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81. 发明公开

EP2798333A2 FLOW CYTOMETRY SYSTEMS AND METHODS FOR BLOCKING DIFFRACTION PATTERNS 无效
标题翻译：术和方法流程用于锁定衍射图
公开(公告)号：EP2798333A2
公开(公告)日：2014-11-05
申请号：EP12861168.8
申请日：2012-12-20
申请人： ABBOTT LABORATORIES
发明人： JUNNARKAR, Mahesh R.
IPC分类号： G01N21/53
CPC分类号： G01N15/1434 , G01N15/1459 , G01N21/53 , G01N2015/1452 , G01N2201/06113
摘要： Flow cytometer systems are provided having intermediate angle scatter detection capability. In some aspects, systems are provided that include an intermediate angle scatter (IAS) light detector positioned to measure intermediate angle scatter emitted from a flow cytometer. The system further includes a mask disposed across a portion of the IAS light detector and positioned between the flow cell and the IAS light detector to cover at least a central portion of the IAS light detector so as to block a diffraction pattern observed at the detector. In some instances, the diffraction pattern is created by a flat beam profile irradiating the sample. Methods are also provided for configuring a flow cytometer to block a diffraction pattern created by (1) a flat laser beam profile irradiating a flow cytometer liquid sample, or (2) a mismatched index of refraction between a sheath fluid and a liquid sample in a flow cytometer.

82. 发明公开

EP1562035A3 Optical apparatus and method 失效
标题翻译：一种光学装置和光学方法
公开(公告)号：EP1562035A3
公开(公告)日：2014-08-20
申请号：EP05009620.5
申请日：1998-02-02
申请人： XY, LLC
发明人： Sharpe, Johnathan , Schaare, Peter, Niven
IPC分类号： G01N15/02 , G01N21/00 , G02B5/00 , G01N15/14 , G02B5/04 , G01N21/64
CPC分类号： G01N15/1436 , G01N15/1434 , G01N15/1459 , G01N21/49 , G01N2015/1452 , G01N2015/149 , G01N2021/6469 , G02B5/04
摘要： Various optical apparatus provide a source of parallel light (7, 75). The parallel light (7, 75) is generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations are also disclosed. The application also discloses the use of reflectors (20, 78, 216, 316, 400) having internal reflective surfaces shaped as three-dimensional figures of revolution, for example paraboloid or ellipsoid. The reflectors (20, 78, 216, 316) focus light incident onto the reflectors at one or more foci (F, 220, 320, 420). The reflectors may be used in combination with the optical apparatus including the prisms (1, 22, 24, 26, 28). The reflectors (20, 78, 216, 316) may be used in flow cytometers for focusing light at a sample stream (237, 337) passing through the focus (F, 220, 320, 420) of the reflector (20, 78, 216, 316). The collection of scattered and/or fluorescent light from an illuminated sample stream (237, 337) in a flow cytometer may be achieved with the use of a collector shaped as a figure of revolution, e.g. paraboloid or ellipsoid. Various optical methods and methods for flow cytometry are also disclosed.

83. 发明公开

EP2264428A3 Optical apparatus with focussing reflector for converging radiation onto a flow of particles 无效
标题翻译：具有用于辐射的收敛聚焦反射器到粒子通量光学设备
公开(公告)号：EP2264428A3
公开(公告)日：2014-05-21
申请号：EP10182142.9
申请日：1998-02-02
申请人： XY, LLC
发明人： Sharpe, Johnathan , Schaare, Peter, Niven
IPC分类号： G01N15/02 , G01N21/00 , G02B5/00 , G01N15/14 , G02B5/04 , G01N21/64
CPC分类号： G01N15/1436 , G01N15/1434 , G01N15/1459 , G01N21/49 , G01N2015/1452 , G01N2015/149 , G01N2021/6469 , G02B5/04
摘要： Various optical apparatus provide a source of parallel light (7, 75). The parallel light (7, 75) is generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations arc also disclosed. The application also discloses the use of reflectors (20, 78, 216, 316, 400) having internal reflective surfaces shaped as three-dimensional figures of revolution, for example paraboloid or ellipsoid. The reflectors (20, 78, 216, 316) focus light incident onto the reflectors at one or more foci (F, 220, 320, 420). The reflectors may be used in combination with the optical apparatus including the prisms (1, 22, 24, 26, 28). The reflectors (20, 78, 216, 316) may be used in flow cytometers for focussing light at a sample stream (237, 337) passing through the focus (F, 220, 320, 420) of the reflector (20, 78, 216, 316). The collection of scattered and/or fluorescent light from an illuminated sample stream (237, 337) in a flow cytometer may be achieved with the use of a collector shaped as a figure of revolution e.g. paraboloid or ellipsoid. Various optical methods and methods for flow cytometry are also disclosed.

