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2. 发明公开

EP1881323A1 METHOD OF STABILIZING PULMONARY SURFACTANT PROTEIN 有权
标题翻译： VERFAHREN ZUR STABILISIERUNG EINESOBERFLÄCHENAKTIVENLUNGENPROTEINS
公开(公告)号：EP1881323A1
公开(公告)日：2008-01-23
申请号：EP06746191.3
申请日：2006-05-10
申请人： YAMASA CORPORATION
发明人： TANAKA, Seiji, c/o Yamasa Corporation , HAMAOKI, Masaru, c/o Yamasa Corporation
IPC分类号： G01N33/531 , G01N33/53
CPC分类号： G01N33/6884 , C07K14/785 , G01N2333/785
摘要： The present invention relates to a method for long-term stabilizing a pulmonary surfactant protein, to a stabilized aqueous solution containing a pulmonary surfactant protein, and to a kit for assaying a pulmonary surfactant protein which kit contains, as a component reagent, a stabilized aqueous solution containing a pulmonary surfactant protein.
The invention provides a method for stabilizing a pulmonary surfactant protein, the method including causing the pulmonary surfactant protein to be present with a calcium ion and an oxidizing/reducing substance.
The invention also provides an aqueous solution containing a pulmonary surfactant protein which has been stabilized by use of a calcium ion and an oxidizing/reducing substance in combination.
The invention also provides a kit for assaying a pulmonary surfactant protein present in a sample through an immunological technique employing antigen-antibody reaction, the kit containing, as a standard solution of pulmonary surfactant protein, an aqueous solution containing a pulmonary surfactant protein which has been stabilized by use of a calcium ion and an oxidizing/reducing substance in combination.
摘要翻译：本发明涉及一种用于长期稳定肺表面活性蛋白的方法，含有肺表面活性蛋白的稳定化水溶液，以及用于测定肺表面活性蛋白的试剂盒，该试剂盒含有作为组分试剂的稳定水溶液含有肺表面活性蛋白的溶液。本发明提供了一种稳定肺表面活性蛋白的方法，该方法包括使肺表面活性蛋白与钙离子和氧化还原物质一起存在。本发明还提供含有通过使用钙离子和氧化还原物质组合而稳定的肺表面活性蛋白质的水溶液。本发明还提供了一种用于通过使用抗原 - 抗体反应的免疫技术测定样品中存在的肺表面活性蛋白的试剂盒，该试剂盒含有作为肺表面活性蛋白的标准溶液的含有肺表面活性蛋白的水溶液通过组合使用钙离子和氧化还原物质来稳定。

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