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1. 发明公开

EP3463070A1 ACOUSTOELECTRIC IMAGE-GUIDED THERAPY 审中-公开
公开(公告)号：EP3463070A1
公开(公告)日：2019-04-10
申请号：EP17807663.4
申请日：2017-06-05
申请人： The Arizona Board of Regents on behalf of the University of Arizona
发明人： WITTE, Russell , INGRAM, Charles M. , LI, Qian , QIN, Yexian
IPC分类号： A61B5/05 , A61B5/06 , A61B8/13

2. 发明公开

EP3384614A1 FAST PROBING OF SIGNAL QUALITY IN A WDM NETWORK 审中-公开
公开(公告)号：EP3384614A1
公开(公告)日：2018-10-10
申请号：EP16871699.1
申请日：2016-12-05
申请人： The Arizona Board of Regents On Behalf of the University of Arizona , The Trustees of Columbia University in the City of New York
发明人： KILPER, Daniel , AHSAN, Atiyah Sayyidah , BERGMAN, Keren
IPC分类号： H04B17/00
CPC分类号： H04B10/0775 , H04J14/0256 , H04J14/0267 , H04Q11/0062 , H04Q2011/0083
摘要： A method of interrogating a WDM optical communication system is provided to obtain one or more performance parameters. In accordance with the method, an optical probe wavelength is generated and possibly modulated in a prescribed manner. The probe signal is transmitted along a selected optical path through the WDM optical communication system for a duration of time that is less than a response time of network elements that impact signal quality along the selected optical path.

3. 发明公开

EP3326054A1 SYSTEMS AND METHODS FOR ANALYZING HEALTHCARE DATA 审中-公开
公开(公告)号：EP3326054A1
公开(公告)日：2018-05-30
申请号：EP16828488.3
申请日：2016-07-20
申请人： The Arizona Board of Regents On Behalf of the University of Arizona
发明人： SLEPIAN, Marvin, J. , RAHMAN, Fuad , MITRA, Arijit
IPC分类号： G06F3/0481 , G06F3/0484 , G06F19/00 , G06Q50/24
CPC分类号： G06F3/0481 , G06F3/0484 , G06F19/00 , G06Q50/24 , G16H10/60 , G16H50/20 , G16H50/70
摘要： Systems, methods, and software products analyze healthcare data. First input data is collected from a first source and second input data is collected from a second source disparate from the first source. The second source has a data format that is different from a format of the first source. The first input data is processed to determine a first concept and the second input data is processed to determine a second concept. A relationship between the first and second concepts is determined. The first and second concepts are stored within a knowledgebase based upon the relationship and a patient medical model is generated from the knowledgebase.

4. 发明公开

EP3207649A1 MULTI-WAVELENGTH BALANCED OPTICAL TRANSMISSION NETWORKS 审中-公开
标题翻译：多波长平衡光传输网络
公开(公告)号：EP3207649A1
公开(公告)日：2017-08-23
申请号：EP15850613.9
申请日：2015-10-14
申请人： The Arizona Board of Regents on behalf of the University of Arizona
发明人： KILPER, Daniel
IPC分类号： H04J14/02
CPC分类号： H04J14/0212 , H04B10/516 , H04J14/0221 , H04Q11/0005 , H04Q2011/0016
摘要： A method for transmitting data over an optical communication system is performed by sequentially tuning a laser beam among a plurality of optical wavelengths. At least one data signal is modulated onto the plurality of optical wavelengths by sequentially switching the modulation of the data signal among the plurality of optical wavelengths such that at any given time the data signal is only modulated onto a single one of the optical wavelengths. The sequential switching is performed at a rate equal to or greater than a response time of one or more optical amplifiers used for amplifying the optical wavelengths.
摘要翻译：通过在多个光波长中顺序调谐激光束来执行通过光通信系统传输数据的方法。通过顺序地切换多个光波长中的数据信号的调制，至少一个数据信号被调制到多个光波长上，使得在任何给定的时间，数据信号仅被调制到光波长中的单个波长上。顺序切换以等于或大于用于放大光波长的一个或多个光放大器的响应时间的速率执行。

