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61. 发明公开

EP1497025A1 IMPROVED SEPARATION 有权
标题翻译：改善的分离
公开(公告)号：EP1497025A1
公开(公告)日：2005-01-19
申请号：EP03713168.7
申请日：2003-04-04
申请人： Alteco Medical AB
发明人： JOHNSON, Bo , LJUNGGREN, Lennart
IPC分类号： B01J20/32
CPC分类号： B01J20/28085 , A61M1/3679 , B01D39/16 , B01D39/20 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3255 , B01J20/3272 , B01J20/3274
摘要： The invention refers to method for selectively binding and separating at least one component from whole blood or a body fluid, whereby the blood or body fluid is allowed to pass through a rigid integral separation matrix without being excluded therefrom. The matrix has a porous structure with a pore size ranging from 5 micron to 500 micron as well as active surface ranging from 0.5 cm2 to 10 m2, and the surface is able to bind such components.

62. 发明公开

EP1432513A1 ALKALISTABILE HYDROPHILE SORBENTIEN FÜR DIE IONENAUSTAUSCHCHROMATOGRAPHIE 有权
标题翻译：用于离子交换色谱法碱稳定的亲水吸附剂
公开(公告)号：EP1432513A1
公开(公告)日：2004-06-30
申请号：EP02779324.9
申请日：2002-09-09
申请人： MERCK PATENT GmbH
发明人： BRITSCH, Lothar , DERWENSKUS, Karl-Heinz
IPC分类号： B01J39/20 , B01J39/06 , B01J41/14 , B01J41/06 , B01J20/32
CPC分类号： B01J41/20 , B01J20/321 , B01J20/3272 , B01J20/3278 , B01J39/20 , B01J39/26 , B01J41/14
摘要： The invention concerns alkali-stable hydrophilic sorbents for ion-exchange chromatography. The invention is characterized in that it consists in using as base material a crosslinked vinyl polymer consisting of vinyl monomers containing diol groups and crosslinking monomers whereof the polymerizable groups are bound by carbonamide-containing chains. Monomers containing ionic groups are grafted on said base material using cerium (IV) salts.

63. 发明公开

EP1264815A3 Separating agent for enantiomeric isomers 有权
标题翻译：对映异构体分离剂
公开(公告)号：EP1264815A3
公开(公告)日：2004-04-28
申请号：EP02012724.7
申请日：2002-06-07
申请人： Daicel Chemical Industries, Ltd.
发明人： Onishi, Atsushi , Suzuki, Shinsuke , Sakai, Masato
IPC分类号： C08B33/02 , G01N30/48 , C07B57/00 , B01D15/08
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , B01J20/3204 , B01J20/3272 , B01J20/328 , C07B57/00
摘要： A separating agent for enantiomeric isomers has an enantiomerically active polymer compound supported thereon. The polymer compound has an exothermic peak before a decomposition temperature of the polymer compound supported is reached in a differential calorimetric curve obtained in a process of temperature elevation in differential scanning calorimetry (DSC) on the separating agent. Also, disclosed is a method of evaluating asymmetry recognition ability of a separating agent for enantiomeric isomers. The method includes performing the differential scanning calorimetry (DSC) of a separating agent for enantiomeric isomers having supported thereon an enantiomerically active polymer compound to obtain a differential calorimetric curve in a process of temperature elevation therein, and observing presence or absence of an exothermic peak of the polymer compound in the differential calorimetric curve before a decomposition temperature of the supported polymer compound is reached. The evaluation method provides a simpler method for the evaluation of asymmetry recognition ability and thus provides a separating agent for enantiomeric isomers having higher ability of recognizing asymmetry.

64. 发明公开

EP1265067A4 COLUMN PACKING FOR CHROMATOGRAPHY 有权
标题翻译：支柱包装色谱
公开(公告)号：EP1265067A4
公开(公告)日：2003-09-17
申请号：EP01902836
申请日：2001-02-09
申请人： EISAI CO LTD
发明人： YAMAMOTO EIICHI , MURATA KAORU , ISHIHAMA YASUSHI , ASAKAWA NAOKI
IPC分类号： B01J20/32 , G01N30/08 , G01N30/48 , B01J20/00
CPC分类号： B01J20/286 , B01J20/3244 , B01J20/327 , B01J20/3272 , B01J20/3285 , B01J2220/54 , B01J2220/58 , G01N2030/085 , Y10T428/31663
摘要： A column packing for chromatography, wherein a carrier having pores has a hydrophilic polymer material bonded to the surface thereof and has a carbon chain bonded chemically to the interior of the pore. The column packing can be used for carrying out the direct analysis of a low molecular weight material in a biological sample without subjecting the sample to a pretreatment such as the removal of protein.

