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81. 发明公开

EP2872493A4 COMPOUNDS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY 有权转让
标题翻译：化合物用于治疗脊髓性肌萎缩
公开(公告)号：EP2872493A4
公开(公告)日：2016-04-13
申请号：EP13817021
申请日：2013-07-12
申请人： UNIV INDIANA RES & TECH CORP , BRIGHAM & WOMENS HOSPITAL , UNIV MASSACHUSETTS
发明人： ANDROPHY ELLIOT J , CHERRY JONATHON J , CUNY GREGORY D , GLICKSMAN MARCIE A
IPC分类号： C07D261/06 , A61K31/42 , A61P21/00 , C07D413/12
CPC分类号： C07D493/04 , C07C311/37 , C07C2601/08 , C07C2603/20 , C07D213/75 , C07D215/227 , C07D215/44 , C07D221/10 , C07D231/14 , C07D233/88 , C07D239/47 , C07D239/82 , C07D261/06 , C07D261/14 , C07D261/18 , C07D263/48 , C07D267/14 , C07D277/46 , C07D285/135 , C07D401/04 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07K14/47
摘要： Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.

82. 发明公开

EP2694667A4 METHODS, COMPOSITIONS AND KITS FOR ASSAYING MITOCHONDRIAL FUNCTION 有权转让
标题翻译：方法，组合物和试剂盒被测试函数线粒体
公开(公告)号：EP2694667A4
公开(公告)日：2015-04-15
申请号：EP12819805
申请日：2012-04-06
申请人： BAYSTATE MEDICAL CT INC , UNIV MASSACHUSETTS
发明人： YADAVA NAGENDRA , KIM CHUL , HEUCK ALEJANDRO PABLO
IPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/32
CPC分类号： G01N33/5079 , C07K14/33 , G01N33/5005 , G01N2333/33
摘要： The invention provides methods, compositions, devices, and kits relating to the use of cholesterol-dependent cytolysins (e.g., PFOs) for measuring intracellular mitochondrial activity.

83. 发明公开

EP2678326A4 MONOMERS AND POLYMERS FOR FUNCTIONAL POLYCARBONATES AND POLY (ESTER-CARBONATES) AND PEG-CO-POLYCARBONATE HYDROGELS 有权转让
标题翻译：聚对苯二甲酸丁二醇酯聚合物聚醚醚酮（ESTER-CARBONAT） - 聚对苯二甲酸丁二醇酯
公开(公告)号：EP2678326A4
公开(公告)日：2015-03-04
申请号：EP12749377
申请日：2012-02-24
申请人： UNIV MASSACHUSETTS MEDICAL
发明人： SONG JIE , XU JIANWEN
IPC分类号： C07D319/06 , A61K47/34 , A61L27/38 , A61L27/52 , A61L33/06 , C08G63/08 , C08G63/64 , C08G64/02 , C08G64/18 , C08L67/04
CPC分类号： C07D405/14 , A61L27/18 , A61L27/52 , C07C247/04 , C07C247/10 , C07D319/06 , C07D405/06 , C08G64/0208 , C08G64/0241 , C08G64/0291 , C08G64/18 , C08G64/183 , C08L69/00
摘要： The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same. The invention also provides cytocompatible poly(ethylene glycol)-co-polycarobonate hydrogels (e.g., crosslinked by copper-free, strain-promoted “click” chemistry).
摘要翻译：本发明一般涉及功能聚合物和水凝胶。更具体地说，本发明提供具有良好界定的官能团的多功能单体和聚合物，例如聚碳酸酯和聚（酯 - 碳酸酯），其组合物，以及制备和使用它们的方法。本发明还提供细胞相容性聚（乙二醇） - 共 - 碳酸氢氧化物水凝胶（例如，通过无铜，应变促进的“点击”化学）交联。

