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81. 发明授权

EP2455493B1 Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases 有权
标题翻译：用于诊断和治疗结肠相关疾病的基于微RNA的方法和组合物
公开(公告)号：EP2455493B1
公开(公告)日：2014-01-08
申请号：EP11196250.2
申请日：2007-07-12
申请人： The Ohio State University Research Foundation , The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
发明人： Croce, Carlo , Schetter, Aaron , Harris, Curtis
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , Y10T436/143333
摘要： The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.

82. 发明公开

EP2678449A2 METHODS AND SYSTEMS FOR HAPLOTYPE DETERMINATION 审中-公开
标题翻译：用于确定HAPLOTYPE的方法和系统
公开(公告)号：EP2678449A2
公开(公告)日：2014-01-01
申请号：EP12749706.3
申请日：2012-02-24
申请人： Illumina, Inc.
发明人： FAN, Jian-Bing , FISHER, Jeffrey S. , KAPER, Fiona
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6809 , C12Q1/6827 , C12Q1/6851 , C12Q1/6858 , C12Q2565/50
摘要： Embodiments of the present disclosure provide methods and systems for determining the haplotype of a biological sample. Particular embodiments provide methods for long range haplotyping of a genome.
摘要翻译：本公开的实施方式提供了用于确定生物样品的单体型的方法和系统。具体实施方式提供了用于基因组的远距单倍型分型的方法。

83. 发明授权

EP2241638B1 Methods for detecting abnormally methylated nucleic acid in heterogeneous biological samples 有权
标题翻译：一种用于非均相检测生物样品中甲基化核酸异常方法
公开(公告)号：EP2241638B1
公开(公告)日：2013-11-27
申请号：EP10168634.3
申请日：2003-04-11
申请人： Esoterix Genetic Laboratories, LLC
发明人： Shuber, Anthony
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/686 , C12Q1/6809 , C12Q1/6827 , C12Q1/6848 , C12Q1/6883 , C12Q1/6886 , C12Q2600/154 , C12Q2531/113 , C12Q2525/161 , C12Q2523/125 , C12Q2549/119 , C12Q2525/149

84. 发明公开

EP2643484A2 METHODS OF IDENTIFYING A CELLULAR NASCENT RNA TRANSCRIPT 审中-公开
标题翻译：一种用于识别RNA转录物细胞来源
公开(公告)号：EP2643484A2
公开(公告)日：2013-10-02
申请号：EP11844470.2
申请日：2011-11-22
申请人： The Regents of the University of California
发明人： WEISSMAN, Jonathan , CHURCHMAN, Lee Stirling
IPC分类号： C12Q1/68 , C12Q1/48
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6809 , C12Q2521/107 , C12Q2527/101 , C12Q2535/122 , C12Q2565/113
摘要： Methods and compositions for identifying a cellular nascent RNA transcript are provided.

85. 发明公开

EP2516681A4 COMPOSITIONS AND METHODS FOR THE DETECTION OF SMALL RNAS 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR ERKENNUNG KLEINER RNAS
公开(公告)号：EP2516681A4
公开(公告)日：2013-09-04
申请号：EP11742859
申请日：2011-02-11
申请人： NANOSTRING TECHNOLOGIES INC
发明人： WEBSTER PHILIPPA JANE , DENNIS LUCAS MICHAEL , BOYKIN RICHARD KEMBLE
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6809 , C12Q1/6816 , C12Q2525/207 , C12Q2537/143 , C12Q2561/125
摘要： The invention provides compositions and methods for the detection of small RNA molecules in a multiplexed reaction. The assays and kits described herein are applicable for the identification, diagnosing, and monitoring of disorders including, but not limited to cancer, developmental and degenerative disease, neurological disorders, and stem cell disorders.
摘要翻译：本发明提供了用于在多重反应中检测小RNA分子的组合物和方法。本文描述的测定和试剂盒适用于疾病的鉴定，诊断和监测，包括但不限于癌症，发育和退行性疾病，神经障碍和干细胞病症。

86. 发明授权

EP1957637B1 IMPROVED HOST CELLS AND CULTURE METHODS 有权
标题翻译：改进HOST细胞和培养方法
公开(公告)号：EP1957637B1
公开(公告)日：2013-08-14
申请号：EP06844853.9
申请日：2006-12-06
申请人： Amgen, Inc.
发明人： CROWELL, Christopher, K.
IPC分类号： C12P21/02 , C12N9/24 , C12N15/52 , C12N15/67 , C12N5/10
CPC分类号： C12P21/005 , C07K14/505 , C12N5/0693 , C12N9/2402 , C12N15/85 , C12N2500/95 , C12N2501/999 , C12N2510/02 , C12Q1/6809 , C12Y302/01024 , G01N33/746

