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71. 发明公开

EP0859855A1 IN VITRO CONSTRUCTION OF SV40 VIRUSES AND PSEUDOVIRUSES 失效
标题翻译：体外及建设SV40病毒拟病毒的
公开(公告)号：EP0859855A1
公开(公告)日：1998-08-26
申请号：EP96935316.0
申请日：1996-11-06
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT CO. LTD.
发明人： SANDALON, Ziv , OPPENHEIM, Amos, B. , OPPENHEIM, Ariella
IPC分类号： A61K48 , C07K14 , C12N15
CPC分类号： C07K14/005 , A61K48/00 , C12N15/86 , C12N15/87 , C12N2710/22022 , C12N2710/22043
摘要： The invention relates to constructs capable of infecting mammalian cells comprising at least one semi-purified or pure SV40 capsid protein and a constituent selected from the group consisting of an exogenous DNA, a vector comprising an exogenous DNA, an exogenous RNA, a vector comprising an exogenous RNA, an exogenous protein or peptide product, and antisense RNA, ribozyme RNA or any RNA or DNA which inhibits or prevents the expression of undesired protein(s) in said mammalian cell and optionally further comprising operatively linked regulatory elements sufficient for the expression and/or replication of said exogenous protein in a mammalian cell. The protein product is preferably a therapeutic protein or peptide product which is not made or contained in mammalian cells, or is made or contained in such cells in abnormally low amount, or is made or contained in such cells in defective form, or is made or contained in mammalian cells in physiologically abnormal or normal amount and can be an enzyme, a receptor, a structural protein, a regulatory protein or a hormone. The invention further relates to a method for the in vitro construction of SV40 viruses or pseudoviruses constructs according to the invention. In a further aspect, the invention relates to mammalian, preferably human cells infected with the constructs of the invention or with constructs obtained by any of the methods of the invention. Still further, the invention relates to a method of providing a therapeutic DNA, RNA, protein or peptide product or antisense RNA to a patient in need of such product by administering to the patient a therapeutically effective amount of the SV40 viruses or pseudoviruses of the invention or a therapeutically effective amount of infected cells according to the invention. Pharmaceutical compositions comprising as active ingredient a therapeutically effective amount of the SV40 viruses or pseudoviruses according to the invention or a therapeutically effective amount of infected cells according to the invention are also within scope of this application.

72. 发明公开

EP0724593A1 COILED-COIL STEM LOOP TEMPLATES 失效
标题翻译：线圈干圈模板
公开(公告)号：EP0724593A1
公开(公告)日：1996-08-07
申请号：EP94920179.0
申请日：1994-06-10
申请人： SMITHKLINE BEECHAM CORPORATION
发明人： CHAIKEN, Irwin Morris , MYSZKA, David Gerard , GRADDIS, Thomas James
IPC分类号： C12N15 , A61K38 , A61K39 , C07H21 , C07K1 , C07K7 , C07K14 , C07K16 , C12P21
CPC分类号： C07K14/005 , A61K38/00 , C07K14/001 , C07K14/5406 , C07K14/5412 , C07K14/75 , C07K16/18 , C12N2710/22022
摘要： The present invention discloses polypeptides that are conformationally constricted in an intramolecular, antiparallel, coiled-coil stem loop arrangement. The coiled-coil stem comprises two α-helical structures arranged longitudinally in an antiparallel orientation such that the helices are capable of forming a superhelical structure. The loop segment comprises a connector between the carboxyl terminus of a first α-helical structure and the amino terminus of a second α-helical structure. Also disclosed are antibodies to the polypeptides of the present invention and DNA molecules which encode the polypeptides of the present invention. The present invention also relates to mimics and antagonists of biological macromolecules.
摘要翻译：本发明公开了在分子内反平行卷曲螺旋茎环结构中构象地收缩的多肽。卷曲螺旋杆包含两个沿反平行方向纵向排列的α-螺旋结构，使得螺旋能够形成超螺旋结构。环段包含第一α-螺旋结构的羧基末端和第二α-螺旋结构的氨基末端之间的连接物。还公开了本发明多肽的抗体和编码本发明多肽的DNA分子。本发明还涉及生物大分子的模拟物和拮抗物。

