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41. 发明公开

EP2833140A4 METHOD FOR DETECTING BIOLOGICAL MATERIAL 有权
标题翻译： VERFAHREN ZUM NACHWEIS VON生物化学材料
公开(公告)号：EP2833140A4
公开(公告)日：2015-12-09
申请号：EP13770335
申请日：2013-03-28
申请人： KONICA MINOLTA INC
发明人： TAKANASHI KENSAKU , GOUDA HIDEKI , TAKANO KEIZU , HOSHINO HIDEKI , NAKANO YASUSHI , GONDA KOHSUKE , OHUCHI NORIAKI , WATANABE MIKA
IPC分类号： G01N33/53 , B82Y30/00 , G01N1/28 , G01N1/30 , G01N33/533 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54393 , B82Y30/00 , G01N1/30 , G01N33/533 , G01N33/582 , G01N33/585
摘要： The present invention provides a staining method in which the fluorescent staining properties in a fluorescently-immunostained specimen are not reduced even when an oil-based mounting medium is used. The present invention also provides a method of preventing deterioration of a fluorescent label caused by irradiation with excitation light and improving the light resistance in a fluorescently-immunostained specimen obtained by the staining method. The biological substance detection method according to the present invention is a biological substance detection method for specifically detecting a biological substance from a pathological specimen, which comprises the steps of: immunostaining the specimen with a fluorescent label; immobilizing the thus stained specimen; and mounting the thus immobilized specimen using a mounting medium comprising an organic solvent not freely miscible with water. In the biological substance detection method, the above-described mounting medium further comprises a discoloration inhibitor.
摘要翻译：本发明提供了即使使用油性安装介质时，荧光免疫染色试样中的荧光染色性也不会降低的染色方法。本发明还提供一种防止由激发光照射引起的荧光标记的劣化，并提高通过染色法得到的荧光免疫染色试样的耐光性的方法。根据本发明的生物物质检测方法是从病理标本特异性检测生物体的生物物质检测方法，其特征在于，包括以下步骤：用荧光标记物免疫染色标本; 固定如此染色的样品; 并且使用包含不能与水自由混溶的有机溶剂的安装介质来安装如此固定的样品。在生物物质检测方法中，上述安装介质还包含变色抑制剂。

42. 发明公开

EP2916835A1 COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE 审中-公开
标题翻译：化合物及其制备方法的共轭
公开(公告)号：EP2916835A1
公开(公告)日：2015-09-16
申请号：EP13853588.5
申请日：2013-09-11
申请人： Redwood Bioscience, Inc.
发明人： KUDIRKA, Romas Alvydas , ALBERS, Aaron Edward , RABUKA, David
IPC分类号： A61K31/4152 , A61K39/00
CPC分类号： A61K47/48061 , A61K38/10 , A61K47/48215 , A61K47/48384 , A61K47/48584 , A61K47/48715 , A61K47/545 , A61K47/60 , A61K47/6803 , A61K47/6855 , A61K47/6889 , A61K49/0041 , A61K49/0058 , C07D231/20 , C07D405/04 , C07K16/22 , C07K16/40 , C12N9/12 , C12N9/96 , C12Y207/10001 , G01N33/533
摘要： The present disclosure provides conjugate structures and compound structures used to produce these conjugates. Also provided are methods of producing drug-polypeptide or detectable label-polypeptide conjugates linked through a modified amino acid. Structures of the modified amino acids used in producing the conjugates are disclosed.

43. 发明公开

EP2895858A1 VERFAHREN ZUM MARKIEREN ODER IMMOBILISIEREN EINER ZIELSTRUKTUR 有权
标题翻译：程序标记或固定目标结构
公开(公告)号：EP2895858A1
公开(公告)日：2015-07-22
申请号：EP13760057.3
申请日：2013-09-13
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： SZARDENINGS, Michael , GRUNWALD, Ingo , RISCHKA, Klaus , RICHTER, Katharina
IPC分类号： G01N33/533 , A61K47/48
CPC分类号： C12Q1/26 , A61K47/542 , G01N33/532 , G01N33/533
摘要： Method for marking a target structure, comprising the steps of: a) providing a compound V which comprises at least one dihydroxy- or trihydroxyphenyl group, b) providing a means for converting the dihydroxy- or trihydroxyphenyl group into a quinone group, c) providing a target structure, d) oxidizing the dihydroxy- or trihydroxyphenyl group of compound V to form the quinone group, and e) establishing contact between compound V and the target structure, with the result that a covalent bond can be formed, characterized in that, in step e), compound V is used in a concentration such that the maximum concentration of dihydroxy-, trihydroxyphenyl groups and quinone groups which have been introduced by compound V is ≤500 µM, preferably ≤300 µM, more preferably ≤100 µM.

