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1. 发明授权

EP3514225B1 CELL STRUCTURE PRODUCTION DEVICE 有权
公开(公告)号：EP3514225B1
公开(公告)日：2020-09-23
申请号：EP17911399.8
申请日：2017-10-30
申请人： Cyfuse Biomedical K. K.
发明人： KISHII, Yasuto , TOKUNAGA, Norihiko
IPC分类号： C12M3/00 , C12M1/12 , C12M1/26 , C12N5/00

2. 发明公开

EP2974751A4 CARDIAC OR VASCULAR TISSUE SPHEROID 审中-公开
标题翻译：心脏和血管组织球体
公开(公告)号：EP2974751A4
公开(公告)日：2016-11-09
申请号：EP13878105
申请日：2013-10-24
申请人： UNIV SAGA , CYFUSE BIOMEDICAL K K
发明人： NOGUCHI RYO , TAMURA TADASHI , NAKAYAMA KOICHI , MORITA SHIGEKI , NODE KOICHI
IPC分类号： A61L27/00 , A61K35/33 , A61K35/34 , A61K35/44 , A61L27/36 , A61L27/38 , A61L27/50 , C12N5/071 , C12N5/077
CPC分类号： A61L27/3625 , A61K35/33 , A61K35/34 , A61K35/44 , A61L27/3804 , A61L27/3886 , A61L27/507 , A61L2300/64 , A61L2430/20 , C12N5/0691 , C12N5/0697 , C12N2502/1323 , C12N2502/1329 , C12N2502/28

3. 发明公开

EP2671539A4 TRANSPLANT GUIDING PART AND TRANSPLANT TOOL 有权转让
标题翻译：移植程序PART AND GRAFT工具
公开(公告)号：EP2671539A4
公开(公告)日：2014-12-24
申请号：EP12741664
申请日：2012-02-03
申请人： CYFUSE BIOMEDICAL K K
发明人： NAKAYAMA KOICHI
IPC分类号： A61F2/02 , A61B17/00 , A61F2/00 , A61L27/56 , A61L31/00
CPC分类号： C12M33/00 , A61B2017/00004 , A61B2017/00907 , A61B2017/00969 , C12M23/06 , C12M25/02 , C12M33/04

4. 发明授权

EP3091067B1 CELL TRAY AND DEVICE, METHOD AND SYSTEM FOR PRODUCING CELL STRUCTURE 有权
标题翻译：细胞托盘和装置，生产细胞结构的方法和系统
公开(公告)号：EP3091067B1
公开(公告)日：2018-03-14
申请号：EP15845301.9
申请日：2015-09-25
申请人： Cyfuse Biomedical K. K.
发明人： KUCHIISHI Koji , TAMURA Tadashi
IPC分类号： C12M1/12 , C12M1/26 , C12M1/32 , C12M1/34 , C12N5/00 , C12N5/07 , C12N11/02 , C12M1/00 , C12M3/00 , C12N11/00
CPC分类号： C12N5/0062 , C12M21/08 , C12M23/12 , C12M25/00 , C12M33/04 , C12M33/06 , C12M41/46 , C12N5/00 , C12N11/00
摘要： Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole. Also provided is a system for producing a cell structure, said system comprising: a determination part that examines the characteristics of cell aggregates; a fractionation part that classifies the cell aggregates depending on the results of the examination by the determination part; a discharge part that disposes the cell aggregates in a cell tray depending on the results of the classification by the fractionation part; a puncture part that pass through a plurality of cell aggregates disposed in the cell tray; and a holding part that aligns and holds a plurality of puncture parts passing through a plurality of cell aggregates.

5. 发明公开

EP3222997A1 QUALITY EVALUATION METHOD AND QUALITY EVALUATION DEVICE 审中-公开
标题翻译：质量评价方法和质量评价装置
公开(公告)号：EP3222997A1
公开(公告)日：2017-09-27
申请号：EP15860167.4
申请日：2015-11-18
申请人： Sumitomo Electric Industries, Ltd. , Cyfuse Biomedical K. K. , Kyoto Stem Cell Innovation Inc.
发明人： SUGANUMA, Hiroshi , OKUNO, Takuya , MOTOMURA, Asako , AKIEDA, Shizuka , TSUJI, Manami , OKINA, Yuna , SUGIYAMA, Yoko , AIBA, Kazuhiro , LIU, Li
IPC分类号： G01N21/359
CPC分类号： G01N21/255 , G01J3/42 , G01N17/004 , G01N21/01 , G01N21/359 , G01N21/4738 , G01N2021/0106 , G01N2201/10 , G01N2201/129 , G06F17/30247 , G06K9/00147 , G06K9/0055 , G06N99/005 , G06T2207/30024
摘要： A quality evaluation method includes an acquisition step of acquiring spectral data related to transmitted light or diffusely reflected light from a cell mass by irradiating the cell mass with measurement light including near-infrared light, and an evaluation step of evaluating quality of the cell mass, based on the spectral data of the cell mass acquired in the acquisition step.
摘要翻译：质量评估方法包括：获取步骤，通过用包括近红外光的测量光照射细胞块来获取与来自细胞块的透射光或漫反射光有关的光谱数据;以及评估步骤，评估细胞块的质量，基于在获取步骤中获取的细胞团的光谱数据。

