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71. 发明公开

EP1891447A1 TWO STEP LATERAL FLOW ASSAY METHODS AND DEVICES 有权
标题翻译：方法及装置有两个台阶的侧向流试验
公开(公告)号：EP1891447A1
公开(公告)日：2008-02-27
申请号：EP06847250.5
申请日：2006-05-23
申请人： Phadia AB
发明人： RUNDSTROM, Gerd , MATSSON, Per , CHRISTOPHER, Paul
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , G01N33/543 , G01N33/6854 , G01N2800/24 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/821 , Y10T436/25125 , Y10T436/255
摘要： Lateral flow assay devices and methods for detecting a first member of a specific binding pair in a sample which comprises a plurality of nonspecific binding pair members are adapted for two step determinations. In one embodiment, a two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location The two step method further comprises allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and is dried on the lateral flow matrix at a location upstream of the delivery of the filtered sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a location downstream of the first location. Further embodiments comprise additional lateral flow immunoassay devices and methods for identifying IgE antibodies in a sample.

72. 发明公开

EP1888236A1 BIOPROBENTRÄGER FÜR MASSENSPEKTROMETRISCHE ANALYSEN 审中-公开
标题翻译： BIOPROBENTRÄGER进行质量分析
公开(公告)号：EP1888236A1
公开(公告)日：2008-02-20
申请号：EP06724518.3
申请日：2006-04-24
申请人： Qiagen GmbH
发明人： REIHS, Karsten
IPC分类号： B01L3/00 , H01J49/26
CPC分类号： H01J49/0418 , B01L3/5088 , B01L2300/166 , Y10T436/255
摘要： A sample carrier has an ultraphobic surface with an affinity zone and a waste zone and/or a zone occupied by a MALDI matrix. Also disclosed is a process for isolating a substance from a mixture of substances, and for its subsequent treatment, as well as a process for purifying a substance.

73. 发明公开

EP1888213A2 FLUIDICS DEVICE 有权
标题翻译：流体装置
公开(公告)号：EP1888213A2
公开(公告)日：2008-02-20
申请号：EP06718719.5
申请日：2006-01-19
申请人： Bio-Rad Laboratories, Inc.
发明人： LOMAS, Lee , DING, Jian , BOSCHETTI, Egisto
IPC分类号： B01D71/06
CPC分类号： G01N30/461 , B01D15/325 , B01D15/362 , B01D15/363 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/026 , B01L2200/028 , B01L2300/0681 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , C07K1/34 , G01N27/44704 , G01N27/44795 , G01N30/466 , G01N30/468 , Y10T137/2224 , Y10T137/794 , Y10T137/86187 , Y10T436/255
摘要： The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.

74. 发明授权

EP1656544B1 A CENTRIFUGATION DEVICE 有权
标题翻译：离心
公开(公告)号：EP1656544B1
公开(公告)日：2007-12-19
申请号：EP04731200.4
申请日：2004-05-05
申请人： Thermo Shandon Limited
发明人： LOMAS, Peter
IPC分类号： G01N1/28
CPC分类号： G01N1/2813 , G01N2001/2846 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A centrifugation device comprising a combined sample chamber and slide holder adapted to be mounted, with a microscope slide, in a centrifuge in a predetermined position, after placing, in the sample chamber, a fluid biological sample containing cells, the centrifugation device comprising a body (10) affording a base (14) adapted for engagement with a microscope slide, structure on one side of the base defining a chamber for a fluid sample, with an opening (15) for the introduction of fluid to said chamber, the base (14) including an aperture (18) and carrying a means for sealing the edges of such aperture with respect to the surface of a microscope slide placed across the base (14), or for allowing the passage of liquid but obstructing the passage of cells, the centrifugation device further including a back plate (12) arranged, when the back plate (12) is closed against the rear of a microscope slide engaged with the base (14), to locate the slide between the base and the cover plate and to hold the cover plate in this closed position, wherein said base (14) comprises a supporting frame (17) and, within said supporting frame, a pressure plate (19) provided with said aperture (18), and wherein the pressure plate is supported from said frame by flexible resilient means (40, 42) such as to allow the pressure plate to "float" and to align itself with a microscope slide located between the pressure plate and the back plate as the back plate is closed.