65. 发明授权

EP1189949B1 METHOD FOR SURFACE MODIFICATION, A NOVEL SUPPORT MATRIX AND THE USE OF THE MATRIX 有权
标题翻译： VERFAHREN ZUROBERFLÄCHENMODIFIZIERUNG，TRÄGERMATRIXUND VERWENDUNG DAVON
公开(公告)号：EP1189949B1
公开(公告)日：2003-08-20
申请号：EP00938766.3
申请日：2000-06-06
申请人： Amersham Biosciences AB
发明人： DERAND, Helene , NASMAN, Jan
IPC分类号： C08F8/00
CPC分类号： C08F8/00 , B01J20/28042 , B01J20/286 , B01J20/321 , B01J20/3272 , Y10T428/2998 , C08F12/00 , C08F16/00 , C08F20/00
摘要： A method for hydrophilization and/or surface area enlargement of a porous base matrix comprising on its inner and/or outer surfaces a polymer (P') carrying nucleophilic groups X'. The method is characterised in (a) ethoxylating a plurality of said X' thereby transforming them to groups comprising -(CH2CH2O)nH, or (b) (i) ethoxylating a polymer (P'') carrying nucleophilic groups X'' thereby transforming P'' to a polyhydroxy polymer (P''') carrying a plurality of -(CH2CH2O)nH groups, whereafter (ii) P''' is attached to the base matrix. n is an integer ≥ 1. A support matrix which is obtainable by the method. The support matrix has a sufficient rigidity and swellability to permit liquid flow of a velocity > 5 cm/h through the matrix when in form of particles packed to a bed or in form of a porous monolithic plug. The use of the support matrix defined in liquid chromatography, cell culturing, stepwise solid phase synthesis of organic molecules, affinity adsorption in suspensions, solid phase catalysis with an immobilized catalyst.
摘要翻译：一种多孔基质基体的亲水化和/或表面积扩大的方法，其在其内表面和/或外表面上包含携带亲核基团X'的聚合物（P'）。该方法的特征在于：（a）使多个所述X'乙氧基化，从而将它们转化成包含 - （CH 2 CH 2 CH 2）n ，或（b）（i）乙氧基化携带亲核基团X“的聚合物（P”），从而将P“转化为携带多个 - （CH 2）2的多羟基聚合物（P” H基团，然后（ii）P“'连接到基础基质上。 n是整数> = 1。可通过该方法获得的支撑矩阵。支撑基质具有足够的刚度和溶胀性，以允许当填充到床上的颗粒形式或多孔整体塞的形式时通过基质流速> 5cm / h的液体流动。使用在液相色谱，细胞培养，有机分子的逐步固相合成，悬浮液中的亲和吸附，固定化催化剂的固相催化中定义的载体基质。

66. 发明公开

EP1294480A1 A CHROMATOGRAPHY MATERIAL AND A PROCESS OF MANUFACTURING THAT MATERIAL 审中-公开
标题翻译：色谱和处理此材料的制备
公开(公告)号：EP1294480A1
公开(公告)日：2003-03-26
申请号：EP01960403.2
申请日：2001-06-27
申请人： Bia Separations D.O.O.
发明人： JUNGBAUER, Alois,c/o Inst Angewandte Mikrobiol Un , HAHN, Rainer , PODGORNIK, Ales , BARUT, Milos , STRANCAR, Ales
IPC分类号： B01J20/26 , B01J20/32 , B01D15/08 , G01N30/48
CPC分类号： G01N30/482 , B01D15/361 , B01D15/3804 , B01D15/3809 , B01J20/26 , B01J20/28042 , B01J20/285 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3282 , B01J2220/54 , B01J2220/82
摘要： A process of manufacturing of a chromatography material comprising the steps of (i) reacting a polymerisable at least bifunctional monomer A with a ligand also having a functional group which binds covalently with one of the functional groups of said polymerisable bifunctional monomer A, (ii) to form a compound B comprising at least one polymerisable functional moiety (iii) polymerizing the compound B essentially alone or with the polymerisable monomers in presence of porogenes to obtain a block of porous polymeri-sate which is self-supporting or (iv) reacting the ligand and a spacer via a covalent bond which is cleavable to form a ligand-spacer conjugate and binding the ligand-spacer conjugate to the surface of a chromatographic support or reacting the ligand-spacer conjugate via a covalent bond to the at least bi-functional monomer A and polymerizing it essentially alone or with the polymerisable monomers in presence of porogenes to obtain a block of porous polymerisate which is self-supporting.