6. 发明公开

EP3091067A4 CELL TRAY AND DEVICE, METHOD AND SYSTEM FOR PRODUCING CELL STRUCTURE 有权
标题翻译： ZELLENTRÄGERUND VORRICHTUNG，VERFAHREN UND SYSTEM ZUR HERSTELLUNG EINER ZELLSTRUKTUR
公开(公告)号：EP3091067A4
公开(公告)日：2017-02-08
申请号：EP15845301
申请日：2015-09-25
申请人： CYFUSE BIOMEDICAL K K
发明人： KUCHIISHI KOJI , TAMURA TADASHI
IPC分类号： C12M1/00 , C12N5/07 , C12N11/02
CPC分类号： C12N5/0062 , C12M21/08 , C12M23/12 , C12M25/00 , C12M33/04 , C12M33/06 , C12M41/46 , C12N5/00 , C12N11/00
摘要： Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole. Also provided is a system for producing a cell structure, said system comprising: a determination part that examines the characteristics of cell aggregates; a fractionation part that classifies the cell aggregates depending on the results of the examination by the determination part; a discharge part that disposes the cell aggregates in a cell tray depending on the results of the classification by the fractionation part; a puncture part that pass through a plurality of cell aggregates disposed in the cell tray; and a holding part that aligns and holds a plurality of puncture parts passing through a plurality of cell aggregates.
摘要翻译：提供有：设置有用于支撑细胞骨架的凹部的细胞托盘和形成在凹部的底部上的孔; 以及用于制造电池结构的装置，所述装置设置有电池托盘和穿过电池托盘和电池组件的穿孔部件，其特征在于，穿刺部件穿过由凹部支撑的电池组件，直到尖端其侵入孔中。还提供了一种用于生产细胞结构的系统，所述系统包括：确定部分，其检查细胞聚集体的特性; 分解部，其根据测定部的检查结果对细胞聚集进行分类; 排出部，其根据分级部的分类结果将细胞聚集体配置在细胞托盘中; 刺穿部，其穿过设置在所述细胞托盘中的多个细胞聚集体; 以及保持部，其对准并保持穿过多个细胞聚集体的多个穿刺部。

7. 发明公开

EP2781590A1 DEVICE FOR MANUFACTURING SUPPORTING BODY FOR CELL STRUCTURE MANUFACTURE 审中-公开
标题翻译： VORRICHTUNG ZUR HERSTELLUNG EINESSTÜTZKÖRPERSZUR HERSTELLUNG EINER ZELLKULTUR
公开(公告)号：EP2781590A1
公开(公告)日：2014-09-24
申请号：EP12848980.4
申请日：2012-11-16
申请人： Saga University , Cyfuse Biomedical K. K.
发明人： NAKAYAMA Koichi
IPC分类号： C12M3/00 , C12N5/071 , C12N11/00
CPC分类号： C12N5/0062 , C12M21/08 , C12M25/00 , C12M25/14 , C12M33/04 , Y10T29/49826 , Y10T29/53961
摘要： A device for manufacturing a support for fixing cells of the present invention is capable of easily manufacturing a support that has needle-like bodies arranged on a base. The manufacturing device 2 is provided with a base 10, a holder 4, an insertion guide 6 and an alignment mechanism. The base 10 is retained by a holder 4. The base 10 is provided with a plurality of openings 15, into which needle-like bodies 20 are inserted and fixed. An insertion guide 6 is provided next to the holder 4 and includes slots 12 for placing a plurality of needle-like bodies 20 generally parallel to each other. The insertion guide 6 is provided with a plurality of slots 12 for placing the needle-like bodies 20 at corresponding positions to the openings 15, so that the alignment mechanism moves the insertion guide 6 such that the feed openings 12a are positioned adjacent to the openings 15. After positioning the feed openings 12a adjacent to the openings 15, the needle-like bodies 20 are introduced into the openings 15, whereby the needle-like bodies 20 are implanted into the base 10 to form a support.
摘要翻译：用于制造本发明的固定单元的支撑体的装置能够容易地制造布置在基部上的具有针状物体的支撑体。制造装置2设置有基部10，保持器4，插入引导件6和对准机构。基座10由保持器4保持。基座10设置有多个开口15，针状体20插入并固定到开口15中。插入引导件6设置在保持器4的旁边，并且包括用于放置大体上彼此平行的多个针状体20的槽12。插入引导件6设置有多个狭缝12，用于将针状物体20放置在与开口15相对应的位置，使得对准机构移动插入引导件6，使得进给开口12a邻近开口在将进给开口12a定位在与开口15相邻的位置之后，将针状体20引入到开口15中，由此将针状体20注入到基部10中以形成支撑体。