75. 发明公开

EP1485179A4 DEVICE FOR SOLID PHASE EXTRACTION AND METHOD FOR PURIFYING SAMPLES PRIOR TO ANALYSIS 有权
标题翻译：装置：用于样本的分析之前清洗固相萃取法
公开(公告)号：EP1485179A4
公开(公告)日：2007-08-08
申请号：EP03714124
申请日：2003-03-12
申请人： WATERS INVESTMENTS LTD
发明人： FISK RAYMOND P , IRANETA PAMELA C , TUVIM YURI , BOUVIER EDOUARD S P , BELANGER JONATHAN , GILAR MARTIN
IPC分类号： B01D15/08 , B01J20/281 , B01L3/00 , G01N1/40 , G01N30/00 , G01N30/06 , G01N30/26 , G01N30/60 , G01N30/80 , G01N30/88
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device (11) having a reservoir(16) with an opening; a well (15) comprising an internally tapered wall, the wall having a wider interior diameter at an end closest to the opening than at an exit spout(17); a first filter(14) with the well(15); a bed(12) of sorbent particles within the well(15) below the first filter(14); and a second filter(13) having a diameter smaller than the first filter(14) within the well(15) below the bed (12)of sorbent particles and above the exit spout(17) is provided. A method of performing SPE using the device (11) is also provided.
摘要翻译：具有在开口的贮存器的固体相提取（SPE）装置; 包括阱在内部锥形壁，所述壁具有在在端最近的抗蚀剂内部直径与开口比在出口喷口; 阱内放置在第一过滤器; 内所放置的远低于第一过滤器的吸附剂颗粒的床; 且具有的直径大于设置在远低于吸附剂颗粒床和上述的出口喷口内放置在第一过滤器小的第二过滤器。因此提供了一种使用该设备进行SPE的方法。

76. 发明公开

EP1474672A4 SAMPLE TESTING DEVICE 审中-公开
标题翻译：样品测试设施
公开(公告)号：EP1474672A4
公开(公告)日：2007-07-11
申请号：EP03702087
申请日：2003-01-14
申请人： RAPID MEDICAL DIAGNOSTICS CORP
发明人： SALVO LAWRENCE , WICKSTEAD JAMES C , SERITELLA KEITH A , SLOWEY PAUL D
IPC分类号： G01N33/543 , B01L3/00 , G01N1/18
CPC分类号： B01L3/502 , B01L2300/046 , B01L2300/0609 , B01L2300/0672 , B01L2300/0825 , B01L2300/0832 , B01L2400/0481 , Y10T436/255
摘要： A sample testing device has a buffer container (10) that can hold buffer fluid, a filter (30) with a securement for holding a test strip (40), a test strip container (50) having a receptacle to accommodate the filter, so that when the filter is held therein the test strip (40) is disposed in the receptacle, and a sample collector (20) for holding a sample. The sample collector (20) receives the buffer container (10), and the sample collector has a piercing member (23) which, when the buffer container is placed in the sample collector, pierces the buffer container. Buffer fluid in the buffer container then contacts the sample. As buffer fluid flows through the sample collector, the buffer fluid that has contacted the sample passes through the filter to the test strip.

77. 发明公开

EP1803717A2 Production of delta 9 tetrahydrocannabinol 有权
标题翻译：生产δ9四氢大麻酚
公开(公告)号：EP1803717A2
公开(公告)日：2007-07-04
申请号：EP07005421.8
申请日：2003-02-03
申请人： Resolution Chemicals Limited
发明人： Greenwood, Alan Kenneth , McHattie, Derek , Goodwin, Neil John , Archer, Nicolas James , Murray, Christopher
IPC分类号： C07D311/80 , A61K31/35
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is then converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.
摘要翻译： Δ9THC酸从植物材料获得并在pH控制条件下提取到水性溶剂中。将酸转化成盐并将盐提取到极性溶剂中，得到高纯度的酸。然后将Δ9THC酸转化为Δ9THC，将其进一步纯化并与药用载体组合。

