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1. 发明公开

EP0637989A1 DEVICE AND METHOD FOR EXTRACORPOREAL BLOOD TREATMENT 失效
标题翻译： VORRICHTUNG UND METHODS ZURAUSSERKÖRPERLICHENBLUTBEHANDLUNG。
公开(公告)号：EP0637989A1
公开(公告)日：1995-02-15
申请号：EP93904972.0
申请日：1993-02-08
申请人： HEMOCLEANSE, INC.
发明人： ASH, Stephen, R.
IPC分类号： A61M1 , B01D61 , B01D63 , B01D65
CPC分类号： B01D65/08 , A61M1/1005 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D63/16 , B01D2321/2083 , Y10T436/255
摘要： Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer.
摘要翻译：公开了优选的装置和方法，其提供血液的体外治疗以有效且一致地从其中长时间地从患者中去除毒素。

2. 发明公开

EP1009315A1 SPLITTABLE MULTIPLE CATHETER ASSEMBLY AND METHODS OF INSERTING THE SAME 失效
标题翻译： PLUGGABLE多导管系统及其引入方法
公开(公告)号：EP1009315A1
公开(公告)日：2000-06-21
申请号：EP98926204.3
申请日：1998-06-08
申请人： Medical Components, Inc. , HEMOCLEANSE, INC.
发明人： ASH, Stephen, R. , MADISON, Anthony, J. , SCHWEIKERT, Timothy, M.
IPC分类号： A61B19/00 , A61M3/00 , A61M5/00 , A61M5/32 , A61M25/00
CPC分类号： A61M25/0021 , A61M25/0043 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037 , A61M2025/004
摘要： A multiple lumen catheter assembly (10'), and methods for inserting the same are provided. The assembly (10') includes a split membrane (46') joining a first catheter (26') and a second catheter (30') for allowing the catheters to be at least partially longitudinally split from each other. Each catheter has at least one lumen (28', 32') extending longitudinally through the catheter. One method for inserting the assembly (10') includes making an incision near the area to be catheterized, at least partially splitting the distal end regions of the catheters from each other by splitting apart the split membrane (46'), inserting the distal end regions of the catheters in a juxtaposed relation through the incision, and into the area to by catheterized.

3. 发明授权

EP0739234B1 HEMOFILTRATION AND PLASMAFILTRATION DEVICE 失效
标题翻译： VORRICHTUNG ZURHÄMOFILTRATIONUND PLASMAFILTRATION
公开(公告)号：EP0739234B1
公开(公告)日：2003-07-02
申请号：EP95908480.7
申请日：1995-01-11
申请人： HEMOCLEANSE, INC.
发明人： ASH, Stephen, R.
IPC分类号： B01D61/00 , B01D63/00 , B01D63/02 , B01D65/00 , B01D65/02 , B01D65/08 , A61M1/34
CPC分类号： B01D63/16 , A61M1/10 , A61M1/1005 , A61M1/1006 , A61M1/1062 , A61M1/1086 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3431 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D65/08 , B01D2321/2066 , B01D2321/2083
摘要： Devices and methods for providing extracorporeal treatment of blood for effective plasmafiltration or hemofiltration are disclosed. The device incorporates a hollow fiber membrane device (HFD) connected in series with a parallel plate dialyzer (PPD). Sorbent suspension from a sorbent bag (101) first passes through the sorbent inlet (102) of the PPD, exits through sorbent outlet (103), is drawn into accumulator reservoir (104), is expelled from accumulator reservoir (104) and passes through check valve (105) in response to alternating positive pressure and negative pressure applied to the accumulator reservoir (104). The sorbent suspension then passes into HFD inlet (106) and through the outer chamber of the HFD, thus agitating and mixing the sorbent suspension into contact with exterior surfaces of the hollow fibers (107) in the HFD. Sorbent suspension exits the HFD from outlet (108) and passes through blood leak detector (109) and back into the sorbent bag (101).
摘要翻译：公开了提供用于血液或其它流体的体外治疗以用于单独或与透析组合的有效等离子体过滤或血液滤过的优选装置和方法。

4. 发明公开

EP0739234A4 HEMOFILTRATION AND PLASMAFILTRATION DEVICES AND METHODS 失效
标题翻译：装置和血液滤过和血浆过滤方法
公开(公告)号：EP0739234A4
公开(公告)日：1999-03-03
申请号：EP95908480
申请日：1995-01-11
申请人： HEMOCLEANSE INC
发明人： ASH STEPHEN R
IPC分类号： A61M1/14 , A61M1/10 , A61M1/16 , A61M1/26 , A61M1/30 , A61M1/34 , B01D61/00 , B01D61/14 , B01D61/24 , B01D61/26 , B01D61/28 , B01D61/30 , B01D61/58 , B01D63/02 , B01D63/16 , B01D65/08 , B01D63/00 , B01D65/00 , B01D65/02
CPC分类号： B01D63/16 , A61M1/10 , A61M1/1005 , A61M1/1006 , A61M1/1062 , A61M1/1086 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3431 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D65/08 , B01D2321/2066 , B01D2321/2083
摘要： Devices and methods for providing extracorporeal treatment of blood for effective plasmafiltration or hemofiltration are disclosed. The device incorporates a hollow fiber membrane device (HFD) connected in series with a parallel plate dialyzer (PPD). Sorbent suspension from a sorbent bag (101) first passes through the sorbent inlet (102) of the PPD, exits through sorbent outlet (103), is drawn into accumulator reservoir (104), is expelled from accumulator reservoir (104) and passes through check valve (105) in response to alternating positive pressure and negative pressure applied to the accumulator reservoir (104). The sorbent suspension then passes into HFD inlet (106) and through the outer chamber of the HFD, thus agitating and mixing the sorbent suspension into contact with exterior surfaces of the hollow fibers (107) in the HFD. Sorbent suspension exits the HFD from outlet (108) and passes through blood leak detector (109) and back into the sorbent bag (101).

