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1. 发明公开

EP0811624A1 PURINE COMPOUNDS AND XANTHINE OXIDASE INHIBITORS 失效
标题翻译： P VER EN EN EN。。。。。。。。。。。
公开(公告)号：EP0811624A1
公开(公告)日：1997-12-10
申请号：EP96903203.6
申请日：1996-02-21
申请人： YAMASA CORPORATION
发明人： NAGAMATSU, Tomohisa , WATANABE, Yoko , ENDO, Kazuki , IMAIZUMI, Masahiro
IPC分类号： C07D473/34 , C07D487/14
CPC分类号： C07D487/14 , C07D473/18 , C07D473/32 , C07D473/34
摘要： Purine or triazolopurine compounds represented by formula (I) or (II):
wherein R 1 and R 4 represent each hydrogen, halogeno, hydroxy, mercapto, or amino; R 2 represents alkyl or aryl; and R 3 and R 5 represent each hydrogen, alkyl, or aryl; and pharmaceutical compositions comprising these compounds as an active ingredient in particular, xanthine oxidase inhibitors, remedies for hyperuricemia, or remedies or preventive agents for gout.
摘要翻译：由式（I）或（II）表示的嘌呤或三唑并嘌呤化合物：其中R 1和R 4各自代表氢，卤代，羟基，巯基或氨基; R 2表示烷基或芳基; R 3和R 5各自代表氢，烷基或芳基; 以及包含这些化合物作为活性成分，特别是黄嘌呤氧化酶抑制剂，高尿酸血症的药物或用于痛风的药物或预防剂的药物组合物。

2. 发明公开

EP1362593A1 PHARMACEUTICAL COMPOSITION FOR DIABETIC NEUROPATHY 有权
标题翻译： CYDIDIN-DIPHOSPHOCHOLIN GEGEN DIABETISCHE NEUROPATHIE
公开(公告)号：EP1362593A1
公开(公告)日：2003-11-19
申请号：EP02765405.2
申请日：2002-09-03
申请人： YAMASA CORPORATION
发明人： ENDO, Kazuki , ABIRU, Toichi , KAMEI, Junzo
IPC分类号： A61K31/7068 , A61P25/00 , C07H19/10
CPC分类号： C07H19/10 , A61K31/7068
摘要： The present invention relates to an agent for the prophylaxis or treatment of diabetic neuropathy, which contains cytidine 5'-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of diabetic neuropathy of the present invention is effective for neuropathy mainly caused by metabolic disturbance of carbohydrate and is also superior in safety. Neuropathy includes peripheral neuropathy and dysautonomia. CDP-choline is effective even by oral administration.
摘要翻译：本发明涉及含有胞苷5'-二磷酸胆碱（CDP-胆碱）作为活性成分的预防或治疗糖尿病性神经病的药剂。用于预防或治疗本发明的糖尿病性神经病的药剂对于主要由碳水化合物的代谢紊乱引起的神经病有效，并且安全性也优异。神经病包括周围神经病变和自主神经障碍。 CDP-胆碱甚至通过口服给药也是有效的。

3. 发明公开

EP1110554A1 MEDICINAL COMPOSITIONS FOR TREATING EYE DISEASES 有权
标题翻译：茉莉花茉莉花ZENAMMENSETZUNGEN ZUR BEHANDLUNG VON AUGENERKRANKUNGEN
公开(公告)号：EP1110554A1
公开(公告)日：2001-06-27
申请号：EP99940582.2
申请日：1999-08-31
申请人： YAMASA CORPORATION , TOA EIYO LTD.
发明人： ENDO, Kazuki , ABIRU, Toichi , HOSOKAWA, Tomokazu , MISAWA, Miwa , KONNO, Takashi, Fukushima Research Laboratories
IPC分类号： A61K31/70 , A61K9/06 , A61K9/08
CPC分类号： A61K31/7076 , A61K9/0048 , C07H19/16 , Y10S514/912 , Y10S514/913
摘要： Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a long-lasting and remarkable effect of lowering ocular tension, these compositions are useful as remedies for eye diseases accompanying increased ocular tension or optic nerve failures, such as glaucoma and hypertonia oculi.
摘要翻译：用于治疗眼部疾病的药物组合物，其含有在腺嘌呤碱基的2-位具有乙炔结合的2-炔基腺苷衍生物作为活性成分。具有降低眼睛张力的持久且显着的效果，这些组合物可用作伴随增加的眼睛张力或视神经衰竭的眼部疾病的补救措施，例如青光眼和高眼压症。

