专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

EP1083824B1 KALIBRIERUNGSFLUID FÜR EINEN SENSOR ZUR MESSUNG EINES BLUTWERTES, SOWIE HERSTELLUNG DES KALIBRIERUNGSFLUIDS 有权
标题翻译：的校准流体传感器，用于测量血值，校准流体的产出
公开(公告)号：EP1083824B1
公开(公告)日：2009-03-18
申请号：EP99936403.7
申请日：1999-06-02
申请人： SPHERE Medical Limited
发明人： GUMBRECHT, Walter
IPC分类号： A61B5/00
CPC分类号： G01N33/96 , G01N2496/70 , Y10T436/10 , Y10T436/109163
摘要： Das Kalibrierungsfluid besteht aus einem biokompatiblen Elektrolyten, der bei 37 DEG C eine Konzentration von Bikarbonat-Ionen, die im normalen physiologischen Bereich der Konzentration der Bikarbonat-Ionen des Blutes liegt, einen pH-Wert, der in einem den Wert 7,41 enthaltenden pH-Wertebereich innerhalb von 2 bis 13 liegt, und eine bestimmte Ionenstärke aufweist. Um eine Kalibrierung des Sensors (1, 2, 3) mit einer im Vergleich zu einem bekannten derartigen Kalibrierungsfluid höheren Präzision sowohl in vivo als auch in vitro zu ermöglichen, ist die Ionenstärke des Fluids bei 37 DEG C so gewählt, dass sie im normalen physiologischen Bereich der Ionenstärke des Blutes liegt.

42. 发明授权

EP1412739B1 HEMATOLOGY CONTROL PRODUCT WITH INCREASED CLOSED VIAL STABILITY 有权
标题翻译：控制产品用于血液学稳定性增加密封容器中
公开(公告)号：EP1412739B1
公开(公告)日：2008-12-31
申请号：EP02748163.9
申请日：2002-07-15
申请人： Beckman Coulter, Inc.
发明人： ELLIOTT, Michael , JACOBS, Dana, B. , ORTIZ, Nery , GOLDSON, Wayne , WHITLEY, Penny , GERULA, Theodore, J.
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/105831 , Y10T436/106664 , Y10T436/108331
摘要： An improved blood suspension media for hematological compositions, having particular utility with a red blood cell component for devices using electronic and optical means for blood determinations, and processes for using the suspension media. The suspension media finds particular utility in providing the hematology control product with a stable and consistent MCV and RDW for an extended product shelf life.

43. 发明公开

EP2005181A1 STANDARD C4D / C4B POUR CYTOMETRIE DE FLUX QUANTITATIVE DU REJET HUMORAL DE TRANSPLANTATION 审中-公开
标题翻译： C4D / C4B标准定量流式细胞术检测体液移植排斥反应
公开(公告)号：EP2005181A1
公开(公告)日：2008-12-24
申请号：EP07731235.3
申请日：2007-03-30
申请人： Université De Reims Champagne-Ardenne
发明人： COHEN, Jacques, Henri, Max , REVEIL, Brigitte , KISSERLI, Aymric , HAIDAR, Fadi , DONVITO, Béatrice
IPC分类号： G01N33/564
CPC分类号： G01N33/96 , G01N33/564 , G01N2333/4716 , G01N2800/245 , Y10T436/105831 , Y10T436/13
摘要： The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient.

44. 发明公开

EP2000800A2 Clinical method for the genetic screening of newborns using tandem mass spectrometry 有权
标题翻译：新生儿的遗传样品的临床方法使用串联质谱
公开(公告)号：EP2000800A2
公开(公告)日：2008-12-10
申请号：EP08161251.7
申请日：2000-07-07
申请人： PerkinElmer Genetics, Inc.
发明人： Chace, Donald H.
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/6848 , G01N33/5091 , G01N33/6812 , G01N33/96 , G01N2800/50 , G01N2800/60 , Y10T436/24
摘要： A high-throughput method for screening newborns using electrospray tandem mass spectrometry (12). The method improves the current protocols using tandem mass spectrometry to provide accurate and consistent results at the clinical level through enhanced quality assurance and quality control (18) protocols for scan profiling and sample preparation (10) of blood from newborns. Precise concentrations of specific internal standards are used to distinguish twenty metabolites. Spectra of the samples are scanned and vigorously compared to known spectra as part of a diagnostic interpretation system (16). Quality assurance flags step compare peaks, metabolite concentration and scan intensities to a range of thresholds to determine whether or not the sample is contaminated, drug-ridden, diagnosable or unacceptable. All results and quality assurance flags are organized for post-acquisition data processing and data reduction (14) where values are compiled and stored for daily output results and trend analysis.
摘要翻译：使用电喷雾串联质谱（12）筛选的新生儿的高通量方法。该方法提高了使用串联质谱法以提供在临床水平通过加强质量保证和质量控制（18），用于扫描分析和从新生儿的血液样品制备（10）协议准确和一致的结果的当前协议。的特定的内部标准精确浓度被用于区分20种代谢物。样品的光谱扫描并剧烈相比已知的光谱作为诊断解释系统（16）的一部分。质量保证标志步骤比较峰，代谢物浓度和扫描强度的范围的阈值来确定的矿井样品是否被污染，药物丛生，可诊断或不可接受的。所有的结果和质量保证标志组织收购后的数据处理，并且其中值被编译并存储日产量结果和趋势分析数据缩减（14）。