5. 发明公开

EP3205189A1 FLOWABLE ELECTRONICS 审中-公开
标题翻译：流动电子
公开(公告)号：EP3205189A1
公开(公告)日：2017-08-16
申请号：EP15848416.2
申请日：2015-10-08
申请人： The Arizona Board of Regents on behalf of the University of Arizona
发明人： SLEPIAN, Marvin J.
IPC分类号： H05K3/00
CPC分类号： A61B5/6847 , A61B5/0024 , A61B5/04 , A61B2562/028 , A61B2562/164 , A61B2562/224 , A61N1/36 , A61N1/36125
摘要： Electronic devices and systems that overcome the limitation of stiffness and rigidity generally associated with electronics and allow for delivery via minimally invasive or percutaneous access and delivery systems are described herein. The devices and systems are able to change in size, such as from a larger electronic construct to a smaller flowable configuration. The devices and systems are configured to open or reconfigure to return to the original size and spatial dimensions at the site. In another embodiment, the devices and systems begin as a plurality of discrete electrical elements in a flowable state, and change to a non-fluent state thereby forming an electrical construct. The electrical elements are able to communicate by direct contact with each other or near field inter-device communication means. This allows the electronic device or system to be applied, adhere and conform to the underlying surface.
摘要翻译：本文描述了克服通常与电子设备相关并且允许经由微创或经皮进入和递送系统递送的刚度和刚性限制的电子设备和系统。这些装置和系统能够改变尺寸，例如从较大的电子结构到较小的可流动结构。设备和系统配置为打开或重新配置，以返回现场的原始尺寸和空间尺寸。在另一个实施例中，装置和系统开始为处于可流动状态的多个分立电气元件，并且变为非流体状态，由此形成电气构造。电气元件能够通过彼此直接接触或近场设备间通信手段进行通信。这允许电子设备或系统被施加，附着并且符合下面的表面。

6. 发明授权

EP2501795B1 ACCORDION BIOREACTOR 有权
标题翻译：手风琴生物反应器
公开(公告)号：EP2501795B1
公开(公告)日：2016-11-09
申请号：EP10832185.2
申请日：2010-11-18
申请人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
发明人： CUELLO, Joel, L. , LEY, Joesph, W.
IPC分类号： C12M1/00 , C12M3/00 , C12M1/02 , C12M1/34
CPC分类号： C12M21/02 , C12M23/04 , C12M23/20 , C12M23/22 , C12M23/26 , C12M23/34 , C12M23/44 , C12M41/08 , C12N1/12

7. 发明公开

EP3041469A1 TREATMENT AND/OR PREVENTION OF BONE METASTASIS 有权转让
标题翻译：治疗和/或骨转移的预防
公开(公告)号：EP3041469A1
公开(公告)日：2016-07-13
申请号：EP14776764.4
申请日：2014-09-04
申请人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
发明人： MEUILLET, Emmanuelle , MOSES, Sylvestor , ZHANG, Shuxing
IPC分类号： A61K31/4196 , A61K45/00 , A61K31/433 , A61K31/5365 , A61P35/00
CPC分类号： A61K31/635 , A61K31/4196 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/519 , A61K31/63 , G01N33/57434 , G01N2333/47
摘要： T-lymphocyte invasion and metastases (Tiam-1) has been identified as a marker and anti-cancer drug target for therapy of metastatic bone cancer in individuals afflicted with prostate cancer. The present disclosure provides methods and compounds for inhibiting metastases by disrupting Tiam-1 expression and activity. One particularly preferred compound comprises a disulfomanide of the formula.

