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1. 发明公开

EP2696785A1 COILED HEAT EXCHANGER FOR CRYOSURGICAL INSTRUMENT 有权
标题翻译： SPULENWÄRMETAUSCHERFÜREIN KRYOCHIRURGISCHES INSTRUMENT
公开(公告)号：EP2696785A1
公开(公告)日：2014-02-19
申请号：EP11760933.9
申请日：2011-09-14
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger. The heat exchanger includes: a plurality of cryogen delivery tubes that spiral around a longitudinal axis thereof; and a diffuser having a plurality of branches, each of the branches supplying received cryogen to a respective one of the delivery tubes. The cryogen delivery tubes, where they spiral, are spaced from each other and in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft.
摘要翻译：一种冷冻手术器械，包括：轴，其具有限定膨胀室的封闭远端和接收冷冻剂流入并排出膨胀冷冻剂流的近端; 以及具有冷却剂输送管的热交换器，所述冷冻剂输送管围绕沿其纵向轴线设置的芯线螺旋形。其螺旋形的冷冻剂输送管与轴的内表面流体紧密接触，以便形成螺旋形的冷冻剂排放通道，其沿着冷冻外科器械长度的一部分从轴的远端延伸。冷冻剂输送管迫使冷冻剂的两相流动通过离心力进行相分离，并将液相推向螺旋线圈的外壁和螺旋间隙的外表面。热交换发生在仪器外壁附近。

2. 发明公开

EP4285849A3 CRYOGENIC SYSTEM WITH MULTIPLE SUBMERGED PUMPS 审中-实审
公开(公告)号：EP4285849A3
公开(公告)日：2024-05-15
申请号：EP23172909.6
申请日：2023-05-11
申请人： IceCure Medical Ltd.
发明人： KAUFMAN, Shai , MUCHNIK, Naum , BRUDNER, Dori , LASKER, Lior , HILLELI, Ron
IPC分类号： A61B18/02 , A61B18/00 , A61M5/142
CPC分类号： A61B18/02 , A61B2018/0000520130101 , A61B2018/0057720130101 , A61B2018/0065420130101 , A61B2018/0074420130101 , A61B2018/0079720130101 , A61B2018/0079120130101 , A61B2018/026220130101 , A61B2018/0001120130101 , A61B18/00 , A61B2018/021220130101 , A61B2018/029320130101 , A61M5/142 , A61M2205/336820130101 , A61M2205/3620130101
摘要： Apparatus, consisting of a single insulated container, configured to contain a cryogen. The apparatus also has a first pump and a second pump, both disposed in the single insulated container and configured to pump the cryogen from the single insulated container while immersed in the cryogen. A first probe and a second probe, having respective first and second proximal ends, are coupled to receive concurrently the cryogen pumped by the first pump and the second pump, respectively. The probes have respective first and second distal ends, which are chilled by the cryogen received through the first and second proximal ends and which are configured to be inserted into a body of a living subject.

3. 发明公开

EP2549941A2 CRYOSURGICAL INSTRUMENT WITH ENHANCED HEAT TRANSFER 有权
标题翻译：与增加的传热冷冻头器械
公开(公告)号：EP2549941A2
公开(公告)日：2013-01-30
申请号：EP11715783.4
申请日：2011-02-22
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , SHARON, Simon , SHTEIMAN, Igal , SHILDER, Eytan
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0268
摘要： Cryosurgical instruments and methods utilizing improved heat transfer characteristics. A cryosurgical device includes: a tubular housing; a cryogen supply passage; a heat exchange enhancing member in the housing, disposed along a longitudinal axis of the housing; an annular cooling passage between the heat exchange enhancing member and the tubular housing; a tip cooling and cryogen flow directing section that transmits a temperature of a cryogen flow to the tip, and an insulation element in the tubular housing.

4. 发明公开

EP3116428A1 PHASE SEPARATION OF CRYOGEN IN CRYOSURGICAL INSTRUMENT 审中-公开
标题翻译：金属制品仪器中的PHASENTRENNUNG EINESKÄLTEMITTELS
公开(公告)号：EP3116428A1
公开(公告)日：2017-01-18
申请号：EP14806769.7
申请日：2014-11-06
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and a proximal end that receives an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger with a cryogen delivery tube that spirals around a core disposed along a longitudinal axis thereof. The cryogen delivery tube, where it spirals, is in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft. The cryogen delivery tube forces a two-phase flow of cryogen to undergo phase separation by centrifugal forces and urges the liquid phase against the external walls of the spiral coil and the outer surface of the spiral gap. Heat exchanging occurs close to the external wall of the instrument.
摘要翻译：一种冷冻手术器械，包括：轴，其具有限定膨胀室的封闭远端和接收冷冻剂流入并排出膨胀冷冻剂流的近端; 以及具有冷却剂输送管的热交换器，所述冷冻剂输送管围绕沿其纵向轴线设置的芯线螺旋形。其螺旋形的冷冻剂输送管与轴的内表面流体密封接触，以形成从轴远端沿着冷冻外科器械长度的一部分延伸的螺旋式冷冻剂排气路径。冷冻剂输送管强制冷冻剂的两相流动通过离心力进行相分离，并将液相推向螺旋线圈的外壁和螺旋间隙的外表面。热交换发生在仪器外壁附近。

