专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明公开

EP2321421A4 PROCESS FOR PREPARATION OF MYCOPHENOLIC ACID, ITS SALT AND ESTER DERIVATIVES 审中-公开
标题翻译：用于生产霉和他的盐及其酯衍生物
公开(公告)号：EP2321421A4
公开(公告)日：2013-01-09
申请号：EP09818884
申请日：2009-09-09
申请人： IPCA LAB LTD
发明人： KUMAR ASHOK , SINGH DHARMENDRA , LUTHARA UMESH , PATEL YOGESH MOHANDHAI
IPC分类号： C12P17/04 , B01D11/00 , C07D307/88
CPC分类号： C07D307/88 , C12P17/04

62. 发明公开

EP2114910A4 A NOVEL CRYSTALLINE MYCOPHENOLATE SODIUM POLYMORPH AND PROCESSES TO MANUFACTURE SAME 审中-公开
标题翻译：新的结晶麦考酚钠晶型和方法及其
公开(公告)号：EP2114910A4
公开(公告)日：2012-02-15
申请号：EP08706277
申请日：2008-01-23
申请人： APOTEX FERMENTATION INC
发明人： GLASS CHAD , KUBELA RUDOLF
IPC分类号： C07D307/88 , C03B7/04 , C03B7/06
CPC分类号： C07D307/88

63. 发明公开

EP2393818A2 TRIPTOLIDE C-RING DERIVATIVES AS ANTICANCER AGENTS AND IMMUNE MODULATORS 审中-公开
标题翻译：雷公藤甲素C-RING衍生物作为抗肿瘤药和免疫调节剂
公开(公告)号：EP2393818A2
公开(公告)日：2011-12-14
申请号：EP10739131.0
申请日：2010-02-04
申请人： Pharmagenesis, Inc.
发明人： MUSSER, John, H.
IPC分类号： C07D493/04 , C07D307/88 , A61P35/00 , A61K31/343
CPC分类号： C07D493/16 , C07D493/14 , C07D493/22
摘要： Disclosed are compounds based on C- and D-ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.

64. 发明公开

EP2220063A1 MYCOPHENOLIC ACID IMMUNOGENS AND ANTIBODIES 审中-公开
标题翻译：霉酚酸和抗体免疫原性
公开(公告)号：EP2220063A1
公开(公告)日：2010-08-25
申请号：EP08849445.5
申请日：2008-11-13
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： GHOSHAL, Mitali , HUI, Raymond , RASHID, Shaker
IPC分类号： C07D307/88 , G01N33/94 , C07K16/44
CPC分类号： C07D307/88
摘要： Described are immunogenic compounds useful for generation of antibodies which are highly specific for mycophenolic acid which do not react or have substantially no cross-reactivity with the glucuronide metabolites of mycophenolic acid, especially the acyl-glucuronide metabolite.

65. 发明公开

EP2123630A1 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative 有权
标题翻译： 2-氨基 - 二环[3.1.0]己烷-2,6-二羧酸酯衍生物
公开(公告)号：EP2123630A1
公开(公告)日：2009-11-25
申请号：EP09166100.9
申请日：2004-06-25
申请人： Taisho Pharmaceutical Co. Ltd.
发明人： Yasuhara, Akito , Sakagami, Kazunari , Ohta, Hiroshi , Nakazato, Atsuro
IPC分类号： C07C229/50 , C07C235/06 , C07C247/04 , C07C323/61 , A61K31/365 , A61K31/357 , C07D307/88 , C07D317/34 , A61P25/00 , A61K31/225 , A61K31/5375 , A61K31/00
CPC分类号： C07C229/50 , C07D307/88
摘要： A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administraiton
A 2-amino-bicyclo [3.1.0] hexane-2,6-dicarboxylic ester derivative represented by formula [I]

[wherein R 1 and R 2 are identical or different, and each represents a hydrogen atom, a C 1-10 alkyl group substituted by one or two aryl groups or other meanings as specified in the claims; X represents a fluorine atom; Y represents -OCHR 3 R 4 (wherein R 3 and R 4 are identical or different, and each represents a hydrogen atom or a phenyl group substituted by one to five halogen atoms, a pharmaceutically acceptable salt thereof or a hydrate thereof.
摘要翻译：一种有效治疗和预防精神障碍如精神分裂症，焦虑及其相关疾病，抑郁症，双相性精神障碍和癫痫的药物。该药物拮抗II类代谢型谷氨酸受体的作用，并在口服给药中显示出高活性，其由式[I]表示的2-氨基 - 二环[3.1.0]己烷-2,6-二羧酸酯衍生物[其中R1和R2为相同或不同，并且各自表示氢原子，被一个或两个芳基取代的C1-10烷基或权利要求中所述的其它含义; X代表氟原子; Y表示-OCHR 3 R 4（其中R 3和R 4相同或不同，且各自表示氢原子或被1至5个卤素原子取代的苯基），其药学上可接受的盐或其水合物。

66. 发明公开

EP2024506A1 METHOD FOR REDUCING IMPURITY LEVEL IN MYCOPHENOLIC ACID FERMENTATION 审中-公开
标题翻译：一种用于减少IN霉酚酸发酵污染程度
公开(公告)号：EP2024506A1
公开(公告)日：2009-02-18
申请号：EP08742796.9
申请日：2008-04-11
申请人： Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság
发明人： TOTH, Laszlo , ERDEI, Janos , SZIKSZAI, Boglarka , BALOGH, Gabor , GULYAS, Eva
IPC分类号： C12P17/04 , C07D307/88
CPC分类号： C12P17/04 , C07D307/88 , Y10T436/142222
摘要： The present invention relates to methods for reducing impurities of mycophenolic acid during fermentation by controlling the level of carbon source during fermentation of mycophenolic acid and for the isolation and use as a standard marker of the impurity homo-mycophenolic acid.