84. 发明授权

EP2034292B1 Light irradiation method, light irradiation device, and fine particle analyzing apparatus 有权
标题翻译：光照射方法，光照射装置以及微粒分析仪
公开(公告)号：EP2034292B1
公开(公告)日：2012-02-08
申请号：EP08013868.8
申请日：2008-08-01
申请人： Sony Corporation
发明人： Shinoda, Masataka
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , G01N2015/1445 , G01N2015/1447 , G01N2015/1452 , G01N2015/1465

85. 发明授权

EP1947443B1 A method for determination of particles in a liquid sample 失效
标题翻译：液体样品中的粒子的测定方法
公开(公告)号：EP1947443B1
公开(公告)日：2011-06-22
申请号：EP08101764.2
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/14 , G01N33/04
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491

86. 发明授权

EP1935983B1 Method for determination of biological particles in blood 失效
标题翻译：一种用于在血液生物颗粒的确定方法
公开(公告)号：EP1935983B1
公开(公告)日：2011-06-22
申请号：EP08101755.0
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491

87. 发明公开

EP2058688A2 Beam-adjusting optics 审中-公开
标题翻译： Strahleinstellungsoptik
公开(公告)号：EP2058688A2
公开(公告)日：2009-05-13
申请号：EP08164246.4
申请日：2008-09-12
申请人： Becton, Dickinson & Company
发明人： Chen, Yong Qin
IPC分类号： G02B7/08 , G01N15/14
CPC分类号： G02B7/08 , G01N15/1434 , G01N15/1459 , G01N2015/1452
摘要： The present invention provides an optical analyzer having illumination optics that include a light source, such as a laser or other source, adapted to emit a collimated, or approximately collimated, light beam, a focusing lens that focuses the beam onto a focus spot within a detection region, and beam-adjusting optics positioned in the light path between the light beam source and the focusing lens, which allow for precise positioning of the focus spot within the detection region. The beam-adjusting optics of the present invention comprise at least one movable focusing lens, mounted in a positioning device that allows repositioning of the lens in a plane perpendicular to the light path.
摘要翻译：本发明提供了一种具有照明光学器件的光学分析器，其包括诸如激光器或其他光源的光源，其适于发射准直或近似准直的光束;聚焦透镜，其将光束聚焦到光束内的焦点上检测区域和位于光束源和聚焦透镜之间的光路中的光束调节光学元件，其允许焦点在检测区域内的精确定位。本发明的光束调节光学器件包括至少一个可移动的聚焦透镜，其安装在定位装置中，该定位装置允许透镜在垂直于光路的平面中重新定位。

88. 发明公开

EP1947442A3 A method and a system for determination of biological particles in a liquid sample 失效
标题翻译：液体样品中的方法和装置用于测定生物颗粒的
公开(公告)号：EP1947442A3
公开(公告)日：2008-07-30
申请号：EP08101762.6
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. Electromagnetic radiation is transmitted onto the sample from a position which forms an angle which forms an angle which is between 180 and 165 degrees from the direction between said sample and an array of detection elements.

89. 发明公开

EP1947442A2 A method and a system for determination of biological particles in a liquid sample 失效
标题翻译：液体样品中的方法和装置用于测定生物颗粒的
公开(公告)号：EP1947442A2
公开(公告)日：2008-07-23
申请号：EP08101762.6
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. Electromagnetic radiation is transmitted onto the sample from a position which forms an angle which forms an angle which is between 180 and 165 degrees from the direction between said sample and an array of detection elements.
摘要翻译：本发明涉及一种方法和用于生物颗粒的数量和质量参数在液体分析物材料的评估的装置。所述方法包括在从哪个曝光域从域中将样品暴露域电磁信号可以传递到外部施加的液体样品的体积，并曝光，走上到有源检测元件的阵列：如CCD元件，空间电磁信号的表示已经从域寻求的方式做了电磁信号的表示从传递，该表示被以由单独的活性检测元件强度可检测的，在曝光期间允许通过检测元件的阵列检测到的强度的加工条件下生物颗粒被确定为从背景信号的电磁信号的表示是不同的。电磁辐射被反mitted到样品上从一个位置哪个角度的形式的哪个角度的形式的所有这些是180分165度之间从所述样品之间，并检测元件的阵列的方向。

90. 发明公开

EP1851529A1 A DEVICE AND A METHOD FOR GENERATING DATA RELATING TO PARTICLES IN A PARTICULATE MATERIAL 审中-公开
标题翻译：装置和方法用于生成数据中有颗粒节点在的颗粒状物质
公开(公告)号：EP1851529A1
公开(公告)日：2007-11-07
申请号：EP06709771.7
申请日：2006-02-16
申请人： Greenbank Terotech Limited
发明人： AROUSSI, Abdelwahab
IPC分类号： G01N15/14 , G01N15/02
CPC分类号： G01N15/147 , G01N15/0227 , G01N15/1475 , G01N2015/1452 , G01N2015/1493 , G01P5/001
摘要： In the field of multi-phase flows there is a need for a device and a method, for generating data relating to particles in a particulate material suspended in a fluid medium flowing within a pipe in a given direction, which provides more accurate data about the particles than conventional direct imaging techniques. A device (30; 50), for generating data relating to particles in a particulate material suspended in a fluid medium flowing within a pipe (34; 54) in a given flow direction (FD), comprises a light source (32) arranged to illuminate a portion of the flow, and an image acquisition unit (40) for capturing an image of the particles as they pass through the illuminated portion of the flow. The image acquisition unit (40) has a predetermined focal plane (41), and is arranged so that the focal plane (41) is inclined relative to the flow direction (FD) of the particles. The device (30; 50) also includes a processing unit which is in communication with the image acquisition unit (40). The processing unit enhances the image and processes the enhanced image to generate data relating to the particles captured therein. A method, for generating data relating to particles in a particulate material suspended in a fluid medium flowing within a pipe (34; 54) in a given flow direction (FD), comprises the steps of (i) illuminating a portion of the flow, (ii) arranging an image acquisition unit (40) having a predetermined focal plane (41) so that the focal plane (41) is inclined relative to the flow direction (FD) of the particles, (iii) capturing an image of the particles as they pass through the illuminated portion of the flow, (iv) enhancing the image, and (v) processing the image to generate data relating to the particles captured therein.

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