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1. 发明授权

EP1933128B1 A method and a system for determination of particles in a liquid sample 失效
标题翻译：为颗粒的液体试样中的测定方法和装置
公开(公告)号：EP1933128B1
公开(公告)日：2012-04-25
申请号：EP08101757.6
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491

2. 发明公开

EP1947443A3 A method and a system for determination of particles in a liquid sample 失效
标题翻译：测定液体样品中颗粒的方法和系统
公开(公告)号：EP1947443A3
公开(公告)日：2008-07-30
申请号：EP08101764.2
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/14 , G01N33/04
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The exposing domain has an average interior thickness of between 20 μm and 200 μm.
摘要翻译：本发明涉及用于评估液体分析物材料中生物颗粒的数量和质量参数的方法。该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的样品暴露域电磁信号可以将该液体样品传递到外部，并且将活性检测元件阵列（例如CCD元件）暴露在曝光区域的空间在允许在曝光期间处理由检测元件阵列检测到的强度的条件下，从该域通过的电磁信号的表示可以作为单个有源检测元件的强度来检测，生物粒子被识别为不同于来自背景信号的电磁信号的表示。曝光区域的平均内部厚度在20μm和200μm之间。

3. 发明公开

EP1933127A1 A method for determination of biological particles in a liquid analyte material 失效
标题翻译： Verfahren zur Bestimmung von biologischen Teilchen in einemflüssigenAnalysematerial
公开(公告)号：EP1933127A1
公开(公告)日：2008-06-18
申请号：EP08101751.9
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fullfil a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
摘要翻译：本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。该方法包括将一定体积的液体样本施加到曝光区域，从该区域中的来自样品的区域电磁信号可以从该域暴露于外部，并将其暴露于诸如CCD元件的主动检测元件的阵列上，在从曝光期间通过检测元件阵列检测到的强度处理的条件下，可以通过单独的有源检测元件作为强度检测该表示作为强度的表示，生物颗粒被识别为不同于来自背景信号的电磁信号的表示。液体样品的体积大小足够大以允许评估数量和质量参数，以基于基本上一次暴露来满足对评估的统计质量的预定要求。

4. 发明公开

EP1935983A3 Method for determination of biological particles in blood 失效
标题翻译：一种用于在血液生物颗粒的确定方法
公开(公告)号：EP1935983A3
公开(公告)日：2008-07-09
申请号：EP08101755.0
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： C12Q1/06 , G01N33/483 , G01N33/04 , G01N24/00 , G01N21/00 , G01N15/06 , G06M11/00
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in blood or blood product. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The enlargement of an image on the array of detection elements is smaller than 10:1.

5. 发明公开

EP1936351A3 A method and a system for determination of particles in a liquid sample 失效
公开(公告)号：EP1936351A3
公开(公告)日：2008-07-02
申请号：EP08101761.8
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a thermal light source, such as a halogen lamp.

6. 发明公开

EP1933128A2 A method and a system for determination of particles in a liquid sample 失效
标题翻译：测定液体样品中颗粒的方法和系统
公开(公告)号：EP1933128A2
公开(公告)日：2008-06-18
申请号：EP08101757.6
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a LED and/or a laser diode, arranged to transmit light onto the sample.
摘要翻译：本发明涉及用于评估液体分析物材料中生物颗粒的数量和质量参数的方法和装置。该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的样品暴露域电磁信号可以将该液体样品传递到外部，并且将活性检测元件阵列（例如CCD元件）暴露在曝光区域的空间在允许在曝光期间处理由检测元件阵列检测到的强度的条件下，从该域通过的电磁信号的表示可以作为单个有源检测元件的强度来检测，生物粒子被识别为不同于来自背景信号的电磁信号的表示。光源是LED和/或激光二极管，被设置为将光透射到样品上。

7. 发明公开

EP1947443A2 A method and a system for determination of particles in a liquid sample 失效
标题翻译： Verfahren zur Bestimmung von Teilchen在einerflüssigen探头
公开(公告)号：EP1947443A2
公开(公告)日：2008-07-23
申请号：EP08101764.2
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/14 , G01N33/04
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The exposing domain has an average interior thickness of between 20 μm and 200 μm.
摘要翻译：本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。该方法包括将一定体积的液体样本施加到曝光区域，从该区域中的来自样品的区域电磁信号可以从该域暴露于外部，并将其暴露于诸如CCD元件的主动检测元件的阵列上，在从曝光期间通过检测元件阵列检测到的强度处理的条件下，可以通过单独的有源检测元件作为强度检测该表示作为强度的表示，从而以这种方式表示电磁信号，生物颗粒被识别为不同于来自背景信号的电磁信号的表示。曝光区域的平均内部厚度在20¼m至200¼m之间。

8. 发明公开

EP1936351A2 A method and a system for determination of particles in a liquid sample 失效
标题翻译：测定液体样品中颗粒的方法和系统
公开(公告)号：EP1936351A2
公开(公告)日：2008-06-25
申请号：EP08101761.8
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a thermal light source, such as a halogen lamp.
摘要翻译：本发明涉及用于评估液体分析物材料中生物颗粒的数量和质量参数的方法。该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的样品暴露域电磁信号可以将该液体样品传递到外部，并且将活性检测元件阵列（例如CCD元件）暴露在曝光区域的空间在允许在曝光期间处理由检测元件阵列检测到的强度的条件下，从该域通过的电磁信号的表示可以作为单个有源检测元件的强度来检测，生物粒子被识别为不同于来自背景信号的电磁信号的表示。光源是热光源，例如卤素灯。

9. 发明公开

EP1933128A3 A method and a system for determination of particles in a liquid sample 失效
标题翻译：为颗粒的液体试样中的测定方法和装置
公开(公告)号：EP1933128A3
公开(公告)日：2008-06-25
申请号：EP08101757.6
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a LED and/or a laser diode, arranged to transmit light onto the sample.

10. 发明公开

EP1935983A2 Method for determination of biological particles in blood 失效
标题翻译： Verfahren zur Bestimmung von biologischen Teilchen im Blut
公开(公告)号：EP1935983A2
公开(公告)日：2008-06-25
申请号：EP08101755.0
申请日：1998-05-05
申请人： ChemoMetec A/S
发明人： Hansen, Frans Ejner Ravn , Glensbjerg, Martin , Arnvidarson, Börkur , Jeppesen, Jesper Myron
IPC分类号： C12Q1/06 , G01N33/483 , G01N33/04 , G01N24/00 , G01N21/00 , G01N15/06 , G06M11/00
CPC分类号： G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in blood or blood product. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The enlargement of an image on the array of detection elements is smaller than 10:1.
摘要翻译：本发明涉及一种评估血液或血液制品中生物颗粒的数量和质量参数的方法。该方法包括将一定体积的液体样本施加到曝光区域，从该区域中的来自样品的区域电磁信号可以从该域暴露于外部，并将其暴露于诸如CCD元件的主动检测元件的阵列上，在从曝光期间通过检测元件阵列检测到的强度处理的条件下，可以通过单独的有源检测元件作为强度检测该表示作为强度的表示，生物颗粒被识别为不同于来自背景信号的电磁信号的表示。检测元件阵列上的图像的放大小于10：1。

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