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1. 发明公开

EP3121188A1 CRYSTALLINE 3',5'-CYCLIC DIGUANYLIC ACID 有权
标题翻译： CRYSTALLINE 3'，5'-CYCLIC DIGUANYLIC ACID
公开(公告)号：EP3121188A1
公开(公告)日：2017-01-25
申请号：EP15759144.7
申请日：2015-02-27
申请人： YAMASA CORPORATION
发明人： TANAKA, Hisaki , ISHIGE, Kazuya
IPC分类号： C07H19/213
CPC分类号： C07H19/207 , C07H1/00 , C07H19/213
摘要： A crystal of free acid of 3',5'-cyclic diguanylic acid containing no metal salt with cobalt, magnesium or the like is provided. A method is sought for obtaining said crystal in a large amount and with ease. By a manufacturing method comprising a step of adding acid to an aqueous solution of 3',5'-cyclic diguanylic acid so as to lower pH to 1 to 3, crystals of 3',5'-cyclic diguanylic acid can be obtained in a large amount with ease. Said crystals are free acid crystals which do not contain a metal salt with cobalt, magnesium or the like.
摘要翻译：提供不含金属盐与钴，镁等的3'，5'-环二
十二烷酸的游离酸结晶。寻求大量且容易地获得所述晶体的方法。通过包括向3'，5'-环二甘氨酸的水溶液中加酸以降低pH至1至3的步骤的制造方法，可以得到3'，5'-环二腺苷酸的晶体大量轻松。所述晶体是游离酸结晶，其不含与钴，镁等金属盐。

2. 发明公开

EP2657236A1 NOVEL 2-ALKYNYL-N9-PROPARGYLADENINE AND MEDICINAL USE THEREOF 审中-公开
标题翻译：新西兰2-ALKYNYL-N9-PROPARGYLADENIN在新疆维吾尔自治区
公开(公告)号：EP2657236A1
公开(公告)日：2013-10-30
申请号：EP11843236.8
申请日：2011-11-24
申请人： YAMASA CORPORATION
发明人： ENDO Kazuki , YAMADA Kohei , DEGUCHI Kazuki
IPC分类号： C07D473/34 , A61K31/52 , A61K45/00 , A61P25/16 , A61P43/00
CPC分类号： A61K31/52 , A61K31/137 , A61K31/198 , A61K31/437 , A61K31/47 , A61K31/519 , A61K31/665 , A61K45/06 , C07D473/34 , A61K2300/00
摘要： In the present invention, a novel 2-alkynyl-N9-propargyladenine represented by formula (I)

wherein R 1 represents a halogen atom, a furyl group, or a triazolyl group; R 2 and R 3 each represents a hydrogen atom or a C1-8 alkyl group, or form a cycloalkyl group by bonding to each other; and X represents a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable salt thereof, has a stronger and longer-lasting effect as a therapeutic agent for Parkinsonian syndromes.
摘要翻译：在本发明中，由式（I）表示的新的2-炔基-N9-炔丙基腺嘌呤其中R 1表示卤素原子，呋喃基或三唑基; R 2和R 3各自表示氢原子或C 1-8烷基，或者通过彼此键合形成环烷基; X表示氢原子或羟基或其药学上可接受的盐作为帕金森综合征的治疗剂具有更强的和更持久的作用。

3. 发明公开

EP2100956A1 Method of enzymatically synthesizing 3'-phosphoadenosine-5'-phophosulfate 有权
标题翻译：维生素Zur酶联免疫球蛋白3'-Phosphoadenosin-5'-磷磷酸
公开(公告)号：EP2100956A1
公开(公告)日：2009-09-16
申请号：EP09004307.6
申请日：2006-01-24
申请人： YAMASA CORPORATION
发明人： Ishige, Kazuya , Noguchi, Toshitada
IPC分类号： C12N9/12 , C12P19/32
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/1241 , C12P19/32
摘要： A DNA fragment comprising a polynucleotide which is formed of nucleotides 101 to 1,171 in a nucleotide sequence of SEQ ID NO: 9, and which encodes polyphosphate-driven nucleoside 5'-diphosphate kinase (PNDK), wherein a nucleotide sequence corresponding to at least 72 N-terminal amino acid residues is deleted.
摘要翻译：一种DNA片段，其包含由SEQ ID NO：9的核苷酸序列中的核苷酸101-1,171形成并且编码多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）的多核苷酸，其中对应于至少72 缺失N-末端氨基酸残基。

