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61. 发明公开

EP1004013A4 AUTOMATED BIOLOGICAL REACTION SYSTEM 有权
标题翻译： AUTOMATED生物反应系统
公开(公告)号：EP1004013A4
公开(公告)日：2006-02-01
申请号：EP98939901
申请日：1998-08-11
申请人： VENTANA MED SYST INC
发明人： DRUYOR-SANCHEZ BOBBI , FORD ANTHONY , HEILMAN BRONWEN , MCDANIEL DARIN , MCGRAW BRIAN J , MEAD STEPHEN , RICHARDS WILLIAM L , SHOWALTER WAYNE A , RIZZO VINCENT R
IPC分类号： G01N1/00 , A47K5/12 , B67D7/06 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/10 , G01N1/14 , B67D5/06
CPC分类号： G01N35/1016 , G01N1/312 , G01N35/00871 , G01N35/1002 , G01N2001/317 , G01N2035/00881 , G01N2035/1034 , Y10T137/7873 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, the dispense chamber (412) is substantially in line with the reservoir chamber (408), the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

62. 发明公开

EP1600759A2 Random access slide stainer with independent slide heating regulation 审中-公开
标题翻译： Objektträgerfärbevorrichtungmit wahlfreiem Zugriff undunabhängigerObjektträgerheizungsregelung。
公开(公告)号：EP1600759A2
公开(公告)日：2005-11-30
申请号：EP05076534.6
申请日：1999-02-25
申请人： Cytologix Corporation
发明人： Bogen, Steven A. , Loeffler, Herbert H. , Purbrick, John A.
IPC分类号： G01N1/31 , B01L7/00
CPC分类号： B01L7/52 , B01L3/0293 , B01L9/52 , B01L2200/147 , B01L2300/0822 , B01L2300/1827 , B01L2400/049 , G01N1/312 , G01N35/0092 , G01N35/025 , G01N2001/317 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00366 , G01N2035/0093 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： A microscope slide stainer, comprising:

a staining protocol program comprising instructions for applying reagents and heat to a plurality of microscope slides bearing biological tissues;
a plurality of slide supports, each support being comprised of a heating element and having a surface on which at least one microscope slide rests so as to transfer heat to the at least one microscope slide;
at least one reagent dispenser that can dispense a liquid reagent onto a microscope slide;
a movable carriage that causes the reagent dispenser to be aligned over a desired microscope slide, as specified in the staining protocol program, so that reagent dispensed out of the reagent dispenser drops onto an underlying microscope slide; and
a control system that issues commands to cause relative motion of the reagent dispenser and microscope slide with respect to each other so that the reagent dispenser is aligned over a desired microscope slide, as specified in the staining protocol program, and that issues commands to cause the heating elements to heat at the times specified in the staining protocol program, the control system being capable of heating one heating element to a different temperature than another.
摘要翻译：一种显微镜载玻片染色机，包括：染色方案程序，包括将试剂和热量施加到具有生物组织的多个显微镜载玻片上的说明书; 多个滑动支撑件，每个支撑件由加热元件组成并且具有至少一个显微镜载玻片搁置在其上的表面，以将热传递到所述至少一个显微镜载玻片; 至少一个能够将液体试剂分配到显微镜载玻片上的试剂分配器; 如在染色方案程序中所规定的，使得试剂分配器在期望的显微镜载玻片上对准的可移动滑架，使得从试剂分配器中分出的试剂滴到下面的显微镜载玻片上; 以及控制系统，其发出命令以使试剂分配器和显微镜相对于彼此相对运动，使得试剂分配器在染色方案程序中指定的期望的显微镜载玻片上对准，并且发出命令导致所述加热元件在染色协议程序中指定的时间加热，所述控制系统能够将一个加热元件加热到与另一个不同的温度。

63. 发明公开

EP1573298A1 AN AUTOMATED SAMPLE PROCESSING APPARATUS AND A METHOD OF AUTOMATED TREATING OF SAMPLES AND USE OF SUCH APPARATUS 有权
标题翻译：自动样品加工装置，样品的这种装置的处理和利用自动的方法
公开(公告)号：EP1573298A1
公开(公告)日：2005-09-14
申请号：EP03779764.4
申请日：2003-12-19
申请人： DakoCytomation Denmark A/S
发明人： LATHROP, Robert , KEY, Marc , FAVUZZI, John
IPC分类号： G01N1/31 , G01N35/10
CPC分类号： G01N1/312 , G01N35/00029 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N35/10 , G01N35/1002 , G01N2001/317 , G01N2035/00138 , G01N2035/00326 , G01N2035/00534 , G01N2035/00881
摘要： An automated staining apparatus (1) and a method for treating samples arranged on carrier means (7) is disclosed, in which portions of two or more selected reagents from a first station (2) containing the reagents are collected individually by means of a robot arm (20) handling a probe (10) and dispensed in a mixing station (9) of the apparatus. After mixing the reagents in the mixing station (9) , e.g. by shaking or rotating the mixing cup containing the reagents, the reagent mixture is applied to selected samples by means of the robot arm (20) and a probe.(10) .By providing a staining apparatus having an automated mixer integrated therein, staining or treatment processes requiring a mixture of unmixable reagents, such as a water based and an oil based reagent, or insoluble reagents, can be performed automatically instead of requiring human interaction or manual performance of some process steps in a much more automated process, and the quality of the staining process may be improved as a desired degree of mixing of reagents may be provided or an optimal application time window for a deteriorating mixture may be reached.

