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51. 发明公开

EP2426147A1 METHOD FOR PRODUCING ANTI-GPCR ANTIBODY AND ANTI-GPCR ANTIBODY 审中-公开
标题翻译：方法生成抗体针对GPCR和抗体的GPCR
公开(公告)号：EP2426147A1
公开(公告)日：2012-03-07
申请号：EP10758759.4
申请日：2010-03-24
申请人： Mie University
发明人： TAMARU, Yutaka
IPC分类号： C07K16/28 , C12N15/09 , G01N33/53
CPC分类号： C07K16/2869 , C07K2317/20 , G01N2333/726
摘要： Disclosed is a discussion of a method for producing anti-mammalian GPCR antibody and of the antibody itself. Anti-mammalian GPCR antibody is produced through immunization involving exposure of fish to full-length or truncated mammalian GPCR, and anti-mammalian GPCR antibody that can be obtained by this method is also discussed.
摘要翻译：公开了一种用于产生抗哺乳动物GPCR抗体和抗体本身的方法的讨论。抗哺乳动物GPCR的抗体通过免疫涉及鱼暴露于全长或截短的哺乳动物GPCR和抗哺乳动物GPCR的抗体也可以通过这种方法来获得被如此讨论制造。

52. 发明公开

EP2397557A1 Beta-1,3-glucan manufacturing method 审中-公开
标题翻译： β-1,3-葡聚糖的制造方法
公开(公告)号：EP2397557A1
公开(公告)日：2011-12-21
申请号：EP10741274.4
申请日：2010-02-11
申请人： Mie University
发明人： ISONO, Naoto , YAMAMOTO, Yutaka , SABURI, Wataru
IPC分类号： C12P19/04 , C12R1/89
CPC分类号： C12P19/04
摘要： [Object]
To provide a method that can easily produce beta-1, 3-glucan, in which several tens of glucose molecules are polymerized.
[Means for Solving]
By using beta-1,3-glucan phosphorylase derived from the genus Ochromonas, the manufacture is achieved by a polymerization reaction with glucose-1-phosphate serving as the substrate. It is preferable here that the Ochramonas genus is Ochramonas danica, that the pH during the polymerization reaction is pH 4∼8, and that the temperature is 20-50°C. It is also preferable that the beta-1, 3-glucan phosphorylase is extracted from cells of the genus Ochramonas, and it is purified to such a degree that the addition of a laminarioligosaccharide as a primer is not required during the manufacture of beta-1,3-glucan.
摘要翻译：本发明提供一种能够容易地制造数十个葡萄糖分子聚合的β-1,3-葡聚糖的方法。 [解决手段]通过使用来自Ochromonas属的β-1,3-葡聚糖磷酸化酶，通过与作为底物的葡萄糖-1-磷酸的聚合反应来实现制造。这里优选Ochramonas属为Ochramonas danica，聚合反应过程中的pH值为4〜8，温度为20〜50℃。还优选从Ochramonas属细胞中提取β-1,3-葡聚糖磷酸化酶，并将其纯化至在制造β-1期间不需要加入作为引物的海带低聚糖的程度，3葡聚糖。

53. 发明公开

EP2366741A1 POLYORGANOSILOXANE COMPOSITION, CURED PRODUCT OF THE COMPOSITION, AND METHOD FOR PRODUCING THE COMPOSITION 审中-公开
标题翻译：聚硅氧烷尺寸产品从制备该组合物组合物和方法
公开(公告)号：EP2366741A1
公开(公告)日：2011-09-21
申请号：EP09825882.5
申请日：2009-11-06
申请人： Shinshu University , Mie University , Japan Science and Technology Agency
发明人： MURAKAMI, Yasushi , KOBAYASHI, Masami , KAWASHIMA, Takuya , SHIMIZU, Wataru , NAKAMURA, Shuhei
IPC分类号： C08L83/06 , C08G79/00 , C08K5/057
CPC分类号： C08G77/398 , C08G77/16 , C08G77/58 , C08K5/057 , C08L83/04 , C08L83/14 , C08L83/06
摘要： Disclosed is an organosiloxane composition which can be produced at low cost and is usable for bonding of glasses, metals and resins. The organosiloxane composition can provide a cured product exhibiting excellent heat resistance and cold resistance, while having high strength and high transparency. Specifically disclosed is a polyorganosiloxane composition containing (A) a polyorganosiloxane wherein at least one end of each molecule is modified with a silanol group, and (B) 0.5-4.0 moles of a metal alkoxide per 1 mole of the polyorganosiloxane, wherein the mean molecular weight (Mw) of the polyorganosiloxane according to the mass fraction is not more than 1,000. Also specifically disclosed are a cured product of the composition and a method for producing the composition.
摘要翻译：本发明公开了能够以低成本制造，并且是的玻璃，金属和树脂键合可用的有机硅氧烷组合物。有机硅氧烷组合物可提供的固化物表现出优异的耐热性和耐寒性，同时具有高强度和高透明性。游离缺失具体盘是含有（A）的聚有机硅氧烷每worin分子的至少一个末端被修饰与硅烷醇基，和（B）每1个摩尔的聚有机硅氧烷的金属醇盐的摩尔数0.5-4.0的worin平均分子量的聚有机硅氧烷组合物 gemäß到的质量分数的聚有机硅氧烷的分子量（Mw）不超过1,000。所以特别游离缺失盘是组合物的固化产物和用于制备该组合物的方法。

