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1. 发明公开

EP3166954A1 METHODS FOR SEPARATING AND REFINING LIGNIN FROM BLACK LIQUOR AND COMPOSITIONS THEREOF 有权
标题翻译：法从黑液以及它们的组合物分离和精制的木质素的
公开(公告)号：EP3166954A1
公开(公告)日：2017-05-17
申请号：EP15819321.9
申请日：2015-07-07
申请人： Virdia, Inc.
发明人： JANSEN, Robert , LAWSON, James Alan , LAPIDOT, Noa
IPC分类号： C07G1/00 , C08L97/02 , D21C11/00
CPC分类号： D21C11/0007 , C07G1/00 , C08H6/00 , C12P5/023 , D21C11/0085 , Y02E50/343 , Y02P20/582
摘要： The invention relates methods and processes for the separation and refining of lignin from spent cooking liquor, called black liquor, present in industrial chemical plants, and compositions thereof. A process is provided for separating black liquor into at least two, three, or four streams selected from: (i) a gaseous stream comprising volatile sulfur compounds; (ii) a lignin-comprising stream produced by extracting lignin into a limited solubility solvent S1; (iii) a salt stream, comprising solid sodium and sulfate salts; and (iv) a salt-depleted and lignin-depleted aqueous stream comprising hydrocarbons.
摘要翻译：本发明涉及用于工业化工厂中分离和从废蒸煮液的木质素精炼，称为黑液，本发明的方法和过程，及其组合物。提供了一种用于分离黑液分成至少两个，三个或四个流选自一种方法：（ⅰ）的气态物流，其包括挥发性硫化合物; （ii）通过提取木质素成具有有限的溶解度溶剂S1产生的木质素料流; （ⅲ）盐流，包括固体酸钠和硫酸的盐; 和（iv）的盐贫化和木质素贫流包括水的烃。

2. 发明授权

EP2870466B1 AN ELECTRODE AND USE THEREOF 有权转让
标题翻译：电极及其用途
公开(公告)号：EP2870466B1
公开(公告)日：2017-04-26
申请号：EP13733454.6
申请日：2013-07-02
申请人： Oxford University Innovation Limited
发明人： DAVIS, Jason
IPC分类号： G01N27/327 , G01N27/02 , G01N33/543
CPC分类号： G01N27/3275 , G01N27/026 , G01N27/3276 , G01N2333/62
摘要： The application relates to an electrode for use in the electrochemical detection of target species, and in particular for the detection of insulin. The application enables insulin to be detected with high selectivity and with a detection limit in the picomolar range or lower. The electrodes of the invention can easily be reused and are ideally suited for use in point-of-care diagnostics. In a preferred embodiment, the electrode comprises an antibody modified, polyethylene glycol (PEG) monolayer assembled on a gold surface. In a second embodiment, the electrode comprises a chemisorbed zwitterionic carboxybetaine polymer obtained by photopolymerisation of carboxybetaine methacrylate (CBMA). This allows the use of non Faradaic analysis to determine the insulin concentration even in undiluted blood serum.
摘要翻译：本申请涉及用于目标物质的电化学检测，特别是用于检测胰岛素的电极。该应用能够以高选择性检测胰岛素并且具有皮摩尔范围或更低的检测极限。本发明的电极可以容易地重复使用并且非常适合用于即时诊断。在优选的实施方案中，电极包含组装在金表面上的抗体修饰的聚乙二醇（PEG）单层。在第二个实施方案中，电极包含通过羧基甜菜碱甲基丙烯酸酯（CBMA）的光聚合获得的化学吸附的两性离子羧基甜菜碱聚合物。这允许使用非法拉第分析来确定即使在未稀释血清中的胰岛素浓度。

3. 发明公开

EP3134482A1 METHODS AND PROCESSES FOR APPLICATION OF DRUG DELIVERY POLYMERIC COATINGS 有权转让
标题翻译： VERFAHREN UND PROZESSE ZUR ANWENDUNG VON WIRKSTOFFFREISETZUNGSPOLYMERBESCHICHTUNGEN
公开(公告)号：EP3134482A1
公开(公告)日：2017-03-01
申请号：EP15782551.4
申请日：2015-04-22
申请人： Ariste Medical, Inc.
发明人： JENNINGS, Lisa, K. , MCCANLESS, Jonathan, D. , CHEN, Xiaoping , COLE, Michael
IPC分类号： C09D133/04 , C09D7/12
摘要： Polymeric coatings, their applications, and the methods of their preparation are described. The coatings may be used to confer desirable properties to the consumer and/or medical products. Also described are methods of loading therapeutic agents on the polymeric coatings and the applications of the drug eluting polymeric coatings thus obtained.
摘要翻译：描述了聚合物涂层及其应用及其制备方法。涂层可以用于赋予消费者和/或医疗产品所需的性质。还描述了将治疗剂加载到聚合物涂层上的方法以及由此获得的药物洗脱聚合物涂层的应用。