44. 发明公开

EP2748615A4 DEVELOPMENT AND USE OF FLUORESCENT PROBES OF UNBOUND BILIRUBIN 有权
标题翻译：开发与未结合胆红素的荧光探针的用途
公开(公告)号：EP2748615A4
公开(公告)日：2015-07-08
申请号：EP12827317
申请日：2012-08-24
申请人： KLEINFELD ALAN M
发明人： HUBER ANDREW HENRY , KAMPF JAMES PATRICK , KWAN THOMAS , ZHU BAOLONG
IPC分类号： G01N33/72 , C07K14/47 , G01N33/533 , G01N33/68 , G06F17/10
CPC分类号： G01N33/728 , C07K14/47 , G01N21/6428 , G01N33/533 , G01N33/582 , G01N33/92 , G01N2800/52 , Y10T436/146666
摘要： Identification and use of proteins fluorescently labeled and that undergo a change in fluorescence index upon binding bilirubin are described. Probes are disclosed which are labeled at a cysteine or lysine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for determination of unbound bilirubin levels in a fluid sample.

45. 发明公开

EP2780480A4 GAMMA-PNA MINIPROBES FOR FLUORESCENT LABELING 失效转让
标题翻译： GAMMA-PNA MINISONDEN ZUR FLUORESZENZMARKIERUNG
公开(公告)号：EP2780480A4
公开(公告)日：2015-06-10
申请号：EP12849889
申请日：2012-11-14
申请人： UNIV CARNEGIE MELLON , UNIV PITTSBURGH
发明人： ARMITAGE BRUCE A , OPRESKO PATRICIA L , LY DANITH , SHANK NATHANIEL
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/533
CPC分类号： C12Q1/6825 , C12N15/113 , C12N2310/3181 , C12N2320/10 , C12Q1/6816 , G01N33/533 , C12Q2525/107 , C12Q2565/101
摘要： A category of γPNA miniprobes and chimeric γPNA probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes to the telomeres, allowing direct visualization of telomeres in cells.
摘要翻译：一类γPNA小分子和嵌合γPNA探针特别适用于检测细胞样品中的RNA和端粒DNA。特别地，探针可以用于将荧光染料递送到端粒，允许在细胞中直接观察端粒。

46. 发明公开

EP2870244A2 SCALABLE BIO-ELEMENT ANALYSIS 有权
标题翻译：可扩展的生物元素分析
公开(公告)号：EP2870244A2
公开(公告)日：2015-05-13
申请号：EP13813011.7
申请日：2013-06-26
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： DIMOV, Ivan, K. , BAER, Thomas, M.
IPC分类号： C12N15/10
CPC分类号： G05B19/124 , B82Y15/00 , C12N15/1065 , G01B11/022 , G01N21/6428 , G01N33/53 , G01N33/5308 , G01N33/533 , G01N33/54313 , G01N33/54373 , G01N33/582 , G01N33/588 , G01N35/1095 , G01N2001/002 , G01N2015/0011 , G05B2219/23189 , G05B2219/24165 , G06K7/10762 , G06K7/1417 , H04N17/002
摘要： A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.
摘要翻译：提供了用于检测样品中的一种或多种分析物的方法。该方法部分依赖于添加到样品中的官能化颗粒部分或完全抑制电磁辐射通过容纳样品的反应容器中的检测表面进入和流出样品的能力。在微阵列格式中，本发明可用于筛选数百万，数十亿或更多生物元素，如生物体，细胞，蛋白质，核酸，脂质，糖类，代谢物或小分子。描述了方法，装置和套件。

47. 发明公开

EP2862871A1 Plectin-1 targeted agents for detection and treatment of pancreatic ductal adenocarcinoma 无效
标题翻译：针对网蛋白1-剂胰腺导管腺癌的检测和治疗
公开(公告)号：EP2862871A1
公开(公告)日：2015-04-22
申请号：EP14190585.1
申请日：2009-04-14
申请人： The General Hospital Corporation
发明人： Kelly, Kimberley , Weissleder, Ralph , Bardeesy, Nabeel
IPC分类号： C07K7/06 , A61K49/14 , A61K38/08 , G01N33/574 , G01N33/68 , C07K16/18
CPC分类号： A61K49/14 , A61K38/00 , A61K38/08 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/1818 , B82Y5/00 , C07K7/06 , C07K16/18 , G01N33/531 , G01N33/533 , G01N33/54326 , G01N33/54346 , G01N33/57438
摘要： Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying "accessible" proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.
摘要翻译：描述的组合物和用于癌症细胞的生物标记物的方法：如胰腺导管腺癌（PDAC）细胞的生物标记物，以及用于诊断和治疗癌症，E. G.，PDAC结合分子。确定“进入”蛋白质组的方法是游离缺失盘用于鉴定癌症生物标志物：如网蛋白1，PDAC生物标志物。此外，成像组合物被提供缀合的肽配体用于鉴定的PDAC包括magnetofluorescent纳米颗粒。

