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1. 发明公开

EP2336357A1 S. pneumoniae antigens 审中-公开
公开(公告)号：EP2336357A1
公开(公告)日：2011-06-22
申请号：EP10178910.5
申请日：2004-04-15
申请人： Intercell AG
发明人： Meinke, Andreas , Nagy, Eszter , Hanner, Markus , Dewasthaly, Shailesh , Stierschneider, Ulrike
IPC分类号： C12Q1/68 , C07K14/31
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.

2. 发明公开

EP2266592A3 Protective proteins of S. agalactiae, combinations thereof and methods of using the same 审中-公开
标题翻译：无乳链球菌的保护性蛋白质，它们的组合和使用的方法
公开(公告)号：EP2266592A3
公开(公告)日：2012-08-08
申请号：EP10010881.0
申请日：2008-01-10
申请人： Intercell AG
发明人： Tschanun, Beatrice , Nagy, Eszter , Meinke, Andreas , Gabain von, Alexander , Maierhofer, Barbara , Stierschneider, Ulrike , Berger, Manfred , Neubauer, Christina , Cohen, Katherine
IPC分类号： A61K38/16 , C07K16/12
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.

3. 发明公开

EP2298934A1 S. pneumoniae antigens 审中-公开
公开(公告)号：EP2298934A1
公开(公告)日：2011-03-23
申请号：EP10178902.2
申请日：2004-04-15
申请人： Intercell AG
发明人： Meinke, Andreas , Nagy, Eszter , Hanner, Markus , Dewasthaly, Shailesh , Stierschneider, Ulrike
IPC分类号： C12Q1/68 , C07K14/31
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.

4. 发明公开

EP2269624A3 Protective proteins of S. agalactiae, combinations thereof and methods of using the same 审中-公开
标题翻译：无乳链球菌的保护性蛋白质，其组合及其使用方法
公开(公告)号：EP2269624A3
公开(公告)日：2012-08-08
申请号：EP10010877.8
申请日：2008-01-10
申请人： Intercell AG
发明人： Tschanun, Beatrice , Nagy, Eszter , Meinke, Andreas , Gabain von, Alexander , Maierhofer, Barbara , Stierschneider, Ulrike , Berger, Manfred , Neubauer, Christina , Cohen, Katherine
IPC分类号： A61K38/16 , C07K16/12
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.
摘要翻译：本发明涉及包含至少两种针对无乳链球菌（无乳链球菌）或其功能活性变体的保护性蛋白质的组合物; 一种针对无乳链球菌的保护肽; 编码所述至少两种蛋白质和/或所述保护肽的一种或多种核酸; 生产该组合物的方法; 包含该组合物和/或至少一种保护肽的药物组合物，特别是疫苗; 生产抗体的方法; 针对组合物的至少两种蛋白质的抗体的混合物; 组合物和/或至少一种保护性肽和/或一种或多种核酸在制造用于免疫或治疗受试者的药物中的用途; 诊断无乳链球菌感染的方法; 鉴定能够结合组合物和/或至少一种保护肽的配体的方法; 以及组合物和/或至少一种保护性肽用于分离和/或纯化和/或鉴定组合物和/或肽的相互作用配偶体的用途。

5. 发明公开

EP2360177A1 Klebsiella antigens 审中-公开
标题翻译：克雷伯菌，反基因
公开(公告)号：EP2360177A1
公开(公告)日：2011-08-24
申请号：EP10010874.5
申请日：2008-04-29
申请人： Intercell AG
发明人： Bakshi, Sharmila , Cipps, Thomas , Hanner, Markus , Pikalo, Jutta , Satke, Christina , Nagy, Eszter , Lundberg, Urban , Wakefield, Dagmar , Meinke, Andreas , Noiges, Birgit , Stierschneider, Ulrike , von Gabain, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自克雷伯杆菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断感染的方法以及用于治疗或预防感染的方法。更具体地，这样的抗原由导致院内感染或由肺炎克雷伯杆菌引起的细菌感染的细菌病原体产生或与之相关。

6. 发明公开

EP2338902A1 Klebsiella antigens 审中-公开
标题翻译：克雷伯菌属抗原
公开(公告)号：EP2338902A1
公开(公告)日：2011-06-29
申请号：EP10010873.7
申请日：2008-04-29
申请人： Intercell AG
发明人： Bakshi, Sharmila , Cipps, Thomas , Hanner, Markus , Pikalo, Jutta , Satke, Christina , Nagy, Eszter , Lundberg, Urban , Wakefield, Dagmar , Meinke, Andreas , Noiges, Birgit , Stierschneider, Ulrike , von Gabain, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含此类核酸分子的载体和包含此类载体的宿主细胞。此外，本发明提供了来自克雷伯氏菌属物种的抗原及其片段和变体，生产这种抗原的方法，以及生产表达这种抗原的细胞的方法。此外，本发明提供了与这样的抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，这种核酸分子，抗原，载体或抗体用于制备药物组合物的方法，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断感染的方法和用于治疗或预防感染的方法。更具体地说，此类抗原由细菌病原体产生或与细菌病原体相关，所述细菌病原体引起由肺炎克雷伯氏菌引起的院内感染或细菌感染。

7. 发明公开

EP2314718A1 S. pneumoniae antigens 审中-公开
标题翻译：肺炎支原体
公开(公告)号：EP2314718A1
公开(公告)日：2011-04-27
申请号：EP10178893.3
申请日：2004-04-15
申请人： Intercell AG
发明人： Meinke, Andreas , Nagy, Eszter , Hanner, Markus , Dewasthaly, Shailesh , Stierschneider, Ulrike
IPC分类号： C12Q1/68 , C07K14/31
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子以及来自肺炎链球菌的超免疫血清反应性抗原或其片段，分离这些抗原的方法及其具体用途。

8. 发明公开

EP2489673A2 Klebsiella antigens 审中-公开
标题翻译：克雷伯菌抗原
公开(公告)号：EP2489673A2
公开(公告)日：2012-08-22
申请号：EP12160364.1
申请日：2008-04-29
申请人： Intercell AG
发明人： Bakshi, Sharmila , Satke, Christina , Stierschneider, Ulrike , Wakefield, Dagmar , Cipps, Thomas , Von Gabain, Alexander , Hanner, Markus , Lundberg, Urban , Meinke, Andreas , Nagy, Eszter , Noiges, Birgit , Pikalo, Jutta
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04 , A61K39/02
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.

9. 发明公开

EP2333114A1 S. pneumoniae antigens 审中-公开
公开(公告)号：EP2333114A1
公开(公告)日：2011-06-15
申请号：EP10178937.8
申请日：2004-04-15
申请人： Intercell AG
发明人： Meinke, Andreas , Nagy, Eszter , Hanner, Markus , Dewasthaly, Shailesh , Stierschneider, Ulrike
IPC分类号： C12Q1/68 , C07K14/31
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.

10. 发明公开

EP2314719A1 S. pneumoniae antigens 审中-公开
标题翻译：肺炎链球菌抗原
公开(公告)号：EP2314719A1
公开(公告)日：2011-04-27
申请号：EP10178932.9
申请日：2004-04-15
申请人： Intercell AG
发明人： Meinke, Andreas , Nagy, Eszter , Hanner, Markus , Dewasthaly, Shailesh , Stierschneider, Ulrike
IPC分类号： C12Q1/68 , C07K14/31
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C12Q1/689 , C12Q2600/158
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子以及来自肺炎链球菌的超免疫血清反应性抗原或其片段，分离此类抗原的方法及其特定用途。

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