基本信息:
- 专利标题： SV40 VP1 CAPSID PROTEINS FOR THE TREATMENT OF PATHOLOGIC DISORDERS
- 专利标题（中）：SV40 VP1衣壳蛋白用于治疗病理病症
- 申请号：EP07736471.9 申请日：2007-06-18
- 公开(公告)号：EP2029176B1 公开(公告)日：2014-02-19
- 发明人： OPPENHEIM, Ariella
- 申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
- 申请人地址： P.O.B 39135 91390 Jerusalem IL
- 专利权人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
- 当前专利权人： BIOCAPSID THERAPEUTICS LTD, IL
- 当前专利权人地址： BIOCAPSID THERAPEUTICS LTD, IL
- 代理机构： Leihkauf, Steffen Falk
- 优先权： IL17637706 20060618
- 国际公布： WO2007148326 20071227
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; C12N7/01 ; C12N7/04 ; A61K39/12 ; A61K35/76
摘要：
The present invention relates to viral capsid proteins, as a medicament for the treatment of a pathologic disorder. More particularly, the invention relates to the viral capsid proteins VP1, VP2 and VP3, preferably, the SV40 VP1 or any peptide, fragment, mutant, derivative and mixtures thereof or of virus-like particles (VLP's) comprising the same, as the active ingredient in compositions for the treatment of pathologic disorders, preferably disorders associated with inactivation of cellular proteins involved with quality control processes, particularly, chaperones. The invention further provides methods for the treatment of such disorders and the use of the SV40 capsid proteins for the preparation of pharmaceutical compositions.