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51. 发明公开

EP3004132A4 BILE ACID-BASIC AMINO ACID CONJUGATES AND USES THEREOF 审中-公开
标题翻译： GALLENSÄURE-BASISCHEAMINOSÄURE-KONJUGATE UND VERWENDUNGEN DAVON
公开(公告)号：EP3004132A4
公开(公告)日：2017-01-18
申请号：EP14807494
申请日：2014-06-05
申请人： YISSUM RES DEV COMPANY OF THE HEBREW
发明人： TIROSH OREN , VOLOSHIN IRA , SASSON SHLOMO , OBERCYGER MICHAL , MADAR ZECHARIA
IPC分类号： C07J9/00 , A61K31/573 , A61K31/575 , A61P3/00 , C07J41/00
CPC分类号： A61K31/575 , A61K31/573 , A61K47/48023 , A61K47/54 , A61K47/542 , C07J41/0005 , C07J41/0061 , C07J41/0088
摘要： Compositions and methods for treating diseases or disorders associated with the metabolic syndrome using conjugates of bile acids with basic amino acids or a decarboxylated amino acid such as agmatine are provided. Further provided are bile acid-basic amino acid conjugates including chenodeoxycholic acid with an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as agmatine.
摘要翻译：提供了使用胆汁酸与碱性氨基酸或脱羧氨基酸如胍丁胺的缀合物治疗与代谢综合征相关的疾病或病症的组合物和方法。还提供了胆汁酸碱性氨基酸缀合物，包括鹅脱氧胆酸与选自精氨酸，赖氨酸，组氨酸，鸟氨酸或脱羧氨基酸如氨基丁酸的氨基酸。

52. 发明公开

EP3113629A1 SERUM CHOLESTEROL LOWERING EDIBLE PRODUCT 审中-公开
标题翻译： ESSBARES PRODUKT ZUR SENKUNG DES SERUMCHOLESTERINSPIEGELS
公开(公告)号：EP3113629A1
公开(公告)日：2017-01-11
申请号：EP15710104.9
申请日：2015-03-03
申请人： Raisio Nutrition Ltd
发明人： WESTER, Ingmar , KUUSISTO, Päivi , NIEMELÄ, Jouni , FÖRBOM, Tuula , DRAGET, Kurt I. , SIWEK, Andrzej , LUNDHAUG, Kamilla , OLSEN, Jan, Erik
IPC分类号： A23L33/10 , A61K31/575 , A61P3/06
CPC分类号： A61K31/575 , A23L29/10 , A23L33/11 , A23P20/00 , A23V2002/00 , A61K9/06 , A61K9/107 , A61K47/10 , A61K47/26 , A61K47/42 , A61K47/44 , A23V2200/3262 , A23V2250/044 , A23V2250/2136 , A23V2250/262 , A23V2250/5432 , A23V2250/6406 , A23V2250/642 , A23V2250/6422
摘要： The present invention relates to a serum LDL cholesterol lowering edible product containing plant sterol ester and/or plant stanol ester, and especially to a dietary supplement product.
摘要翻译：本发明涉及含有植物甾醇酯和/或植物甾烷醇酯的血清低密度脂蛋白胆固醇降低食用产品，特别涉及膳食补充剂产品。

53. 发明公开

EP2988607A4 ANIMAL FEED INCLUDING CATIONIC CHOLESTEROL ADDITIVE 审中-公开
标题翻译： FUTTERMITTEL MIT KATIONISCHEM CHOLESTERINADDITIV
公开(公告)号：EP2988607A4
公开(公告)日：2016-12-14
申请号：EP14804468
申请日：2014-04-22
申请人： UNIV BRIGHAM YOUNG
发明人： BEUS CHAD S , SAVAGE PAUL B
IPC分类号： A23K10/00 , A23K20/168 , A23K50/00 , A61P31/00
CPC分类号： A61K31/575 , A23K20/10 , A23K20/168 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/45 , A23K50/75 , A23V2002/00 , A23V2200/32
摘要： Methods and feed compositions for increasing health of agricultural animals include administering a cationic cholesterol additive through the diet of the animal, such as through solid feed or drinking water of the animals. The method includes feeding an animal a diet comprised of a cationic cholesterol additive, such as a compound with a sterol backbone and a plurality of cationic groups attached thereto. The feed composition may include a solid or liquid feed component and a cationic cholesterol additive. The methods and compositions are useful for animals raised in confined feed operations, such as cattle, swine, horses, sheep, or poultry, and can reduce harmful bacteria in the digestive tract, increase beneficial bacteria flora, improve feed conversion efficiency, reduce morbity and/or mortality, and/or yield harvested meat having reduced content of harmful bacteria.
摘要翻译：用于增加农业动物健康的方法和饲料组合物包括通过动物的饮食施用阳离子胆固醇添加剂，例如通过动物的固体饲料或饮用水。该方法包括向动物喂食由阳离子胆固醇添加剂（例如化合物与固醇主链）和多个连接到其上的阳离子基团组成的饮食。饲料组合物可以包括固体或液体进料组分和阳离子胆固醇添加剂。所述方法和组合物可用于在限制饲料操作中饲养的动物，例如牛，猪，马，绵羊或家禽，并且可以减少消化道中的有害细菌，增加有益菌群，提高饲料转化效率，降低病情， /或死亡率，和/或产生具有降低的有害细菌含量的收获肉。

