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51. 发明公开

EP3136965A1 DIAGNOSTIC TOOL FOR MEASURING OSSICULAR CHAIN COMPLIANCE 审中-公开
标题翻译：诊断高血压链合规性的诊断工具
公开(公告)号：EP3136965A1
公开(公告)日：2017-03-08
申请号：EP15786131.1
申请日：2015-05-04
申请人： The Regents of the University of Colorado, a Body Corporate
发明人： CASEY, Justin
IPC分类号： A61B5/12
CPC分类号： A61B5/125 , A61B5/1126 , A61B5/6817 , A61B5/6847 , A61B17/24 , A61B17/3423 , A61B2017/3445 , A61B2017/3447 , A61B2017/345
摘要： The disclosure provides systems and methods of use pertaining to precise measurements of middle ear mechanics to aid physicians in the determination of pre-operative, intraoperative, and post-repair stiffness of the ossicular chain to assist in the diagnosis and treatment and/or repair of all types of conductive hearing loss. One embodiment provides a handheld diagnostic tool having a load cell operably coupled between a linear actuator and a rigid probe configured to rest against the ossicular chain. When the actuator displaces the load cell and the rigid probe a predetermined distance in an oscillating manner, the load cell measures a force required to displace the ossicular chain a corresponding distance. Force and displacement data is sent to a processing element, which calculates a stiffness of the ossicular chain and reports information regarding the stiffness to a display. Other embodiments are also disclosed.
摘要翻译：本公开提供了涉及精确测量中耳机械的系统和方法，以帮助医师确定听骨链的手术前，手术中和修复后僵硬，以帮助诊断和治疗和/或修复所有类型的传导性听力损失。一个实施例提供了一种手持式诊断工具，该手持式诊断工具具有可操作地联接在线性致动器和刚性探针之间的负载单元，该刚性探针被配置为抵靠听骨链。当致动器以振荡方式将测压元件和刚性探针移位预定距离时，测力传感器测量将听骨链移位相应距离所需的力。力和位移数据被发送到处理元件，处理元件计算听骨链的刚度，并将关于刚度的信息报告给显示器。其他实施例也被公开。

52. 发明公开

EP3129036A1 YEAST-BASED IMMUNOTHERAPY AND TYPE I INTERFERON SENSITIVITY 无效转让
标题翻译： HEFEBASIERTE IMMUNTHERAPIE UND TYP-I-INTERFERON-EMPFINDLICHKEIT
公开(公告)号：EP3129036A1
公开(公告)日：2017-02-15
申请号：EP15776226.1
申请日：2015-04-10
申请人： Globeimmune, Inc. , The Regents of the University of Colorado, a body corporate
发明人： BELLGRAU, Donald , KING, Thomas H.
IPC分类号： A61K35/741 , A61K36/06 , A61P31/00 , A61P35/00 , A61P33/00
CPC分类号： A61K39/0011 , A61K36/064 , A61K2039/52 , A61K2039/57 , G01N33/573 , G01N2333/555 , G01N2333/914 , G01N2800/52
摘要： Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).
摘要翻译：公开的是使用基于酵母的免疫治疗的个体进行预先选择为对I型干扰素敏感的方法，以及选择用于用酵母基免疫治疗组合物治疗的个体的方法和用于增强或改善个体对酵母 - 基于个体对1型干扰素（T1IFN）的敏感性。