8. 发明公开

EP3035950A1 GLYCOSYLATED PACAP/VIP ANALOGUES WITH ENHANCED CNS PENETRATION FOR TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译： GLYKOSYLIERTE PACAP / VIP-ANALOGA MIT VERBESSERTER PENETRATION ZUR BEHANDLUNG NEURODEGENERATIVER ERKRANKUNGEN
公开(公告)号：EP3035950A1
公开(公告)日：2016-06-29
申请号：EP14835775.9
申请日：2014-08-14
申请人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
发明人： POLT, Robin , FALK, Torsten, A E
IPC分类号： A61K38/16 , A61P25/02 , A61K38/00
CPC分类号： A61K38/1709 , A61K38/2278 , C07K2317/21 , C07K2317/41 , C12N5/0619 , G01N33/6896 , G01N2800/2814 , G01N2800/2821
摘要： A glycosylated pleiotropic peptide pituitary adenylate cyclase-activating polypeptide (PACAP) which can both agonize PAC1 receptors, causing neuroprotective effects, and antagonize VPAC receptors, causing anti-inflammation in several models of acute neuronal damage and neurodegenerative diseases, including ALS, PD, migraines, and certain forms of dementia, is described. Also described is a method of relieving symptoms of ALS, PD, migraines, and certain forms of dementia, comprising administering to a subject in need thereof an effective amount of a glycosylated PACAP.
摘要翻译：一种能够激活PAC1受体，引起神经保护作用并拮抗VPAC受体的糖基化多效肽垂体腺苷酸环化酶活化多肽（PACAP），在几种模型的急性神经损伤和神经变性疾病（包括ALS，PD，偏头痛）中引起抗炎。，以及某些形式的痴呆症。还描述了一种减轻ALS，PD，偏头痛和某些形式的痴呆症状的方法，包括向有需要的受试者施用有效量的糖基化PACAP。

9. 发明授权

EP2363146B1 Method for inhibiting metastasis in a stem cell fusion model of carcinogenesis 有权
标题翻译：在致癌作用的干细胞融合模型抑制转移方法
公开(公告)号：EP2363146B1
公开(公告)日：2015-06-24
申请号：EP11165870.4
申请日：2006-08-25
申请人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
发明人： Harris, David T. , Tsang, Tom C. , He, Xianghui , Pipes, Brian L. , Meade-Tollin, Linda C.
IPC分类号： A61K39/395 , C07K16/30 , A61P35/04
CPC分类号： C07K16/18 , A61K2039/505 , C12N5/16 , G01N33/5011

10. 发明公开

EP2847249A1 SMART POLYMER MATERIALS WITH EXCESS REACTIVE MOLECULES 审中-公开
标题翻译： INTELLIGENTE POLYMERMATERIALIEN MITÜBERSCHÜSSIGENREAKTIVENMOLEKÜLEN
公开(公告)号：EP2847249A1
公开(公告)日：2015-03-18
申请号：EP13760829.5
申请日：2013-03-13
申请人： Medipacs, Inc. , The Arizona Board Of Regents On Behalf Of The University of Arizona
发明人： BANISTER, Mark , GERONOV, Yordan , MCGRATH, Dominic
IPC分类号： C08G65/00 , C08L63/10 , C08L65/00
CPC分类号： C08G65/2624 , C08G59/22 , C08G59/504 , C08G83/004 , C08G2650/50 , C08L63/00 , C08L67/00
摘要： A three-dimensional smart polymer matrix is formed by a first epoxy chemical reaction linking a linear polymer chain and a branched polymer chain, wherein the polymer chains are flexible and one or more reactive molecule species remain unreacted, at a predetennined mathematical ratio of reacted to un-reacted molecules and molecule species, and the un-reacted molecular species are available for further chemical reaction, protonation or deprotonation after the first chemical reaction. The resulting smart polymer matrix is hydrophilic and non-soluble to a solvent or electrolyte.
摘要翻译：通过连接线性聚合物链和支链聚合物链的第一环氧化学反应形成三维智能聚合物基质，其中聚合物链是柔性的并且一个或多个反应性分子物质保持未反应，以预定的数学比率反应未反应的分子和分子物质，以及未反应的分子物质可用于在第一次化学反应后进一步的化学反应，质子化或去质子化。所得到的智能聚合物基质是亲水的并且不溶于溶剂或电解质。

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