73. 发明公开

EP0589851A1 Transgenic non-human mammals with an oncogene under the control of an inducible liver-specific promoter 失效
标题翻译：非人类转基因哺乳动物与诱导，肝特异性启动子控制下的癌基因。
公开(公告)号：EP0589851A1
公开(公告)日：1994-03-30
申请号：EP93830362.5
申请日：1993-09-06
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
发明人： Ciliberto, Gennaro
IPC分类号： C12N15/00 , A01K67/027 , C12N15/85 , C12N15/37
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , C07K14/005 , C12N15/85 , C12N2710/22022 , C12N2830/002 , C12N2830/008 , C12N2830/85
摘要： A transgenic non-human mammal, characterized in that all its germ cells and somatic cells contain a recombinant activated oncogene - under the control of an inducible liver specific promoter - introduced into said mammal, or an ancestor of said mammal, at an embryonic stage of its development. Extremely satisfactory results were obtained when the oncogenic sequence comprised the sequence coding for the big T-antigen of SV 40 virus and when the inducible liver specific promoter controlling the oncogene is the promoter of the human gene coding for C-reactive protein.
The figure represents the genetic map of a plasmid containing the above genic construct.
摘要翻译：一种转基因非人哺乳动物，在做了其所有的生殖细胞和体细胞含有一个重组活化癌基因化 - 可诱导的肝特异性启动子的控制下， - 引入所述哺乳动物，或向所述哺乳动物的祖先，在在胚胎阶段它的发展。非常令人满意的结果，获得当致癌序列包含编码序列SV40病毒的大T抗原，并且当可诱导的肝特异性启动子控制的癌基因是人类基因编码C-反应蛋白的启动子。 darstellt含有上述核不构建体的质粒的遗传图谱的附图。

74. 发明公开

EP3299468A1 A NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP 审中-公开
标题翻译：一种基于JCV-VLP的新型药物递送系统
公开(公告)号：EP3299468A1
公开(公告)日：2018-03-28
申请号：EP17200325.3
申请日：2013-03-06
申请人： Life Science Inkubator Betriebs GmbH & Co. KG
发明人： Demina, Victoria , Manninga, Heiko , Götzke, Armin , Glassmann, Alexander
IPC分类号： C12N15/86 , A61K48/00
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
摘要： The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
摘要翻译：本发明涉及源自载有药物（货物）的人多瘤病毒的VLP作为用于将所述药物输送到CNS，特别是活的人类中的药物递送系统。

75. 发明公开

EP3230306A2 POLYOMAVIRUS VIRUS-LIKEPARTICLES (VLPS) COMPRISING A FUSION PROTEIN 审中-公开
标题翻译：包含融合蛋白的多形病毒体病毒 - 凝胶细胞（VLPS）
公开(公告)号：EP3230306A2
公开(公告)日：2017-10-18
申请号：EP15832731.2
申请日：2015-12-08
申请人： Life Science Inkubator Betriebs GmbH & Co. KG
发明人： FRANKEN, Sebastian , GLASSMANN, Alexander , TEMME, Nadine
IPC分类号： C07K14/005 , C12N7/04
CPC分类号： C07K14/005 , C07K2319/06 , C07K2319/70 , C12N7/00 , C12N7/04 , C12N15/113 , C12N2310/14 , C12N2320/32 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042
摘要： The disclosure relates to a fusion protein comprising a VP1 binding protein and an exogenous peptide, wherein the exogenous peptide comprises a cargo-securing peptide (CSP) and/or an endosome translocating peptide (ETP) and to virus like particles (VLP) comprising the fusion protein for use as drug delivery system. Also provided are polynucleotides encoding the fusion protein, suitable expression vectors, host cells, production methods for the fusion protein and the VLP comprising the fusion protein.
摘要翻译：本公开涉及包含VP1结合蛋白和外源肽的融合蛋白，其中所述外源肽包含货物保护肽（CSP）和/或内体转位肽（ETP）并且包含病毒样颗粒（VLP）融合蛋白用作药物递送系统。还提供了编码融合蛋白的多核苷酸，合适的表达载体，宿主细胞，融合蛋白的生产方法和包含融合蛋白的VLP。

76. 发明公开

EP3199633A1 HERABREGULATION DER GENEXPRESSION MITTELS NUKLEINSÄURE-BELADENER VIRUS-ÄHNLICHER PARTIKEL 有权
标题翻译：通过载有核酸的病毒样颗粒来下调基因表达
公开(公告)号：EP3199633A1
公开(公告)日：2017-08-02
申请号：EP17151870.7
申请日：2008-09-12
申请人： Deutsches Primatenzentrum GmbH
发明人： Lüke, Wolfgang , Gruber, Jens
IPC分类号： C12N15/11 , C12N7/04 , A61K31/713 , A61K47/42 , C07K14/025
CPC分类号： C12N15/113 , A61K39/39 , A61K48/0025 , C07K2319/09 , C12N15/111 , C12N15/1138 , C12N15/117 , C12N2310/14 , C12N2320/32 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2710/22045
摘要： Die vorliegende Erfindung betrifft Zusammensetzungen aus virusähnlichen Partikeln für das Einbringen von RNA-Interferenz (RNAi-) induzierenden Molekülen in eukaryontische Zellen sowie Verfahren zur zelltypspezifischen Transduktion einer Vielzahl eukaryontischer Zellen mit RNAi-induzierenden Molekülen. Weiterhin betrifft die vorliegende Erfindung Verfahren zur Diagnose, Prävention und/oder Behandlung von Krankheiten oder Krankheitszuständen, die mit einer erhöhten Expressionsrate mindestens eines endogenen Gens und/oder mit der unerwünschten Expression mindestens eines endogenen Gens und/oder fremder Nukleinsäuren, insbesondere viraler Nukleinsäuren, einhergeht.
摘要翻译：本发明涉及一种用于在真核细胞和方法引入RNA干扰（RNAi）分子诱导针对多个真核细胞与RNAi诱导分子中的细胞类型特异性转导的病毒样颗粒的组合物。此外，本发明提供了用于诊断，预防和/或治疗的疾病或疾病状态的方法，具有至少一个内源基因和/或至少一种内源基因和/或外源核酸的不希望的表达的增加的表达速率相关联，特别是病毒核酸涉及，