54. 发明公开

EP1965202A2 Responsive glass membrane and glass electrode 有权转让
标题翻译： Glaselektrode
公开(公告)号：EP1965202A2
公开(公告)日：2008-09-03
申请号：EP08003378.0
申请日：2008-02-25
申请人： HORIBA, LTD. , Mie University
发明人： Nishio, Yuji , Iwamoto, Yasukazu , Tadanori, Hashimoto
IPC分类号： G01N27/36
CPC分类号： G01N27/36 , Y10T428/24999
摘要： This invention intends to provide a responsive glass membrane (3) and a glass electrode (1) comprising the responsive glass membrane to which taint is hardly attached and easily detached without hindering a function of measuring the ionic concentration.
A thin film (7) containing titanium dioxide of an anatase type is formed on a surface of the responsive glass membrane (3) and whole of the thin film is continuously formed to be an integrated body.
摘要翻译：本发明旨在提供一种响应性玻璃膜（3）和玻璃电极（1），该玻璃电极（1）包括不易附着污点的易反应玻璃膜，并且容易脱离，而不会妨碍测量离子浓度的功能。在响应性玻璃膜（3）的表面上形成含有锐钛矿型二氧化钛的薄膜（7），整个薄膜连续形成为一体。

55. 发明公开

EP1930433A1 T-CELL RECEPTOR AND NUCLEIC ACID ENCODING THE RECEPTOR 有权
标题翻译： T-ZELLREZEPTOR UNDFÜRDEN REZEPTOR CODIERENDENUKLEINSÄURE
公开(公告)号：EP1930433A1
公开(公告)日：2008-06-11
申请号：EP06797633.2
申请日：2006-09-07
申请人： Mie University , Takara Bio, Inc.
发明人： SHIKU, Hiroshi , HIASA, Atsunori , OKUMURA, Satoshi , NAOTA, Hiroaki , MIYAHARA, Yoshihiro
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/725 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4 143-151 -specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.
摘要翻译：一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽，能够构成HLA-A24限制性MAGE-A4 143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。

56. 发明公开

EP1894574A1 ANTI-CANCER AGENT COMPRISING PROTEIN C INHIBITOR 审中-公开
标题翻译： ANTIKREBSMITTEL MIT蛋白C抑制剂
公开(公告)号：EP1894574A1
公开(公告)日：2008-03-05
申请号：EP06732024.2
申请日：2006-04-18
申请人： Mie University , CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： SUZUKI, Koji
IPC分类号： A61K38/55 , A61P35/00 , A61P35/04 , A61P43/00 , C07K14/81
CPC分类号： C07K14/811 , A61K38/57
摘要： The present invention provides anti-cancer agents comprising protein C inhibitor (PCI) or derivatives thereof as an active ingredient. The anti-cancer agents of the present invention have activities of suppressing cancer cell growth, and cancer metastasis, infiltration, and angiogenesis. Further, the present invention has shown that derivatives containing a heparin-binding domain of PCI inhibit the growth, metastasis and angiogenesis of cancer cells. Therefore, according to the present invention, PCI or derivatives thereof are useful for inhibiting the growth, metastasis and angiogenesis of cancer.
摘要翻译：本发明提供包含蛋白C抑制剂（PCI）或其衍生物作为活性成分的抗癌剂。本发明的抗癌剂具有抑制癌细胞生长，癌转移，浸润和血管生成的作用。此外，本发明已经显示含有PCI的肝素结合结构域的衍生物抑制癌细胞的生长，转移和血管生成。因此，根据本发明，PCI或其衍生物可用于抑制癌症的生长，转移和血管生成。

