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1. 发明公开

EP0691980A1 7-DEAZAPURINE MODIFIED OLIGONUCLEOTIDES 失效转让
标题翻译： 7-脱氮嘌呤修饰的寡核苷酸
公开(公告)号：EP0691980A1
公开(公告)日：1996-01-17
申请号：EP94913923.0
申请日：1994-03-21
申请人： STERLING WINTHROP INC.
发明人： COOK, Phillip, D. , DELECKI, Daniel, J.
IPC分类号： C12N15 , A61K31 , A61P31 , A61P35 , C07H21
CPC分类号： C07H21/00

2. 发明公开

EP0691979A1 NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM 失效
标题翻译：新5'-取代核苷的低聚物制成
公开(公告)号：EP0691979A1
公开(公告)日：1996-01-17
申请号：EP94912265.0
申请日：1994-03-21
申请人： STERLING WINTHROP INC.
发明人： SAHA, Ashis, Kumar
IPC分类号： C12N15 , A61K31 , A61P35 , C07H19 , C07H21
CPC分类号： C07H19/06 , C07H19/04 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要： Disclosed are novel 5'-substituted nucleosides and oligonucleotide analog compounds prepared therefrom having from 2 to about 60 bases and having an internucleoside backbone containing one or more 3'-O-PO2H-O-5'-CR1R2- internucleoside linkages instead of the naturally occurring backbone of phosphodiester internucleoside linkages. The present invention also discloses a method of synthesizing oligonucleotide compounds having from 2 to about 60 bases and having an internucleoside backbone containing one or more 3'-O-PO2H-O-5'-CR1R2 internucleoside linkages instead of the naturally occurring backbone of phosphodiester internucleoside linkages, this process comprising preparation of 5'-substituted nucleoside compounds, for example, as illustrated in Figure 1, and utilizing them as synthons in automated DNA synthesizers. Oligonucleotide analogs of the present invention are useful as nuclease resistant, sequence specific antisense compounds.

3. 发明授权

EP0412149B1 USE OF IL-7 IN PROVIDING MEDICATIONS FOR STIMULATION OF PLATELET PRODUCTION 有权转让
标题翻译： IL-7用于药物用途增加生产滑动。
公开(公告)号：EP0412149B1
公开(公告)日：1995-11-08
申请号：EP90904051.1
申请日：1990-02-06
申请人： STERLING WINTHROP INC.
发明人： WILLIAMS, Douglas, E.
IPC分类号： A61K39/00 , C07K14/54
CPC分类号： C07K14/5418 , A61K38/00
摘要： The use of IL-7 in providing medications for stimulating platelet production in mammals is disclosed

4. 发明授权

EP0377439B1 Controlled-release, low-dose aspirin 有权转让
标题翻译：低剂量阿司匹林控释。
公开(公告)号：EP0377439B1
公开(公告)日：1995-09-13
申请号：EP90100032.3
申请日：1990-01-02
申请人： STERLING WINTHROP INC.
发明人： Frisbee, Steven Edgar , Fitzgerald, Garret Adare , Charman, William Neil
IPC分类号： A61K9/52 , A61K9/20 , A61K31/60
CPC分类号： A61K9/2081 , A61K31/60

5. 发明公开

EP0664819A1 CHELATING POLYMERS 失效转让
标题翻译： CHELATPOLYMERE。
公开(公告)号：EP0664819A1
公开(公告)日：1995-08-02
申请号：EP93923302.0
申请日：1993-10-07
申请人： STERLING WINTHROP INC.
发明人： SNOW, Robert, A. , LADD, David, L. , TONER, John, L.
IPC分类号： A61K49 , A61K31 , A61K51 , A61P35 , C08G65 , C09K3
CPC分类号： C08G65/3324
摘要： In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeutic and diagnostic imaging compositions and as an antistatic agent.