67. 发明公开

EP1679070A1 USE OF L-BUTYLPHTHALIDE IN THE MANUFACTURE OF MEDICAMENTS FOR PREVENTION AND TREATMENT OF CEREBRAL INFARCT 审中-公开
标题翻译： L-丁苯酞药品的脑梗塞的预防和治疗生产中使用
公开(公告)号：EP1679070A1
公开(公告)日：2006-07-12
申请号：EP04762256.8
申请日：2004-09-29
申请人： Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. , THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES
发明人： FENG, Yipu , WANG, Xiaoliang , YANG, Jinghua , PENG, Ying
IPC分类号： A61K31/343 , C07D307/88 , A61P9/10
CPC分类号： C07D307/88 , A61K31/343
摘要： The present invention discloses the use of L-butylphthalide of formula (I) in the manufacture of medicaments for the prevention and treatment of cerebral infarct, especially induced by focal cerebral ischemia.
摘要翻译：本发明光盘失去在药物用于预防和治疗的制造中使用的式（I）的L-丁基苯酞脑梗塞，爱尤其局灶性脑缺血诱导。

68. 发明公开

EP1667987A2 PROCESS FOR THE PRODUCTION OF MYCOPHENOLATE MOFETIL 有权
标题翻译：生产霉酚酸酯的方法MOFETIL
公开(公告)号：EP1667987A2
公开(公告)日：2006-06-14
申请号：EP04765061.9
申请日：2004-09-10
申请人： SANDOZ AG
发明人： GREIL, Julia , LUDESCHER, Johannes , WOLF, Siegfried
IPC分类号： C07D307/88
CPC分类号： C07D307/88
摘要： The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of mycophenolate mofetil by removing its by products, in particular its dimeric by-products, by means of treatment with a primary or secondary amine.
摘要翻译：本发明涉及一种以高度药学上可接受的纯度生产霉酚酸吗啉乙酯的新的且经济上有吸引力的方法，其包括霉酚酸的反应性衍生物与4-（2-羟乙基）吗啉在酸性反应条件下反应并随后通过盐形成和游离碱的释放来提取纯麦考酚酸吗乙酯。本发明的另一方面涉及通过用伯胺或仲胺处理除去其副产物，特别是其二聚副产物来纯化麦考酚酸吗啉乙酯。

69. 发明公开

EP1352904A4 (METH)ACRYLATE ESTERS, STARTING ALCOHOLS FOR THE PREPARATION THEREOF, PROCESSES FOR PREPARING BOTH, POLYMERS OF THE ESTERS, CHEMICALLY AMPLIFIABLE RESIST COMPOSITIONS, AND METHOD FOR FORMING PATTERNS 有权
标题翻译：（甲基）丙烯酸酯，醇的起始化合物的生产，用于生产这两种化合物酯的聚合物，化学扩增保护涂料组合物和方法形成模式的
公开(公告)号：EP1352904A4
公开(公告)日：2005-08-17
申请号：EP01999568
申请日：2001-12-05
申请人： MITSUBISHI RAYON CO
发明人： KAMON YOSHIHIRO , FUJIWARA TADAYUKI , KUWANO HIDEAKI , MOMOSE HIKARU , KOIZUMI ATSUSHI
IPC分类号： C07D307/88 , C07D307/93 , C07D493/18 , C08F220/18 , C08F220/28 , G03F7/039 , C07D307/04 , C07D307/33 , C07D307/77
CPC分类号： G03F7/0397 , C07D307/88 , C07D307/93 , C08F220/18 , C08F220/28
摘要： (Meth)acrylate esters represented by the general formula (1). These esters can be prepared by preparing a product of addition of a 1,3-diene with maleic anhydride by Diels-Alder reaction, reducing this product into a lactone, hydrating this lactone into an alcohol, and esterifying this alcohol with (meth)acrylic acid. The (co)polymers produced by (co)- polymerizing monomer compositions containing the (meth)- acrylate esters are excellent in transparency, dry-etching resistance, and solubility in organic solvents, and useful as resins for chemically amplifiable resist compositions. (1) (In the general formula (1), R?1, R2, R3, and R4¿ are each hydrogen, methyl, or ethyl; one of X?1 and X2¿ is (meth)acryloyloxy and the other is hydrogen; and both A?1 and A2¿ are hydrogen, or alternatively A?1 and A2¿ are united to form -O-, -CH¿2?-, or -CH2CH2-.)

70. 发明公开

EP1309571A1 NICHTSTEROIDALE ENTZÜNDUNGSHEMMER 审中-公开
标题翻译： NICHTSTEROIDALEENTZÜNDUNGSHEMMER
公开(公告)号：EP1309571A1
公开(公告)日：2003-05-14
申请号：EP01960536.9
申请日：2001-07-23
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： JAROCH, Stefan , LEHMANN, Manfred , SCHMEES, Norbert , BUCHMANN, Bernd , REHWINKEL, Hartmut , DROESCHER, Peter , SKUBALLA, Werner , KROLIKIEWICZ, Konrad , HENNEKES, Hartwig , SCHÄCKE, Heike , SCHOTTELIUS, Arndt
IPC分类号： C07D265/02 , C07D307/88 , C07D413/12 , A61K31/536 , A61K31/365 , A61P29/00
CPC分类号： C07D413/12 , A61K31/365 , A61K31/536 , C07D265/02 , C07D307/88
摘要： The invention relates to the use of compounds of the general formula (I) as non-steroidal inflammation inhibitors, to a method for the production of the same and to selected compounds.
摘要翻译：本发明涉及通式（I）的化合物作为非甾体类炎症抑制剂的用途，涉及其制备方法和选择的化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式