5. 发明授权

EP0637989B1 DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT 失效
标题翻译： VORRICHTUNG ZURAUSSERKÖRPERLICHENBLUTBEHANDLUNG
公开(公告)号：EP0637989B1
公开(公告)日：2004-04-14
申请号：EP93904972.2
申请日：1993-02-08
申请人： HEMOCLEANSE, INC.
发明人： ASH, Stephen, R.
IPC分类号： A61M1/30 , B01D61/24 , B01D65/08
CPC分类号： B01D65/08 , A61M1/1005 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D63/16 , B01D2321/2083 , Y10T436/255
摘要： Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer.
摘要翻译：公开了优选的装置和方法，其提供血液的体外治疗以有效且一致地从其中长时间地从患者中去除毒素。

6. 发明公开

EP1017434A2 CONTINUOUS FLOW-THROUGH PERITONEAL DIALYSIS (CFPD) METHOD WITH CONTROL OF INTRAPERITONEAL PRESSURE 失效
标题翻译：设备与持续流动和控制压力腹膜INNERPERITONEALEN
公开(公告)号：EP1017434A2
公开(公告)日：2000-07-12
申请号：EP97913813.8
申请日：1997-10-22
申请人： HEMOCLEANSE, INC.
发明人： ASH, Stephen, R.
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/1696 , A61M1/281 , A61M1/284 , A61M1/285 , A61M1/32 , A61M1/3489
摘要： The present invention relates generally to advantageous devices and methods for treating patients suffering from renal insufficiency and/or hepatic insufficiency. More particularly, the invention relates in certain aspects to devices and methods for performing continuous flow-through peritoneal dialysis (CFPD). In other aspects of the invention, peritoneal dialysis systems (30) are provided which utilizes a bio-reactor (41) to regenerate peritoneal fluid for re-infusion into a peritoneal cavity (13). The invention, therefore, provides advantageous systems for passing fluid through a patient's peritoneal cavity at a relatively high flow rate, while maintaining in the peritoneal cavity an optimal dialysate pressure, to thereby alter the contents of the patient's blood by diffusion of molecules through the peritoneal membrane.
摘要翻译：本发明涉及基因的反弹有利的装置和用于治疗患有肾功能不全和/或肝功能不全的患者的方法。更具体地，本发明涉及到某些方面的装置和用于执行连续流通腹膜透析（CFPD）方法。在本发明的其他方面，提供了腹膜透析系统，其利用一个生物反应器中用于再输注腹膜液再生为腹膜腔。因此本发明，提供有利的系统使流体通过患者的腹膜腔中以相对高的流率，而在腹膜腔中保持，以最佳的透析液的压力，从而通过分子扩散通过腹膜改变的患者的血液中的内容膜。

7. 发明公开

EP0637989A4 DEVICE AND METHOD FOR EXTRACORPOREAL BLOOD TREATMENT. 失效
标题翻译： DEVICE AND METHOD FOR其他比身体血液处理。
公开(公告)号：EP0637989A4
公开(公告)日：1997-06-11
申请号：EP93904972
申请日：1993-02-08
申请人： HEMOCLEANSE INC
发明人： ASH STEPHEN R
IPC分类号： A61M1/14 , A61M1/10 , A61M1/16 , A61M1/26 , A61M1/30 , A61M1/34 , B01D61/00 , B01D61/14 , B01D61/24 , B01D61/26 , B01D61/58 , B01D63/16 , B01D65/08
CPC分类号： B01D65/08 , A61M1/1005 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D63/16 , B01D2321/2083 , Y10T436/255
摘要： Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer.

8. 发明公开

EP0739234A1 HEMOFILTRATION AND PLASMAFILTRATION DEVICES AND METHODS 失效
标题翻译： VORRICHTUNGEN UND METHODEN ZURHÄMOFILTRATIONUND PLASMAFILTRATION
公开(公告)号：EP0739234A1
公开(公告)日：1996-10-30
申请号：EP95908480.0
申请日：1995-01-11
申请人： HEMOCLEANSE, INC.
发明人： ASH, Stephen, R.
IPC分类号： A61M1 , B01D61 , B01D63 , B01D65
CPC分类号： B01D63/16 , A61M1/10 , A61M1/1005 , A61M1/1006 , A61M1/1062 , A61M1/1086 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3431 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D65/08 , B01D2321/2066 , B01D2321/2083
摘要： Devices and methods for providing extracorporeal treatment of blood for effective plasmafiltration or hemofiltration are disclosed. The device incorporates a hollow fiber membrane device (HFD) connected in series with a parallel plate dialyzer (PPD). Sorbent suspension from a sorbent bag (101) first passes through the sorbent inlet (102) of the PPD, exits through sorbent outlet (103), is drawn into accumulator reservoir (104), is expelled from accumulator reservoir (104) and passes through check valve (105) in response to alternating positive pressure and negative pressure applied to the accumulator reservoir (104). The sorbent suspension then passes into HFD inlet (106) and through the outer chamber of the HFD, thus agitating and mixing the sorbent suspension into contact with exterior surfaces of the hollow fibers (107) in the HFD. Sorbent suspension exits the HFD from outlet (108) and passes through blood leak detector (109) and back into the sorbent bag (101).
摘要翻译：公开了提供用于血液或其它流体的体外治疗以用于单独或与透析组合的有效等离子体过滤或血液滤过的优选装置和方法。

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