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61. 发明授权

EP0168255B1 Method and apparatus for co-extrusion of a dough mass with particulate matter in the outer dough 失效
标题翻译：在外部共挤出具有颗粒物质的粗大质量的方法和装置
公开(公告)号：EP0168255B1
公开(公告)日：1992-09-23
申请号：EP85304966.6
申请日：1985-07-11
申请人： NABISCO, INC.
发明人： Thulin, Robert , Polifromi, Nicholas , Ross, Robert E.
IPC分类号： A21C9/06 , A23P1/12 , A21C9/04
CPC分类号： A21C9/06 , A21C11/163 , A23G3/2015 , A23P30/25 , Y10S425/243

62. 发明公开

EP0502698A1 Bioabsorbable interference bone fixation screw 失效
标题翻译： Bioabsorbierbare selbsthemmende Befestigungsknochenschraube。
公开(公告)号：EP0502698A1
公开(公告)日：1992-09-09
申请号：EP92301816.2
申请日：1992-03-03
申请人： LINVATEC CORPORATION
发明人： Ross, Randall D , Bassetti, Kevin J
IPC分类号： A61B17/58 , A61F2/08
CPC分类号： A61B17/8645 , A61B17/8615 , A61B17/863 , A61B17/888 , A61B2017/00004 , Y10S606/908
摘要： An interference bone fixation screw fabricated from bioabsorbable material includes a body having a proximal end, a distal end and a screw thread disposed therealong from the proximal end to the distal end. A drive recess is formed in the body to extend longitudinally from the proximal end toward the distal end for receiving a rotatable driver. The drive recess defines a plurality of radial force receiving surfaces for receiving concentric forces from the driver applied perpendicularly to the force receiving surfaces.
摘要翻译：由生物可吸收材料制造的干涉骨固定螺钉包括具有近端，远端和从近端至远端设置的螺纹的主体。驱动凹部形成在主体中，从近端向远端纵向延伸，用于接收可旋转的驱动器。驱动凹部限定多个径向力接收表面，用于接收来自驾驶员的垂直于力接收表面施加的同心力。

63. 发明公开

EP0499465A1 Surgical cutting instrument 失效
标题翻译： Chirurgisches施氏仪器。
公开(公告)号：EP0499465A1
公开(公告)日：1992-08-19
申请号：EP92301181.1
申请日：1992-02-13
申请人： LINVATEC CORPORATION
发明人： Schuler, Donald K.
IPC分类号： A61B17/32
CPC分类号： A61B17/32002
摘要： The cutting strength of a rotary surgical cutting instrument (12) is increased by an on-axis bearing contact between the distal end of its rotatable inner member (16) and the interior surface of its outer member (14). The outer member (14) is provided with a distal cutting aperture (88) angularly oriented to the rotation axis and circumscribed by an oval outer cutting edge. The inner member (16) has two symmetrical rows of straight-sided triangular cutting teeth (102) positioned to cooperate with the outer cutting edge (88) to shear tissue, including bone, disposed in the cutting aperture. A clearance gap (134) between the inner and outer members (16,14) narrows in width in the region between the teeth (102) and the aperture (88) to prevent severed tissue from lodging between the inner and outer members. The height of the cutting teeth (102) is at least 50% of their width, and 15% to 22% of the outer diameter of the inner member. The straight sides of the teeth converge to crests (124) disposed in a first common longitudinal plane. The teeth (102) are separated by roots disposed in a second plane parallel to the first plane but disposed closer than the first plane to the rotation axis.
摘要翻译：通过其可旋转的内部构件（16）的远端和其外部构件（14）的内表面之间的轴上轴承接触，旋转外科切割器具（12）的切割强度增加。外部构件（14）设置有远离切割孔（88），该远端切割孔（88）成角度地定向到旋转轴线并且被椭圆形外切割边缘限定。内部构件（16）具有两个对称排的直立三角形切割齿（102），定位成与外部切割边缘（88）协作以剪切设置在切割孔中的包括骨骼的组织。内部和外部构件（16,14）之间的间隙（134）在齿（102）和孔（88）之间的区域中宽度变窄，以防止被切断的组织倒入内部和外部构件之间。切割齿（102）的高度为其内部构件的至少50％的宽度和15％至22％的外径。齿的直边会聚到设置在第一公共纵向平面中的波峰（124）上。齿（102）由设置在与第一平面平行的第二平面中的根分开，但是设置成比第一平面更靠近旋转轴线。

