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41. 发明公开

EP2782587A4 STEM CELL-DERIVED NEURAL CELLS FOR CELL THERAPY IN NEUROLOGICAL DISORDERS 审中-公开
标题翻译： AUS STAMMZELLEN GEWONNENE NERVENZELLEN ZUR ZELLTHERAPIE BEE神经病学KRANKHEITEN
公开(公告)号：EP2782587A4
公开(公告)日：2015-05-27
申请号：EP12852394
申请日：2012-11-21
申请人： UNIV RAMOT
发明人： PITARU SANDU , GANZ JAVIER , OFFEN DANIEL , MELAMED ELDAD
IPC分类号： A61K35/12 , A61K48/00 , A61P25/00 , A61P25/16 , A61P25/28 , C12N5/0797
CPC分类号： A61K35/30 , A61K2035/124 , C12N5/0619 , C12N5/0622 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/135 , C12N2501/41 , C12N2501/415 , C12N2501/999 , C12N2506/097
摘要： The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
摘要翻译：本发明提供了从口腔粘膜成体干细胞分化的神经细胞用于神经和精神疾病和病症的细胞治疗的方法和用途。还提供了将口腔粘膜干细胞分化为神经元或神经元支持细胞的方向的方法。

42. 发明授权

EP2248899B1 NOGO receptor binding protein 失效转让
标题翻译： NOGO受体结合蛋白
公开(公告)号：EP2248899B1
公开(公告)日：2015-05-06
申请号：EP10171533.2
申请日：2004-03-17
申请人： Biogen Idec MA Inc.
发明人： Mi, Sha , McCoy, John , Pepinsky, R., Blake , Lee Daniel, H. S. , Lugovskoy, Alexey, A.
IPC分类号： A61K38/00 , C07K16/18 , C07K16/28 , C07K14/47 , C07K14/705 , G01N33/50 , G01N33/68
CPC分类号： G01N33/56966 , A61K38/00 , C07K14/4702 , C07K14/70571 , C07K16/18 , C07K16/2803 , C07K2319/30 , C12N5/0619 , C12N2500/46 , G01N33/5058 , G01N33/6896

43. 发明公开

EP2843049A4 NEURONAL DIFFERENTIATION PROMOTER 有权
标题翻译：启动子神经分化
公开(公告)号：EP2843049A4
公开(公告)日：2015-04-22
申请号：EP13781077
申请日：2013-04-26
申请人： UNIV KEIO
发明人： KANEDA HAYATO , OKANO HIDEYUKI , SHIMAZAKI TAKUYA
IPC分类号： C12N15/09 , A61K31/4439 , A61K31/7088 , A61K31/7105 , A61K35/76 , A61K45/00 , A61K48/00 , A61P25/00 , A61P25/14 , A61P25/28 , A61P43/00 , C12N5/0797 , C12N5/10 , C12N15/113
CPC分类号： C12N5/0623 , A61K31/4439 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K35/30 , C12N5/0619 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2501/65 , C12N2501/727 , C12N2501/999 , C12N2506/08 , C12Y207/11024
摘要： The present invention provides an agent for promoting neuronal differentiation of neural stem cells, which contains a p38 inhibitor. In addition, the present invention provides a method of promoting neuronal differentiation of neural stem cells, which includes cultivating neural stem cells in the presence of a p38 inhibitor. Neural stem cells are gliogenic or neurogenic. The p38 inhibitor is a nucleic acid which hybridizes to DNA or mRNA encoding p38 under physiological conditions, thereby inhibiting the transcription and/or translation thereof, an expression vector of the nucleic acid, a low molecular p38 inhibitor and the like.

44. 发明公开

EP2857519A1 Cell line, system and method for optical control of secondary messengers 有权
标题翻译： Zelllinie，System und Verfahren zur optischen Steuerung vonsekundärenBotenstoffen
公开(公告)号：EP2857519A1
公开(公告)日：2015-04-08
申请号：EP14191235.2
申请日：2009-05-29
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Airan, Raag D. , Disseroth, Karl
IPC分类号： C12P21/06 , C12P21/04
CPC分类号： C07K14/723 , A61B5/0059 , A61B5/4848 , A61K41/00 , A61K48/0058 , A61K49/00 , A61N5/062 , C07K14/705 , C07K14/70571 , C07K2319/00 , C12N5/0619 , C12N13/00 , C12N2510/00 , G01N33/5035 , G01N2333/726
摘要： A variety of methods, devices and compositions are implemented for light- activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alphal, Beta2)}. The light responsive membrane protein is expressed in a cell for producing a secondary messenger in response to light.
摘要翻译：多种方法，装置和组合物被实现用于光活化分子。实现一种这样的方法用于在小区中生成次要信使。用一个或多个异源受体亚单位（例如肾上腺素能受体（alphal，β2）}修饰用于表达嵌合光响应性膜蛋白（例如视紫质）的核苷酸序列。光响应膜蛋白在用于产生响应于光的第二信使的细胞中表达。