53. 发明公开

EP3097443A1 OPTICAL IMAGING DEVICES AND VARIABLE-FOCUS LENS ELEMENTS, AND METHODS FOR USING THEM 有权
标题翻译：光学成像装置和使及其使用变焦和方法镜片
公开(公告)号：EP3097443A1
公开(公告)日：2016-11-30
申请号：EP15740974.9
申请日：2015-01-22
申请人： The Regents of the University of Colorado, a body corporate
发明人： GOPINATH, Juliet, T. , GIBSON, Emily, A. , BRIGHT, Victor, M. , WEIR, Richard , RESTREPO, Diego
IPC分类号： G02B3/14
CPC分类号： G02B23/243 , G02B3/14 , G02B6/06 , G02B21/0032 , G02B21/006 , G02B21/0076 , G02B23/2446 , G02B23/2469 , G02B23/26 , G02B26/005 , H04N5/2256 , H04N2005/2255
摘要： The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.
摘要翻译：本发明涉及光学成像装置和在生物和医学成像应用中是有用的方法。在一个实施方式中，在光学成像装置包括具有第一端和第二端，脉冲的红外辐射被光学耦合到所述柔性光导的第一端的源极的输出端的柔性光导; 透镜组件附接到并光学耦合到所述柔性光导的第二端，所述透镜组件包括一个可变焦距透镜元件，具有可调焦距的可变焦距透镜元件; 以及耦合到所述柔性的引导光的光检测器，以从朝向柔性光导的所述第一端的第二端检测辐射传播。的光学成像装置和方法可在两个共焦和多光子技术一起使用。

54. 发明公开

EP3057494A1 NONINVASIVE MONITORING FOR FLUID RESUSCITATION 审中-公开
标题翻译： NICHTINVASIVEÜBERWACHUNGFÜREINEFLÜSSIGKEITSWIEDERBELEBUNG
公开(公告)号：EP3057494A1
公开(公告)日：2016-08-24
申请号：EP14862921.5
申请日：2014-11-14
申请人： Flashback Technologies, Inc. , The Regents of The University of Colorado, A Body Corporate
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/021 , A61B5/1455
CPC分类号： A61B5/7275 , A61B5/002 , A61B5/02042 , A61B5/0205 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/031 , A61B5/0402 , A61B5/0476 , A61B5/0496 , A61B5/4836 , A61B5/4875 , A61B5/7267 , A61B2562/0219 , G06F19/00 , G16H50/50
摘要： Novel tools and techniques for assessing, predicting and/or estimating effectiveness of hydration of a patient and/or an amount of fluid needed for effective hydration of the patient, in some cases, noninvasively.
摘要翻译：用于评估，预测和/或估计患者水合的有效性和/或患者有效水合所需的液体量的新型工具和技术，在某些情况下，非侵入性地。

55. 发明公开

EP3041524A2 INTRAOCULAR DRUG DELIVERY AND FILTER DEVICE AND METHODS OF USING SAME 审中-公开
标题翻译： FOR USE眼内-RELEASE和过滤装置及其方法
公开(公告)号：EP3041524A2
公开(公告)日：2016-07-13
申请号：EP14842818.8
申请日：2014-09-08
申请人： The Regents of the University of Colorado, a body corporate
发明人： OLSON, Jeffrey
IPC分类号： A61L27/54
CPC分类号： A61L31/026 , A61F9/0017 , A61K9/0051 , A61K41/0028 , A61L31/028 , A61L31/146 , A61L31/16 , A61L2300/112
摘要： The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.

56. 发明授权

EP2575467B1 MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASES 有权转让
标题翻译：组蛋白的抑制剂脱乙酰酶SUITABLE大环化合物
公开(公告)号：EP2575467B1
公开(公告)日：2016-07-06
申请号：EP11787462.8
申请日：2011-05-26
申请人： The Regents of the University of Colorado, a body corporate
发明人： LIU, Xuedong , PHILLIPS, Andrew, J. , UNGERMANNOVA, Dana , NASVESCHUK, Christopher, G. , ZHANG, Gan
IPC分类号： C07K5/08 , A01N43/78 , A61K31/425
CPC分类号： C07K11/02 , A61K31/425 , A61K38/005 , A61K38/15 , A61K39/3955 , A61K45/06 , C07K5/0821 , C07K11/00