78. 发明公开

EP1800105A2 ANALYSIS OF METALS IN ACIDIC SOLUTIONS 审中-公开
标题翻译： AENLYZE VON METALLEN在SAURENLÖSUNGEN
公开(公告)号：EP1800105A2
公开(公告)日：2007-06-27
申请号：EP05805672.2
申请日：2005-09-30
申请人： Metara, Inc.
发明人： SAINI, Harmesh, K.
IPC分类号： G01N1/10
CPC分类号： B01J47/016 , B01J41/07 , C22B3/42 , G01N1/4044 , G01N30/96 , G01N2030/143 , Y02P10/234 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： In one embodiment, a method of neutralizing the matrix of an acidic solution including at least one metal using a weak anion exchange resin is provided. The method , includes the acts of: activating the weak anion exchange resin with a weakly acidic metal complexing reagent, the weakly acidic metal complexing reagent partially disassociating into protons and metal complexing anions, whereby some functional groups in the weak anion exchange resin are protonated and bind with the metal complexing anions (400); and neutralizing a sample of the acidic solution with the activated weak anion exchange resin (405).
摘要翻译：在一个实施方案中，提供了使用弱阴离子交换树脂中和包含至少一种金属的酸性溶液的基质的方法。该方法包括：用弱酸性金属配位试剂活化弱阴离子交换树脂，弱酸性金属络合剂部分分解成质子和金属络合阴离子，由此弱阴离子交换树脂中的一些官能团被质子化并结合与金属络合阴离子; 并用活化的弱阴离子交换树脂中和酸性溶液样品。

79. 发明公开

EP1765502A2 DISSOLVABLE FILMS AND METHODS INCLUDING THE SAME 有权
标题翻译：水溶性薄膜和程序
公开(公告)号：EP1765502A2
公开(公告)日：2007-03-28
申请号：EP05857484.9
申请日：2005-06-27
申请人： Becton, Dickinson and Company
发明人： LIZZI, Michael, Justin , COPERTINO, Donald, W.
IPC分类号： B01L3/00
CPC分类号： C12Q1/6806 , B01L3/502 , B01L3/5082 , B01L3/5085 , B01L3/52 , B01L2200/026 , B01L2200/0642 , B01L2200/16 , B01L2300/0829 , B01L2400/0677 , B03C1/01 , B03C1/286 , B03C2201/26 , C12Q1/6846 , C12Q1/689 , G01N2035/00277 , Y10T436/25 , Y10T436/255
摘要： A method includes providing a container, introducing a substance into the container, and introducing a readily dissolvable film into the container such that the dissolvable film overlies the substance within the container. An alternative method includes providing a container, providing a readily dissolvable film, the film comprising a substance carried by the film, and introducing the film into the container.

80. 发明授权

EP1446210B1 VERFAHREN ZUR EXTRAKTION UND ANALYSE VON INHALTSSTOFFEN AUS ORGANISCHEM MATERIAL 有权
标题翻译：提取及原料来自有机材料的分析
公开(公告)号：EP1446210B1
公开(公告)日：2007-02-14
申请号：EP02787628.3
申请日：2002-11-11
申请人： Metanomics GmbH
发明人： HEROLD, Michael, Manfred , DOSTLER, Martin , LOOSER, Ralf , WALK, Tilmann, B. , FEGERT, Achim , KLUTTIG, Martin , LEHMANN, Britta , HEIDEMANN, Silke , HENNIG, Annette , KOPKA, Joachim
IPC分类号： B01D11/02
CPC分类号： B01D11/0288 , Y10T436/255
摘要： The invention relates to a method for the isolation of contents made from organic material, comprising the following method steps: (a) freeze-drying the organic material, (b) extraction of the contents with a polar solvent or solvent mixture (A) and an organic solvent or solvent mixture (B), whereby the extracts from the extractions with (A) and (B) can form one phase, (c) combination of extracts (A) and (B) to give one phase and (d) carrying out an esterification/transesterification in the non-polar phase with an alcohol. The esterification/transesterification is carried out in the presence of a liquid acid. The method is a high-throughput method.

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