8. 发明公开

EP2671539A1 TRANSPLANT GUIDING PART AND TRANSPLANT TOOL 有权转让
标题翻译： TRANSPLANTATFÜHRUNGSTEILUND TRANSPLANTATWERKZEUG
公开(公告)号：EP2671539A1
公开(公告)日：2013-12-11
申请号：EP12741664.2
申请日：2012-02-03
申请人： Cyfuse Biomedical K. K.
发明人： NAKAYAMA Koichi
IPC分类号： A61F2/02 , A61L31/00
CPC分类号： C12M33/00 , A61B2017/00004 , A61B2017/00907 , A61B2017/00969 , C12M23/06 , C12M25/02 , C12M33/04
摘要： The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein:
a cell mass supplied from the open end side is placed on the base material, and
the guide is used as a mold for forming a three-dimensional cell construct by culturing the cell mass placed on the base material by immersing the base material side in an excessive amount of a culture fluid.
摘要翻译：本发明提供一种移植引导件，其形成为具有允许培养流体连通的基材的有底圆筒，其中：从开口端供给的细胞块放置在基材上，将引导件用作通过将基材侧浸渍在过量的培养液中来培养放置在基材上的细胞块来形成三维细胞构建体的模具。

9. 发明公开

EP4428812A1 QUALITY EVALUATION METHOD FOR SPHEROID INCLUDING HEPATOCYTES 审中-公开
公开(公告)号：EP4428812A1
公开(公告)日：2024-09-11
申请号：EP24158147.9
申请日：2024-02-16
申请人： SCREEN Holdings Co., Ltd. , Cyfuse Biomedical K. K.
发明人： HASEBE, Ryo , MAEKAWA, Toshihiko , INOUE, Ayu
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/1010120130101 , G06T2207/2008120130101 , G06T2207/3002420130101 , G06T2207/3005620130101
摘要： According to this evaluation method, first, spheroids obtained by three-dimensional culture of multiple kinds of liver-derived cells are imaged by optical coherence photography (image acquisition step), a localization region is extracted from the photographic image (region extraction step), the localization region is analyzed (analysis step), and the condition of the spheroid is evaluated (evaluation step). The analysis step includes a first calculation step (S41) of calculating the area of the entire spheroid in the photographic image, a second calculation step (S42) of calculating the area of the localization region, a third calculation step (S43) of calculating the ratio of the localization region on the basis of the two areas, and a fourth calculation step (S44) of calculating an evaluation parameter on the basis of the ratio. With the use of this evaluation parameter, there is provided an evaluation method that makes it possible to noninvasively observe a localization region of a spheroid used in a bio 3D printer and evaluate the condition of the spheroid without processing cells by staining or the like.

10. 发明公开

EP4428811A1 FIBROSIS EVALUATION METHOD FOR BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：EP4428811A1
公开(公告)日：2024-09-11
申请号：EP24154633.2
申请日：2024-01-30
申请人： SCREEN Holdings Co., Ltd. , Cyfuse Biomedical K. K.
发明人： HASEBE, Ryo , MAEKAWA, Toshihiko , INOUE, Ayu
IPC分类号： G06T7/00 , G06T7/12 , G06T7/136 , G06T7/62
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/136 , G06T7/62 , G06T2207/1010120130101 , G06T2207/2008420130101 , G06T2207/2022420130101 , G06T2207/3002420130101 , G06T2207/3005620130101
摘要： According to an evaluation method, first, a biological sample is taken an image, and an image in which intensity values are distributed is acquired. After that, a localization region corresponding to a fibrotic region is extracted from the taken image. At that time, a region of which intensity value satisfies a predetermined requirement in the taken image is extracted as the localization region. Alternatively, the taken image is input to a trained model created in advance, and a localization region output from the trained model is obtained. This makes it possible to noninvasively observe the fibrotic region of the biological sample, to evaluate the condition of the biological sample, without processing cells by staining or the like.

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