64. 发明公开

EP0498532A1 Necrotic tissue debridement powder composition containing a proteolytic enzyme 失效
标题翻译：蛋白多糖酶enthaltende Puderzusammensetzung zur Entfernung von nekrotischem Gewebe。
公开(公告)号：EP0498532A1
公开(公告)日：1992-08-12
申请号：EP92300228.1
申请日：1992-01-10
申请人： E.R. SQUIBB & SONS, INC.
发明人： Constantine, Barry E. , Freeman, Frank , Cilento, Rodolfo D. , Monte, Karen Ann
IPC分类号： A61L15/16 , A61K37/54 , A61K37/48
CPC分类号： A61K38/482 , A61L15/38 , C12Y304/21062
摘要： A powder composition useful for debriding wounds comprising an enzyme dispersed in a pharmaceutically acceptable excipient.
摘要翻译：一种用于清创包含分散在药学上可接受的赋形剂中的酶的伤口的粉末组合物。

65. 发明公开

EP0272816A3 Ostomy pouch particularly suited for a disposal by flushing, method of assembling an ostomy pouch and method of disposing of a used pouch 失效
标题翻译：通过冲洗处理废物处理手段和特殊处置方法
公开(公告)号：EP0272816A3
公开(公告)日：1992-05-27
申请号：EP87310534.0
申请日：1987-11-30
申请人： E.R. Squibb & Sons, Inc.
发明人： Keyes, Denis E. , Aronoff, Marvin S.
IPC分类号： A61F5/445
CPC分类号： A61F13/47 , A61F5/445 , A61F13/15211 , A61F13/551 , A61F2005/4402 , A61F2013/15048 , Y10T428/1307
摘要： Flexible, soft objects such as ostomy pouches, wound dressings, bandages, diapers, etc. can be flushed down a conventional toilet by covering the article with a sheet of material which rapidly becomes slimy or exudes a slimy material on contact with the water in a toilet bowl or by adding such materials directly to the bowl. An ostomy pouch constructed from materials particularly suited for disposal in a toilet bowl is also disclosed. The pouch is constructed from laminates of water swellable, cold water insoluble films (18,34) and water resistant tissue paper (19,33).

66. 发明公开

EP0484602A1 Pneumatic tyre wheel with pivotable ground pads 失效
标题翻译： Rad mit einem Luftreifen mit schwenkbarenGrundkörpern。
公开(公告)号：EP0484602A1
公开(公告)日：1992-05-13
申请号：EP90312267.9
申请日：1990-11-09
申请人： McLaughlin, Hugh Rogers
发明人： McLaughlin, Hugh Rogers
IPC分类号： B60C11/02
CPC分类号： B60C11/02 , B60B15/18 , B60C27/20
摘要： The invention provides a pneumatic tyre (12) for mounting on a wheel hub (11), the tyre having a plurality of ground engaging pads (14) disposed around the periphery (15) of the tyre. Each pad (14) is capable of at least a limited degree of angular displacement about a radial axis relative to the tyre, so that the tyre (12) may turn through the limited angle relative to any pad (14) which is in ground contact. A means (31, 36) is provided for returning each pad (14) to its undisplaced position when the pad has moved out of contact with the ground.
摘要翻译：本发明提供了一种用于安装在轮毂（11）上的充气轮胎（12），该轮胎具有设置在轮胎周边（15）周围的多个地面接合垫（14）。每个垫（14）能够相对于轮胎至少具有围绕径向轴线的有限角度位移，使得轮胎（12）可相对于处于地面接触的任何垫（14）转过限制的角度。提供了一种装置（31,36），用于当垫已经离开与地面接触时将每个垫（14）返回到其未放置的位置。

67. 发明公开

EP0467710A3 Method for treating Parkinson's disease employing the ATP-sensitive potassium channel blocker quinine 失效
标题翻译：使用ATP敏感性钾通道阻断剂治疗帕金森病的方法
公开(公告)号：EP0467710A3
公开(公告)日：1992-05-13
申请号：EP91306613.0
申请日：1991-07-19
申请人： E.R. SQUIBB & SONS, INC.
发明人： Greenfield, Susan A. , Levesque, Denyse
IPC分类号： A61K31/49 , A61K31/00
CPC分类号： A61K31/64 , A61K31/00 , A61K31/49
摘要： A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.

