专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1474428A1 CRYSTALLINE HYDROCHLORIDE OF 7- [(5-AMINO-1,2,4-THIADIAZOL-3-YL)(FLUOROMETHOXYIMINO)ACETYL]AMINO -3-[(IMINO-1-PIPERAZINYLMETHYL)METHYLHYDRAZONO]-METHYL-3-CEPHEM-4-CARBOXYLIC ACID 审中-公开
标题翻译：酮（7-氨基-1,2,4-噻二唑-3-基）（氟代甲基咪唑）乙酰氨基-3-（IMINO-1-哌嗪基甲基）甲基]甲基] - 乙基]
公开(公告)号：EP1474428A1
公开(公告)日：2004-11-10
申请号：EP03704505.1
申请日：2003-01-31
申请人： SANDOZ AG
发明人： GREIL, Julia , WOLF, Siegfried , LUDESCHER, Johannes
IPC分类号： C07D501/38 , A61K31/545 , A61P31/04
CPC分类号： C07D501/00
摘要： A crystalline hydrochloride of the compound 7-{[5-amino-1,2,4-thiadiazol-3-yl-(fluoromethoxy-imino)acetyl]amino}-3-[(imino-1-piperazinylmethyly)methylhydrazano]-methyl-3-cephem-4carboxylic acid and the pharmaceutical use thereof.

2. 发明公开

EP1667987A2 PROCESS FOR THE PRODUCTION OF MYCOPHENOLATE MOFETIL 有权
标题翻译：生产霉酚酸酯的方法MOFETIL
公开(公告)号：EP1667987A2
公开(公告)日：2006-06-14
申请号：EP04765061.9
申请日：2004-09-10
申请人： SANDOZ AG
发明人： GREIL, Julia , LUDESCHER, Johannes , WOLF, Siegfried
IPC分类号： C07D307/88
CPC分类号： C07D307/88
摘要： The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of mycophenolate mofetil by removing its by products, in particular its dimeric by-products, by means of treatment with a primary or secondary amine.
摘要翻译：本发明涉及一种以高度药学上可接受的纯度生产霉酚酸吗啉乙酯的新的且经济上有吸引力的方法，其包括霉酚酸的反应性衍生物与4-（2-羟乙基）吗啉在酸性反应条件下反应并随后通过盐形成和游离碱的释放来提取纯麦考酚酸吗乙酯。本发明的另一方面涉及通过用伯胺或仲胺处理除去其副产物，特别是其二聚副产物来纯化麦考酚酸吗啉乙酯。

3. 发明授权

EP1554289B1 A CEFDINIR INTERMEDIATE 有权
标题翻译：中间头孢地尼
公开(公告)号：EP1554289B1
公开(公告)日：2011-03-09
申请号：EP03787771.9
申请日：2003-08-12
申请人： SANDOZ AG
发明人： KREMMINGER, Peter , WOLF, Siegfried , LUDESCHER, Johannes
IPC分类号： C07D501/00 , A61K31/546
CPC分类号： C07D501/00
摘要： 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula (I) in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.

4. 发明公开

EP1753759A2 NOVEL CO-PRECIPITATE OF AMORPHOUS ROSIGLITAZONE 审中-公开
标题翻译：非晶罗格列酮的新共沉淀物
公开(公告)号：EP1753759A2
公开(公告)日：2007-02-21
申请号：EP05716450.1
申请日：2005-03-30
申请人： SANDOZ AG
发明人： GREIL, Julia , WOLF, Siegfried , LUDESCHER, Johannes
IPC分类号： C07D417/12
CPC分类号： A61K9/1635 , A61K9/1623 , A61K9/1694 , C07D417/12
摘要： A novel coprecipitate of amorphous rosiglitazone maleate with a pharmaceutically acceptable carrier, e.g. polyvinylpyrolidone, mannitol, lactose, methylcellulose, cyclodextrin or silicon dioxide, a process for the preparation of said novel coprecipitate and the use of said novel coprecipitate of amorphous rosiglitazone with a pharmaceutically acceptable carrier in the treatment and / or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof, are disclosed. A novel solid solution of rosiglitazone maleate with a pharmaceutically acceptable carrier, preferably with polyethyelene glycol PEG from 4000 to 40.000 of average mol. wt., a process for the preparation thereof and use are disclosed. A novel coprecipitate of amorphous rosiglitazone maleate with a pharmaceutically acceptable carrier and a novel solid solution of rosiglitazone maleate with a pharmaceutically acceptable inert carrier are stable and may be particularly suitable for bulk preparation, handling and formulation advantages.