84. 发明公开

EP1940862A4 ALLELE-SPECIFIC RNA INTERFERENCE 审中-公开
标题翻译： ALLELSPEZIFISCHE RNA-INTERFERENZ
公开(公告)号：EP1940862A4
公开(公告)日：2009-01-07
申请号：EP06836174
申请日：2006-10-02
申请人： UNIV MASSACHUSETTS
发明人： XU ZUOSHANG
IPC分类号： A61K38/00 , A61K48/00 , C12N5/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/333 , C12N2310/336 , C12N2310/53 , C12N2320/51 , C12Y115/01001
摘要： Human diseases caused by dominant, gain-of-function mutations develop in heterozygotes bearing one mutant and one wild-type copy of a gene. Because the wild- type gene often performs important functions, whereas the mutant gene is toxic, any therapeutic strategy must selectively inhibit the mutant while retaining wild-type gene expression. The present invention includes methods of specifically inhibiting the expression of a mutant allele, while preserving the expression of a co-expressed wild-type allele using RNAi, a therapeutic strategy for treating genetic disorders associated with dominant, gain-of-function gene mutations. The invention also includes small interfering RNAs (siRNAs) and small hairpin RNAs (shRNAs) that selectively suppress mutant, but not wild-type, expression of copper zinc superoxide dismutase (SODl), which causes inherited amyotrophic lateral sclerosis (ALS). The present invention further provides asysmmetric siRNAs and shRNAs with enhanced efficacy and specificity and mediating RNAi.
摘要翻译：由携带一个突变体和一个野生型基因拷贝的杂合子发生显性，功能获得性突变引起的人类疾病。由于野生型基因经常执行重要功能，而突变基因是有毒的，所以任何治疗策略都必须选择性抑制突变体，同时保留野生型基因表达。本发明包括特异性抑制突变等位基因表达的方法，同时使用RNAi保留共表达野生型等位基因的表达，所述治疗策略用于治疗与显性功能获得性基因突变相关的遗传疾病。本发明还包括选择性抑制引起遗传性肌萎缩性侧索硬化症（ALS）的铜锌超氧化物歧化酶（SOD1）的突变而非野生型表达的小干扰RNA（siRNA）和小发夹RNA（shRNA）。本发明进一步提供了具有增强的功效和特异性并介导RNAi的不对称siRNA和shRNA。

85. 发明公开

EP1913153A4 GLUCOSE TRANSPORT-RELATED GENES, POLYPEPTIDES, AND METHODS OF USE THEREOF 审中-公开
标题翻译：基因，多肽涉及到使用葡萄糖运输和方法
公开(公告)号：EP1913153A4
公开(公告)日：2008-10-15
申请号：EP06788597
申请日：2006-07-26
申请人： UNIV MASSACHUSETTS
发明人： CZECH MICHAEL P , CHAKLADAR ABHIJIT , GUILHERME ADILSON L , TANG XIAOQING
IPC分类号： G01N33/68 , C12Q1/48 , C12Q1/68
CPC分类号： G01N33/6872 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2320/12 , C12Q1/485 , G01N33/66 , G01N2500/00 , G01N2800/044
摘要： The present invention relates to methods and compositions for modulating glucose transport. More particularly, the present invention relates to the identification of polypeptides, including CDK7, which are involved in the modulation of glucose transport. The invention further relates to methods for identifying and using agents, including small biomolecules, antibodies, peptides, nucleic acids, RNAi and antisense, that modulate glucose transport by altering the expression or activity of the glucose transport related polypeptides identified.

86. 发明公开

EP1778614A4 INVERTIBLE AMPHIPHILIC POLYMERS 审中-公开
标题翻译：可逆两亲性聚合物
公开(公告)号：EP1778614A4
公开(公告)日：2008-09-24
申请号：EP05857535
申请日：2005-07-19
申请人： UNIV MASSACHUSETTS
发明人： THAYUMANAVAN SANKARAN
IPC分类号： C08G63/00 , A61K9/51 , C07C59/72 , C07C233/49 , C08F12/22
CPC分类号： C07C69/712 , A61K47/34 , C07C43/2055 , C07C69/708 , C07C229/12 , C07C233/07 , C07C233/20 , C07C233/49 , C07C237/22 , C07C323/41 , C07F9/3808 , C07F9/3882 , C08F8/32 , C08F112/14 , C08F120/36 , C08F120/58 , C08F2438/03 , C08F2/38
摘要： Amphiphilic monomeric compounds and corresponding homopolymers and copolymers capable of assembly and invertible configuration in introduction to and change in fluid medium.