67. 发明公开

EP0999866A4 METHOD OF REMOVING BETA-2 MICROGLOBULIN FROM BLOOD 失效
标题翻译：方法去除β2微球蛋白血的
公开(公告)号：EP0999866A4
公开(公告)日：2003-02-26
申请号：EP98937325
申请日：1998-07-29
申请人： ADVANCED RENAL TECHNOLOGIES LL
发明人： BRAVERMAN ANDREW , DAVANKOV VADIM
IPC分类号： A61M1/36 , B01J20/32 , A61M37/00 , A61K35/14 , B01J20/26
CPC分类号： A61M1/3679 , A61M2202/0421 , B01J20/261 , B01J20/264 , B01J20/267 , B01J20/28019 , B01J20/2808 , B01J20/28085 , B01J20/3092 , B01J20/321 , B01J20/3217 , B01J20/3221 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J2220/58 , B01J2220/62 , A61M2202/0057
摘要： A method of removing beta-2 microglobulin from blood has the steps of removing blood from a patient, passing the blood through a material with a size and a structure selected so as to remove beta-2 microglobulin from the blood, and re-entering the blood from which the beta-2 microglobulin is removed into the patient.

68. 发明公开

EP1264815A2 Separating agent for enantiomeric isomers 有权
标题翻译： Testernungsmittelfür对映异构体Isomere
公开(公告)号：EP1264815A2
公开(公告)日：2002-12-11
申请号：EP02012724.7
申请日：2002-06-07
申请人： Daicel Chemical Industries, Ltd.
发明人： Onishi, Atsushi , Suzuki, Shinsuke , Sakai, Masato
IPC分类号： C07B57/00 , G01N30/48
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , B01J20/3204 , B01J20/3272 , B01J20/328 , C07B57/00
摘要： A separating agent for enantiomeric isomers has an enantiomerically active polymer compound supported thereon. The polymer compound has an exothermic peak before a decomposition temperature of the polymer compound supported is reached in a differential calorimetric curve obtained in a process of temperature elevation in differential scanning calorimetry (DSC) on the separating agent. Also, disclosed is a method of evaluating asymmetry recognition ability of a separating agent for enantiomeric isomers. The method includes performing the differential scanning calorimetry (DSC) of a separating agent for enantiomeric isomers having supported thereon an enantiomerically active polymer compound to obtain a differential calorimetric curve in a process of temperature elevation therein, and observing presence or absence of an exothermic peak of the polymer compound in the differential calorimetric curve before a decomposition temperature of the supported polymer compound is reached. The evaluation method provides a simpler method for the evaluation of asymmetry recognition ability and thus provides a separating agent for enantiomeric isomers having higher ability of recognizing asymmetry.
摘要翻译：用于对映异构体的分离剂具有负载在其上的对映体活性聚合物化合物。高分子化合物在分离剂的差示扫描量热法（DSC）的温度升高过程中得到的差示量热曲线达到负载的高分子化合物的分解温度之前的放热峰。此外，公开了评价对映异构体的分离剂的不对称识别能力的方法。该方法包括对对映体异构体的分离剂进行差示扫描量热法（DSC），其中负载有对映体活性聚合物化合物，以在其中升温过程中得到差示量热曲线，观察是否存在放热峰在达到负载的高分子化合物的分解温度之前的差示量热曲线中的高分子化合物。评价方法提供了用于评价不对称识别能力的更简单的方法，从而提供了具有较高识别不对称性的对映异构体的分离剂。

69. 发明公开

EP1255603A1 PACKING MATERIALS FOR SEPARATION OF BIOMOLECULES 审中-公开
标题翻译：包装材料的生物分子的分离
公开(公告)号：EP1255603A1
公开(公告)日：2002-11-13
申请号：EP00904138.5
申请日：2000-02-09
申请人： RESQ Lab B.V.
发明人： RHEMREV-BOOM, Maria, Martha
IPC分类号： B01D15/08 , B01J20/32 , G01N30/48
CPC分类号： B01J20/286 , B01D15/1807 , B01D15/3804 , B01J20/284 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3268 , B01J20/3272 , B01J20/328 , B01J20/3282 , B01J2220/54
摘要： The invention relates to the field of separation of molecules, in particular biomolecules, from media containing said molecules. The invention provides a sorbent for use in separation of molecules, comprising a, preferably crosslinked, polymer coating (to prevent non-selective adsorption), preferably having been provided with a spacer molecule and/or a functional moiety to allow coupling of an affinity ligand.

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