54. 发明公开

EP3024438A4 FORMULATIONS FOR EPIDERMAL REPAIR 审中-公开
标题翻译：配方修复表皮
公开(公告)号：EP3024438A4
公开(公告)日：2016-12-07
申请号：EP14829731
申请日：2014-07-25
申请人： EBERTING CHERYL LEE
发明人： EBERTING CHERYL LEE
IPC分类号： A61K8/68 , A61P17/00
CPC分类号： A61K31/164 , A61K8/361 , A61K8/365 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/4926 , A61K8/55 , A61K8/63 , A61K8/68 , A61K9/0014 , A61K31/133 , A61K31/19 , A61K31/20 , A61K31/23 , A61K31/455 , A61K31/573 , A61K31/575 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/183 , A61K47/24 , A61K47/28 , A61K2800/48 , A61K2800/5922 , A61Q19/00 , A61Q19/007

55. 发明公开

EP3096748A1 MATERIALS, METHODS AND DEVICES FOR ALTERING CELL REACTIVITY 审中-公开
标题翻译： MATERIALIEN，VERFAHREN UND VORRICHTUNGEN ZURVERÄNDERUNGDERZELLREAKTIVITÄT
公开(公告)号：EP3096748A1
公开(公告)日：2016-11-30
申请号：EP15704426.4
申请日：2015-01-26
申请人： The Arizona Board of Regents on behalf of the University of Arizona
发明人： SLEPIAN, Marvin J.
IPC分类号： A61K31/10 , C12N5/078 , A61K31/165 , A61K31/202
CPC分类号： A61K31/10 , A61K31/165 , A61K31/202 , A61K31/337 , A61K31/407 , A61K31/575 , A61K31/685 , A61K35/19 , A61M1/10 , C12N5/0006 , C12N5/0644 , C12N2500/36 , C12N2500/62
摘要： Methods, compositions, and devices to limit, modulate, insulate, and/or otherwise alter the effects of exogenous physical stimuli on cells are described herein. The cells may be removed from the body, preferably isolated, and treated ex vivo with the composition to limit the effects of physical stimuli on the cells and then returned to the patient. Alternatively, the cells may be treated in vivo. The compositions can be administered a variety of manners, such as systemically, locally or regionally.
摘要翻译：本文描述了限制，调节，绝缘和/或以其它方式改变外源物理刺激对细胞的作用的方法，组合物和装置。细胞可以从体内移除，优选分离，并且用组合物离体处理以限制物理刺激对细胞的影响，然后返回到患者体内。或者，可以在体内处理细胞。组合物可以以各种方式施用，例如全身，局部或区域。

56. 发明公开

EP3094337A1 PHOSPHOLIPID COMPOSITIONS AND THEIR PREPARATION 有权
标题翻译： PHOSPHOLIPID-ZUSAMMENSETZUNGEN UND DEREN HERSTELLUNG
公开(公告)号：EP3094337A1
公开(公告)日：2016-11-23
申请号：EP15701109.9
申请日：2015-01-09
申请人： Aker Biomarine Antarctic AS
发明人： MYHREN, Finn , HOEM, Nils , THØGERSEN, Håvard
IPC分类号： A61K35/612 , A61K31/683 , A61K31/685
CPC分类号： A61K35/612 , A61K31/122 , A61K31/20 , A61K31/201 , A61K31/575 , A61K31/683 , A61K31/685
摘要： The invention provides improved processes for extracting and preparing polar lipids (in particular, desirable phospholipids) from krill and other biological sources. The inventors have discovered processes through which it is possible to extract phospholipids to give high phospholipid content and a reduction of undesired components.
摘要翻译：本发明提供了从磷虾和其他生物来源提取和制备极性脂质（特别是所需磷脂）的改进方法。本发明人已经发现了可以提取磷脂以提供高磷脂含量和减少不希望的组分的方法。

