.4
申请日：1998-06-29
申请人： Medical Research Council
发明人： Griffiths, Andrew, MRC Laboratory of , Tawfik, Dan, MRC Laboratory of
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1058 , C12N15/1062 , C12N15/1075 , C12Q1/6811 , C12Q2563/159
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.
摘要翻译：本发明描述了一种用于分离编码具有所需活性的基因产物的一种或多种遗传元件的方法，包括以下步骤：（a）将遗传元件分隔成微胶囊; （b）表达遗传元件以在微胶囊内产生它们各自的基因产物; （c）分选产生具有所需活性的基因产物的遗传元件。本发明能够通过本发明方法的重复诱变和迭代应用来体外进化核酸。

7. 发明授权

EP1067142B1 Antibody against cleavage product of vimentin 有权
标题翻译：针对波形蛋白裂解产物抗体
公开(公告)号：EP1067142B1
公开(公告)日：2004-12-29
申请号：EP00305736.1
申请日：2000-07-07
申请人： Riken
发明人： Morishima, Nobuhiro, c/o Riken , Nakanishi, Keiko , Shibata, Takehiko, c/o Riken
IPC分类号： C07K16/18 , G01N33/573 , G01N33/577 , G01N33/68
CPC分类号： C07K16/18

8. 发明公开

EP1485102A2 SEQUENTIAL THERAPY COMPRISING A 20(S)-CAMPTOTHECIN COMPOUND AND A PYRIMIDINE BASE ANALOG 审中-公开
标题翻译：序贯疗法与20（S） - 喜树碱化合物的嘧啶碱基类似物
公开(公告)号：EP1485102A2
公开(公告)日：2004-12-15
申请号：EP03707767.4
申请日：2003-02-06
申请人： SuperGen, Inc.
发明人： RUBINFELD, Joseph , METTINGER, Karl, L. , LYONS, John , ROMEL, Lawrence, A.
IPC分类号： A61K31/545 , A61K31/47
CPC分类号： A61K31/513 , A61K31/4745 , A61K31/7072 , A61K2300/00
摘要： A method is provided for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation, the method comprising: administering to the patient a 20(S)-camptothecin compound for a period of time during which a pyrimidine base analog is not being administered to the patient; and administering a pyrimidine base analog to the patient.

9. 发明公开

EP1478730A2 RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
标题翻译： RNA干扰介导的表达FOR THE TNF和TNF受体超族基因USING siNA的抑制率（短干扰核酸）
公开(公告)号：EP1478730A2
公开(公告)日：2004-11-24
申请号：EP03713502.7
申请日：2003-02-20
申请人： RIBOZYME PHARMACEUTICALS, INC.
发明人： McSWIGGEN, James , BEIGELMAN, Leonid
IPC分类号： C12N1/00
CPC分类号： C12N15/1138 , C12N15/1136 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/53 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating TNF superfamily and TNF receptor superfamily gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against TNF superfamily and TNF receptor superfamily gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of septic shock, rheumatoid arthritis, HIV and AIDS, psoriasis, inflammatory or autoimmune disorders and any other disease or condition that responds to modulation of TNF and/or TNF receptor expression or activity.

10. 发明公开

EP1476458A2 RNA INTERFERENCE MEDIATED INHIBITION OF PLATELET DERIVED GROWTH FACTOR (PDGF) AND PLATELET DERIVED GROWTH FACTOR RECEPTOR (PDGFR) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 审中-公开
标题翻译：通过RNA干扰介导的BLUTPLÄTCHEN衍生生长因子（PDGF）JOURNAL基因的表达抑制与血小板衍生WACHTUMSFAKTORS使用所述受体（PDGFR）的核酸小干扰（新浪）
公开(公告)号：EP1476458A2
公开(公告)日：2004-11-17
申请号：EP03715980.3
申请日：2003-02-05
申请人： Sirna Therapeutics, Inc.
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00 , C12N15/00
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

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