5. 发明公开

EP2593028A1 CRYOSURGICAL INSTRUMENT FOR TREATING LARGE VOLUME OF TISSUE 失效
标题翻译：克朗仪器仪表（ZUR BEHANDLUNG VON GROSSEN GEWEBEMENGEN）
公开(公告)号：EP2593028A1
公开(公告)日：2013-05-22
申请号：EP11754809.9
申请日：2011-09-01
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , SHARON, Simon , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B5/7232 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293
摘要： A cryosurgical instrument that is selectively positioned in a patient tissue by rotation. The instrument includes: a manipulation section that permits a user to rotate the instrument; a cryogen supply portion; and a positioning section having a sharp tip at an end and a helical configuration, the positioning section configured to receive cryogen and to permit the received cryogen to cool the positioning section. The positioning section urges the cryosurgical instrument deeper into the patient when the instrument is rotated in a first direction, via the manipulation section, and urges the cryosurgical instrument outward when the instrument is rotated in a second direction that is opposite the first, via the manipulation section.
摘要翻译：通过旋转选择性地定位在患者组织中的冷冻手术器械。仪器包括：允许用户旋转仪器的操作部分; 制冷剂供应部分; 以及定位部分，其端部具有尖锐的尖端和螺旋形状，所述定位部分构造成接收冷冻剂并允许接收的冷冻剂冷却定位部分。当仪器通过操作部分沿着第一方向旋转时，定位部件将冷冻手术器械推入患者体内，并且当仪器通过操作方向在与第一方向相反的第二方向旋转时向外推动冷冻外科器械部分。

6. 发明公开

EP2533716A1 HEATING AND COOLING OF CRYOSURGICAL INSTRUMENT USING A SINGLE CRYOGEN 有权
标题翻译：加热和冷却冷冻外科仪器使用单一制冷剂
公开(公告)号：EP2533716A1
公开(公告)日：2012-12-19
申请号：EP11725226.2
申请日：2011-04-08
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , SHARON, Simon
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0212 , A61B2018/0262 , A61B2018/048
摘要： A cryosurgical system featuring both cooling and heating utilizing a single type of cryogen but from two different sources. The liquid cryogen cools the tip of a cryosurgical instrument in the cryosurgical system, such as a cryoprobe or cryocatheter. The gaseous cryogen is further heated by a heating element, preferably an electrical heating element, supplying the heating needed for the thaw and release parts of the cryo treatment procedure. Thus, the cryosurgical system supports the freeze/thaw cycle of the operation of the cryosurgical instrument.

7. 发明授权

EP2593028B1 CRYOSURGICAL INSTRUMENT FOR TREATING LARGE VOLUME OF TISSUE 失效
标题翻译：治疗大体积组织的冷冻外科器械
公开(公告)号：EP2593028B1
公开(公告)日：2017-08-16
申请号：EP11754809.9
申请日：2011-09-01
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , SHARON, Simon , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B5/7232 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293

8. 发明授权

EP2696785B1 COILED HEAT EXCHANGER FOR CRYOSURGICAL INSTRUMENT 有权
标题翻译：盘管换热换取冷冻头器械
公开(公告)号：EP2696785B1
公开(公告)日：2016-11-02
申请号：EP11760933.9
申请日：2011-09-14
申请人： Icecure Medical Ltd.
发明人： BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger. The heat exchanger includes: a plurality of cryogen delivery tubes that spiral around a longitudinal axis thereof; and a diffuser having a plurality of branches, each of the branches supplying received cryogen to a respective one of the delivery tubes. The cryogen delivery tubes, where they spiral, are spaced from each other and in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft.

9. 发明授权

EP2683315B1 CRYOSURGICAL INSTRUMENT WITH REDIRECTED FLOW 有权
标题翻译：冷冻外科器械与重定向电源
公开(公告)号：EP2683315B1
公开(公告)日：2016-10-12
申请号：EP11819145.1
申请日：2011-12-29
申请人： Icecure Medical Ltd.
发明人： SHARON, Assaf , BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2018/0281

10. 发明公开

EP2683315A1 CRYOSURGICAL INSTRUMENT WITH REDIRECTED FLOW 有权
标题翻译：冷冻外科器械与重定向电源
公开(公告)号：EP2683315A1
公开(公告)日：2014-01-15
申请号：EP11819145.1
申请日：2011-12-29
申请人： Icecure Medical Ltd.
发明人： SHARON, Assaf , BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2018/0281
摘要： A cryosurgical instrument that includes: an external shaft with a cryotip; a heat exchanger that cools a portion of the external shaft and the tip when cryogen is received thereby; and a flow diverter that receives a flow of cryogen, that splits the received flow of cryogen into two or more split cryogen flows, and that delivers the split cryogen flows to the heat exchanger, the flow diverter including a first passage with one or more inlet ports at an upstream side of the diverter that receive the flow of cryogen and two or more outlet ports at a downstream side of the diverter and in fluid communication with the heat exchanger.

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