87. 发明公开

EP2514820A4 METHOD FOR DESIGNING PROBE IN DNA MICROARRAY, AND DNA MICROARRAY PROVIDED WITH PROBE DESIGNED THEREBY 有权转让
标题翻译： PROCESS用于探针在DNA微阵列的构建与FACT设计的探针DNA EQUIPPED MICRO ARRAY
公开(公告)号：EP2514820A4
公开(公告)日：2013-08-07
申请号：EP10837536
申请日：2010-12-13
申请人： TOYOTA MOTOR CO LTD
发明人： ENOKI HIROYUKI , NISHIMURA SATORU , MURAKAMI AYA
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68 , G01N33/53 , G01N37/00
CPC分类号： C12Q1/683 , C12Q1/6806 , C12Q1/6809 , C12Q1/6837 , C12Q1/6855 , C12Q2565/501 , C12Q2535/125 , C12Q2521/307
摘要： Provided is a probe to be used in a DNA microarray having an excellent detection rate of a polymorphism such as SNP contained in genomic DNA. A method for designing a probe according to the invention includes the steps of: specifying one or more regions covering at least a part of fragments flanked by restriction enzyme recognition sites recognized by a restriction enzyme, contained in genomic DNA derived from an organism to be tested; and designing a probe for the specified one or more regions for detecting the fragment in the organism to be tested.
摘要翻译：本发明提供在具有优异的速率检测的多态性的DNA微阵列中使用的样品：如SNP包含在基因组DNA。一种用于雅丁发明设计的探针方法包括以下步骤：指定至少覆盖由限制性内切酶识别的限制性内切酶识别位点，包含在从在生物体的基因组DNA侧接片段的一部分的一个或多个区域被测试 ; 和设计为在生物体检测片段指定的一个或多个区域的测试进行测试。

88. 发明公开

EP2613149A1 Exosome-Associated MicroRNA as a Diagnostic Marker 有权
标题翻译： Exosomassoziierte microRNA als Diagnosemarker
公开(公告)号：EP2613149A1
公开(公告)日：2013-07-10
申请号：EP13162506.3
申请日：2008-07-25
申请人： University Of Louisville Research Foundation, Inc.
发明人： Taylor, Douglas D. , Gercel-Taylor, Cicek
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178 , Y10T436/143333 , C12Q2563/161 , C12Q2525/207
摘要： The presently disclosed subject matter provides a method for assessing the presence of one or more microRNAs in microvesicles, comprising isolating a population of cancer-derived microvesicles from a biological sample using a microvesicle surface marker, isolating microRNA from said population of cancer-derived microvesicles and determining a presence of one or more microRNAs in said cancer-derived microvesicles.
摘要翻译：目前公开的主题提供了用于评估微泡中一种或多种微小RNA存在的方法，其包括使用微泡表面标志物从生物样品中分离癌症衍生的微泡群，从所述癌症来源的微泡群体中分离出微RNA;以及确定所述癌症来源的微泡中存在一种或多种微小RNA。

89. 发明公开

EP2609217A1 CELL CHARACTERISATION 有权转让
标题翻译： ZELLCHARAKTERISIERUNG
公开(公告)号：EP2609217A1
公开(公告)日：2013-07-03
申请号：EP11760806.7
申请日：2011-08-19
申请人： Sistemic Scotland Limited
发明人： O'BRIEN, Vincent , HILLIER, Chris
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
摘要： The present invention concerns the finding that non-coding RNA profiles can be exploited as a means of monitoring, assessing, comparing, establishing and/or determining certain cell characteristics and/or profiles. Accordingly, the invention provides the use of non-coding RNA molecules for characterising and/or profiling cells.

90. 发明公开

EP2598874A2 METHODS OF DETERMINING ACUTE MYELOID LEUKEMIA RESPONSE TO TREATMENT WITH FARNESYLTRANSFERASE INHIBITORS 有权转让
标题翻译： PROCEDURE用于确定响应于治疗急性髓性白血病法尼基转移
公开(公告)号：EP2598874A2
公开(公告)日：2013-06-05
申请号：EP11813168.9
申请日：2011-07-28
申请人： Veridex, LLC
发明人： VENER, Tatiana, I. , DERECHO, Carlo, C. , PALMA, John, F. , RAPONI, Mitch
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： The disclosed method rapidly identifies with desired accuracy AML patients, including elderly AML patients, likely to respond to treatment with a combination of a farnesyltransferase inhibitor and one or more of etoposide, teniposide, tamoxifen, sorafenib, paclitaxel, temozolomide, topotecan, trastuzumab and cisplatinum. In an embodiment, the improvements include the use of whole blood rather than the customary bone marrow sample, thus making the assay more accurate, rapid, less intrusive, less expensive as well as less painful. The method includes evaluation of a two-gene expression ratio (RASGRP1 :APTX), which with a corresponding threshold, provides sufficient accuracy for predicting the response to the combination treatment. In the preferred embodiment the combination treatment combines tipifarnib (Rl 15777, ZARNESTRA®) with etoposide. Further, the elderly AML patients identified as being likely responsive to the combination treatment with tipinifarb and etoposide have a complete recovery rate comparable to the best therapy available for younger patients.
摘要翻译：盘游离缺失方法具有所需精度的AML患者，包括老年AML患者，可能对治疗用法尼基转移酶抑制剂和一种或多种依托泊苷，替尼泊苷他莫昔芬，索拉非尼，紫杉醇，替莫唑胺，拓扑替康，曲妥珠单抗和顺铂的组合响应迅速标识，，实施例中的改进包括使用全血而不是常规的骨髓样品，从而使测定更准确，快速，较少干扰，更便宜，以及更小的痛苦。该方法包括将两基因表达比率的评价（RASGRP1：APTX），这与相应的阈值时，提供了足够的精度预测该组合治疗的反应。依托泊苷在优选实施例的组合治疗结合替比法尼器（R1 15777，ZARNESTRA®）。此外，老年人AML患者经鉴定为可能响应依托泊苷tipinifarb的联合治疗，并有一个完整的恢复速度堪比可供年轻患者最好的治疗。

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