68. 发明公开

EP0482260A1 Novel reagent and method for peptide synthesis 失效
标题翻译： Neues Reagenz und Verfahren zur Peptidsynthese。
公开(公告)号：EP0482260A1
公开(公告)日：1992-04-29
申请号：EP90311774.5
申请日：1990-10-26
申请人： PROTEIN TECHNOLOGIES, INC.
发明人： Barstow, Leon E. , Ward, Glen D.
IPC分类号： C07K1/04 , C07K1/08
CPC分类号： C07K1/04 , C07K1/082
摘要： A novel and convenient process is described for providing protected amino acids and activating agents for solid phase synthesis which drastically reduces the capital costs of equipment required for the preparation of peptides. The two normally very reactive reagents, when mixed as anhydrous powders are shelf stable and yet form an active compound rapidly when mixed together in solution. This invention presents a method for combining these highly reactive dry solids in a manner which makes them unreactive and shelf stable at room temperature for extended periods of time. Once the solids are dissolved in solvent, a highly reactive amino acid ester that can readily be used in solid phase peptide synthesis is formed. This method of delivery of reagents to an automated peptide synthesizer allows a very simplified instrument to be constructed using fewer and less expensive components and significantly reducing the associated software required.
摘要翻译：描述了一种新颖而方便的方法，用于提供用于固相合成的受保护的氨基酸和活化剂，其显着降低了制备肽所需的设备的资本成本。两种通常非常活泼的试剂当以无水粉末混合时是稳定的，并且当在溶液中混合在一起时迅速形成活性化合物。本发明提出了一种将这些高反应性干固体以使其在室温下长时间不反应和稳定的方式组合的方法。一旦固体溶解在溶剂中，就可以形成易于用于固相肽合成的高反应性氨基酸酯。将试剂递送到自动化肽合成仪的这种方法允许使用更少和更少成本的组分构建非常简化的仪器，并显着减少所需的相关软件。

69. 发明公开

EP0479623A1 Banding tool with included clamping means 失效
标题翻译： Bandwerkzeug mit Klemmittel。
公开(公告)号：EP0479623A1
公开(公告)日：1992-04-08
申请号：EP91309148.4
申请日：1991-10-04
申请人： Band-It-IDEX, Inc.
发明人： Jansen, George A.
IPC分类号： B25B25/00 , B65B13/34
CPC分类号： B65B13/345 , B25B25/005 , B65B13/027 , B65B13/305
摘要： A banding tool (10) is provided to tension and lock a band (12) and a buckle (14) around an object (16). The tool (10) has a housing (18) and a pull-up/cut-off handle (20) for cooperatingly tensioning the band (12). Upon properly tensioning the band (12) around the object (16), the handle (20) is further manipulated to engage a locking/cutting lever (26). The lever (26) engages a head (42) which holds a punch (46) therein and includes a surface (49). The punch (46) first contacts the band (12) to deform and lock the band (12) to itself. The surface (49) of the head (48) then bends and cuts the tail (134) from the band (12).
摘要翻译：提供捆扎工具（10）以围绕物体（16）张紧和锁定带（12）和带扣（14）。工具（10）具有壳体（18）和用于协同地张紧带（12）的上拉/切断手柄（20）。在围绕物体（16）适当地张紧带（12）时，手柄（20）进一步被操纵以接合锁定/切割杆（26）。杠杆（26）接合在其中保持冲头（46）的头部（42），并包括表面（49）。冲头（46）首先接合带（12）以将带（12）变形并锁定到其自身。头部（48）的表面（49）然后从带（12）弯曲并切割尾部（134）。

70. 发明公开

EP0476994A1 7-Oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease 失效
标题翻译：用于血栓形成和血管痉挛遭受适当7- Oxabicycloheptyl取代的杂环硫代酰胺前列腺素的治疗。
公开(公告)号：EP0476994A1
公开(公告)日：1992-03-25
申请号：EP91308513.0
申请日：1991-09-18
申请人： E.R. SQUIBB & SONS, INC.
发明人： Misra, Raj N. , Sher, Philip M. , Stein, Philip D. , Hall, Steven E. , Floyd, David , Barrish, Joel C.
IPC分类号： C07D493/08 , A61K31/557
CPC分类号： C07D493/08
摘要： 7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula

wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is -(CH₂)₂-, -CH=CH- or

wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is

then Y cannot be O, and when Z is -CH=CH-, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO₂H, CO₂lower alkyl, CH₂OH, CO₂alkali metal, CONHSOR³, CONHR 3a or -CH₂-5-tetrazolyl, X is O, S or NH; and where R¹, R², R³ and R 3a are as defined herein.
摘要翻译： 7氧杂二环庚治疗血栓形成和血管痉挛性疾病有用substituiertem前列腺素类似物具有结构式 worin m为1，2或3; n是1，2，3或4; Z是 - （CH 2）2，-CH = CH-或 worin Y为O，为单键或乙烯基，条件做当n是O，如果Z是，则Y不能是O，当Z是-CH = CH-，n是1，2，3或4; 并且当Y =乙烯基，正= 0; R是CO 2 H，CO2lower烷基，CH 2 OH，CO2alkali金属，CONHSOR <3>，CONHR <3A>或-CH 2 -5-四唑基，X为O，S或NH; 且其中R <1>，R <2> [R <3>和R <3>是如所定义。

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