4. 发明公开

EP3129753A1 COMPOSITIONS AND METHODS FOR DELIVERY OF CARBON DIOXIDE 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR LIEFERUNG VON KOHLENDIOXID
公开(公告)号：EP3129753A1
公开(公告)日：2017-02-15
申请号：EP15776706.2
申请日：2015-03-09
申请人： Carboncure Technologies Inc.
发明人： FORGERON, Dean Paul , BROWN, Joshua Jeremy , MONKMAN, George Sean , SANDBERG, Paul J.
IPC分类号： G01F1/74 , B28C7/02 , B60P3/16 , G05D7/06
CPC分类号： G05D7/0635 , B28C5/468 , B28C7/024 , B28C7/0418 , C04B40/0231 , Y02P40/18 , C04B28/04
摘要： Compositions and methods are provided for a system in which liquid carbon dioxide, or a mixture of liquid and gaseous carbon dioxide, is converted to solid carbon dioxide by exiting an orifice at a sufficient pressure drop, e.g., for delivery of carbon dioxide to a concrete mixture in a mixer.
摘要翻译：提供了组合物和方法，其中液体二氧化碳或液体和气态二氧化碳的混合物通过以足够的压降离开孔而转化为固体二氧化碳，例如将二氧化碳输送到混凝土混合物。

5. 发明公开

EP3082730A1 HAIR COLOURING COMPOSITION 无效
标题翻译：发色组合物
公开(公告)号：EP3082730A1
公开(公告)日：2016-10-26
申请号：EP14803199.0
申请日：2014-11-19
申请人： Herb Uk Limited
发明人： PERFITT, Raoul John , CARIMBOCAS, Cicely Andrea Ruth
IPC分类号： A61K8/34 , A61K8/37 , A61K8/45 , A61Q5/06 , A61Q5/10 , A61K8/36 , A61K8/22
CPC分类号： A61K8/42 , A61K8/22 , A61K8/34 , A61K8/361 , A61K8/37 , A61K8/41 , A61K8/45 , A61Q5/06 , A61Q5/10
摘要： The present application relates to a hair colouring composition comprising: an N-PEG amide of a fatty acid; an N-ethoxylated alkyl amine; and one or more alcohols selected from ethanol, ethanediols, propanol, propanediols, and propanetriols.
摘要翻译：本发明涉及一种染发组合物，其包含：脂肪酸的N-PEG酰胺; N-乙氧基化烷基胺; 和选自乙醇，乙二醇，丙醇，丙二醇和丙三醇的一种或多种醇。

6. 发明公开

EP3079668A1 PHARMACEUTICALLY ACTIVE AGENT COMPLEXES, POLYMER COMPLEXES, AND COMPOSITIONS AND METHODS INVOLVING THE SAME 无效
标题翻译：药物活性活性复合物，聚合物复合和组成，并且为了方法
公开(公告)号：EP3079668A1
公开(公告)日：2016-10-19
申请号：EP14824227.4
申请日：2014-12-08
申请人： Durect Corporation
发明人： SEKAR, Michael , THEEUWES, Felix , BRANHAM, Keith , GIBSON, John W. , MATRIANO, James , MORO, Whitney , TIPTON, John , VAN OSDOL, William W. , YUM, Su Il
IPC分类号： A61K9/16 , A61K47/48 , A61K9/19
CPC分类号： A61K47/482 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K31/352 , A61K31/706 , A61K31/785 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K39/39516 , A61K47/593
摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

