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    • 53. 发明公开
    • Tetrabromobisphenol-A process
    • 四溴双酚-A-Herstellungsverfahren。
    • EP0367869A1
    • 1990-05-16
    • EP88310440.8
    • 1988-11-07
    • ETHYL CORPORATION
    • Mitchell, Olan WayneMcKinnie, Bonnie Gary
    • C07C37/62C07C39/367B01F5/04
    • B01F5/0471B01J19/1868C07C37/62C07C39/367
    • Tetrabromobisphenol-A is made in high purity by adding a methanol-bromine solution to a methanol-­bisphenol-A solution with vigorous agitation. Use of the bromine-methanol solution reduces the amount of by-­products compared to the use of liquid bromine feed to a methanol-bisphenol-A solution. The process is readily adapted to large scale equipment by circulating the reac­tion mixture from the reaction vessel through an external closed loop which includes an impingement mixer. The bromine-methanol feed is pumped at the proper rate and ratio into the impingement mixture whereby it impinges with the circulating reaction mixture. The resultant bromination mixture is then returned to the reaction vessel.
    • 四溴双酚A通过在剧烈搅拌下向甲醇 - 双酚A溶液中加入甲醇 - 溴溶液制成高纯度。 使用溴 - 甲醇溶液与使用液体溴进料到甲醇 - 双酚A溶液相比减少了副产物的量。 通过使反应混合物通过包括冲击混合器的外部闭环循环反应混合物,该方法容易适应于大规模设备。 以适当的速率和比例将溴 - 甲醇进料泵入冲击混合物,由此与循环反应混合物碰撞。 然后将所得溴化混合物返回到反应容器中。
    • 55. 发明公开
    • Method and compositions for treating Alzheimer's disease, related dementias & epilepsy
    • 方法和用于治疗阿尔茨海默氏病,痴呆有关的癫痫和手段。
    • EP0366480A2
    • 1990-05-02
    • EP89311089.0
    • 1989-10-27
    • BAR ILAN UNIVERSITY
    • Yehuda, Shlomo
    • A61K31/20
    • A61K31/23A23L33/12A61K31/20
    • Alzheimer's disease, related dementias and epilepsy are treated by administering in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C₈₋₁₈ saturated fatty acids, oleic acid and derivatives of these acids, to a person having the symptoms thereof, or to a person susceptible to epilepsy, a symptom-alleviating amount of a composition of matter which comprises (a) from about 13.0 to about 27.5% by weight of linolenic acid and/or derivatives thereof, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and/or derivatives thereof, the derivatives of linolenic and linoleic acid being calculated as the free acids, and being both physiologically hydrolyzable and pharmacologically acceptable, or of a pharmaceutical formulation or nutritional composition containing ingredients (a) and (b) in the recited proportions.
    • 阿尔茨海默氏病,痴呆有关的癫痫和通过在不存在,它包括所述组包括C8-18饱和脂肪酸,油酸和酸合成的衍生物中的至少一个成员的油性载体或稀释剂的治疗管理,给具有人 其症状,或易患癫痫的人,无论哪个重量亚麻酸和/或其衍生物的方法包括:(a)约13.0至约27.5%的组合物的症状减轻的量,和(b)约87.0 重量的至少一种化合物的选自亚油酸和/或它们的衍生物中选择的约72.5%,亚麻酸和亚油酸的衍生物被计算为游离酸,并且是这两种生理上可水解的和药理学上可接受的,或 药物制剂或营养组合物含有成分(A)和(b)中所叙述的比例。
    • 57. 发明公开
    • Chloroethylation of aromatic hydrocarbons
    • 芳香烃的氯化
    • EP0356236A3
    • 1990-05-02
    • EP89308597.7
    • 1989-08-24
    • ETHYL CORPORATION
    • Knesel, George Albert
    • C07C22/04C07C17/26C07C57/30
    • C07C51/08C07C17/32C07C51/10C07C22/04C07C57/30
    • An aromatic hydrocarbon is chloroethylated to a 1-­chloro-1-arylethane with minimal co-formation of diaryl­alkane by-product by reacting it with hydrogen chloride and acetaldehyde at a temperature in the range of -10°C to -35°C in the presence of at least about 1.4 mols of hydro­gen sulfate per mol of the aromatic hydrocarbon and in the absence of more than about 15% by weight of water, based on the weight of the hydrogen sulfate. The process is of particular advantage in the chloroethylation of the less reactive aromatic hydrocarbons, such as isobutylbenzene and other monoalkylaromatic hydrocarbons, which have previously yielded an undesirable amount of diarylalkane when chloroethylated with acetaldehyde.
    • 芳族烃被氯乙基化成1-氯-1-芳基乙烷,其中二芳基烷烃副产物在-10℃〜-35℃的温度范围内与氯化氢和乙醛反应最少,在 基于硫酸氢盐的重量,每摩尔芳族烃存在至少约1.4摩尔硫酸氢盐,并且在不存在大于约15重量%的水的情况下。 该方法在较少反应性的芳族烃例如异丁基苯和其它单烷基芳族烃的氯乙基化中是特别有利的,当用乙醛氯乙基化时,其已经产生了不需要量的二芳基烷烃。
    • 60. 发明公开
    • Bromoethylation of aromatic hydrocarbons
    • Verfahren zur Bromethylierung von aromatischen Kohlenwassertoffen。
    • EP0356235A2
    • 1990-02-28
    • EP89308596.9
    • 1989-08-24
    • ETHYL CORPORATION
    • Knesel, George Albert
    • C07C22/04C07C17/26C07C57/30
    • C07C51/08C07C17/32C07C51/10C07C22/04C07C57/30
    • An aromatic hydrocarbon is bromoethylated to a 1-bromo-1-arylethane with minimal co-formation of diaryl­alkane by-product by reacting it with hydrogen bromide and acetaldehyde at a temperature in the range of +10°C to -35°C in the presence of at least about one mol of hydro­gen sulfate per mol of the aromatic hydrocarbon and in the absence of more than bout 15% by weight of water, based on the weight of the hydrogen sulfate. The process is of particular advantage in the bromoethylation of the less reactive aromatic hydrocarbons, such as isobutylbenzene and other monoalkylaromatic hydrocarbons, which have previously yielded an undesirable amount of diarylalkane when bromoethylated with acetaldehyde and hydrogen bromide.
    • 通过在+10℃至-35℃的温度范围内与溴化氢和乙醛反应,芳基烃被溴乙基化成1-溴-1-芳基乙烷,同时最小程度地与二芳基烷烃副产物共形成 每摩尔芳族烃存在至少约1摩尔硫酸氢盐,并且基于硫酸氢盐的重量,不存在15重量%以上的水。 该方法在反应活性较低的芳族烃例如异丁基苯和其它单烷基芳族烃的溴乙基化中具有特别的优点,当用乙醛和溴化氢溴乙基化时,其已经预先产生不需要量的二芳基烷烃。