专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明公开

EP2707714A1 CHAPERONE INTERACTION ASSAYS AND USES THEREOF 审中-公开
标题翻译：安东尼·达文的CHAPERON-INTERAKTIONSASSAY
公开(公告)号：EP2707714A1
公开(公告)日：2014-03-19
申请号：EP12782991.9
申请日：2012-05-09
申请人： Whitehead Institute For Biomedical Research
发明人： TAIPALE, Mikko , LINDQUIST, Susan
IPC分类号： G01N33/53 , G01N33/547 , G01N33/543 , G01N33/487
CPC分类号： G01N33/573 , C12Q1/485 , C12Q1/66 , G01N33/502 , G01N33/54306 , G01N33/57484 , G01N33/6845 , G01N33/6872 , G01N2500/02 , G01N2800/60
摘要： In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein activity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some aspects, the invention provides methods for identifying and/or characterizing compounds and/or for assessing compound specificity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some embodiments, a client protein is a kinase. In some embodiments, a compound is a kinase inhibitor. In some aspects, the invention provides methods of profiling kinase inhibitor specificity. In some aspects, the invention provides assay systems and/or reagents useful for performing one or more of the inventive methods. In some aspects, the invention provides newly identified targets of a variety of kinase inhibitors. In some aspect, the invention provides methods of inhibiting kinases identified herein as targets of certain kinase inhibitors. In some aspects, the invention provides methods of treating a disease, e.g., cancer, by inhibiting one or more kinase(s) newly identified as targets of certain kinase inhibitors.
摘要翻译：在一些方面，本发明提供鉴定，检测和/或测量蛋白质 - 蛋白质相互作用的方法。在一些方面，本发明提供鉴定和/或表征蛋白质 - 蛋白质相互作用的调节剂的方法。在一些方面，本发明提供鉴定和/或表征蛋白质活性调节剂的方法，其中所述方法至少部分地基于测量分子伴侣和客体蛋白质之间的相互作用。在一些方面，本发明提供用于鉴定和/或表征化合物和/或用于评估化合物特异性的方法，其中所述方法至少部分地基于测量分子伴侣和客体蛋白质之间的相互作用。在一些实施方案中，客户蛋白质是激酶。在一些实施方案中，化合物是激酶抑制剂。在一些方面，本发明提供了分析激酶抑制剂特异性的方法。在一些方面，本发明提供了用于执行本发明一种或多种方法的测定系统和/或试剂。在一些方面，本发明提供了新鉴定的各种激酶抑制剂的靶标。在一些方面，本发明提供抑制本文鉴定的激酶作为某些激酶抑制剂靶标的方法。在一些方面，本发明提供了通过抑制新鉴定为某些激酶抑制剂的靶标的一种或多种激酶来治疗疾病例如癌症的方法。

72. 发明公开

EP2695515A1 EPO KNOCKOUT GFP ANEMIC MOUSE 有权
标题翻译：贫血EPO-GFP基因敲除小鼠
公开(公告)号：EP2695515A1
公开(公告)日：2014-02-12
申请号：EP12768270.6
申请日：2012-03-29
申请人： Tohoku Techno Arch Co., Ltd.
发明人： YAMAMOTO, Masayuki , MINEGISHI, Naoko , YAMAZAKI, Shun
IPC分类号： A01K67/027 , C12N5/10 , C12N15/09 , C12Q1/02
CPC分类号： A61K49/0008 , A01K67/0276 , A01K67/0278 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , G01N33/502 , G01N2333/505
摘要： The present invention relates to a model animal spontaneously developing anemia. More specifically, the invention relates to a transgenic non-human mammal spontaneously developing anemia associated with a postnatal decrease in production of erythropoietin (Epo), Epo-producing cells prepared from the transgenic non-human mammal, and a screening method using the Epo-producing cells.