6. 发明公开

EP0645155A2 Holder for cartridge-needle unit 失效
标题翻译： Halterfüreine Kartuschennadel Einheit。
公开(公告)号：EP0645155A2
公开(公告)日：1995-03-29
申请号：EP94202781.4
申请日：1994-09-27
申请人： STERLING WINTHROP INC.
发明人： Stiehl, Mark A. , Bergstresser, William A. , Niedospial, John J.
IPC分类号： A61M5/32 , A61M5/24
CPC分类号： A61M5/24 , A61M5/31511 , A61M5/31515 , A61M5/3243 , A61M5/50 , A61M2005/2407 , A61M2005/247 , A61M2005/31518 , A61M2005/3246
摘要： This invention relates to a holder for use in combination with a pre-filled cartridge-needle unit, the holder comprising a hollow body (36) sized for housing the cartridge-needle unit therein having proximal and distal ends; means (32,34) for permitting the body (36) to move axially relative to the cartridge-needle unit and for retaining the cartridge-needle unit within the holder; wherein the distal end of the body (36) is elliptical in cross-section and the proximal end of the body (36) is circular in cross-section. In another preferred embodiment, the body comprises a pair of cam slots (39) at the distal end and a pair or retaining slots (37) at the proximal end, the slots (39,37) being sized to accept a circumferential ring (32) on the cartridge-needle unit and positioned to hold the cartridge-needle units in use and safe positions. The holder is easier to use and manufacture and reduces the susceptibility of health care workers to accidental needle strikes.
摘要翻译：本发明涉及一种用于与预填充的针筒单元组合使用的保持器，该保持器包括中空体（36），其尺寸适于容纳其中具有近端和远端的盒 - 针单元; 用于允许主体（36）相对于盒 - 针单元轴向移动并用于将盒 - 针单元保持在保持器内的装置（32,34）其中所述主体（36）的远端的横截面是椭圆形的，并且所述主体（36）的近端是横截面为圆形。在另一个优选实施例中，主体包括在远端处的一对凸轮槽（39）和在近端处的一对或固定槽（37），所述槽（39,37）的尺寸被设计成接纳周向环）并且被定位成将盒式针单元保持在使用和安全位置。持有人更容易使用和制造，并降低卫生保健工作者意外针刺的敏感性。

7. 发明公开

EP0645152A2 Disposable holder for pre-filled cartridge-needle unit 失效
标题翻译：预装墨盒针单元的一次性支架
公开(公告)号：EP0645152A2
公开(公告)日：1995-03-29
申请号：EP94202780.6
申请日：1994-09-27
申请人： STERLING WINTHROP INC.
发明人： Stiehl, Mark A. , Bergstresser, William A. , Chapman, Raymond P. , Niedospial, John J., Sterling Winthrop Inc.
IPC分类号： A61M5/24 , A61M5/32 , A61M5/50 , A61M5/00 , A61M5/315
CPC分类号： A61M5/3243 , A61M5/002 , A61M5/24 , A61M5/31511 , A61M5/31515 , A61M5/32 , A61M5/5086 , A61M2005/2407 , A61M2005/247 , A61M2005/31518
摘要： This invention relates to a holder for use in combination with pre-filled cartridge-needle units having a proximal end and a needle (22) at the distal end thereof, the holder comprising a hollow body (36) sized for housing the cartridge-needle unit therein, means for permitting the body (36) to move axially relative to the cartridge-needle unit and for retaining the cartridge-needle unit within the holder; and a cap (40) for the proximal end of the cartridge-needle unit, wherein the cartridge-needle unit can be activated by application of force or torque to the cap (40). In a preferred embodiment, the cap (40) is tamper-evident and attached to the proximal end of the body (36). The holder reduces the susceptibility of health care workers to accidental needle strikes and enables the cartridge-needle unit to be activated safely and easily.
摘要翻译：本发明涉及一种与预装药筒式针头单元结合使用的保持器，该预装药筒式针头单元具有近端和位于其远端的针（22），该保持器包括中空体（36），其大小适合容纳药筒针装置，用于允许所述主体（36）相对于所述盒针单元轴向移动并且将所述盒针单元保持在所述保持器内; 和用于针筒单元的近端的帽（40），其中，针筒单元可以通过对帽（40）施加力或扭矩而启动。在优选实施例中，帽（40）是防篡改的并且附接到主体（36）的近端。该夹持器减少了医护人员意外针刺的敏感性，并且可以安全且容易地启动卡式针头单元。

