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1. 发明公开

EP1930315A1 PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF 审中-公开
标题翻译：用于生产单取代烷基化的连接，使用醛亚胺或其衍生物
公开(公告)号：EP1930315A1
公开(公告)日：2008-06-11
申请号：EP06782315.3
申请日：2006-07-28
申请人： NAGASE & COMPANY, LTD.
发明人： MARUOKA, Keiji, c/o Department of Chemistry, , INOUE, Toru, c/o NAGASE & CO., LTD. , MATSUMOTO, Jun, c/o NAGASE & CO., LTD.
IPC分类号： C07C249/02 , B01J31/02 , C07B53/00 , C07B61/00 , C07C227/04 , C07C229/36 , C07C251/24
CPC分类号： C07B53/00 , B01J31/0239 , B01J31/0244 , B01J2231/46 , B01J2531/98 , C07C227/32 , C07C231/18 , C07C249/02 , C07C229/36 , C07C237/20 , C07C251/24
摘要： The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of α-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.
摘要翻译：本发明提供了产生的±氨基酸并通过特定的公式利用在阿尔迪矿型船被表示，基部不对称单烷基化的化合物substituiertem的方法。在本发明中，在碱的存在下在培养基中，在阿尔迪矿型船烷基化的过程中的方法，以光学活性季铵盐相转移催化剂的无机碱和被启动，并随后将反应物在骤冷的时间超过一个时间用于烷基化反应的化学计量反应完成早些时候，所以没有具有高光学纯度的单烷基化的产物substituiertem可以得到。

2. 发明公开

EP1712549A1 OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME 失效转让
标题翻译：光有源季铵盐轴不对称及其制造方法的α-氨基酸和它们的衍生物中的应用
公开(公告)号：EP1712549A1
公开(公告)日：2006-10-18
申请号：EP05704383.8
申请日：2005-01-27
申请人： NAGASE & COMPANY, LTD.
发明人： MARUOKA, Keiji
IPC分类号： C07D223/14 , C07D498/10 , C07D487/10 , C07D471/10 , C07D405/14 , C07D409/14 , C07C249/02 , C07C251/24 , C07C229/34 , C07C227/10
CPC分类号： C07D223/14 , B01J31/0237 , B01J31/0239 , B01J2231/4272 , B01J2531/98 , C07C229/36 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/10
摘要： The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.
摘要翻译：本发明提供了下面的下式（I）的化合物。该化合物（I）可以通过使2,2'-二亚甲基 - 1,1'-联萘溴衍生物，其可以通过一个相对小数目的方法生产，与容易获得的仲胺制备。该化合物（I）是作为手性相转移催化剂是有用的。

3. 发明公开

EP1375574A1 POLYPHENYLENE SULFIDE MEMBER AND ITS MANUFACTURING METHOD 有权
标题翻译： VERFAHREN ZU SEINER HERSTELLUNG的POLYPHENYLENSULFID-ELEMENT
公开(公告)号：EP1375574A1
公开(公告)日：2004-01-02
申请号：EP02700658.4
申请日：2002-02-21
申请人： TORAY INDUSTRIES, INC. , Nagase Colors & Chemicals Co., Ltd. , NAGASE & COMPANY, LTD.
发明人： KUBO, Kenzo , NAKAHARA, Makoto , HORIIKE, Taizo , YAMAMOTO, Hideyuki , ITO, Ryutaro , SUMI, Koji
IPC分类号： C08J7/00 , C08L81/02 , C08K5/07 , C08K5/34 , C08K5/101 , D01F6/76 , D01F6/94 , C09K3/00
CPC分类号： C08K5/07 , C08K5/0008 , C08K5/3475 , C08L81/02 , D01F6/76 , Y10T428/2933 , Y10T428/2967
摘要： Disclosed is a PPS member having an excellent fastness to lights such as ultraviolet light, and of which color does not change even when the member is used outdoors, while retaining the characteristics of PPS. The polyphenylene sulfide member according to the present invention is characterized by having a light-fastness rating of Class 1 or higher, against light from an ultraviolet carbon arc lamp, which rating is measured in accordance with JIS L-0842.
摘要翻译：公开了一种具有优异的耐紫外光等耐光性的PPS构件，即使在室外使用时，颜色也不变化，同时保持PPS的特性。根据本发明的聚苯硫醚构件的特征在于耐紫外线弧光灯的光的耐光等级为1级以上，该等级根据JIS L-0842测量。

