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71. 发明公开

EP0016731A1 Meta-Cyanoalkoxy-Phenylharnstoffe mit herbizider Wirkung, deren Herstellung und sie enthaltende Mittel 有权
标题翻译：具有除草活性的元氰基烷基 - 苯基脲，它们的制备和含有它们的组合物。
公开(公告)号：EP0016731A1
公开(公告)日：1980-10-01
申请号：EP80810090.3
申请日：1980-03-20
申请人： CIBA-GEIGY AG
发明人： Pissiotas, Georg, Dr. , Rohr, Otto, Dr.
IPC分类号： C07C127/19 , C07D211/16 , C07D295/20 , A01N47/30 , A01N47/38
CPC分类号： C07D295/215 , A01N47/30 , A01N47/38 , C07C275/34 , C07C275/64
摘要： Die meta-Cyanoalkoxy-Phenylharnstoffe der Formel
worin X Wasserstoff oder Halogen, YO- eine möglichst verzweigte Cyanoalkoxygruppe, R 1 Wasserstoff oder Niederalkyl, -NR 2 R 3 einen primären, sekundären oder heterocyclischen Aminorest bedeuten, zeigen überraschend gute herbizide Wirkung gegen mono- und dicotyle Pflanzen mit Selektivitäten in Mais, Getreiden sowie Baumwolle, Soja und für einzelne Verbindungen auch in Raps.
摘要翻译：式其中X是氢或卤素的元氰基烷苯基脲，YO-意味着支可能氰基烷，R 1是氢或低级烷基，-NR 2 R 3是伯，仲或杂环氨基令人意外地显示良好的除草活性对单子叶和双子叶植物与玉米，谷物和棉花，大豆选择性和对油菜单个连接。

72. 发明公开

EP0003835A1 A hydroxy-urea, process for producing the same and a process for producing a phenyl-substituted N-methoxy-N-methyl-urea 有权
标题翻译：羟基脲和其生产过程中，以及用于生产苯基取代的N-甲氧基-N-甲基 - 脲。
公开(公告)号：EP0003835A1
公开(公告)日：1979-09-05
申请号：EP79100518.4
申请日：1979-02-21
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Fujita, Fumio , Kishida, Hiroshi , Itaya, Nobushige , Takemoto, Ichiki
IPC分类号： C07C127/19 , A01N47/30
CPC分类号： C07C275/64 , C07C205/37 , C07C273/1854
摘要： A compound of the formula:
which is useful as a herbicide, is effectively produced by reacting a compound of the formula:
with dimethyl sulfate in a two phase reaction medium consisting of water and a hydrophobic organic solvent in the presence of a phase transfer catalyst, or produced through a novel intermediate of the formula:
摘要翻译：下式的化合物：所有这是有用的作为除草剂，被有效地通过使下式的化合物制备：在存在水和疏水性有机溶剂的硫酸二甲酯在两相反应介质由......组成 T：相转移催化剂的，或通过新中间体式产生

73. 发明授权

EP3778563B1 PHENOXYUREA COMPOUND AND PEST CONTROL AGENT 有权转让
公开(公告)号：EP3778563B1
公开(公告)日：2024-05-29
申请号：EP19785992.9
申请日：2019-04-03
IPC分类号： C07C275/64 , A01N47/28 , A01P5/00 , A01P7/02 , A01P7/04 , A23K20/111
CPC分类号： A01N47/28 , A23K20/111 , C07C275/64 , A01P7/04