45. 发明授权

EP1397388B1 FXIII SUBUNIT A DETECTION FOR VERIFYING SERUM SAMPLE 有权
标题翻译： FXIIIA-PROOF进行验证血清样本
公开(公告)号：EP1397388B1
公开(公告)日：2008-10-15
申请号：EP02726954.7
申请日：2002-05-28
申请人： BIO-RAD LABORATORIES, INC.
发明人： BINDER, Steven, R. , GOODRICH, Jodi, L. , SAFARIAN, Zara
IPC分类号： C07K16/36 , C07K16/00 , G01N33/96
CPC分类号： G01N33/96 , G01N2333/9108 , Y10S435/973
摘要： Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. For serum samples, a negative result of an analysis for the presence of subunit a is a means of verifying that a sample is indeed serum, while a negative or positive result for subunit a serves to distinguish serum (negative) from plasma (positive). A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.

46. 发明公开

EP1688438A3 FXIII subunit b detection for verifying serum sample and sample size and for detecting dilution 有权
标题翻译： FXIII B亚基检测血清样品和样本大小的核实和用于检测稀释的
公开(公告)号：EP1688438A3
公开(公告)日：2008-07-02
申请号：EP06006417.7
申请日：2002-05-28
申请人： BIO-RAD LABORATORIES, INC.
发明人： Binder, Steven R. , Goodrich, Jodi L. , Safarian, Zara
IPC分类号： C07K16/36 , C07K16/00 , G01N33/96
CPC分类号： G01N33/96 , G01N2333/9108 , Y10S435/973
摘要： Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.

47. 发明授权

EP1021728B8 ASSAYS, ANTIBODIES, AND STANDARDS FOR DETECTION OF OXIDIZED AND MDA-MODIFIED LOW DENSITY LIPOPROTEINS 失效
标题翻译：用于检测氧化和MDA修饰的低密度脂蛋白的测定，抗体和标准
公开(公告)号：EP1021728B8
公开(公告)日：2008-04-23
申请号：EP97930493.8
申请日：1997-07-01
申请人： Leuven Research & Development vzw
发明人： HOLVOET, Paul, Noel , COLLEN, Désiré, José
IPC分类号： G01N33/92 , G01N33/96 , C07K16/44 , G01N33/577 , C12P21/08
CPC分类号： C07K16/18 , G01N33/92 , G01N33/96 , G01N2800/044
摘要： Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrator and/or control) are disclosed. MDA-modified LDL and OxLDL are implicated in atherosclerosis and its etiology.
摘要翻译：用于测定的丙二醛修饰的低密度脂蛋白（MDA修饰的LDL）和氧化的低密度脂蛋白（OxLDL），单克隆抗体（和它们的细胞系）的免疫测定和储存稳定标准（可以使用作为校准器和/或控制器）。 MDA修饰的LDL和OxLDL与动脉粥样硬化及其病因有关。

48. 发明授权

EP0997735B1 Stabilisierung von biologischen Flüssigkeiten durch Zusatz von Sterinestern 有权
标题翻译：通过添加植物甾醇酯的生物液体的稳定
公开(公告)号：EP0997735B1
公开(公告)日：2008-01-30
申请号：EP99119336.8
申请日：1999-09-29
申请人： Dade Behring Marburg GmbH
发明人： Althaus, Harald
IPC分类号： G01N33/96
CPC分类号： G01N33/96 , G01N33/743 , G01N33/92 , G01N2496/05 , Y10T436/10 , Y10T436/104165 , Y10T436/105831 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/2525

49. 发明公开

EP1869977A1 Suspension medium for red blood cells 有权转让
标题翻译： Verwendung eines悬挂中药Blutkörperchen
公开(公告)号：EP1869977A1
公开(公告)日：2007-12-26
申请号：EP07380137.5
申请日：2007-05-14
申请人： Grifols, S.A.
发明人： Martorell Pena, Daniel , Través Polo, Mª del Carmen , Farré León, Jordi , Castells Parera, Josefina
IPC分类号： A01N1/02 , A61K35/14 , A61K35/18
CPC分类号： G01N33/80 , A01N1/02 , A01N1/0226 , G01N33/96 , Y10T436/108331
摘要： The suspension medium for red blood cells comprises a combination of amino acids of any group, as well as phosphate buffer, sodium chloride, glucose, adenine, preservatives, EDTA and glycine, and also inosine, citrate, citric acid and bicarbonate, the concentrations of the amino acids being higher than those necessary for reducing the ionic strength.
摘要翻译：用于红细胞的悬浮介质包括任何组的氨基酸以及磷酸盐缓冲液，氯化钠，葡萄糖，腺嘌呤，防腐剂，EDTA和甘氨酸以及肌苷，柠檬酸盐，柠檬酸和碳酸氢盐的组合，其浓度氨基酸高于降低离子强度所需的氨基酸。

50. 发明公开

EP1869457A1 A METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE 失效转让
标题翻译：区分同一化验含有血液和控制解决方案之间的方法
公开(公告)号：EP1869457A1
公开(公告)日：2007-12-26
申请号：EP05854032.9
申请日：2005-12-12
申请人： Bayer HealthCare LLC
发明人： MARFURT, Karen, L.
IPC分类号： G01N33/50 , G01N33/96
CPC分类号： G01N33/66 , G01N1/28 , G01N33/96 , Y10T436/10 , Y10T436/110833 , Y10T436/144444
摘要： Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式