57. 发明授权

EP2803677B1 STRESS RELAXATION IN CROSSLINKED POLYMERS 有权
标题翻译：在交联聚合物应力松弛
公开(公告)号：EP2803677B1
公开(公告)日：2016-06-08
申请号：EP14173097.8
申请日：2006-02-10
申请人： The Regents of the University of Colorado, a Body Corporate
发明人： Bowman, Christopher N. , Scott, Timothy F.
IPC分类号： C08F2/46 , C08F2/50
CPC分类号： C08F2/50 , C08F2/38 , C08F293/005 , C08L51/003 , C08L53/00 , Y10S522/904 , C08L2666/02

58. 发明公开

EP3010520A1 PLANT-BASED INHIBITORS OF KETOHEXOKINASE FOR THE SUPPORT OF WEIGHT MANAGEMENT 审中-公开
标题翻译：蔬菜抑制剂Ketohexokinase支持减肥
公开(公告)号：EP3010520A1
公开(公告)日：2016-04-27
申请号：EP14736568.8
申请日：2014-06-16
申请人： Access Business Group International LLC , The Regents of the University of Colorado, a body corporate
发明人： RANA, Jatinder , RANDOLPH, Russell, Keith , SCHOLTEN, Jeffrey , LE, Myphuong, Thi , JOHNSON, Richard, J. , LANASPA GARCIA, Miguel, Angel
IPC分类号： A61K36/75 , A61K36/12 , A61K36/185 , A61K36/19 , A61K36/23 , A61K36/232 , A61K36/38 , A61K36/44 , A61K36/487 , A61K36/539 , A61K36/605 , A61K36/62 , A61K36/73 , A61P3/04 , A61P3/10
CPC分类号： A61K36/73 , A61K36/12 , A61K36/185 , A61K36/19 , A61K36/23 , A61K36/232 , A61K36/38 , A61K36/44 , A61K36/487 , A61K36/539 , A61K36/605 , A61K36/62 , A61K36/75
摘要： A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 μg/mL to about 1000 μg/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may include administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 μg/mL to about 1000 μg/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.

59. 发明公开

EP3004154A1 IL-1beta-IL-1Ra CHIMERA AND METHODS OF USING THE SAME 审中-公开
标题翻译： IL-1 BETTA IL-1RA马中皇以及它们的使用方法
公开(公告)号：EP3004154A1
公开(公告)日：2016-04-13
申请号：EP14807762.1
申请日：2014-06-05
申请人： Ben Gurion University of The Negev Research and Development Authority , The Regents of the University of Colorado, a body corporate
发明人： LEWIS, Eli , RIDER, Peleg , DINARELLO, Charles A.
IPC分类号： C07K14/545 , A61P29/00 , C07K19/00 , C12N15/62
CPC分类号： A61K38/2006 , A61K38/1709 , C07K14/47 , C07K14/545 , C07K14/7155 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C07K2319/74
摘要： The present invention provides a chimera protein made of amino acid residues derived from IL-1beta propeptide and the IL-1Ra mature peptide and polynucleotides encoding the protein. The present invention also provides usages of the protein and the polynucleotides in pharmaceutical compositions that treat inflammation.

60. 发明公开

EP2951299A1 CYSTATHIONINE BETA-SYNTHASE ENZYME FOR TREATMENT OF HOMOCYSTINURIA 无效
标题翻译： CYSTATHIONIN-BETA-SYNTHASEENZYM ZUR BEHANDLUNG VON HOMOCYSTINURIE
公开(公告)号：EP2951299A1
公开(公告)日：2015-12-09
申请号：EP14705634.5
申请日：2014-01-29
申请人： The Regents of The University of Colorado, A Body Corporate
发明人： KRAUS, Jan, P. , MAJTAN, Tomas , BUBLIL, Erez
IPC分类号： C12N9/88 , A61K38/51
CPC分类号： A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , C12Y402/01022 , A61K2300/00
摘要： The invention provides reagents and methods for enzyme replacement therapy using human cystathionine ²-synthase (CBS) homologues, variants or mutants thereof to treat homocystinuria and other related diseases and disorders.
摘要翻译：本发明提供使用化学修饰的人类胱硫醚β合成酶（CBS）来治疗同胱尿蛋白尿和其它相关疾病和病症的酶替代疗法的试剂和方法。

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