4. 发明公开

EP2033647A1 AGENT AGAINST PSYCHOSOCIAL STRESSES 审中-公开
标题翻译： MITTEL GEGEN PSYCHOSOZIALEN STRESS
公开(公告)号：EP2033647A1
公开(公告)日：2009-03-11
申请号：EP07790211.2
申请日：2007-06-26
申请人： YAMASA CORPORATION
发明人： ENDO, Kazuki , ASHIDA, Noriyuki
IPC分类号： A61K31/513 , A61K31/7072 , A61P25/00 , C07D239/54 , C07H19/067 , C07H21/02
CPC分类号： C07H21/02 , A61K31/513 , A61K31/7072 , C07D239/54 , C07H19/067
摘要： To provide a novel anti-psychosocial stress agent which is highly safety and can be continuously taken, more particularly, a novel anti-psychosocial stress agent which prevents or alleviates psychosocial stress.
The invention provides an anti-psychosocial stress agent containing, as an active ingredient, uridylic acid, uridine, or uracil. Since uridylic acid, uridine, or uracil, which is an active ingredient of the anti-psychosocial stress agent of the present invention, is inexpensively available and is a biological component, the agent exhibits high safety and can be continuously taken. Therefore, the anti-psychosocial stress agent of the present invention is effective for mitigating, alleviating, or relieving psychosocial stress, which is an issue in modern society. When the anti-psychosocial stress agent is taken before development of symptoms associated with psychosocial stress, the symptoms can be prevented. The anti-stress effect of the agent is superior to that of GABA, which has become of interest and has been incorporated into, for example, foods.
摘要翻译：提供一种高度安全，可持续服用的新型抗心理应激药，更具体地说，是一种防止或缓解心理社会压力的新型抗心理应激药。本发明提供一种抗心理应激剂，其包含尿苷酸，尿苷或尿嘧啶作为活性成分。由于作为本发明的抗心理应激药物的有效成分的尿苷酸，尿苷或尿嘧啶是廉价可得的并且是生物成分，所以该试剂表现出高安全性并且可以连续服用。因此，本发明的抗心理应激药对减轻，减轻或缓解心理社会压力是有效的，这是现代社会的一个问题。在心理社会压力症状发展前采取抗心理应激药物时，可以预防症状。该试剂的抗应激作用优于已经成为感兴趣且已被掺入到例如食品中的GABA的抗应激作用。

5. 发明授权

EP1362593B1 CYTIDINE-PHOSPHOCHOLINE FOR THE TREATMENT OF DIABETIC NEUROPATHY 有权
标题翻译： CYDIDIN-DIPHOSPHOCHOLIN GEGEN DIABETISCHE NEUROPATHIE
公开(公告)号：EP1362593B1
公开(公告)日：2005-12-07
申请号：EP02765405.2
申请日：2002-09-03
申请人： YAMASA CORPORATION
发明人： ENDO, Kazuki , ABIRU, Toichi , KAMEI, Junzo
IPC分类号： A61K31/7068 , A61P25/02
CPC分类号： C07H19/10 , A61K31/7068
摘要： Preventives/remedies for diabetic neuropathy which contain cytidine 5'-diphosphocholine CDP-choline as the active ingredient. These preventives/remedies for diabetic neuropathy are efficacious against neuropathy mainly caused by hydrocarbonate metabolic errors and have a high safety. The term neuropathy includes peripheral neuropathy and autonomic neuropathy. CDP-choline is effective in oral administration too.

6. 发明授权

EP1110554B1 MEDICINAL COMPOSITIONS FOR TREATING EYE DISEASES 有权
标题翻译：眼疾组合物用于医疗
公开(公告)号：EP1110554B1
公开(公告)日：2006-03-08
申请号：EP99940582.2
申请日：1999-08-31
申请人： YAMASA CORPORATION , TOA EIYO LTD.
发明人： ENDO, Kazuki , ABIRU, Toichi , HOSOKAWA, Tomokazu , MISAWA, Miwa , KONNO, Takashi, Fukushima Research Laboratories
IPC分类号： A61K31/70 , A61K9/06 , A61K9/08 , A61K9/00 , C07H19/16 , C07H19/167
CPC分类号： A61K31/7076 , A61K9/0048 , C07H19/16 , Y10S514/912 , Y10S514/913
摘要： Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene bond at the 2-position of adenine base. Because of having a long-lasting and remarkable effect of lowering ocular tension, these compounds are useful as remedies for eye diseases with increased ocular tension or optic nerve failures such as glaucoma and hypertonia oculi.

7. 发明公开

EP1541154A1 MEDICINAL COMPOSITION FOR DRUG-INDUCED NEUROPATHY 审中-公开
标题翻译：神经病学神经病学
公开(公告)号：EP1541154A1
公开(公告)日：2005-06-15
申请号：EP03764145.3
申请日：2003-07-09
申请人： YAMASA CORPORATION
发明人： ENDO, Kazuki , KAMEI, Junzo
IPC分类号： A61K31/7068 , A61P25/00 , C07H19/10
CPC分类号： C07H19/10 , A61K31/7068
摘要： The present invention relates to an agent for the prophylaxis or treatment of drug-induced neuropathy, which contains cytidine 5'-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of drug-induced neuropathy of the present invention shows a potent ameliorating effect on drug-induced neuropathy and is also superior in safety.
摘要翻译：本发明涉及含有胞苷5'-二磷酸胆碱（CDP-胆碱）作为有效成分的药物性神经病的预防或治疗药物。用于预防或治疗本发明的药物性神经病的药剂对药物诱发的神经病变具有有效的改善作用，并且安全性也优异。

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