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71. 发明授权

EP2648846B1 APPARATUS AND METHOD USING ANTI-ADSORPTION AGENT TO FACILITATE SAMPLE MIXING AND ANALYSIS 有权
标题翻译：使用抗吸附剂促进样品混合和分析的装置和方法
公开(公告)号：EP2648846B1
公开(公告)日：2018-02-07
申请号：EP11806032.6
申请日：2011-12-08
申请人： Abbott Point Of Care, Inc.
发明人： LALPURIA, Niten V. , UNFRICHT, Darryn W. , NIKONOROV, Igor , PORTS, Benjamin , OLSON, Douglas R.
IPC分类号： B01L3/00 , B01F5/06 , B01F13/00 , G01N15/14
CPC分类号： B01L3/5027 , B01F11/0071 , B01F13/0059 , B01L3/502707 , B01L2200/14 , B01L2300/0816 , B01L2300/161 , B01L2300/165 , G01N15/1463 , G01N15/1484 , G01N21/0303 , G01N21/05 , G01N33/48 , G01N33/487 , Y10T436/2575
摘要： An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.

72. 发明授权

EP2502074B1 REDUCING LEUKOCYTE INTERFERENCE IN NON-COMPETITIVE IMMUNOASSAYS 有权
公开(公告)号：EP2502074B1
公开(公告)日：2017-08-23
申请号：EP10784381.5
申请日：2010-11-17
申请人： Abbott Point Of Care, Inc.
发明人： CAMPBELL, John Lewis Emerson , MOSS, Adam Roger , DAVIS, Graham
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , G01N33/54393 , Y10T436/25125

73. 发明公开

EP3198281A1 ELLAGIC ACID FORMULATIONS FOR USE IN COAGULATION ASSAYS 有权
标题翻译：用于混凝测试的ELELAGIC酸配方
公开(公告)号：EP3198281A1
公开(公告)日：2017-08-02
申请号：EP15782124.0
申请日：2015-09-25
申请人： Abbott Point Of Care, Inc.
发明人： COLLIER, G. Bruce , JOHNS, Paul Willis, Jr. , SUTRALA, Smitha RK , WANG, Dan , DI TULLIO, Katrina Petronilla
IPC分类号： G01N33/86 , B01L3/00
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502715 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N2333/974
摘要： The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.
摘要翻译：本发明涉及用于进行凝固测定的鞣花酸制剂，其对于长期储存高度稳定且减少测定时间。特别地，本发明的各方面涉及制备用于凝血测定的高度可溶形式的鞣花酸的组合物和方法。例如，鞣花酸可以溶解在氢氧化钠，甲醇，聚醚化合物，特别是聚乙二醇，聚环氧乙烷或聚氧乙烯，以及环糊精客体 - 主体复合物中的一种或多种中。

74. 发明公开

EP3198280A1 SENSORS FOR ASSAYING COAGULATION IN FLUID SAMPLES 有权
标题翻译：检测流体样品中混凝的传感器
公开(公告)号：EP3198280A1
公开(公告)日：2017-08-02
申请号：EP15778491.9
申请日：2015-09-25
申请人： Abbott Point Of Care, Inc.
发明人： ZHAO, Tian-Xian , WONG, Anjulia Chiu-Yuk , MARTIN, Glenn Brian , DI TULLIO, Katrina Petronilla , THIBODEAU, Isabelle Louisette , BREEZE, Steven Roy , SUTRALA, Smitha RK , HONG, Eric , BALL, Sheila Diane
IPC分类号： G01N33/86 , B01L3/00
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502715 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N2333/96463 , G01N2333/974
摘要： The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
摘要翻译：本发明涉及分析测试装置，其包括微环境传感器和用于测定施加到微环境传感器的流体样品中的凝结物的方法，并且具体地，使用一个或多个微环境传感器执行一种或多种类型的凝结测定在单点护理组合测试墨盒。例如，本发明可以涉及包括涂覆有聚合物层的至少一个换能器的测试传感器。聚合物层包含具有可检测部分的凝血酶可裂解肽。