8. 发明授权

EP0324007B1 A PHARMACEUTICAL COMPOSITION CONTAINING S(+) IBUPROFEN SUBSTANTIALLY FREE OF ITS R(-) ANTIPODE 有权转让
标题翻译：含S-的药物组合物（+）异丁苯丙酸在主不含R（ - ）对映体。
公开(公告)号：EP0324007B1
公开(公告)日：1994-12-14
申请号：EP88906506.6
申请日：1988-07-08
申请人： STERLING WINTHROP INC.
发明人： Sunshine, Abraham , Laska, Eugene M.
IPC分类号： A61K31/19 , C07C57/30
CPC分类号： A61K31/19 , C07C57/30 , Y10S514/947 , Y10S514/96 , Y10S514/962
摘要： Onset-hastened and enhanced analgesic response is elicited in a mammalian organism in need of such treatment, i.e., a mammal suffering pain, by administering thereto a unit dosage onset-hastening/enhancing analgesically effective amount of the S(+) ibuprofen enantiomer, said enantiomer being substantially free of its R(-) ibuprofen antipode.

9. 发明公开

EP0614666A1 Lyophilized polyalkylene oxide modified protein and polypeptide complexes with cyclodextrin 失效
标题翻译：嗜血杆菌聚亚烷基氧化酶修饰蛋白和多肽 - 复合物Zyklodextrin。
公开(公告)号：EP0614666A1
公开(公告)日：1994-09-14
申请号：EP94200491.2
申请日：1994-02-24
申请人： STERLING WINTHROP INC.
发明人： Snow, Robert A., c/o STERLING WINTHROP INC. , Phillips, Christopher P.
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/60 , A61K47/6951 , C07K7/083 , C07K14/5406 , C07K14/77 , C12N9/0065 , C12N9/0089 , C12N9/96 , Y02A90/22 , Y02A90/26
摘要： An aqueous physiologically active proteinaceous composition for lyophilization comprising: from about 150 to about 150,000 unit/ml of a covalently bound low diol polyalkylene oxide/protein, preferably polyethylene glycol/protein; from about 0.1 to about 20% w/v of cyclodextrin, preferably β-cyclodextrin; and from about 0.01 to about 50 mM buffer, said composition having a pH of from about 5.7 to about 6.5, is disclosed, together with a process for its preparation and its use for the preparation of a medicament for treating a disease condition caused by superoxide anions on tissue in a mammal.
摘要翻译：重构的亲水化制剂包含（a）聚乙二醇和具有150-150,000U / ml的酶活性的生物活性超氧化物歧化酶蛋白质的缀合物，PEG具有重量由1,000-15,000道尔顿组成，由少于10重量％的非单乙氧基化PEG和大于90重量％的单乙氧基化PEG组成; （G）0.1-20％（w / v）的B-环糊精; 和（c）0.01-50nM缓冲制剂，pH为5.7-6.5。超氧化物歧化酶具有人或重组幽默超氧化物歧化酶。这是指与环糊精复合的低二醇聚环氧烷共价结合的生理活性蛋白质的稳定的肠胃外制剂。涉及范围广泛的蛋白质，多肽和激素。

10. 发明公开

EP0584876A3 Low diol polyalkylene oxide biologically active proteinaceous substances 失效
标题翻译：低二异丙氧基氧化物生物活性蛋白质物质
公开(公告)号：EP0584876A3
公开(公告)日：1994-06-29
申请号：EP93202462.3
申请日：1993-08-21
申请人： STERLING WINTHROP INC.
发明人： Snow, Robert A., c/o Sterling Winthrop Inc. , Ladd, David L., c/o Sterling Winthrop Inc. , Hoyer, Denton W., c/o Sterling Winthrop Inc. , Phillips, Christopher P., c/o Sterling Winthrop
IPC分类号： A61K47/48
CPC分类号： A61K47/60 , Y10S514/886
摘要： A biologically active proteinaceous composition comprising: a biologically active protein covalently attached to polyalkylene oxide, said polyalkylene oxide having a molecular weight of from about 1,000 to about 15,000 daltons and being comprised of monomethoxylated and non-methoxylated polyalkylene oxide such that less than about 10% w/w is non-monomethoxylated polyalkylene oxide is disclosed, together with a method for its preparation. Preferably the low diol polyalkylene oxide is polyethylene glycol having a preferred molecular weight of from about 4,000 to about 6,000 daltons and containing less than about 7% w/w non-methoxylated polyethylene glycol. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.

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