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81. 发明授权

EP1671974B1 PENICILLIN CRYSTAL AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：青霉素晶体和方法及其
公开(公告)号：EP1671974B1
公开(公告)日：2010-12-08
申请号：EP04773756.4
申请日：2004-10-08
申请人： Otsuka Chemical Co., Ltd. , TAIHO PHARMACEUTICAL CO., LTD.
发明人： WADA, Isao, c/o OTSUKA CHEMICAL CO., LTD. , KAMEYAMA, Yutaka, c/o OTSUKA CHEMICAL CO., LTD.
IPC分类号： C07D499/00
CPC分类号： C07D499/86
摘要： 2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals having excellent stability; and a process for producing CMPB crystals which comprises (A) the step of concentrating a CMPB-containing solution, (B) the step of subjecting the resultant concentrate to column chromatography, (C) the step of concentrating a CMPB-containing fraction, and (D) the step of dissolving the resultant CMPB-containing concentrate in an ether solvent and subsequently adding a hydrocarbon solvent to this solution to precipitate CMPB crystals.

82. 发明公开

EP2072496A4 METHOD FOR PRODUCING HIGH-PURITY QUATERNARY AMMONIUM SALT 有权
标题翻译：生产高纯度季铵盐的方法
公开(公告)号：EP2072496A4
公开(公告)日：2010-10-27
申请号：EP07828372
申请日：2007-09-18
申请人： OTSUKA CHEMICAL CO LTD , STELLA CHEMIFA CORP
发明人： NISHIDA TETSUO , HIRANO KAZUTAKA , OKA AKINORI , ABE YOSHINOBU , NABESHIMA AKIHIRO
IPC分类号： C07C213/10 , C07C209/12 , C07C209/84 , C07C211/63 , C07C217/08 , C07D207/06 , C07D233/58 , H01B1/20 , H01B13/00 , H01G9/00 , H01G9/035 , H01G11/62
CPC分类号： H01G9/038 , C07C213/10 , C07D207/06 , C07D233/58 , H01B1/122 , H01G9/022 , H01G9/035 , H01G11/62 , Y02E60/13 , C07C217/08
摘要： A process for preparing a high-purity quaternary ammonium salt comprising: (1) adding an oxide or hydroxide of a Group 1, 2, 12 or 13 metal to a quaternary ammonium salt containing a protonic acid salt of a tertiary amine as an impurity and thereby neutralizing the tertiary amine protonic acid salt with the metal oxide or hydroxide to convert the acid salt to a tertiary amine and water and to convert the metal oxide or hydroxide to a metal salt at the same time, and (2) removing the tertiary amine, water and metal salt produced from the system.

83. 发明公开

EP1813619A4 PROCESS FOR PRODUCING PENAM COMPOUND 有权
标题翻译：一种用于生产连接青霉烷
公开(公告)号：EP1813619A4
公开(公告)日：2010-06-02
申请号：EP05799318
申请日：2005-10-25
申请人： OTSUKA CHEMICAL CO LTD
发明人： WADA ISAO , TOKUMARU YOSHIHISA , SHIMABAYASHI AKIHIRO
IPC分类号： C07D499/04 , C07B53/00
CPC分类号： C07D499/00

84. 发明公开

EP2172479A1 GLP-1 PEPTIDE HAVING SUGAR CHAIN ATTACHED THERETO 有权转让
标题翻译： GLP-1-PEPTID MIT DARAN GEBUNDENER ZUCKERKETTE
公开(公告)号：EP2172479A1
公开(公告)日：2010-04-07
申请号：EP08764149.4
申请日：2008-06-17
申请人： Otsuka Chemical Co., Ltd.
发明人： KAJIHARA, Yasuhiro , TSUJI, Takashi , SAKAMOTO, Izumi , NAMBU, Yuri , FUKAE, Kazuhiro , TEZUKA, Katsunari , ASAI, Hiroaki
IPC分类号： C07K14/605 , A61K38/00 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in:(a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
摘要翻译：本发明涉及与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽，优选表现出比GLP-1更高的控制血糖水平的活性。本发明涉及：（a）GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽，其中至少一个氨基酸被寡糖链添加的氨基酸取代。（b）具有缺失，取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。