4. 发明公开

EP0527058A1 Apparatus for controlling a developing solution 失效
标题翻译： Vorrichtung zur Kontrolle einerEntwicklerlösung。
公开(公告)号：EP0527058A1
公开(公告)日：1993-02-10
申请号：EP92307245.8
申请日：1992-08-07
申请人： HIRAMA RIKA KENKYUJO LTD. , NAGASE & COMPANY, LTD.
发明人： Nakagawa, Toshimoto , Tsukada, Kouzo , Ogawa, Shu , Shiotsu, Shinichiro
IPC分类号： G03F7/30
CPC分类号： G03F7/30
摘要： The developing solution is used in developing photosensitive organic resin (photoresist) in a liquid crystal board manufacturing process, printed circuit board manufacturing process or the like.
The apparatus comprises means, such as an absorption photometer (16), for detecting the dissolved resin concentration in the developing solution and means, such as an electric conductivity meter (15), for detecting the alkali concentration of the developing solution. Means (3, 18, 21, 22, 24, 25, 26, 28) respond to the two detection means (15, 16) by replenishing the developing solution with undiluted developing solution and/or pure water to produce a desired dissolved resin concentration and a desired alkali concentration. Thus, the developing performance of the developing solution may be kept constant. Down time is save by removing the need to stop the manufacturing process to completely change the developing solution.
摘要翻译：显影液用于制造液晶板制造工艺，印刷电路板制造工艺等中的感光性有机树脂（光致抗蚀剂）。该装置包括用于检测显影液中溶解的树脂浓度的装置，例如吸收光度计（16），以及用于检测显影液的碱浓度的诸如电导率计（15）的装置。手段（3,18,21,22,24,25,26,28）通过用未稀释的显影液和/或纯水补充显影液以产生所需的溶解树脂浓度来响应两个检测装置（15,16）和所需的碱浓度。因此，显影液的显影性能可以保持恒定。通过消除停止制造过程以完全改变开发解决方案的需要，节省了时间。

5. 发明公开

EP0496345A1 Method for detecting and quantifying cariogenic bacteria 失效
标题翻译：巴伐利亚州的维拉法尼亚。
公开(公告)号：EP0496345A1
公开(公告)日：1992-07-29
申请号：EP92100923.9
申请日：1992-01-21
申请人： NAGASE & COMPANY, LTD.
发明人： Miyazaki, Toshitsugu , Matsuda, Yoko , Nakamura, Tsutomu , Ota, Fusao , Nishino, Mizuho
IPC分类号： G01N33/569 , C12Q1/04 , C12Q1/14 , C12Q1/06
CPC分类号： C12Q1/14 , G01N33/56944 , G01N2333/315
摘要： A novel method for detecting and quantifying cariogenic bacteria is provided, said method being characterized by the following steps:

(a) Streptococcus mutans in a sample to be examined is reacted with at least one polyclonal or monoclonal antibody having a specific reactivity to the microorganism;
(b) the antibody bound to the microorganism is separated from the unbound antibody by filtration through a membrane filter; and
(c) the bound antibody captured on the filter is detected by a suitable means.

The present method enables to rapidly and conveniently detect S. mutans in a high sensitivity, without the need of selective cultivation of a sample before detection, and without the problem of decrease of survival rate of bacteria caused by the time-lag between collection of a sample from a subject and its detection.
摘要翻译：提供了一种用于检测和定量致龋菌的新方法，所述方法的特征在于以下步骤：（a）待检样品中的变形链球菌与至少一种对微生物具有特异性反应性的多克隆或单克隆抗体反应; （b）通过膜过滤器过滤将与微生物结合的抗体与未结合的抗体分离; 和（c）通过合适的方法检测在过滤器上捕获的结合的抗体。本方法能够以高灵敏度快速方便地检测变形链球菌，而不需要在检测前对样品进行选择性培养，并且不存在由收集之前的时间滞后引起的细菌存活率降低的问题来自受试者的样本及其检测。

6. 发明授权

EP1712549B1 OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME 失效转让
标题翻译：具有轴向不对称性的光学活性季铵盐及其生产α-氨基酸及其衍生物的方法
公开(公告)号：EP1712549B1
公开(公告)日：2018-04-11
申请号：EP05704383.8
申请日：2005-01-27
申请人： NAGASE & COMPANY, LTD.
发明人： MARUOKA, Keiji
IPC分类号： C07D223/14 , C07D498/10 , C07D487/10 , C07D471/10 , C07D405/14 , C07D409/14 , C07C249/02 , C07C251/24 , C07C229/34 , C07C227/10
CPC分类号： C07D223/14 , B01J31/0237 , B01J31/0239 , B01J2231/4272 , B01J2531/98 , C07C229/36 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/10
摘要： The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.