64. 发明公开

EP1446649A1 METHOD AND APPARATUS FOR AUTOMATIC TISSUE STAINING 有权
标题翻译：方法和设备的组织样本自动染色
公开(公告)号：EP1446649A1
公开(公告)日：2004-08-18
申请号：EP02789592.9
申请日：2002-11-12
申请人： Lab Vision Corporation
发明人： RHETT, Norman, K. , TSEUNG, Ken, K. , CORL, Mark, V. , WONG, Wai, Bun , LE, Ngoc, Van , TAKAYAMA, Glenn, K.
IPC分类号： G01N1/31
CPC分类号： G01N35/00584 , G01N1/312 , G01N35/00663 , G01N2001/317 , G01N2035/0091
摘要： To simplify the process of preparing microscope slides, an advanced automatic staining apparatus (100) is disclosed. The disclosed automatic staining apparatus (100) comprises an electromechanical automatic staining device that is coupled to a personal computer system (190) using an interface card (180). An autostainer control program (170) runs on the personal computer system (190). The autostainer control program (170) allows a user to simply program the automatic staining apparatus (100) using simple commands entered in the graphical user interface. The autostainer control program (170) includes several features that simplify the programming such as safeguards that ensure compatible reagents are being used; automatic buffer solution requirement calculator; and the ability to determine optimal staining procedure. The electromechanical automatic staining device includes features such as dual waste bins for hazardous and nonhazardous waste storage, an automatic dispenser cleansing system; and unique slide clip that minimizes capillary effect.

65. 发明公开

EP1398613A2 Random access slide stainer with liquid waste segregation 有权
标题翻译：随机访问幻灯片染色剂与液体废物分离
公开(公告)号：EP1398613A2
公开(公告)日：2004-03-17
申请号：EP03078714.7
申请日：1999-02-25
申请人： Cytologix Corporation
发明人： Bogen, Steven A. , Loeffler, Herbert H.
IPC分类号： G01N1/31
CPC分类号： G01N1/312 , G01N2001/317
摘要： A liquid aspiration system for removing liquids from a microscope slide comprising:

a microscope slide from which liquid is to be aspirated;
a source of vacuum and
a hollow chamber with an attachment to a source of vacuum;
char acterized by:

a flat surface on the exterior of said hollow chamber having at least one hole communicating between the exterior and interior of said hollow chamber;
an actuator which causes said flat surface to contact liquid on the microscope slide.
摘要翻译：一种用于从显微镜载玻片上除去液体的液体抽吸系统，包括：显微镜载玻片，液体将从该显微镜载玻片上被抽吸; 真空源和带有与真空源连接的中空腔室; 其特征在于：所述中空腔室外部的平坦表面具有至少一个在所述中空腔室的外部和内部之间连通的孔; 致动器，其致使所述平坦表面接触显微镜载玻片上的液体。

66. 发明授权

EP1058826B1 RANDOM ACCESS SLIDE STAINER WITH LIQUID WASTE SEGREGATION 有权
标题翻译：染色与“随机访问”和液体废物的分离显微镜幻灯片
公开(公告)号：EP1058826B1
公开(公告)日：2004-01-02
申请号：EP99908460.1
申请日：1999-02-25
申请人： Cytologix Corporation
发明人： BOGEN, Steven, A. , LOEFFLER, Herbert, H.
IPC分类号： G01N1/31
CPC分类号： G01N1/312 , G01N2001/317
摘要： An automated slide stainer with slides mounted in a horizontal position on a rotary carousel. Reagents and rinse liquids are automatically dispensed onto tissue sections or cells mounted on slides for the purpose of performing chemical or immunohistochemical stains. The rinse liquids are removed by an aspiration head (31) connected to a source of vacuum. The aspiration head (31) is a hollow chamber (40) with a flattened bottom aspect. Eight holes (41) in the bottom of the aspiration head provide for fluid communication between the exterior and interior of the aspiration head. To aspirate liquid off of a slide, the aspiration head is lowered so that the bottom aspect contacts the liquid. The liquid is sucked into the hollow interior (40) of the aspiration head and collected into a liquid waste collection bottle. Several different liquid waste collection bottles (59) are placed in parallel, between the source of vacuum and the aspiration head. A solenoid valve (80) is positioned in line with each liquid waste collection bottle. Depending upon which solenoid valve is opened, the operator can direct the liquid waste to be collected into a specified liquid waste collection bottle.