87. 发明公开

EP1745006A4 METHODS OF 1,3-ENYNE PREPARATION USING COPPER (I) CATALYSTS 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG冯1,3-ENYNEN MITTELS KUPFER-（I）-KATALYSATOREN
公开(公告)号：EP1745006A4
公开(公告)日：2008-04-23
申请号：EP05780040
申请日：2005-04-27
申请人： UNIV MASSACHUSETTS
发明人： VENKATARAMAN DHANDAPANI , BATES CRAIG G , SEAJUENG PRANORM
IPC分类号： C07C69/73 , C07B37/04 , C07C2/02 , C07C2/86 , C07C67/04 , C07C67/10 , C07C67/343 , C07C205/56 , C07C319/20 , C07C323/62 , C07D213/55 , C07D333/16 , C07D333/24 , C12N9/00
CPC分类号： C07C205/56 , B01J31/1805 , B01J31/1815 , B01J31/183 , B01J31/2217 , B01J2231/4266 , B01J2531/16 , C07B37/04 , C07C2/861 , C07C67/343 , C07C201/12 , C07C253/30 , C07C319/20 , C07C2527/167 , C07C2531/24 , C07C2602/10 , C07D213/55 , C07D333/16 , C07D333/24 , C12N9/00 , C07C11/28 , C07C69/65 , C07C69/606 , C07C69/738 , C07C69/76 , C07C69/618 , C07C69/734 , C07C323/62 , C07C255/57
摘要： A copper(I) bi-dentate ligand complex-catalyzed procedure for synthesis of 1,3-enynes. The methods and/or systems of this invention afford a variety of enynes, tolerate a variety of sensitive functional groups, and can be employed without resort to expensive palladium reagents.
摘要翻译：铜（I）双齿配体配合物催化的1,3-烯炔合成方法。本发明的方法和/或系统提供各种烯炔，可耐受各种灵敏的官能团，并且可以在不使用昂贵的钯试剂的情况下使用。

88. 发明公开

EP1466353A4 CONTAMINATION SUPPRESSION IN CHEMICAL FLUID DEPOSITION 审中-公开
标题翻译：减少污染，化工流体存储
公开(公告)号：EP1466353A4
公开(公告)日：2008-04-16
申请号：EP02796032
申请日：2002-12-20
申请人： UNIV MASSACHUSETTS
发明人： WATKINS JAMES J , CABANAS ALBERTINA , BLACKBURN JASON W
IPC分类号： C23C16/18 , C23C16/52 , C23C18/08 , C23C18/40 , H01L21/285 , H01L21/31 , H01L21/44 , H01L21/469
CPC分类号： H01L21/28556 , C23C18/08
摘要： Methods for depositing materials onto a substrate surface or into a porous solid are disclosed. These methods include suppressing contamination of the deposited materials.

89. 发明公开

EP1670518A4 RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS 有权
标题翻译： RNA干扰技术用于功能性障碍增加治疗
公开(公告)号：EP1670518A4
公开(公告)日：2007-10-10
申请号：EP04783980
申请日：2004-09-13
申请人： UNIV MASSACHUSETTS
发明人： ARONIN NEIL , ZAMORE PHILLIP D
IPC分类号： A61K48/00 , C07H21/04 , C12N15/113
CPC分类号： C07H21/04 , A61K48/00 , C12N15/113 , C12N2310/14

90. 发明公开

EP1268087A4 NANOCYLINDER ARRAYS 审中-公开
标题翻译： MATRIZE AUS NANOZYLINDERN
公开(公告)号：EP1268087A4
公开(公告)日：2007-05-23
申请号：EP01922532
申请日：2001-03-22
申请人： UNIV MASSACHUSETTS
发明人： TUOMINEN MARK , SCHOTTER JOERG , THURN-ALBRECHT THOMAS , RUSSELL THOMAS P
IPC分类号： B82B3/00 , B05D3/02 , B82B1/00 , C08J9/00 , C08L20060101 , C08L53/00 , C09D153/00 , C30B29/60 , G11B5/65 , H01F10/12 , H01L21/31 , H01L21/326 , H01L21/469 , H01L21/479 , H01L43/08 , H01L43/12
CPC分类号： H01L21/326 , B82Y15/00 , C30B29/605 , H01L43/12 , Y10S977/72 , Y10S977/893 , Y10S977/897
摘要： Pathways to the fabrication of nanocylinder arrays are provided. Methods are described for the production of well-ordered arrays of nanopores, nanowired, and other materials. This is accomplished by orienting copolymer films and removing a component from the film to produce nanopores that in turn can be filled with materials to produce the arrays. The resulting arrays can be used to produce nanoscale media, devices, and systems.
摘要翻译：提供了快速可靠地制造纳米圆柱阵列的途径。描述了用于生产纳米孔，纳米线和其它材料的有序排列的简单方法。这是通过使共聚物膜定向并从膜去除组分以产生纳米孔而实现的，而纳米孔也可以填充以产生阵列的材料。所得阵列可用于生产纳米级介质，器件和系统。

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