4. 发明公开

EP2033647A1 AGENT AGAINST PSYCHOSOCIAL STRESSES 审中-公开
标题翻译： MITTEL GEGEN PSYCHOSOZIALEN STRESS
公开(公告)号：EP2033647A1
公开(公告)日：2009-03-11
申请号：EP07790211.2
申请日：2007-06-26
申请人： YAMASA CORPORATION
发明人： ENDO, Kazuki , ASHIDA, Noriyuki
IPC分类号： A61K31/513 , A61K31/7072 , A61P25/00 , C07D239/54 , C07H19/067 , C07H21/02
CPC分类号： C07H21/02 , A61K31/513 , A61K31/7072 , C07D239/54 , C07H19/067
摘要： To provide a novel anti-psychosocial stress agent which is highly safety and can be continuously taken, more particularly, a novel anti-psychosocial stress agent which prevents or alleviates psychosocial stress.
The invention provides an anti-psychosocial stress agent containing, as an active ingredient, uridylic acid, uridine, or uracil. Since uridylic acid, uridine, or uracil, which is an active ingredient of the anti-psychosocial stress agent of the present invention, is inexpensively available and is a biological component, the agent exhibits high safety and can be continuously taken. Therefore, the anti-psychosocial stress agent of the present invention is effective for mitigating, alleviating, or relieving psychosocial stress, which is an issue in modern society. When the anti-psychosocial stress agent is taken before development of symptoms associated with psychosocial stress, the symptoms can be prevented. The anti-stress effect of the agent is superior to that of GABA, which has become of interest and has been incorporated into, for example, foods.
摘要翻译：提供一种高度安全，可持续服用的新型抗心理应激药，更具体地说，是一种防止或缓解心理社会压力的新型抗心理应激药。本发明提供一种抗心理应激剂，其包含尿苷酸，尿苷或尿嘧啶作为活性成分。由于作为本发明的抗心理应激药物的有效成分的尿苷酸，尿苷或尿嘧啶是廉价可得的并且是生物成分，所以该试剂表现出高安全性并且可以连续服用。因此，本发明的抗心理应激药对减轻，减轻或缓解心理社会压力是有效的，这是现代社会的一个问题。在心理社会压力症状发展前采取抗心理应激药物时，可以预防症状。该试剂的抗应激作用优于已经成为感兴趣且已被掺入到例如食品中的GABA的抗应激作用。

5. 发明授权

EP1277839B1 L-GLUTAMATE OXIDASE 有权
标题翻译： L-GLUTAMATOXIDASE
公开(公告)号：EP1277839B1
公开(公告)日：2008-02-27
申请号：EP01921904.7
申请日：2001-04-19
申请人： YAMASA CORPORATION
发明人： INAGAKI, Kenji , ARIMA, Jiro , ASHIUCHI, Makoto , YAGI, Toshiharu , KUSAKABE, Hitoshi
IPC分类号： C12N15/53 , C12N9/06
CPC分类号： C12Y104/03011 , C12N9/0022