75. 发明公开

EP3198270A1 CARTRIDGE DEVICE WITH FLUIDIC JUNCTIONS FOR COAGULATION ASSAYS IN FLUID SAMPLES 审中-公开
标题翻译：具有流体接头的流体装置用于流体样本中的混凝测定
公开(公告)号：EP3198270A1
公开(公告)日：2017-08-02
申请号：EP15777815.0
申请日：2015-09-25
申请人： Abbott Point Of Care, Inc.
发明人： DI TULLIO, Katrina Petronilla , TAYLOR, Jay Kendall , LEE-YOW, Niko Daniel , BALL, Sheila Diane , CAMPBELL, John Lewis Emerson
IPC分类号： G01N33/49
CPC分类号： G01N33/86 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0645 , B01L2300/0663 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0672 , B01L2400/0688 , B01L2400/0694 , G01N27/4166 , G01N33/4905 , G01N2333/974
摘要： The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.
摘要翻译：本发明涉及包含流体接头的分析测试装置和用于测定在流体接头内接收的流体样本中的凝结的方法。例如，本发明可以涉及一种样本分析盒，该样本分析盒包括入口室，第一导管，第一导管和第二导管，所述第一导管包括被配置为将生物样本分成至少第一段和第二段的第一接头，包含第一试剂的第二导管，传感器区域和第一流体锁定阀，以及包括第二试剂，第二传感器区域和第二流体锁定阀的第三导管。样本分析盒还包括泵，该泵构造成将第一区段推过第一传感器区域到达第一流体锁定阀，并且将第二区段推过第二传感器区域到达第二流体锁定阀。

76. 发明公开

EP3197602A1 MICROFABRICATED DEVICE WITH MICRO-ENVIRONMENT SENSORS FOR ASSAYING COAGULATION IN FLUID SAMPLES 有权
标题翻译：具有微环境传感器的微开发装置用于测定流体样品中的凝结
公开(公告)号：EP3197602A1
公开(公告)日：2017-08-02
申请号：EP15778152.7
申请日：2015-09-25
申请人： Abbott Point Of Care, Inc.
发明人： DI TULLIO, Katrina Petronilla , TAYLOR, Jay Kendall , ZHAO, Tian-Xian , WONG, Anjulia Chiu-Yuk , MARTIN, Glenn Brian , THIBODEAU, Isabelle Louisette , BREEZE, Steven Roy , SUTRALA, Smitha RK , HONG, Eric , BALL, Sheila Diane
IPC分类号： B01L3/00 , G01N33/49
CPC分类号： G01N33/86 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/04 , B01L2200/0684 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0663 , B01L2300/0672 , B01L2300/0809 , B01L2300/0816 , B01L2400/0481 , G01N27/403 , G01N27/4166 , G01N27/4167 , G01N33/4905 , G01N2333/96463
摘要： The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
摘要翻译：本发明涉及包括微环境传感器和用于测定施加到微环境传感器的流体样本中的凝血的方法的样本分析盒，并且具体地涉及使用微观环境传感器在护理点样本分析中执行凝血测定墨盒。例如，本发明可涉及样本分析盒，样本分析盒包括被配置为接收生物样本的入口腔室和流体连接到入口腔室并被配置为从入口腔室接收生物样本的导管。导管可以包括微环境凝血酶原时间（PT）传感器和微环境激活的部分凝血激酶时间（aPTT）传感器。

77. 发明授权

EP1901646B1 PHOTOFORMED SILICONE SENSOR MEMBRANE 有权
标题翻译：光由硅传感器REED
公开(公告)号：EP1901646B1
公开(公告)日：2017-04-05
申请号：EP06786926.3
申请日：2006-07-12
申请人： Abbott Point of Care Inc.
发明人： MCCANN, Margot, Leanne , SHAW, Sandra, Kay , UNDERWOOD, Karl John Anthony , RABE, Harvey, Eric
IPC分类号： A61B5/00 , A61B5/05 , C12Q1/00 , B01D71/70
CPC分类号： C12Q1/002

