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51. 发明公开

EP2971033A1 MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS 有权转让
标题翻译： PROCESS FOR RNA转录物的制备
公开(公告)号：EP2971033A1
公开(公告)日：2016-01-20
申请号：EP14769839.3
申请日：2014-03-13
申请人： Moderna Therapeutics, Inc.
发明人： BANCEL, Stephane , ISSA, William, Joseph , AUNINS, John, Grant , CHAKRABORTY, Tirtha
IPC分类号： C12P19/34 , C12P19/30 , C12P19/26
CPC分类号： C12P19/34 , C12N15/101 , C12Q1/6865 , C12Q2525/173 , C12Q2565/629
摘要： Described are methods for production of RNA transcripts using a non-amplified, linearized DNA template in an in vitro transcription reaction. Enzymatic 5′ capping and oligo dT purification can also be included in the methods.

52. 发明公开

EP2905341A1 Methods for producing nucleotide-activated sugars and recombinant microorganism host cells used therefor 有权转让
标题翻译：一种用于生产糖和nukleotidaktivierten重组微生物宿主细胞中的过程
公开(公告)号：EP2905341A1
公开(公告)日：2015-08-12
申请号：EP14154335.5
申请日：2014-02-07
申请人： Jennewein Biotechnologie GmbH
发明人： Dr. Albermann, Christoph , Prof. Dr. Sprenger, Georg , Dr. Jennewein, Stefan
IPC分类号： C12P19/30 , C12P19/18
CPC分类号： C12P19/305 , C12P19/18 , C12Y204/00
摘要： The present invention relates to a method for producing a nucleotide-activated sugar in a recombinant prokaryotic microorganism host cell, wherein the recombinant prokaryotic microorganism is transformed to express an eukaryotic transporter protein for the nucleotide-activated sugar. The present invention also relates to the recombinant prokaryotic microorganism used in the method and its use for the production of nucleotide-activated sugars.
摘要翻译：本发明涉及一种方法，用于在重组原核微生物宿主细胞中生产核苷酸，活化的糖，worin重组原核微生物转化中的核苷酸活化的糖真核转运蛋白来表达。因此，本发明涉及在该方法及其用于生产核苷酸激活的糖的使用中使用的重组原核微生物。

53. 发明公开

EP2099316A1 FLAVOUR MODULATING DERIVATIVE OF A CARBOXYLIC ACID AND A PURINE, PYRIMIDINE, NUCLEOSIDE OR NUCLEOTIDE 有权转让
标题翻译： GESCHMACKSMODULIERENDES DERIVAT EINERCARBONSÄUREUND EINES PURINS，PYRIMIDIN，NUKLEOSIDS ODER NUKLEOTIDS
公开(公告)号：EP2099316A1
公开(公告)日：2009-09-16
申请号：EP07851907.1
申请日：2007-12-13
申请人： Givaudan Nederland Services B.V.
发明人： DE KLERK, Adri , BAALBERGEN, Marieke , RENES, Harry , WINKEL, Chris
IPC分类号： A23L1/229 , A23L1/226 , C07H19/04 , C07H19/16 , C12P19/30 , C12P19/32
CPC分类号： C07H19/04 , A23L27/202 , A23L27/23 , C07H19/16
摘要： The present invention relates to the field of improving the flavour of foodstuffs, beverages, tobacco products, pharmaceutics and oral care products. More particularly, the present invention provides flavour modulating substances selected from the group represented by formula (I): and edible salts thereof and edible esters thereof, which can advantageously be used for modulating the flavour of foodstuffs, beverages, tobacco products, pharmaceutics and oral care products. These flavour modulating substances can be used to impart desirable taste attributes in a wide variety of applications and products. In addition, the present flavour modulating substances are capable of modulating the taste and/or aroma impact of other, flavour imparting, substances contained within these same products, thereby improving the overall flavour quality of these products. Suitable examples of these substances include N- acetyl GMP, N-formyl GMP, N-propanoyl GMP, N-butanoyl GMP, N-pentanoyl GMP, N- hexano yl GMP, N-heptanoyl GMP, N-octanoyl GMP, N-oxalyl GMP, N-succinyl GMP, N- glutaryl GMP, N-fumaryl GMP, N-maleyl GMP, N-adipyl GMP, N-citryl GMP, N-galloyl GMP, N-oxalacetyl-GMP, N-feruloyl GMP, N-pyruvyl GMP, N-benzoyl GMP, N-vanilloyl GMP, N-anthranoyl GMP, N-caffeoyl GMP, N-cinnamoyl GMP, edible salts thereof and edible esters thereof.
摘要翻译：本发明涉及改善食品，饮料，烟草制品，制药和口腔护理产品的风味的领域。更具体地，本发明提供了选自式（I）表示的组中的风味调节物质及其食用盐和其食用酯，其可有利地用于调节食品，饮料，烟草产品，药物和口服的风味护理产品。这些风味调节物质可用于在各种应用和产品中赋予所需的味道特性。此外，本发明的风味调节物质能够调节这些相同产品中含有的其它赋香味物质的味道和/或香气的影响，从而提高这些产品的整体风味品质。

54. 发明授权

EP1502956B1 PROCESS FOR PRODUCING CYTIDINE 5'-DIPHOSPHATE CHOLINE 有权
标题翻译：用于生产胞苷5'-DIPHOSPHATCHOLIN
公开(公告)号：EP1502956B1
公开(公告)日：2009-07-29
申请号：EP03728046.8
申请日：2003-05-08
申请人： Kyowa Hakko Bio Co., Ltd
发明人： HASHIMOTO, Shin-ichi , ODA, Hideki
IPC分类号： C12P19/30
CPC分类号： C12P19/30
摘要： A process for producing CDP-choline characterized by comprising bringing a biocatalyst, which has an activity of forming CDP-choline from choline, phosphorylcholine or a salt thereof and uracil, into contact with choline, phosphorylcholine or a salt thereof and uracil in an aqueous medium, thus allowing the formation and accumulation of CDP-choline in the aqueous medium, and then collecting the CDP-choline from the aqueous medium.