5. 发明授权

EP1278754B1 CEPHALOSPORIN INTERMEDIATES 有权
标题翻译：头孢菌素中间体
公开(公告)号：EP1278754B1
公开(公告)日：2005-01-26
申请号：EP01933896.1
申请日：2001-04-26
申请人： SANDOZ AG
发明人： KREMMINGER, Peter , LUDESCHER, Johannes , WOLF, Siegfried
IPC分类号： C07D501/04 , C07D277/46 , C07D501/36
CPC分类号： C07D501/00 , C07D277/46
摘要： A process and intermediates in the production of cefotiam (hexetil).

6. 发明公开

EP1735291A2 ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS 审中-公开
标题翻译：罗格列酮磷酸盐和多晶型
公开(公告)号：EP1735291A2
公开(公告)日：2006-12-27
申请号：EP05707330.6
申请日：2005-02-11
申请人： SANDOZ AG
发明人： GREIL, Julia , LUDESCHER, Johannes , WOLF, Siegfried
IPC分类号： C07D277/00
CPC分类号： C07D417/12
摘要： The present invention relates to 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione phosphate, a novel salt of rosiglitazone and to novel polymorphic forms thereof. The invention is also directed to processes for preparation of rosiglitazone phosphate and its polymorphs. The compounds of the invention are useful for treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
摘要翻译：本发明涉及5 - [[4- [2-（甲基-2-吡啶基氨基）乙氧基]苯基]甲基] -2,4-噻唑烷二酮磷酸盐，罗格列酮的新盐及其新的多晶形式。本发明还涉及制备罗格列酮磷酸酯及其多晶型物的方法。本发明化合物可用于治疗和/或预防糖尿病，与糖尿病有关的病症及其某些并发症。

7. 发明授权

EP1173444B1 CRYSTALLINE BETA-LACTAM INTERMEDIATE 有权
标题翻译： CRYSTALβ-内酰胺中间体
公开(公告)号：EP1173444B1
公开(公告)日：2006-03-22
申请号：EP00943708.8
申请日：2000-05-03
申请人： SANDOZ AG
发明人： GREIL, Julia , LUDESCHER, Johannes , TOTSCHNIG, Klaus , WOLF, Siegfried
IPC分类号： C07D501/04 , C07D501/12 , C07D501/34
CPC分类号： C07D501/00
摘要： The novel intermediate compound crystalline 7-[2-(2-fomylaminothiazol-4-yl)-2 -(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1 -(isopropoxy/crystallization of cefpodoxime proxetil. The crystallization process comprises dissolving or suspending the intermediate in the presence of a nitrile or a ketone or mixtures thereof; at a ratio of 1 gm of the intermediate to 2-15 ml nitrile; or at a ratio of 1 gm of the intermediate to 3-15 ml ketone; in the presence of 5-80 ml water; and thereafter isolating the intermediate in crystalline form and converting the intermediate by splitting off the formyl group from the amino group attached to the thiazolyl group, to obtain the desired product cefpodoxime proxetil, in the form of a diastereoisomeric mixture in a ratio of B/(A+B) of 0.5 to 0.6.

8. 发明授权

EP1045852B1 PROCESS FOR THE PREPARATION OF CEFPODOXIM PROXETIL DIASTEREOISOMERS 有权
标题翻译：用于生产头孢泊肟酯对映异构体
公开(公告)号：EP1045852B1
公开(公告)日：2005-10-26
申请号：EP99906108.8
申请日：1999-01-07
申请人： SANDOZ AG
发明人： GREIL, Julia , LUDESCHER, Johannes , TOTSCHNIG, Klaus , WOLF, Siegfried
IPC分类号： C07D501/34
CPC分类号： C07D501/00

9. 发明授权

EP1618114B1 PROCESSES FOR THE PREPARATIONS OF CEFEPIME 有权
标题翻译：用于生产头孢吡肟
公开(公告)号：EP1618114B1
公开(公告)日：2010-07-14
申请号：EP04727526.8
申请日：2004-04-15
申请人： SANDOZ AG
发明人： LUDESCHER, Johannes , STURM, Hubert , WOLF, Siegfried
IPC分类号： C07D501/06 , C07D501/44
CPC分类号： C07D513/04

10. 发明授权

EP1667987B1 PROCESS FOR THE PRODUCTION OF MYCOPHENOLATE MOFETIL 有权
标题翻译： PROCESS FOR霉酚酸酯PRODUCING
公开(公告)号：EP1667987B1
公开(公告)日：2008-07-23
申请号：EP04765061.9
申请日：2004-09-10
申请人： SANDOZ AG
发明人： GREIL, Julia , LUDESCHER, Johannes , WOLF, Siegfried
IPC分类号： C07D307/88
CPC分类号： C07D307/88
摘要： The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of mycophenolate mofetil by removing its by products, in particular its dimeric by-products, by means of treatment with a primary or secondary amine.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式