77. 发明公开

EP2888366A4 A NOVEL POLYMAVIRUS ASSOCIATED WITH DIARRHEA IN CHILDREN 审中-公开
标题翻译：新的腹泻有关的儿童POLYMAVIRUS
公开(公告)号：EP2888366A4
公开(公告)日：2016-03-30
申请号：EP13830498
申请日：2013-08-22
申请人： UNIV CALIFORNIA , UNIV LELAND STANFORD JUNIOR , UNIV MEXICO NACIONAL AUTONOMA
发明人： CHIU CHARLES , YU GUIXIA , GRENINGER ALEXANDER , ISA PAVEL , ARIAS CARLOS F , DE RISI JOSEPH , PARSONNET JULIE , MILLER STEVE
IPC分类号： C12N15/37 , C07K14/025 , C07K16/08 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/56983 , C07K2/00 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2710/22021 , C12N2710/22022 , C12Q1/701 , G01N33/57446 , G01N33/6854 , G01N33/6893 , G01N2800/06 , G01N2800/065 , G01N2800/24

78. 发明公开

EP2734218A2 POLYOMA VIRUS JC PEPTIDES AND PROTEINS IN VACCINATION AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：抗肿瘤药物多肽 - 丙型肝炎病毒
公开(公告)号：EP2734218A2
公开(公告)日：2014-05-28
申请号：EP12737822.2
申请日：2012-07-23
申请人： Universität Zürich
发明人： JELCIC, Ilijas , MARTIN, Roland , SCHIPPLING, Sven , SOSPEDRA, Mireia , YOUSEF, Sara
IPC分类号： A61K38/04 , A61K38/16 , C07K14/025
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K38/2046 , A61K39/12 , A61K2039/55511 , A61K2039/55527 , C07K7/08 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2710/22034 , C12N2710/22071 , C12Q1/70
摘要： The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable ofeliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.
摘要翻译：本发明涉及疫苗接种或免疫领域，特别是治疗性疫苗接种和诊断。公开了能够引起针对多瘤病毒JC（JCV）的保护性免疫应答的药物组合物和试剂盒，其可用于例如用于治疗或预防进行性多灶性脑白质脑病（PML）和/或进行性多灶性脑白质脑病 - 免疫重建炎症综合征（PML-IRIS）。危及此类PML或PML-IRIS的个体可能例如免疫功能低下或免疫抑制患者或患有自身免疫性疾病的患者符合免疫抑制治疗。本发明还涉及包含JCV蛋白质的至少一种CD4 +表位的组合物及其诊断用途。

79. 发明授权

EP2029176B1 SV40 VP1 CAPSID PROTEINS FOR THE TREATMENT OF PATHOLOGIC DISORDERS 有权转让
标题翻译： SV40 VP1衣壳蛋白用于治疗病理病症
公开(公告)号：EP2029176B1
公开(公告)日：2014-02-19
申请号：EP07736471.9
申请日：2007-06-18
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人： OPPENHEIM, Ariella
IPC分类号： C12N7/00 , C12N7/01 , C12N7/04 , A61K39/12 , A61K35/76
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2710/22032 , Y02A50/467
摘要： The present invention relates to viral capsid proteins, as a medicament for the treatment of a pathologic disorder. More particularly, the invention relates to the viral capsid proteins VP1, VP2 and VP3, preferably, the SV40 VP1 or any peptide, fragment, mutant, derivative and mixtures thereof or of virus-like particles (VLP's) comprising the same, as the active ingredient in compositions for the treatment of pathologic disorders, preferably disorders associated with inactivation of cellular proteins involved with quality control processes, particularly, chaperones. The invention further provides methods for the treatment of such disorders and the use of the SV40 capsid proteins for the preparation of pharmaceutical compositions.

80. 发明公开

EP2476753A4 CONSTRUCT COATED WITH VIRUS COAT-CONSTITUTING PROTEIN AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：带有病毒被膜的形成其制备蛋白包物品和方法，
公开(公告)号：EP2476753A4
公开(公告)日：2013-10-09
申请号：EP10815279
申请日：2010-08-30
申请人： TOKYO INST TECH
发明人： HANDA HIROSHI , DOI KOJI , ENOMOTO TERUYA , KAWANO MASAAKI
IPC分类号： C12N15/09 , A61K9/127 , A61K9/51 , A61K47/42 , C07K14/005 , C07K14/025 , C07K17/00 , C12N15/87 , C12N15/88
CPC分类号： A61K9/5184 , C07K14/005 , C12N15/87 , C12N15/88 , C12N2710/22022 , C12N2710/22023 , C12N2810/6009 , C12N2810/851

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