85. 发明公开

EP1925591A4 FLAKY TITANIC ACID HAVING POLYMERIZABLE FUNCTIONAL GROUPS, SUSPENSION OF THE SAME, AND COATING FILMS MADE THEREFROM 审中-公开
标题翻译：板形TITAN酸聚合的官能团，它暂停及由其制得的涂膜
公开(公告)号：EP1925591A4
公开(公告)日：2010-03-24
申请号：EP06782605
申请日：2006-08-10
申请人： OTSUKA CHEMICAL CO LTD
发明人： YAMAMOTO MINORU , NOMOTO TAKUYA
IPC分类号： C01G23/00 , B05D3/06 , C09D7/12 , C09D201/00
CPC分类号： C09C1/0018 , C01G23/003 , C01G23/005 , C01P2004/24 , C09C1/36 , C09C1/3669 , C09D1/00 , C23C26/00 , C23C30/00

86. 发明授权

EP1840124B1 QUATERNARY AMMONIUM SALT, ELECTROLYTE, ELECTROLYTE SOLUTION AND ELECTROCHEMICAL DEVICE 有权
标题翻译：季铵盐，电解液，电解液的电化学装置
公开(公告)号：EP1840124B1
公开(公告)日：2010-03-17
申请号：EP06700857.3
申请日：2006-01-12
申请人： Otsuka Chemical Co., Ltd. , Stella Chemifa Corporation
发明人： NISHIDA, Tetsuo , HIRANO, Kazutaka , TOMISAKI, Megumi , NABESHIMA, Akihiro , ABE, Yoshinobu , TOKUDA, Hiroaki , OKA, Akinori
IPC分类号： C07D295/08 , H01M10/05 , H01M14/00 , H01L31/04 , H01G9/038
CPC分类号： H01G9/038 , C07D295/08 , H01G9/2013 , H01G11/62 , H01M10/056 , H01M2300/0025 , Y02E10/542 , Y02E60/13 , Y02P70/521
摘要： Disclosed are a quaternary ammonium salt represented by the formula (1) below, an electrolyte solution and an electrochemical device. (1) (In the formula, R1 represents a straight chain or branched alkyl group having 1-4 carbon atoms, R2 represents a straight chain or branched alkyl group having 1-3 carbon atoms, and X-1 represents N(CN)2-, SCN-, NO3-, NCO- or NO2-.)

87. 发明公开

EP2123655A1 BIS(TETRAHYDROFURAN) COMPOUND, METHOD FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND 有权
标题翻译： BIS（四氢呋喃）化合物，用于生产连接的连接和使用
公开(公告)号：EP2123655A1
公开(公告)日：2009-11-25
申请号：EP08712090.3
申请日：2008-02-28
申请人： Otsuka Chemical Co., Ltd.
发明人： NISHIZAWA, Mugio , FUKUYAMA, Yoshiyasu , IMAGAWA, Hiroshi
IPC分类号： C07D493/04 , A61K31/343 , A61K31/365 , A61P25/16 , A61P25/28 , A61P43/00
CPC分类号： C07D493/10
摘要： The present invention provides a new bis(tetrahydrofuran) compound having an excellent neurotrophic factor activity-enhancing effect, and a process for producing the same. The bis(tetrahydrofuran) compound of the present invention is represented by formula (1):