74. 发明公开

EP2763531A1 NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1 审中-公开
标题翻译：的新分子FOR组蛋白脱乙酰6的相对于组蛋白脱乙酰1选择性抑制
公开(公告)号：EP2763531A1
公开(公告)日：2014-08-13
申请号：EP12838935.0
申请日：2012-10-03
申请人： The Trustees of Columbia University in the City of New York , Sloan Kettering Institute For Cancer Research
发明人： BRESLOW, Ronald , MARKS, Paul, A.
IPC分类号： A01N37/18
CPC分类号： C07C259/10 , C07C259/06 , C07C275/64 , C07C2602/10 , C07D209/08 , C07D209/18 , C07D209/24 , C07D209/42 , C07D215/06 , C07D215/40 , C07D235/06
摘要： This invention provides a compound having the structure: wherein R1 is H, halogen, —NR5R6, —NR5—C(═O)—R6, —NH—C(═O)—OR7, —OR7, —NO2, —CN, —SR7, —SO2R7, —CO2R7, CF3, —SOR7, —POR7, —C(═S)R7, —C(═O)—NR5R6, —CH2—C(═O)—NR5R6, —C(═NR5)R6, —P(═O)(OR5)(OR6), —P(OR5)(OR6), —C(═S)R7, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, aryl, heteroaryl, or heterocyclyl, wherein R5, R6, and R7 and are each, independently, H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; m is an integer from 0 to 2; R2 and R3 are each, independently, H, halogen, —NH2, —CX3, —C(═O)OR8, C(═O)R8, —C(═O)NR9R10, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, heteroalkyl, aryl, heteroaryl, or heterocyclyl; wherein X is Cl, Br, or F; R8, R9 and R10 are each, independently, H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Q is —Ar1—Z— or —Z—Ar1—Z—, wherein Ar1 is aryl or heteroaryl; and each occurrence of Z is independently present or absent, and when present is —O—, —S—, —CH2—, —C(O)——NH—, —NH—NH—, —NHC(═O)—, —C(═O)NH—, —NHC(═O)CH2NH—, —NHC(═O)CH2C(═O)—, —N(OH)—, —CH2CH2— or —NHC(═O)CH═CH—; and R4 is alkyl, —OR11 or —NH—OR11, wherein R11 is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, or heterocyclyl, and when Q is —Ar1—Z—, Z is absent, Ar1 is phenyl, R2 and R3 are H, n=1, and R4 is —NHOH, then R1 is other than carbazole, tetrahydro-&bgr;-carboline, tetrahydro-γ-carboline, —C(═O)—NR5R6 and —NR5—C(═O)—R6, wherein one of R5 or R6 is quinoline and the other of R5 or R6 is H; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有以下结构的化合物：其中R1是H，卤素，-NR 5 R 6，-NR 5 C（= O）-R 6，-NH-C（= O）-OR 7，-OR 7，-NO 2，-CN， -SR 7，-SO 2 R 7，-CO 2 R 7，CF 3，-SOR7，-POR7，-C（= S）R 7，-C（= O）-NR 5 R 6，-CH 2 -C（= O）-NR5R6，（-C═NR5 （）R 6，-P = O）（OR 5）（OR 6），P（OR 5）（OR 6）， - C（= S）R 7，C 1-5烷基，C 2-5烯基，C 2-5炔基，芳基，杂芳基，或杂环基，worin R5，R6，和R7和各自独立地为H，C 1-5烷基，C 2-5烯基，C 2-5炔基，杂烷基，环烷基，杂环，芳基或杂芳基; m是从0至2的整数; R2和R3是各自独立地为H，卤素，-NH 2，-CX 3，-C（= O）OR 8，C（= O）R8，-C（= O）NR 9 R 10，C 1-10烷基，C 2-10烯基，C 2-10炔基，杂烷基，芳基，杂芳基，或杂环基; 其中X是Cl，Br或F; R8，R9和R10各自独立地为H，C 1-5烷基，C 2-5烯基，C 2-5炔基，杂烷基，环烷基，杂环，芳基或杂芳基; Q是-Ar1-Z或-Z-AR1-Z，worin Ar 1是芳基或杂芳基; 和Z在每次出现时独立地为存在或不存在，并且当存在时是-O - ， - S - ， - CH 2 - ， - C（O） - NH - ， - NH-NH - ， - NHC（= O） - ，-C（= O）NH-，-NHC（= O）CH 2 NH-，-NHC（= O）CH 2 C（= O） - ， - N（OH） - ，-CH 2 CH 2或-NHC（= O）CH = CH-; 且R 4是烷基，-OR 11或-NH-OR11，R11 worin是H，C 1-10烷基，C 2-10烯基，C 2-10炔基，芳基，杂芳基，或杂环基，并且当Q是-Ar1-Z-， Z不存在; Ar 1为苯基，R 2和R 3是H，n = 1时，R4为-NHOH，那么R 1不是咔唑，四氢-β-咔啉，四氢γ咔啉，-C其他（= O） -NR5R6和-NR 5 C（= O）-R 6，worin R5或R6中的一个是喹啉和其它R5或R6是H; 或其药学上可接受的盐。