55. 发明公开

EP2021479A2 MODIFIED MOLECULE 审中-公开
标题翻译：修饰的分子
公开(公告)号：EP2021479A2
公开(公告)日：2009-02-11
申请号：EP07732909.2
申请日：2007-05-25
申请人： The University of York
发明人： LIM, Eng, Kiat
IPC分类号： C12N15/54 , C12N9/10 , C12N9/04 , C12N1/21 , C12P19/30
CPC分类号： C12N9/0006 , C12N9/1051 , C12P19/305
摘要： We describe a microbial cell, typically a bacterial cell, genetically engineered to produce a modified sugar nucleotide, for example UDP glucuronic acid, and the use of the modified sugar to transfer glucuronic acid to small acceptor molecules.

56. 发明公开

EP1937825A2 MODIFIED 4'-NUCLEOSIDES AS ANTIVIRAL AGENTS 有权转让
标题翻译：改进4,4'-核苷作为抗病毒药剂
公开(公告)号：EP1937825A2
公开(公告)日：2008-07-02
申请号：EP06825120.6
申请日：2006-09-26
申请人： Pharmasset, Inc.
发明人： DU, Jinfa , FURMAN, Phillip , SOFIA, Michael
IPC分类号： C12P19/38 , C12P19/40 , C12P19/30
CPC分类号： C07H19/06 , C07H19/16
摘要： Compounds, methods and compositions for treating a host infected with human immunodeficiency virus and hepatitis B virus comprising administering an effective amount of a described 4'-C-substituted /3-D- and /3-L-nucleoside or a pharmaceutically acceptable salt or prodrug thereof, are provided.

57. 发明公开

EP1829965A1 INDUSTRIALLY USEFUL MICROORGANISM 审中-公开
标题翻译：工业上有用的微生物
公开(公告)号：EP1829965A1
公开(公告)日：2007-09-05
申请号：EP05809612.4
申请日：2005-11-25
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： MIZOGUCHI, Hiroshi , HARA, Kiyotaka , MORI, Hideo
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12P7/64 , C12P13/00 , C12P13/04 , C12P17/00 , C12P19/00 , C12P19/30 , C12P19/38 , C12P21/02
CPC分类号： C12P13/08 , C12N1/20 , C12R1/185
摘要： According to the present invention, the E . coli mutant strain having chromosomal DNA that is at least 470 kbp shorter than that of a wild-type E . coli strain exhibits such a property that the number of the cells after a certain period of culture is greater than a wild-type strain. Thus, by culturing the mutant strain in a medium so as to generate and accumulate a useful substance in the culture, a useful substance such as proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids can be efficiently produced.
摘要翻译：根据本发明，具有比野生型大肠杆菌菌株短至少470kbp的染色体DNA的大肠杆菌突变株显示出这样的性质，即培养一段时间后的细胞数目是大于野生型菌株。因此，通过在培养基中培养突变菌株以在培养物中产生并积累有用物质，可以有效地使蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质等有用物质产生的。

58. 发明公开

EP1379536A4 BUILDING BLOCKS FOR THE SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES 审中-公开
标题翻译：构建块的寡核苷酸的液相合成
公开(公告)号：EP1379536A4
公开(公告)日：2007-07-25
申请号：EP02715168
申请日：2002-03-20
申请人： ISIS PHARMACEUTICALS INC , UNIV OVIEDO
发明人： SANGHVI YOGESH S , GOTOR VICENTE , FERRERO MIGUEL , FERNANDEZ SUSANA , GARCIA JAVIER
IPC分类号： C07H19/04 , C07H21/04 , C12P19/30 , C07H21/02 , C07H19/00 , C12P41/00 , C12Q1/68
CPC分类号： C07H21/04 , C07H19/04 , C12P19/30
摘要： The present invention is directed to methods for the preparation of 3' 0 and 5' 0- levulinyl nucleosides from common precursors using an enzymatic approach.

59. 发明公开

EP1587939A2 DEOXYRIBONUCLEOTIDES MANUFACTURING BY ENZYMATIC REDUCTION OF RIBONUCLEOTIDES 审中-公开
标题翻译：受理并酶促还原核糖核苷酸的脱氧核糖核苷酸PRODUCING
公开(公告)号：EP1587939A2
公开(公告)日：2005-10-26
申请号：EP03813701.4
申请日：2003-12-23
申请人： ScinoPharm Biotech Ltd.
发明人： YU, Kuo-Ming
IPC分类号： C12P19/30 , C12P19/32 , C07H19/10 , C07H19/20
CPC分类号： C07H19/10 , C07H19/20 , C12P19/30 , C12P19/305 , C12P19/32
摘要： A method for in vitro preparation of deoxyribonucleotides is disclosed. The deoxyribonucleotides in the present invention are converted from ribonucleotides extracted from yeast in the presence of E. coli RNA reductase and a reducing agent.

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