专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明公开

EP3197473A1 PROTEINS INCREASING PANCREATIC BETA CELL NUMBER AND METHODS OF USE 有权
标题翻译：蛋白增加胰腺β细胞数量和使用方法
公开(公告)号：EP3197473A1
公开(公告)日：2017-08-02
申请号：EP15775552.1
申请日：2015-09-23
申请人： University Of Oregon
发明人： HAMPTON, Jennifer , GUILLEMIN, Karen
IPC分类号： A61K38/00 , C07K14/195 , C12N5/071
CPC分类号： C12N5/0676 , A61K35/39 , A61K38/00 , A61K38/02 , C07K14/195 , C07K14/26 , C07K14/315 , C07K14/474 , C07K2319/00 , C12N2506/22 , G01N33/5088 , Y02A50/473
摘要： Disclosed herein are bacterial proteins that increase pancreatic beta (β) cell number and/or proliferation, methods of increasing β cell number and/or proliferation using such proteins, and methods of treating or inhibiting diabetes in a subject by administering such proteins to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as any one of SEQ ID NOs: 1-7, or fragments thereof. Recombinant vectors including a nucleic acid encoding the protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to any one of SEQ ID NOs: 1-7 or fragments thereof) operably linked to a heterologous promoter are also disclosed. Also disclosed are methods of identifying compounds that increase β cell number and/or proliferation by determining the effect of test compounds on β cell number or proliferation in zebrafish pancreas.
摘要翻译：本文公开了增加胰腺β（β）细胞数量和/或增殖的细菌蛋白质，使用这些蛋白质增加β细胞数量和/或增殖的方法，以及通过将所述蛋白质施用于受试者来治疗或抑制受试者中的糖尿病的方法。在一些实施方案中，蛋白质与SEQ ID NO：1-7中任一项所示的氨基酸序列或其片段具有至少80％的序列同一性。还公开了包含编码与异源启动子有效连接的蛋白质的核酸（例如编码与SEQ ID NO：1-7中任一个具有至少80％序列同一性的蛋白质或其片段的核酸）的重组载体。还公开了通过确定测试化合物对斑马鱼胰腺中β细胞数量或增殖的影响来鉴定增加β细胞数量和/或增殖的化合物的方法。

62. 发明公开

EP3193918A1 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS 审中-公开
标题翻译：广谱联合疫苗预防肺炎克雷伯菌和肺炎假单胞菌感染
公开(公告)号：EP3193918A1
公开(公告)日：2017-07-26
申请号：EP15841265.0
申请日：2015-09-18
申请人： University of Maryland, Baltimore
发明人： SIMON, Raphael , CROSS, Alan , TENNANT, Sharon
IPC分类号： A61K39/00 , A61K39/104 , A61K39/108 , C12N1/20 , C12N1/21 , C12R1/22 , C12R1/42
CPC分类号： C07K14/26 , A61K39/0266 , A61K39/104 , A61K39/116 , A61K47/4833 , A61K47/61 , A61K47/646 , A61K2039/70 , C07K14/21 , C07K2319/00
摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and O12. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.
摘要翻译：本发明涉及缀合物和疫苗组合物，其包含与一种或多种克雷伯氏菌表面多糖抗原（例如来自血清型O1，O2a，O2a，c，O3，O4的肺炎克雷伯菌O多糖）连接的假单胞菌鞭毛蛋白或其抗原片段或衍生物 O5，O7，O8和012.本发明还提供了制备缀合物和疫苗组合物的血清变型试剂菌株以及用缀合物和疫苗组合物诱导免疫应答的方法。

63. 发明公开

EP2721153A2 SYNTHETIC GENE CLUSTERS 有权
标题翻译： SYNTHETICHE GENERUSTER
公开(公告)号：EP2721153A2
公开(公告)日：2014-04-23
申请号：EP12800054.4
申请日：2012-06-14
申请人： The Regents of the University of California
发明人： MIRSKY, Ethan , TEMME, Karsten , VOIGT, Chris , ZHAO, Dehua
IPC分类号： C12N15/09 , C12N15/31 , C12N15/63
CPC分类号： C12N15/635 , C07K14/255 , C07K14/26 , C12N9/0095 , C12N15/52 , C12N15/63 , C12N15/67 , C12N15/74 , C12Y118/06001 , G16B25/00 , G16B30/00
摘要： Methods for making synthetic gene clusters are described.
摘要翻译：描述了制备合成基因簇的方法。

64. 发明公开

EP2336150A3 Replikin peptides and uses thereof 审中-公开
标题翻译： Replikin肽及其用途
公开(公告)号：EP2336150A3
公开(公告)日：2011-09-21
申请号：EP10012946.9
申请日：2002-03-26
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
摘要翻译：公开了流感病毒血凝素蛋白和恶性疟原虫疟疾抗原的肽，肽特异性抗体，流感疫苗，疟疾疫苗和刺激受试者免疫应答以产生针对流感病毒或疟疾的抗体的方法。还公开了用于配制流感病毒疫苗的方法。炭疽芽孢杆菌炭疽毒素的分离肽致死因子蛋白pX01-107，肽特异性抗体和刺激受试者产生抗炭疽杆菌炭疽炭疽毒素致死因子蛋白pX01-107的免疫应答的方法。还公开了小痘病毒表面抗原S前体蛋白的分离肽，对肽特异的抗体和刺激受试者产生抗小痘病毒表面抗原S前体蛋白抗体的免疫应答的方法。