67. 发明授权

EP0768519B1 Container for staining of cells and tissues in combination with a roller and a support 失效
标题翻译：容器用于染色的细胞和组织在用辊和保持器连接
公开(公告)号：EP0768519B1
公开(公告)日：2003-09-03
申请号：EP96307500.7
申请日：1996-10-15
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： Belly, Robert Troconis , Chemelli, John Benjamin , Steinmann, Michele McWilliams
IPC分类号： G01N1/31 , B01L3/02 , B01L3/00
CPC分类号： B01L3/505 , B01L3/0241 , B01L2300/0867 , B01L2400/0481 , G01N1/31 , G01N35/1002 , G01N2001/317 , Y10S435/81

68. 发明公开

EP1333287A2 Method and apparatus for modifying pressure within a fluid dispenser 有权
标题翻译： Verfahren und Vorrichtung zurDruckänderungin einemFlüssigkeitspender
公开(公告)号：EP1333287A2
公开(公告)日：2003-08-06
申请号：EP03000532.6
申请日：2003-01-09
申请人： VENTANA MEDICAL SYSTEMS, INC.
发明人： Lemme, Charles , Rizzo, Vincent R. Jr.
IPC分类号： G01N35/10 , G01N35/00
CPC分类号： G01N35/1016 , G01N1/312 , G01N35/1002 , G01N2001/317 , G01N2035/1034
摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber (412) is substantially in line with the reservoir chamber (410), the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.
摘要翻译：提供了一种用于自动生物反应系统的方法和装置。在生物反应系统的处理中，需要将一定量的流体放置在载玻片上。为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。除此之外，为了实现这一点，分配室（412）基本上与储存室（410）一致，储存室活塞被移除，并且通过分配器的流体流动被简化。此外，为了更可靠地操作自动化生物反应系统，该系统被设计为具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

69. 发明公开

EP1174702A1 Automatic equipment for processing microscope slides for colouring biological specimens 审中-公开
标题翻译：为显微镜的自动处理装置滑动进行染色的生物样品
公开(公告)号：EP1174702A1
公开(公告)日：2002-01-23
申请号：EP00830515.3
申请日：2000-07-20
申请人： Medic SRL
发明人： Giodice, Antonio
IPC分类号： G01N1/31
CPC分类号： G01N1/312 , G01N2001/317 , G01N2035/00039
摘要： An automatic equipment allows processing microscope slides for staining biological specimens with IFA, IF, immunoperoxidase, immunoistological staining and other techniques entailing procedures of reagent dispensing and microscope slide washing to allow immunological and other reactions. Said equipment comprises a washing and staining group (5) that may comprise either a collecting tray (20) for the residual liquids, a slide holding tray (21) and a sealing tray (22) or, in the alternative, a tray acting as both collecting tray for the residual liquids and slide holding tray and a sealing tray (22). The sealing tray is made to co-operate, under the control of a control unit of the equipment, with an upper face of the slide holding tray (21) in order to define on said face a plurality of reagent application areas and make them liquid-tight with respect to the adjacent areas.
摘要翻译：一种自动设备允许处理显微镜载玻片染色生物标本与IFA，IF，免疫过氧化物酶，immunoistological染色和其他技术将会导致试剂分注和显微镜载玻片洗涤的程序，以允许免疫学和其他反应。所述设备包括洗涤和染色组（5）也可用于将残余的液体包括要么一个收集盘（20），滑动保持托盘（21）和密封盘（22）或，可替代的，一个托盘用作两个收集盘用于将残余液体和滑动保持托盘和密封盘（22）。该密封盘被制成配合，该设备的控制单元的控制下，具有在滑动保持托盘（21）的上表面上，以限定在所述面对试剂的应用领域的多元化和使它们液体相对于邻近地区-tight。

70. 发明公开

EP0974827A2 Sample preparation apparatus including spray apparatus 审中-公开
标题翻译：装置制备样品，包括喷雾器的
公开(公告)号：EP0974827A2
公开(公告)日：2000-01-26
申请号：EP99305438.6
申请日：1999-07-07
申请人： SAPPORO BREWERIES LTD. , Nihon Millipore Kabushiki Kaisha
发明人： Takahashi, Toshihiro, c/o Sapporo Breweries Ltd. , Monji, Yoshio
IPC分类号： G01N1/30
CPC分类号： G01N1/312 , G01N2001/317
摘要： A sample preparation apparatus for preparing a sample to be used for detecting specimens such as microorganisms isolated on a filter so as to enumerate microorganisms in the sample has a turntable on which multiple sample bases are formed, a filter insertion unit, an extractant spray apparatus, a luminescent reagent spray apparatus and a filter removal unit, disposed in order along a periphery of the turntable in a direction of rotation of the turntable. By eliminating the need to move filters between processing operations as well as any special skill required in the spraying of the extractant and reagent, the sample preparation apparatus can provide accurate microorganism counts quickly and efficiently.

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