73. 发明公开

EP2659884A2 Selective apoptotic induction in cancer cells including activation of procaspase-3 审中-公开
标题翻译： Serektive凋亡诱导在Krebszellen mit Aktivierung von Procaspase-3
公开(公告)号：EP2659884A2
公开(公告)日：2013-11-06
申请号：EP13166145.6
申请日：2006-05-26
申请人： The Board of Trustees of the University of Illinois
发明人： Hergenrother, Paul J. , Putt, Karson S , Chen, Grace W. , Pearson, Jennifer M.
IPC分类号： A61K31/00 , A61K31/495 , C07D295/15 , A61P35/00 , C12Q1/37 , G01N33/50
CPC分类号： A61K31/495 , C07D295/15 , C12Q1/37 , G01N33/502 , G01N33/574 , G01N2333/96466 , G01N2510/00 , G01N2800/52
摘要： Compounds and related methods for synthesis, and the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3, and particular embodiments are capable of direct activation of procaspase-3 and procaspase-7 to the effector forms of caspase-3 and caspase-7. Procaspase-3 levels can vary among cancer cell types; several types have relatively high levels and can have increased susceptibility to chemotherapy by compounds and methods herein. Therapeutic applications are relevant for a variety of cancer conditions and cell types, e.g. breast, lung, brain, colon, renal, adrenal, melanoma, and others.
摘要翻译：公开了合成的化合物和相关方法，以及化合物在治疗中用于治疗癌症和选择性诱导细胞凋亡的用途。公开了关于胱天蛋白酶例如胱天蛋白酶-3修饰的化合物，特定实施方案能够将胱天蛋白酶-3和胱天蛋白酶-7的效应物形式直接活化胱天蛋白酶-3和胱天蛋白酶原-7。 Procaspase-3水平可以在癌细胞类型之间变化; 几种类型具有相对较高的水平，并且可以通过本文化合物和方法增加对化学疗法的易感性。治疗应用与各种癌症状况和细胞类型相关，例如，乳腺，肺，脑，结肠，肾，肾上腺，黑素瘤等。

74. 发明公开

EP2653534A1 METHOD FOR FORMING CELL AGGREGATE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES ZELLVERBUNDS
公开(公告)号：EP2653534A1
公开(公告)日：2013-10-23
申请号：EP11848080.5
申请日：2011-12-07
申请人： SHISEIDO CO., LTD.
发明人： FUJIWARA, Shigeyoshi , TAKEI, Keigo , SUDA, Yukimitsu
IPC分类号： C12N5/071 , C12Q1/02 , C12M1/22
CPC分类号： G01N33/502 , C12M23/20 , C12M35/08 , C12N5/0068 , C12N5/0667 , C12N5/0671 , C12N5/0693 , C12N2533/30 , G01N33/5032 , G01N33/5082
摘要： A method for forming a cell aggregate in the present invention is a method for forming a cell aggregate by using a culturing vessel and culturing an adhesive cell, wherein the culturing vessel is such that an amino group, a carboxyl group, and/or a hydroxyl group, and a group represented by a general formula of

(in the formula, each of R 1 , R 2 , and R 3 is independently an alkyl group with a carbon number greater than or equal to 1 and less than or equal to 6 and m is an integer greater than or equal to 2 and less than or equal to 6.) are present near a surface thereof and the adhesive cell is a mesenchymal stem cell, a hepatic cell, or a cancer cell.
摘要翻译：本发明的细胞聚集体的形成方法是使用培养容器形成细胞聚集体并培养粘合剂细胞的方法，其中培养容器为氨基，羧基和/或羟基（通式中，R 1，R 2和R 3各自独立地为碳数大于等于1且小于等于6的烷基，和 m是大于或等于2并且小于或等于6的整数）存在于其表面附近，并且粘合剂细胞是间充质干细胞，肝细胞或癌细胞。

75. 发明授权

EP1639097B1 METHODS AND COMPOSITIONS FOR MODULATING STEM CELL GROWTH AND DIFFERENTIATION 有权
标题翻译：干细胞生长和分化的方法和组合物调节
公开(公告)号：EP1639097B1
公开(公告)日：2013-08-07
申请号：EP04737880.7
申请日：2004-06-25
申请人： Ottawa Health Research Institute
发明人： RUDNICKI, Michael , SEALE, Patrick , POLESSKAYA, Anna , FORTIN, Anouk
IPC分类号： C12N5/07 , C07K14/475 , A61K35/12 , A61K38/17 , A61K35/34
CPC分类号： G01N33/5061 , A61K35/28 , A61K35/34 , A61K38/00 , C07K14/47 , C07K14/475 , C12N5/0658 , C12N2501/41 , C12N2501/415 , C12N2503/00 , G01N33/5008 , G01N33/5017 , G01N33/502 , G01N33/5073 , A61K2300/00
摘要： Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.