65. 发明公开

EP2360177A1 Klebsiella antigens 审中-公开
标题翻译：克雷伯菌，反基因
公开(公告)号：EP2360177A1
公开(公告)日：2011-08-24
申请号：EP10010874.5
申请日：2008-04-29
申请人： Intercell AG
发明人： Bakshi, Sharmila , Cipps, Thomas , Hanner, Markus , Pikalo, Jutta , Satke, Christina , Nagy, Eszter , Lundberg, Urban , Wakefield, Dagmar , Meinke, Andreas , Noiges, Birgit , Stierschneider, Ulrike , von Gabain, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自克雷伯杆菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断感染的方法以及用于治疗或预防感染的方法。更具体地，这样的抗原由导致院内感染或由肺炎克雷伯杆菌引起的细菌感染的细菌病原体产生或与之相关。

66. 发明公开

EP2339034A1 Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
标题翻译：物种特异性的，性别特异性通用DNA探针和扩增引物的快速检测和的常规细菌和抗真菌病原体和从临床样品相关的抗生素抗性基因在微生物实验室诊断标识
公开(公告)号：EP2339034A1
公开(公告)日：2011-06-29
申请号：EP10181608.0
申请日：1997-11-04
申请人： Geneohm Sciences Canada, Inc.
发明人： Bergeron, Michel G. , Picard, Francois , Ouellette, Marc , Roy, Paul H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12Q1/6895 , C12Q2600/156
摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB , aacC1, aacC2 , aacC3 , aacA4, aac6'-IIa , ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6')-aph(2"), aad(6') , vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.
摘要翻译：基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIA，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA，AAC（6“） - APH（2“），AAD（6' ），大桶，VGA，MSRA，SUL和所以INT被光盘游离缺失。上述的微生物物种，属和抗性基因弧所有临床相关并在各种临床标本的通常遇到的，这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。这些新的诊断工具应该是提高速度和微生物感染，从而允许更有效的治疗的诊断的准确性是有用的。对于（i）所述通用检测和细菌的定量，和/或（ii）检测，鉴定和定量的诊断试剂盒上述BAC的 TERIAL和真菌种类和/或属，和/或（iii）检测，鉴定和上述抗生素抗性基因的定量弧这样声称。

67. 发明公开

EP2338902A1 Klebsiella antigens 审中-公开
标题翻译：克雷伯菌属抗原
公开(公告)号：EP2338902A1
公开(公告)日：2011-06-29
申请号：EP10010873.7
申请日：2008-04-29
申请人： Intercell AG
发明人： Bakshi, Sharmila , Cipps, Thomas , Hanner, Markus , Pikalo, Jutta , Satke, Christina , Nagy, Eszter , Lundberg, Urban , Wakefield, Dagmar , Meinke, Andreas , Noiges, Birgit , Stierschneider, Ulrike , von Gabain, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含此类核酸分子的载体和包含此类载体的宿主细胞。此外，本发明提供了来自克雷伯氏菌属物种的抗原及其片段和变体，生产这种抗原的方法，以及生产表达这种抗原的细胞的方法。此外，本发明提供了与这样的抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，这种核酸分子，抗原，载体或抗体用于制备药物组合物的方法，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断感染的方法和用于治疗或预防感染的方法。更具体地说，此类抗原由细菌病原体产生或与细菌病原体相关，所述细菌病原体引起由肺炎克雷伯氏菌引起的院内感染或细菌感染。

68. 发明公开

EP2330116A1 Replikin peptides and uses thereof 审中-公开
标题翻译：的Replikin肽及其用途
公开(公告)号：EP2330116A1
公开(公告)日：2011-06-08
申请号：EP10012953.5
申请日：2002-03-26
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

69. 发明公开

EP2325196A1 Replikin peptides and uses thereof 审中-公开
公开(公告)号：EP2325196A1
公开(公告)日：2011-05-25
申请号：EP10012951.9
申请日：2002-03-26
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

70. 发明授权

EP0943009B1 SPECIES-SPECIFIC, GENUS-SPECIFIC AND UNIVERSAL DNA PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL AND FUNGAL PATHOGENS AND ASSOCIATED ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR DIAGNOSIS IN MICROBIOLOGY LABORATORIES 失效
标题翻译：物种特异性的，属特异性和通用DNA探针和扩增引物的快速检测和病原性细菌和真菌和从临床样品中微生物实验室诊断相关的抗生素抗性基因的鉴定。
公开(公告)号：EP0943009B1
公开(公告)日：2009-06-24
申请号：EP97911094.7
申请日：1997-11-04
申请人： GENEOHM SCIENCES CANADA INC.
发明人： BERGERON, Michel, G. , PICARD, François, J. , OUELLETTE, Marc , ROY, Paul, H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12Q1/6895 , C12Q2600/156
摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of blatem, blarob, blashv, blaoxa, blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6'-IIa, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6'-aph(2''), aad(6'), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes are all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes are also claimed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式