7. 发明授权

EP1785492B1 Process for preparing docosahexaenoic acid and docosapentaenoic acid 失效
标题翻译：一种用于制备十二碳六烯酸和Docosapentansäure过程
公开(公告)号：EP1785492B1
公开(公告)日：2010-05-26
申请号：EP06022844.2
申请日：1997-06-06
申请人： Nagase ChemteX Corporation , Suntory Holdings Limited , NAGASE & COMPANY, LTD.
发明人： Tanaka, Satohiro , Yaguchi, Toshiaki , Shimizu, Sakayu , Sogo, Tsutomu , Fujikawa, Shigeaki
IPC分类号： C12Q1/68
CPC分类号： C12P7/6427 , A23D9/007 , A23K20/158 , A23L33/12 , C11C1/045 , C12P7/6472 , C12R1/645 , C12R1/89

8. 发明公开

EP1870403A8 OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME 审中-公开
标题翻译：光有源季铵盐AXIALasymétrieAND METHOD FOR PRODUCING的α-氨基酸和使用它们的衍生物，其
公开(公告)号：EP1870403A8
公开(公告)日：2008-03-12
申请号：EP06730739.7
申请日：2006-03-24
申请人： NAGASE & COMPANY, LTD.
发明人： MARUOKA, Keiji c/o Department of Chemistry Graduate School of Science Kyoto University , NISHIMOTO, Yukifumi c/o NAGASE & CO., LTD. , YAMAMOTO, Kenichiro c/o NAGASE & CO., LTD.
IPC分类号： C07D223/18 , C07D487/10 , C07D498/10 , C07D513/10 , C07C227/04 , C07C227/32 , C07C229/36 , C07C249/02 , C07C251/24 , B01J31/02 , C07B53/00 , C07B61/00
CPC分类号： C07B53/00 , B01J31/0239 , B01J2531/985 , C07C227/32 , C07C249/02 , C07D223/18 , C07D487/10 , C07C229/36 , C07C251/24
摘要： The present invention provides a chiral phase-transfer catalyst of the following formula (I):

The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

9. 发明公开

EP1870403A1 OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING -AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME 审中-公开
标题翻译：光有源季铵盐AXIALasymétrieAND METHOD FOR PRODUCING的α-氨基酸和使用它们的衍生物，其
公开(公告)号：EP1870403A1
公开(公告)日：2007-12-26
申请号：EP06730739.7
申请日：2006-03-24
申请人： NAGASE & COMPANY, LTD.
发明人： MARUOKA, Keiji Graduate School Science Kyoto Univ. , NISHIMOTO, Yukifumi c/o NAGASE&CO., LTD. , YAMAMOTO, Kenichiro c/o NAGASE&CO., LTD.
IPC分类号： C07D223/18 , C07D487/10 , C07D498/10 , C07D513/10 , C07C227/04 , C07C227/32 , C07C229/36 , C07C249/02 , C07C251/24 , B01J31/02 , C07B53/00 , C07B61/00
CPC分类号： C07B53/00 , B01J31/0239 , B01J2531/985 , C07C227/32 , C07C249/02 , C07D223/18 , C07D487/10 , C07C229/36 , C07C251/24
摘要： The present invention provides a chiral phase-transfer catalyst of the following formula (I):

The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.
摘要翻译：本发明提供下式（I）的手性相转移催化剂：化合物（I）可以通过使2,2'-二亚甲基-1,1'-联苯溴衍生物，其可通过应当产生相对小的数目的步骤，与容易获得的仲胺。

10. 发明公开

EP1098317A2 Oscillating actuator 审中-公开
标题翻译： Oszillierender Aktuator
公开(公告)号：EP1098317A2
公开(公告)日：2001-05-09
申请号：EP00112349.6
申请日：2000-06-09
申请人： NAGASE & COMPANY, LTD. , TORAY INDUSTRIES, INC.
发明人： Ikemoto, Masaya, c/o Nagase & Co., Ltd. , Nakamura, Kiyokazu, c/o Toray Industries Inc. , Matsumoto, Michiyoshi, c/o Toray Industries Inc. , Fujino, Shingo, c/o Toray Industries Inc. , Sato, Hiroyuki, c/o Toray Industries Inc.
IPC分类号： G11B21/10
CPC分类号： G11B21/16 , G11B5/4833 , Y10T74/20305
摘要： An oscillating actuator which comprises a coil-holding member and a carriage member comprising a bearing hole and one or more arms, wherein the arm has an intermediate portion and a head portion arranged in this order from the bearing hole in the carriage member and the intermediate portion has a thickness smaller than the thickness of the heat portion.
The oscillating actuator is used for disk apparatuses, exhibits excellent dimensional stability and can be produced easily and economically.
摘要翻译：一种振荡致动器，包括线圈保持构件和支架构件，该支架构件包括轴承孔和一个或多个臂，其中所述臂具有中间部分和头部部分，其从所述滑架构件中的所述轴承孔和所述中间部件部分的厚度小于加热部分的厚度。振荡致动器用于盘装置，显示出优异的尺寸稳定性，并且可以容易且经济地制造。

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