57. 发明公开

EP1872788A1 EXTERNAL AGENT FOR TREATING WOUND 有权
标题翻译： TOPISCHES MITTEL ZUR BEHANDLUNG冯武登
公开(公告)号：EP1872788A1
公开(公告)日：2008-01-02
申请号：EP06731419.5
申请日：2006-04-07
申请人： Mie University , Maruishi Pharmaceutical Co., Ltd.
发明人： MIZUTANI, Hitoshi c/o Mie University , MIYAMOTO, Yoshiaki MARUISHI PHARMACEUTICAL CO.LTD. , NISHIKAWA, Atsushi MARUISHI PHARMACEUTICAL CO.LTD.
IPC分类号： A61K33/18 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/70 , A61K47/06 , A61K47/32 , A61K47/44 , A61P17/02
CPC分类号： A61K47/06 , A61K9/0014 , A61K9/06 , A61K31/79 , A61K33/18
摘要： [Problems] The objective is to provide a new low-toxic drug for external use for intractable diseases, such as erosion, decubitus, and skin ulcer, that prevents cicatrization and reduces iodine accumulation on wound surfaces with sufficiently promoting healing.
[Means for solving problem] Preparation of a wound treatment drug for external use containing oily bases and iodine but substantially no white soft sugar, which is a characteristic of the drug of this invention. The invented drug prevents infection through the wound surface due to a sufficient bactericidal effect of iodine, and promotes wound healing, prevents cicatrization and reduces iodine accumulation on the wound surface by maintenance of appropriate moisture in the wound surface due to a moisturizing effect of oily bases.
摘要翻译： [问题]目的是提供一种新的低毒药物，用于难治性疾病，如侵蚀，褥疮和皮肤溃疡，可防止瘢痕形成，减少伤口表面的碘积累，充分促进愈合。 [解决问题的方法]作为本发明药物特征的含有油性基质和碘但基本上不含白色软糖的外用伤口治疗药物的制备。本发明的药物由于碘的足够的杀菌作用而防止了伤口表面的感染，并且由于油性基质的保湿作用，通过维持伤口表面的适当水分，促进伤口愈合，防止瘢痕形成和减少伤口表面的碘积累。

58. 发明公开

EP1810687A1 LIVER REGENERATION/REPAIR CONTROLLING AGENT 审中-公开
标题翻译： MITTEL ZUR KONTROLLE DER LEBERREGENERATION / REPARATUR
公开(公告)号：EP1810687A1
公开(公告)日：2007-07-25
申请号：EP05793705.4
申请日：2005-10-11
申请人： Mie University , CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： SUZUKI, Koji , SAITO, Hiroyuki, c/o CHUGAI SEIYAKU K.K.
IPC分类号： A61K39/395 , A61K38/55 , A61P1/16
CPC分类号： A61K38/57 , A61K2039/505 , C07K16/38 , C07K2317/76
摘要： The present invention relates to uses of PCI, which inhibits HGFa activity, and to uses of anti-PCI antibodies, which neutralize HGFa inhibition; and to agents for regulating and controlling tissue regeneration and/or repair, with PCI as an active ingredient; and to agents for enhancing tissue regeneration and/or repair, with anti-PCI antibodies as active ingredients (particularly, anti-PCI antibodies with the action of neutralizing PCI (anti-PCI neutralizing antibodies)).
摘要翻译：本发明涉及抑制HGFa活性的PCI的用途以及中和HGFa抑制的抗PCI抗体的用途; 和用于调节和控制组织再生和/或修复的药剂，其中PCI作为有效成分; 和用于增强组织再生和/或修复的药物，其中抗PCI抗体作为活性成分（特别是具有中和PCI作用的抗PCI抗体（抗PCI中和抗体））。

60. 发明授权

EP3415159B1 PRETREATMENT DRUG FOR T CELL INFUSION THERAPY FOR IMMUNE-CHECKPOINT INHIBITOR-RESISTANT TUMOR 有权
公开(公告)号：EP3415159B1
公开(公告)日：2023-12-13
申请号：EP17750278.8
申请日：2017-02-08
发明人： SHIKU, Hiroshi , HARADA, Naozumi , MURAOKA, Daisuke , AKIYOSHI, Kazunari
IPC分类号： A61K39/00 , A61P43/00 , A61P37/04 , A61P35/00 , A61K47/36 , A61K45/00 , A61K35/17 , A61K9/14 , A01K67/027 , A61K9/00 , A61K9/51 , A61K45/06

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