wherein R 1 and R 2 are the same or different, and represent a C 1-4 alkyl group, a C 1-5 alkoxy group, an aryl C 1-5 alkoxy group, a C 2-5 alkenyloxy group, or an aryl C 2-5 alkenyloxy group, or R 1 and R 2 together represent =O or =CH 2 ; R 3 represents a hydrogen atom or a group -CH 2 -O-R 4 ; R 4 represents a C 1-4 alkyl group, a C 1-5 alkylcarbonyl group, or an aryl C 1-4 alkyl group that may have a substituent on an aryl ring; and a carbon-carbon bond between "a" and "b" represents a single bond or a double bond. The bis(tetrahydrofuran) compound has an excellent neurotrophic factor activity-enhancing effect.
摘要翻译：本发明提供具有优异的神经营养因子活性增强作用的新的双（四氢呋喃）化合物，和用于生产它们的方法。本发明的双（四氢呋喃）化合物由式（1）：worin R 1和R 2是相同的或不同的，并表示C 1-4烷基，C 1-5的烷氧基，以芳的C 1-5烷氧基，一个C 2-5链烯氧基，或2-5ç芳烯基氧基，或R 1和R 2一起表示= O或= CH 2; ，R 3 darstellt一个氢原子或基团-CH 2 -O-R 4; R 4表示C 1-4烷基，C 1-5的烷基羰基，或C 1-4烷基的芳基可具有在芳基环上没有取代基。并且“a”和“b”之间的碳 - 碳键darstellt单键或双键。双（四氢呋喃）化合物具有优异的神经营养因子活性增强作用。

88. 发明公开

EP1918338A4 COMPOSITE TITANIC ACID COATING FILM AND COMPOSITE TITANIC ACID-COATED RESIN SUBSTRATE 有权
标题翻译：复合TITAN ACID涂膜复合镀钛酸树脂基板
公开(公告)号：EP1918338A4
公开(公告)日：2009-10-14
申请号：EP06782603
申请日：2006-08-10
申请人： OTSUKA CHEMICAL CO LTD
发明人： YAMAMOTO MINORU , NOMOTO TAKUYA
IPC分类号： C09D183/04 , B05D7/24 , C01G23/00 , C09D1/00
CPC分类号： C01G23/002 , B05D3/144 , B82Y30/00 , C01G23/003 , C01G23/005 , C01G23/006 , C01P2002/52 , C01P2002/88 , C01P2004/20 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C09C1/36 , C09C1/3684 , C09D1/00

89. 发明公开

EP1970412A4 POLYARYLENE SULFIDE RESIN COMPOSITION 审中-公开
标题翻译：聚亚芳基硫醚树脂
公开(公告)号：EP1970412A4
公开(公告)日：2009-09-16
申请号：EP06834979
申请日：2006-12-13
申请人： POLYPLASTICS CO , OTSUKA CHEMICAL CO LTD
发明人： KONDOH HIDEMI , FUKASAWA YOSHIHITO , MONDE HIROYUKI
IPC分类号： C08L81/02 , C08K3/22 , C08K3/24
CPC分类号： C08K3/22 , C08K3/24 , C08K7/00 , C08L81/02

90. 发明公开

EP2065341A1 METAL OXIDE PARTICLES CARRYING CARBON NANOTUBES AND GRANULAR CARBON NANOTUBES 审中-公开
标题翻译：科林斯顿奥地利奥地利克朗
公开(公告)号：EP2065341A1
公开(公告)日：2009-06-03
申请号：EP07807613.0
申请日：2007-09-20
申请人： Otsuka Chemical Co., Ltd.
发明人： GOTO, Toshiki , TANI, Masato
IPC分类号： C01B31/02 , B01J23/88 , C01B33/24 , C01G23/00 , C08K9/02 , C08L101/00
CPC分类号： B01J23/883 , B01J23/28 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/08 , C01B2202/34 , C01G23/005 , C01G23/006 , C01G51/00 , C01G53/00 , C01P2002/52 , C01P2002/72 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C01P2004/13 , C01P2004/20 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2006/40 , C08J5/005 , C08J2369/00 , Y10T428/2991
摘要： The invention provides novel metal oxide particles on which carbon nanotubes are supported. Needle- or flake-like crystalline metal oxide particles characterized in that carbon nanotubes grown parallel to each other in the direction nearly perpendicular to the surface of each particle are supported on the surfaces of the particles and that the carbon nanotubes supported on the particles are 1 to 500µm in length in the direction nearly perpendicular to the surface of each particle.
摘要翻译：本发明提供了支撑碳纳米管的新型金属氧化物颗粒。针状或片状结晶金属氧化物颗粒的特征在于，在与颗粒的表面几乎垂直的方向上彼此平行地生长的碳纳米管被支撑在颗粒的表面上，并且负载在颗粒上的碳纳米管为1 在与每个颗粒的表面几乎垂直的方向上长度为500μm。

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