6. 发明公开

EP1881323A1 METHOD OF STABILIZING PULMONARY SURFACTANT PROTEIN 有权
标题翻译： VERFAHREN ZUR STABILISIERUNG EINESOBERFLÄCHENAKTIVENLUNGENPROTEINS
公开(公告)号：EP1881323A1
公开(公告)日：2008-01-23
申请号：EP06746191.3
申请日：2006-05-10
申请人： YAMASA CORPORATION
发明人： TANAKA, Seiji, c/o Yamasa Corporation , HAMAOKI, Masaru, c/o Yamasa Corporation
IPC分类号： G01N33/531 , G01N33/53
CPC分类号： G01N33/6884 , C07K14/785 , G01N2333/785
摘要： The present invention relates to a method for long-term stabilizing a pulmonary surfactant protein, to a stabilized aqueous solution containing a pulmonary surfactant protein, and to a kit for assaying a pulmonary surfactant protein which kit contains, as a component reagent, a stabilized aqueous solution containing a pulmonary surfactant protein.
The invention provides a method for stabilizing a pulmonary surfactant protein, the method including causing the pulmonary surfactant protein to be present with a calcium ion and an oxidizing/reducing substance.
The invention also provides an aqueous solution containing a pulmonary surfactant protein which has been stabilized by use of a calcium ion and an oxidizing/reducing substance in combination.
The invention also provides a kit for assaying a pulmonary surfactant protein present in a sample through an immunological technique employing antigen-antibody reaction, the kit containing, as a standard solution of pulmonary surfactant protein, an aqueous solution containing a pulmonary surfactant protein which has been stabilized by use of a calcium ion and an oxidizing/reducing substance in combination.
摘要翻译：本发明涉及一种用于长期稳定肺表面活性蛋白的方法，含有肺表面活性蛋白的稳定化水溶液，以及用于测定肺表面活性蛋白的试剂盒，该试剂盒含有作为组分试剂的稳定水溶液含有肺表面活性蛋白的溶液。本发明提供了一种稳定肺表面活性蛋白的方法，该方法包括使肺表面活性蛋白与钙离子和氧化还原物质一起存在。本发明还提供含有通过使用钙离子和氧化还原物质组合而稳定的肺表面活性蛋白质的水溶液。本发明还提供了一种用于通过使用抗原 - 抗体反应的免疫技术测定样品中存在的肺表面活性蛋白的试剂盒，该试剂盒含有作为肺表面活性蛋白的标准溶液的含有肺表面活性蛋白的水溶液通过组合使用钙离子和氧化还原物质来稳定。

7. 发明公开

EP1842910A1 METHOD OF ENZYMATICALLY SYNTHESIZING 3'-PHOSPHOADENOSINE-5'-PHOSPHOSULFATE 审中-公开
标题翻译： VERFAHREN ZUR ENZYMATISCHEN SYNTHESE EINES 3'-磷脂酰-5'-磷脂
公开(公告)号：EP1842910A1
公开(公告)日：2007-10-10
申请号：EP06712278.8
申请日：2006-01-24
申请人： YAMASA CORPORATION
发明人： ISHIGE, Kazuya, c/o Yamasa Corporation , NOGUCHI, Toshitada, c/o Yamasa Corporation
IPC分类号： C12N15/00 , C12N9/12 , C12N15/09
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/1241 , C12P19/32
摘要： The invention provides a method for producing 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5'-triphosphate sulfurylase (ATPS) and adenosine 5'-phosphosulfate kinase (APSK), wherein an adenosine 5'-triphosphate (ATP) supply/regeneration system including adenosine 5'-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5'-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5'-triphosphate (ATP) supply/regeneration system including adenosine 5'-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5'-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP.
摘要翻译：本发明提供了制备3'-磷酸腺苷5'-磷酸硫酸（PAPS）的方法，该方法包括使用腺苷5'-三磷酸硫酸化酶（ATPS）和腺苷5'-磷酸硫酸激酶（APSK）对ATP进行硫酸化和磷酸化，其中包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和多磷酸盐：AMP磷酸转移酶（PAP）的腺苷5'-三磷酸（ATP）供应/再生系统，或使用包括腺苷5'-磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和腺苷酸激酶（ADK）的腺苷5'-三磷酸（ATP）供应/再生系统代替ATP。