57. 发明公开

EP3074031A1 METHOD AND COMPOSITION FOR SYNCHRONIZING TIME OF INSEMINATION IN GILTS 审中-公开
标题翻译：新泽西州ZUSAMMENSETZUNG ZUR SYNCHRONISIERUNG DER BEFRUCHTUNGSZEIT JUNGSAUEN VERFAHREN
公开(公告)号：EP3074031A1
公开(公告)日：2016-10-05
申请号：EP14865320.7
申请日：2014-11-26
申请人： JBS United Animal Health II LLC
发明人： WEBEL, Stephen Kent , JOHNSTON, Michael E. , SWANSON, Mark E.
IPC分类号： A61K38/09 , A61K38/23
CPC分类号： A61K38/09 , A01K29/005 , A61D17/002 , A61D19/02 , A61K9/0034 , A61K9/0056 , A61K31/575 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/38
摘要： Methods and compositions for synchronizing the time of insemination in gilts are provided. More particularly, methods and compositions for synchronizing the time of insemination in gilts using a gonadotropin-releasing hormone and a hormone for synchronizing estrus are provided.
摘要翻译：提供了在后备母猪中同步授精时间的方法和组合物。更具体地，提供了使用促性腺激素释放激素和用于同步发情的激素来同步授精后备时间的方法和组合物。

58. 发明公开

EP3041477A1 DENDROGENIN A AND ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CHEMOSENSITIVE OR CHEMORESISTANT TUMORS 有权
标题翻译： DENDROGENIN A UND ANTINEOPLASTISCHE MITTEL ZUR BEHANDLUNG CHEMOSSISIERERERER CHEMORESISTENTER TUMOREN
公开(公告)号：EP3041477A1
公开(公告)日：2016-07-13
申请号：EP14759168.9
申请日：2014-09-03
申请人： Affichem , INSERM - Institut National de la Santé et de la Recherche Médicale
发明人： DE MEDINA, Philippe , PAILLASSE, Michaël , RECHER, Christian , POIROT, Marc , SILVENTE POIROT, Sandrine
IPC分类号： A61K31/575 , A61K31/58 , A61K45/06 , A61P35/00 , A61P35/02
CPC分类号： A61K31/58 , A61K31/575 , A61K31/704 , A61K33/24 , A61K33/36 , A61K45/06 , A61K2300/00
摘要： Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors. The invention concerns a kit-of-parts comprising 5α-hydroxy-6β-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3β-ol (Dendrogenin A) or a pharmaceutically acceptable salt thereof and an antineoplastic agent for use in the treatment of cancer. Furthermore, the invention concerns Dendrogenin A or a pharmaceutically acceptable salt thereof for use for treating a chemoresistant cancer.
摘要翻译： Dendrogenin A和抗肿瘤剂用于治疗化疗敏感性或化疗耐药性肿瘤。本发明涉及包含5α-羟基-6β-[2-（1H-咪唑-4-基）乙基氨基]胆甾烷-3β-醇（Dendrogenin A）或其药学上可接受的盐和抗肿瘤剂的试剂盒用于治疗癌症的药剂。此外，本发明涉及用于治疗化学耐药性癌症的Dendrogenin A或其药学上可接受的盐。

59. 发明公开

EP3040342A1 PURIFIED DEOXYCHOLIC ACID AND ITS COSMETIC USE IN THE NON-SURGICAL REMOVAL OF UNDESIRABLE FAT DEPOSITS 无效
标题翻译： CLEAN脱氧胆酸和多余脂肪堆积的非手术切除的美容用途
公开(公告)号：EP3040342A1
公开(公告)日：2016-07-06
申请号：EP15202046.7
申请日：2010-12-17
申请人： Kythera Biopharmaceuticals, Inc.
发明人： MORIARTY, Robert M. , REID, John Gregory , SWARINGEN Jr, Roy A.
IPC分类号： C07J9/00 , A61K31/575 , C07J5/00 , C07J13/00 , C07J41/00 , C07J1/00
CPC分类号： C07J9/005 , A61K31/575 , C07J1/0011 , C07J5/0053 , C07J9/00 , C07J13/007 , C07J41/0061 , Y02P20/55
摘要： Compositions of deoxycholic acid (DCA) containing a steroidal DCA precursor or by-product containing a 12.beta.-hydroxy group (in particular 12.beta.-DCA) and their use in a cosmetic method of non-surgical removal of undesirable fat deposits.
摘要翻译：的脱氧胆酸（DCA）含类固醇前体DCA或副产品含一个12.beta.羟基基团的组合物（特别是12.beta.-DCA）及其在非手术去除的不希望的脂肪的美容方法使用存款。

60. 发明授权

EP2392336B1 24-norUDCA for treating autoimmune hepatitis 有权
标题翻译： 24 norUDCA为自身免疫性肝炎的治疗
公开(公告)号：EP2392336B1
公开(公告)日：2016-06-22
申请号：EP11176271.2
申请日：2005-05-12
申请人： Medizinische Universität Graz
发明人： Trauner, Michael , Hofmann, Alan , Fickert, Peter
IPC分类号： A61K31/575 , A61P1/16 , A61P37/00
CPC分类号： A61K31/575

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