48. 发明公开

EP2753924A4 METHODS AND COMPOSITIONS FOR CYTOMETRIC DETECTION OF RARE TARGET CELLS IN A SAMPLE 有权
标题翻译：方法和组合物检测稀有细胞计数的靶细胞在样本
公开(公告)号：EP2753924A4
公开(公告)日：2015-04-22
申请号：EP12830820
申请日：2012-09-06
申请人： BECTON DICKINSON CO
发明人： KIRAKOSSIAN HRAIR , GOLDBERG EDWARD , RECKTENWALD DIETHER
IPC分类号： G01N33/574 , G01N15/14
CPC分类号： G01N33/56966 , G01N15/1459 , G01N33/533 , G01N33/56972 , G01N33/57484 , G01N33/57492 , G01N33/57496 , G01N2015/1402 , G01N2015/1477
摘要： The present disclosure provides cytometric methods for the detection of rare target cells in a sample. In certain aspects, the methods and compositions may facilitate the detection of rare target cells, such as circulating tumor cells (CTCs), in a biological sample such as blood. Aspects of the methods include contacting the sample with first and second binding members that specifically bind to a marker of the rare target cell, and cytometrically assaying the sample for the presence of cells comprising bound first and second binding members to detect the rare target cell in the sample. Also provided are systems, compositions, and kits for practicing the subject methods.
摘要翻译：本发明提供一种用于检测样品中的罕见的靶细胞的流式细胞术方法。在某些方面，该方法和组合物可以促进稀有靶细胞的检测，循环肿瘤细胞：生物样品中的如（的CTC）：诸如血液。的方法的各方面包括使与第一样品和第二结合成员并特异性地结合至该稀少目标细胞的标志物，并进行细胞计数测定为细胞的存在的样品，其包括结合第一和第二结合成员来检测稀少目标细胞中样品。因此，提供了系统，组合物和用于实施本发明方法的试剂盒。

49. 发明公开

EP2839284A1 A MICROPARTICLE ASSEMBLY 有权
标题翻译：微粒安排
公开(公告)号：EP2839284A1
公开(公告)日：2015-02-25
申请号：EP13793390.9
申请日：2013-05-22
申请人： National University of Singapore
发明人： TRAU, Dieter , LEAR, Martin James , OCHS, Christopher
IPC分类号： G01N33/542 , G01N33/533
CPC分类号： G01N21/6428 , G01N33/533 , G01N33/542 , G01N33/5432 , G01N33/54353 , G01N33/545 , G01N33/582 , G01N2021/6432 , Y10T428/2982
摘要： A bead construct includes a bead, a fluorophore molecule, first and second linker molecules and a ligand molecule. The fluorophore molecule comprises at least two subunits connected to each other by at least one internal linker that provides conformational freedom to the at least two subunits. An optical signal emitted by the fluorophore molecule changes when reducing the conformational freedom of the at least two subunits to each other. The first linker molecule is connected to the bead and to one of the subunits of the flurophore molecule. The second linker molecule is connected to another one of the subunits of the fluorophore molecule. The ligand molecule is connected to the second linker molecule.

50. 发明公开

EP2821793A1 Development and use of fluorescent probes of unbound analytes 有权
标题翻译：分析和分析Fluoreszenzsonden ungebundener分析
公开(公告)号：EP2821793A1
公开(公告)日：2015-01-07
申请号：EP14177527.0
申请日：2005-03-21
申请人： FFA Sciences, LLP
发明人： Kleinfeld, Alan, Marc , Huber, Andrew, Henry , Kampf, James, Patrick , Kwan, Thomas , Zhu, Baolong
IPC分类号： G01N33/92 , G01N33/58 , G01N33/533 , G01N33/72 , C12P21/02
CPC分类号： C12P21/02 , G01N33/533 , G01N33/582 , G01N33/728
摘要： A method for high throughput screening of probes is described. These probes are useful for characterization and measurement of unbound metabolites in a fluid sample, particularly characterization and measurement of levels of unbound free fatty acids. By practice of the disclosed invention, a profile of unbound metabolites can be determined for an individual which can be used to determine the individual's relative risk for disease such as stroke, cardiac disease and cancer.
摘要翻译：描述了探针的高通量筛选方法。这些探针可用于表征和测量流体样品中未结合的代谢物，特别是未结合的游离脂肪酸的表征和测量。通过实践所公开的发明，可以确定可以用于确定个体相对于疾病如中风，心脏病和癌症的相对风险的个体的未结合代谢物的概况。

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