8. 发明授权

EP1362593B1 CYTIDINE-PHOSPHOCHOLINE FOR THE TREATMENT OF DIABETIC NEUROPATHY 有权
标题翻译： CYDIDIN-DIPHOSPHOCHOLIN GEGEN DIABETISCHE NEUROPATHIE
公开(公告)号：EP1362593B1
公开(公告)日：2005-12-07
申请号：EP02765405.2
申请日：2002-09-03
申请人： YAMASA CORPORATION
发明人： ENDO, Kazuki , ABIRU, Toichi , KAMEI, Junzo
IPC分类号： A61K31/7068 , A61P25/02
CPC分类号： C07H19/10 , A61K31/7068
摘要： Preventives/remedies for diabetic neuropathy which contain cytidine 5'-diphosphocholine CDP-choline as the active ingredient. These preventives/remedies for diabetic neuropathy are efficacious against neuropathy mainly caused by hydrocarbonate metabolic errors and have a high safety. The term neuropathy includes peripheral neuropathy and autonomic neuropathy. CDP-choline is effective in oral administration too.

9. 发明公开

EP1589026A1 4'-C-Substituted-2-Haloadenosine derivative 有权
标题翻译： 4'-C-取代物2-卤代腺嘌呤
公开(公告)号：EP1589026A1
公开(公告)日：2005-10-26
申请号：EP05006326.2
申请日：2005-03-23
申请人： YAMASA CORPORATION
发明人： Kohgo, Satoru , Ohrui, Hiroshi , Kodama, Eiichi c/o Institute for Virus Research , Matsuoka, Masao , Mitsuya, Hiroaki
IPC分类号： C07H19/16 , C07H19/173 , C07H19/20 , A61K31/7076 , A61P31/18
CPC分类号： C07H19/16
摘要： The present invention provides a 4'-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]:
(wherein X represents a halogen atom, R 1 represents an ethynyl group or a cyano group, and R 2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor.
摘要翻译：本发明提供由下式表示的4'-C-取代-2-卤代腺苷衍生物：ÄIÜ，ÄIIÜ或ÄIIIÜ：（其中X表示卤素原子，R 1表示乙炔基或氰基基团，R 2表示氢，磷酸酯残基或磷酸酯衍生物残基）。本发明还提供含有该衍生物和其药学上可接受的载体的药物组合物。

10. 发明公开

EP1457568A1 PROCESS FOR PRODUCING 2 -DEOXYGUANOSINE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON 2-DESOXYGUANOSIN
公开(公告)号：EP1457568A1
公开(公告)日：2004-09-15
申请号：EP02786164.0
申请日：2002-12-20
申请人： YAMASA CORPORATION
发明人： NOGUCHI, Toshitada , HAMAMOTO, Tomoki , OKUYAMA, Kiyoshi , SHIBUYA, Susumu
IPC分类号： C12P19/40
CPC分类号： C12P19/40
摘要： The invention provides a process for producing 2'-deoxyguanosine, characterized in that the process includes reacting one compound selected from the group consisting of guanosine, guanosine 5'-monophosphate, and 2-amino-6-substituted purine with 2'-deoxynucleoside in the presence of nucleoside deoxyribosyl transferase and a hydrolase.
According to the process of the present invention, 2'-deoxyguanosine can be synthesized efficiently from inexpensive and easily available starting materials. Since no guanosine, which disturbs purification, is virtually present in a reaction mixture, isolation and purification of 2'-deoxyguanosine can be performed in a very simple manner. Thus, the process for producing 2'-deoxyguanosine is practical.
摘要翻译：本发明提供了一种生产2'-脱氧鸟苷的方法，其特征在于该方法包括使选自鸟苷，鸟苷5'-单磷酸和2-氨基-6-取代嘌呤的一种化合物与2'-脱氧核苷在核苷脱氧核糖基转移酶和水解酶的存在。根据本发明的方法，可以从廉价且易于获得的起始原料中有效地合成2'-脱氧鸟苷。由于没有干扰纯化的鸟苷实际上存在于反应混合物中，所以可以以非常简单的方式进行2'-脱氧鸟苷的分离和纯化。因此，生产2'-脱氧鸟苷的方法是实用的。

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