7. 发明公开

EP2970253A1 COMPOSITIONS WITH THIXOTROPY AND ENHANCED DISSOLUTION REPRODUCIBILITY AND STABILITY 无效
标题翻译：具有触变性和增强溶解可重复性和稳定性的组合物
公开(公告)号：EP2970253A1
公开(公告)日：2016-01-20
申请号：EP14765802.5
申请日：2014-03-14
申请人： DURECT Corporation
发明人： ZAMLOOT, Michael S. , FU, Roger , YUM, Su Il , CHAO, Wendy , SU, Huey-Ching
IPC分类号： C07D471/00
CPC分类号： A61K31/485 , A61K9/48 , A61K9/4816 , A61K9/485 , A61K9/4858 , A61K9/4866
摘要： The present disclosure provides extended release compositions including, formulations that comprise such compositions, which exhibit desirable dissolution of an active agent while maintaining its physical stability in a dosage form including, for example, providing reduced sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.
摘要翻译：本公开内容提供了缓释组合物，其包含含有这样的组合物的制剂，所述组合物表现出期望的活性剂溶解，同时维持其在剂型中的物理稳定性，包括例如提供降低的样品变异性，例如以减少的样品间 - 胶囊变异性和/或活性剂从组合物中平均释放的储存时间依赖性变化。还提供了制造和施用所公开的组合物和制剂的相关方法。

8. 发明公开

EP2959893A1 ORAL DRUG DELIVERY SYSTEM COMPRISING HIGH VISCOSITY LIQUID CARRIER MATERIALS 审中-公开
标题翻译：口服ARZNEIMITTELVERABREICHUNGSSYSTEM MIT HOCHVISKOSENFLÜSSIGKEITSTRÄGERMATERIALIEN
公开(公告)号：EP2959893A1
公开(公告)日：2015-12-30
申请号：EP15180598.3
申请日：2003-12-15
申请人： DURECT Corporation
发明人： Yum, Su Il , Schoenhard, Grant , Tipton, Arthur J. , Gibson, John W. , Middleton, John C.
IPC分类号： A61K9/52 , A61K9/48 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： An oral dosage form comprises a formulation comprising a high viscosity liquid carrier material (HVLCM), a network former, and a drug. The HVLCM is typically sucrose acetate isobutyrate.
摘要翻译：口服剂型包含包含高粘度液体载体材料（HVLCM），网络形成剂和药物的制剂。 HVLCM通常是蔗糖乙酸异丁酸酯。

9. 发明公开

EP2814512A1 LYSOSOME-CLEAVABLE LINKER 审中-公开
公开(公告)号：EP2814512A1
公开(公告)日：2014-12-24
申请号：EP13702827.0
申请日：2013-02-05
申请人： UCL Business Plc.
发明人： SMITH, Mark Edward Brennan
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/6803 , A61K31/704 , A61K47/6809 , A61K47/6811 , A61K47/6853 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07D207/24 , C07H15/26 , C07K16/18 , C07K2317/24 , C07K2317/50
摘要： The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic acid moiety that is susceptible to cleavage under the pH conditions prevalent in the lysosome.
摘要翻译：本发明涉及用于形成蛋白质或肽与治疗活性剂的缀合物并且包含易于在溶酶体中普遍存在的pH条件下切割的硫代马来酰胺酸部分的接头。

10. 发明公开

EP2810325A1 METHODS AND DEVICES FOR GENERATING ELECTRICITY FROM A FUEL AND AN OXIDANT USING A CAPACITOR 审中-公开
标题翻译：方法和装置用于发电从燃料及抗氧化与电容器
公开(公告)号：EP2810325A1
公开(公告)日：2014-12-10
申请号：EP13743555.8
申请日：2013-02-04
申请人： University Of Washington Through Its Center For Commercialization
发明人： HILLHOUSE, Hugh
IPC分类号： H01M8/02 , H01M8/04 , H01G9/00 , H01M8/06
CPC分类号： H01M16/003 , H01G4/008 , H01G4/30 , H01M8/00 , H01M8/04 , H01M8/04089 , H01M14/00 , H02J7/0042 , H02J7/345 , Y02E60/50
摘要： Devices and methods are provided for generating electrical power using a capacitor. The capacitor has a catalytic working electrode, a dielectric, and a counter electrode. Power is generated by flowing a fuel (e.g., hydrogen gas) over the working electrode, charging the capacitor (e.g. by applying a voltage), flowing an oxidant (e.g., oxygen gas) over the working electrode, and connecting the electrodes to a resistive load, which allows current to flow through the load, between the electrodes. The inverse device (i.e., oxidant first, then fuel) functions similarly.

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