75. 发明公开

EP1778214A2 NOVEL BIPHENYL COMPOUNDS AND THEIR USE 审中-公开
标题翻译：新型联苯及其用途
公开(公告)号：EP1778214A2
公开(公告)日：2007-05-02
申请号：EP05807320.6
申请日：2005-07-27
申请人： SMITHKLINE BEECHAM CORPORATION , Cytokinetics, Inc.
发明人： CHAUDHARI, Amita, M. , DHANAK, Dashyant , KNIGHT, Steven, David , MORGANS, David, J., Jr. , PARRISH, Cynthia, A.
IPC分类号： A61K31/335 , A61K31/17 , A61K31/167 , C07C335/16 , C07C335/20 , C07C275/40 , C07C275/32 , C07C275/28 , C07C233/15 , C07D319/06
CPC分类号： C07C275/28 , C07C233/15 , C07C233/43 , C07C259/06 , C07C275/30 , C07C275/40 , C07C275/42 , C07C275/64 , C07C317/24 , C07C317/42 , C07C323/44 , C07C335/16 , C07D209/02 , C07D307/79 , C07D317/66 , C07D319/18
摘要： The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.

76. 发明公开

EP1535607A1 Increased moisturization efficacy using hydroxyalkylurea 有权转让
标题翻译：通过使用羟烷基增加Befeuchtungswirksamkeit
公开(公告)号：EP1535607A1
公开(公告)日：2005-06-01
申请号：EP04027723.8
申请日：2004-11-23
申请人： National Starch and Chemical Investment Holding Corporation
发明人： Landa, Peter A. , Cao, Hongjie , Martino, Gary T. , Morosov, Irina M. , Drovetskaya, Tatiana
IPC分类号： A61K7/48 , C07C275/10 , C08K5/21
CPC分类号： A61K8/046 , A61K8/365 , A61K8/42 , A61K8/732 , A61K2800/59 , A61Q5/06 , A61Q5/12 , A61Q19/00 , C07C273/1863 , C08K5/21 , C07C275/64
摘要： A personal care composition having at least one hydroxyalkylurea (HAU) optionally in combination with at least one other moisturizing agent. The at least one HAU, alone or together with the at least one moisturizing agent, provides not only the perception of moisturization, but also actual increased moisturization efficacy. When the two are used in combination in a personal care composition, they are provided in a synergistically moisturizing effective ratio to provide that perception of moisturization and increased moisturization efficacy. Such personal care compositions provide an enhanced smooth feel as well as enhanced flexibility, elasticity, suppleness and firmness without leaving a heavy or greasy feel.

77. 发明授权

EP0850217B1 PROCESS FOR THE PREPARATION OF ARYLALKYNYL-N-HYDROXYUREA DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY 失效转让
标题翻译：用于生产芳基炔基-N-羟基脲衍生物有效地作为脂氧合酶抑制剂
公开(公告)号：EP0850217B1
公开(公告)日：2000-04-05
申请号：EP96931435.0
申请日：1996-08-27
申请人： Abbott Laboratories
发明人： CHEMBURKAR, Sanjay, R. , PATEL, Hemantkumar H., Apartment 112 , SAWICK, David, P. , THOMAS, Albert, V.
IPC分类号： C07C273/18 , C07C275/64
CPC分类号： C07C43/29 , C07C43/295 , C07C273/1827 , C07C275/64
摘要： The present invention provides a process for the preparation of a compound of formula (I), wherein R is a straight or branched alkyl group of from one to twelve carbon atoms; M represents hydrogen or a pharmaceutically acceptable cation; and A is selected from optionally substituted carbocyclic phenyl.