78. 发明授权

EP2274612B1 VIRTUAL SEPARATION OF BOUND AND FREE LABEL IN A LIGAND ASSAY FOR PERFORMING IMMUNOASSAYS OF BIOLOGICAL FLUIDS, INCLUDING WHOLE BLOOD 有权
标题翻译：结合和游离的商标在配体测试程序虚拟分离免疫测试程序与对生物液体的执行情况，包括全血
公开(公告)号：EP2274612B1
公开(公告)日：2016-10-26
申请号：EP09727858.4
申请日：2009-04-02
申请人： Abbott Point Of Care, Inc.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N33/543 , G01N21/64
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386

79. 发明授权

EP2269033B1 METHOD FOR MEASURING THE AREA OF A SAMPLE DISPOSED WITHIN AN ANALYSIS CHAMBER 有权
标题翻译： EERER ANALYSEKAMMER的VERFAHREN ZUR MESSUND DES BEREICHS EINER PROBE
公开(公告)号：EP2269033B1
公开(公告)日：2016-09-21
申请号：EP09731372.0
申请日：2009-04-09
申请人： Abbott Point Of Care, Inc.
发明人： LALPURIA, Niten, V. , WARDLAW, Stephen, C.
IPC分类号： G01N15/14 , G06T7/00 , G06T7/60
CPC分类号： G01N21/17 , G01N15/05 , G01N2015/055 , G06T7/0012 , G06T7/62 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , Y10T436/11

80. 发明公开

EP3026433A1 METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS 无效
标题翻译：方法和设备来检测和计数单血小板及血小板单位HEAP
公开(公告)号：EP3026433A1
公开(公告)日：2016-06-01
申请号：EP16150962.5
申请日：2009-03-20
申请人： Abbott Point Of Care, Inc.
发明人： WARDLAW, Stephen C. , LEVINE, Robert A. , LALPURIA, Niten V.
IPC分类号： G01N33/50 , G01N33/49 , G01N15/02 , G01N15/14 , G01N33/80 , G01N33/58
CPC分类号： G01N33/49 , G01N15/147 , G01N15/1475 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/0092 , G01N2015/1486
摘要： A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; 2) admixing a colorant with the sample, which colorant is operative to cause the platelets to fluoresce upon exposure to one or more predetermined first wavelengths of light; 3) illuminating at least a portion of the sample containing the platelets at the first wavelengths; 4) imaging the sample, including producing image signals indicative of fluorescent emissions from the platelets, which fluorescent emissions have an intensity; 5) identifying the platelets by their fluorescent emissions, using the image signals; 6) determining an average fluorescent emission intensity value for the individual platelets identified within the sample; 7) identifying clumps of platelets within the sample using one or more of their fluorescent emissions, area, shape, and granularity; and 8) enumerating platelets within each platelet clump using the average fluorescent emission intensity value determined for the individual platelets within the sample.
摘要翻译：提供了一种用于血液样本中的血小板枚举方法。该方法包括如下步骤：1）沉积该样品成分析室angepasst静止地保持用于分析的样品，由第一面板和第二面板，这两个面板是透明的限定的腔室; 2）将与样本，其中着色剂是可操作以使血小板在曝光时发出荧光以的光的一个或多个预定的第一波长的着色剂; 3）至少含照明在所述第一波长下的血小板的样本的至少一部分; 4）使样品成像，包括产生表示来自血小板，其中荧光发射强度必须荧光发射的图像信号; 5）确定由它们的荧光发射的血小板，使用图像信号; 6）对样品中所确定的个体的血小板的平均荧光发射强度值确定性开采; 7）确定使用一个或多个他们的荧光发射，面积，形状和粒度的样本内的血小板凝块; 和8）使用开采样品内的单个血小板的平均荧光发射强度值确定性列举每个血小板凝块内的血小板。

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