76. 发明公开

EP2598146A1 METHODS TO IDENTIFY TARGETS AND MOLECULES REGULATING PURINOSOMES AND THEIR USES 审中-公开
标题翻译：方法目标是恰当PURINOSOMENREGULIERUNG及其用途鉴定和分子的
公开(公告)号：EP2598146A1
公开(公告)日：2013-06-05
申请号：EP11740760.1
申请日：2011-07-14
申请人： Corning Incorporated
发明人： BENKOVIC, Stephen , FANG, Ye , AN, Songon , VERRIER, Florence
IPC分类号： A61K31/506 , G01N33/50
CPC分类号： A61K31/506 , A61K31/00 , A61K31/404 , A61K31/436 , A61K31/4412 , A61K31/517 , G01N33/502
摘要： The present invention discloses methods to identify targets, pathways and molecules regulating purinosomes and their uses for treating pathophysiological disorders associated with purinosomes. Disclosed are methods related to both label-free cellular assays and fluorescence imaging to confirm the regulatory roles of various targets and molecules in purinosome dynamics. Disclosed are methods to classify molecules and the uses of these molecules for different indications. Specifically, the purinosome-disrupting molecules can be used for improved prevention and treatment of cancer development.

77. 发明授权

EP2137537B1 Compositions and Uses for Treating Multiple Sclerosis 有权转让
标题翻译：组合物和他们的多发性硬化症的治疗
公开(公告)号：EP2137537B1
公开(公告)日：2013-05-29
申请号：EP08725256.5
申请日：2008-02-07
申请人： Biogen Idec MA Inc.
发明人： LUKASHEV, Matvey, E. , O'NEILL, Gilmore
IPC分类号： G01N33/68
CPC分类号： A61K9/0065 , A61K9/28 , A61K9/4891 , A61K31/137 , A61K31/194 , A61K31/197 , A61K31/225 , A61K31/277 , A61K31/436 , A61K31/4704 , A61K31/7076 , A61K38/217 , A61K45/06 , G01N33/502 , G01N33/5041 , G01N2333/90209 , G01N2800/285 , A61K2300/00

78. 发明公开

EP2551670A1 NIK inhibitors cell-based assay 审中-公开
标题翻译： Zellenbasierte NIK-Hemmeranalyse
公开(公告)号：EP2551670A1
公开(公告)日：2013-01-30
申请号：EP11175584.9
申请日：2011-07-27
申请人： Merck Patent GmbH
发明人： The designation of the inventor has not yet been filed
IPC分类号： G01N33/50 , G01N33/542
CPC分类号： G01N33/502 , C12Q1/485 , G01N33/5005 , G01N33/5008 , G01N33/542 , G01N2333/9121 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to a cell-based assay for the screening and the identification of inhibitors of NIK protein. The method according to the present invention allows the identification of compounds that inhibit NIK activity related to the phosphorylation of IKK1. The assay combines the use of transfected Human Embryonic Kidney (HEK) cells with a non-radioactive, homogeneous proximity assay using an "acceptor" bead and a "donor" bead.
摘要翻译：本发明涉及用于筛选和鉴定NIK蛋白抑制剂的基于细胞的测定。根据本发明的方法允许鉴定抑制与IKK1的磷酸化相关的NIK活性的化合物。该测定结合了使用转染的人类胚胎肾细胞（HEK）细胞与非放射性同质邻近测定法，使用“受体”珠和“供体”珠。

79. 发明公开

EP2528619A1 SCREENING METHOD FOR IDENTIFYING COMPOUNDS WHICH BLOCK TUMOUR GROWTH BY INDUCING IRREVERSIBLE SENESCENCE IN TUMOUR CELLS 有权
标题翻译：筛选方法，识别肿瘤生长的化合物，通过诱导不可逆衰老阻断肿瘤细胞
公开(公告)号：EP2528619A1
公开(公告)日：2012-12-05
申请号：EP11702413.3
申请日：2011-01-26
申请人： Centre Léon Bérard , Centre National de la Recherche Scientifique CNRS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BERNARD, David , BARTHOLIN, Laurent , LELIEVRE, Etienne , AUGERT, Arnaud
IPC分类号： A61K38/44 , G01N33/50
CPC分类号： G01N33/5011 , A61K31/275 , G01N33/502
摘要： Screening methods for compounds which are able to block tumour growth by inducing irreversible senescence and treatment of pancreatic cancer with a compound inhibiting escape from cellular senescence such as BAPN.

80. 发明公开

EP2524226A1 PROMYELOCYTIC LEUKEMIA PROTEIN AS A REDOX SENSOR 审中-公开
标题翻译：作为氧化还原传感器的早幼期白血病蛋白
公开(公告)号：EP2524226A1
公开(公告)日：2012-11-21
申请号：EP11700269.1
申请日：2011-01-13
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人： DE THE, Hugues , LALLEMAND-BREITENBACH, Valérie
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/502 , C07K14/47 , C07K14/555 , G01N33/5008 , G01N33/6875
摘要： The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of PML nuclear bodies in said cell or tissue.
摘要翻译：本发明涉及用于确定细胞或组织的氧化还原状态的方法，其包括由确定所述细胞或组织中的PML核体的水平组成的步骤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式