78. 发明授权

EP0667855B1 SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 失效
标题翻译：取代芳和杂芳基炔-N-羟基脲衍生物作为抑制剂白三烯生物合成
公开(公告)号：EP0667855B1
公开(公告)日：1999-03-24
申请号：EP94902209.9
申请日：1993-11-05
申请人： ABBOTT LABORATORIES
发明人： BASHA, Anwer , BHATIA, Pramila , BROOKS, Dee, W. , CRAIG, Richard, A. , RATAJCZYK, James, D. , STEWART, Andrew, O.
IPC分类号： C07C275/20 , A61K31/17 , C07C275/64 , C07D307/52
CPC分类号： C07D405/06 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D409/06
摘要： The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.

79. 发明公开

EP0798285A2 3,4,4-Trifluoro-3-butenoic acid or its methyl ester 失效
标题翻译： 3,4,4-三氟-3-丁酸甲酯
公开(公告)号：EP0798285A2
公开(公告)日：1997-10-01
申请号：EP97107054.5
申请日：1992-02-27
申请人： MONSANTO COMPANY
发明人： Ruminsky, Peter, Gerrard
IPC分类号： C07C57/52 , C07C51/16 , C07C69/65
CPC分类号： C07D295/185 , A01N33/04 , A01N33/06 , A01N33/18 , A01N33/26 , A01N35/10 , A01N37/06 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/22 , A01N37/26 , A01N37/28 , A01N37/30 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/52 , A01N41/06 , A01N41/12 , A01N43/10 , A01N43/28 , A01N43/36 , A01N43/56 , A01N43/90 , A01N47/12 , A01N47/28 , A01N47/34 , A01N47/40 , A01N47/44 , C07C57/52 , C07C57/76 , C07C203/04 , C07C205/03 , C07C205/09 , C07C205/43 , C07C211/24 , C07C211/48 , C07C211/63 , C07C219/08 , C07C229/12 , C07C229/24 , C07C229/56 , C07C229/60 , C07C233/09 , C07C233/13 , C07C233/38 , C07C233/49 , C07C233/55 , C07C237/06 , C07C237/20 , C07C237/22 , C07C237/24 , C07C239/10 , C07C243/10 , C07C243/16 , C07C243/30 , C07C243/34 , C07C243/38 , C07C251/24 , C07C259/06 , C07C265/06 , C07C271/20 , C07C271/22 , C07C275/20 , C07C275/64 , C07C279/06 , C07C309/66 , C07C309/73 , C07C311/16 , C07C311/58 , C07C323/60 , C07C327/22 , C07C327/30 , C07C327/32 , C07C2601/02 , C07D207/16 , C07D231/20 , C07D317/24 , C07D333/38
摘要： Trifluorobutenoic acid, its methyl ester and a process of preparation thereof.
摘要翻译：三氟丁酸，其甲酯及其制备方法。

80. 发明授权

EP0625140B1 CYCLOPROPYL N-HYDROXYUREA AND N-HYDROXYACETAMIDES WHICH INHIBIT LIPOXYGENASE 失效
标题翻译：环丙基-N-羟基硫代氨基甲酸
公开(公告)号：EP0625140B1
公开(公告)日：1996-12-11
申请号：EP92922190.1
申请日：1992-10-27
申请人： PFIZER INC.
发明人： IKEDA, Takafumi , KAWAI, Akiyoshi , MANO, Takashi , OKUMURA, Yoshiyuki , STEVENS, Rodney W.
IPC分类号： C07C275/64 , A61K31/17 , C07C323/44 , C07C259/06 , C07D295/15 , A61K31/16 , A61K31/40
CPC分类号： C07D295/15 , C07C259/06 , C07C275/64 , C07C323/44 , C07C2601/02
摘要： Compounds of formula (I) wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or (II), R' is hydrogen or C2 to C8 alkylthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 to 5, with the proviso that when R' is hydrogen then Ar is styryl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：式（I）的化合物，其中A为C1至C3亚烷基，Ar为苯基或苯乙烯基，R为卤素取代的C1至C3烷基，NHR'或（II），R'为氢或C2至C8烷硫基烷基，n为 1至4，p为2至5的整数，条件是当R'为氢时，Ar为苯乙烯基，其药学上可接受的盐抑制酶脂氧合酶，可用于治疗过敏和炎症和心血管已经涉及脂氧合酶作用的条件。这些化合物在用于治疗这些病症的药物组合物中形成活性成分。

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