45. 发明公开

EP2845899A1 Dopaminergic neuron-like cell cluster and method for preparing the same 有权
标题翻译：多巴胺神经元ähnlicherZellhaufen und Verfahren zur Herstellung davon
公开(公告)号：EP2845899A1
公开(公告)日：2015-03-11
申请号：EP14179316.6
申请日：2014-07-31
申请人： Daegu Gyeongbuk Institute of Science and Technology
发明人： Jeon, Won Bae , Lee, Kyeong Min , Jung, Gwon Soo
IPC分类号： C12N5/0793
CPC分类号： C12N5/0619 , C12N2501/01 , C12N2501/113 , C12N2501/727 , C12N2501/999 , C12N2533/50
摘要： Disclosed are a dopaminergic neuron-like cell cluster exhibiting a far higher level of a dopaminergic neuron marker, compared to conventional 2D or 3D cultured cells, and a method for preparing the same. The cell cluster can be more effectively differentiated into dopaminergic neurons in the presence of a differentiation-inducing factor, so that it is suitable for use in studying neurodegenerative diseases such as Parkinson's disease. In addition, the cell cluster can express factors reinforcing intercellular interaction at an improved level, and is free of cellular toxicity and safe to the body, easy to culture with high productivity, superior in biocompatibility, and highly unlikely to undergo mutations. Also provided is a dish for culturing a 3D dopaminergic neuron-like cell cluster on a mass scale; which guarantees the 3D dopaminergic neuron-like cell cluster superior biocompatibility, freedom of cellular toxicity, minimal mutagenicity, and improvement in the expression of factors reinforcing intercellular interaction.
摘要翻译：与传统的2D或3D培养细胞相比，公开了表现出更高水平的多巴胺能神经元标记物的多巴胺能神经元样细胞簇及其制备方法。在分化诱导因子的存在下，细胞簇可以更有效地分化为多巴胺能神经元，使其适用于研究神经变性疾病如帕金森病。此外，细胞簇可以表达增强细胞间相互作用的因子，并且没有细胞毒性并且对身体安全，容易以高生产率培养，生物相容性优异，并且极不可能经历突变。还提供了用于大规模培养3D多巴胺能神经元样细胞簇的皿; 其保证3D多巴胺能神经元样细胞簇优异的生物相容性，细胞毒性自由，最小致突变性，以及增强细胞间相互作用因子表达的改善。

46. 发明授权

EP1480521B1 MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS 有权
标题翻译：维吾尔族维吾尔族维吾尔族维吾尔族
公开(公告)号：EP1480521B1
公开(公告)日：2015-02-25
申请号：EP03742750.7
申请日：2003-02-14
申请人： CORNELL RESEARCH FOUNDATION, INC.
发明人： GOLDMAN, Steven A. , ROY, Neeta , WINDREM, Martha
IPC分类号： A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method ofremyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. This further aspect of the present invention involves removing neurons and neuronal progenitor cells from the mixed population to produce a treated mixed population. Oligodendrocyte progenitor cells are then separated from the treated mixed population to form an enriched population of oligodendrocyte progenitor cells.
摘要翻译：本发明的一种形式涉及通过在允许轴突再髓鞘化的条件下用少突胶质祖细胞处理脱髓鞘化的轴突来再髓鞘化的轴突的方法。本发明的另一方面涉及通过在有效治疗由髓磷脂损失介导的病症的条件下给予少突胶质祖细胞的方法来治疗具有由髓磷脂损失或少突胶质细胞损失介导的病症的受试者的方法，或少突胶质细胞的丧失。本发明的另一方面涉及从含有其它哺乳动物脑或脊髓细胞类型的混合群体中鉴定和分离少突胶质祖细胞祖细胞的体外方法。本发明的另一方面涉及从混合群体中去除神经元和神经元祖细胞以产生经处理的混合群体。然后从处理的混合群体中分离少突胶质细胞祖细胞以形成少突胶质细胞祖细胞的富集群体。

47. 发明公开

EP2829605A1 METHOD FOR SCREENING THERAPEUTIC AND/OR PROPHYLACTIC AGENTS FOR ALZHEIMER'S DISEASE 有权
标题翻译： VERFAHREN ZUM SCREENING VON THERAPEUTIKA UND / ODER PROPHYLAKTIKAFÜRMORBUS ALZHEIMER
公开(公告)号：EP2829605A1
公开(公告)日：2015-01-28
申请号：EP13763448.1
申请日：2013-02-20
申请人： Kyoto University
发明人： INOUE, Haruhisa , TAKAHASHI, Ryosuke , KONDO, Takayuki , IWATA, Nobuhisa , ASAI, Masashi
IPC分类号： C12N15/09 , C12N5/10 , C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/68 , C07K14/47 , C12Q1/68
CPC分类号： G01N33/5058 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2503/02 , C12N2506/45 , C12Q1/37 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5073 , G01N2333/4709 , G01N2800/2821
摘要： The present invention provides a method for screening a therapeutic and/or prophylactic agent for Alzheimer's disease using at least one index selected from the group consisting of the levels of Aβ oligomers, BiP, cleaved caspase 4, PRDX4 and ROS in nerve cells or the like whose differentiation has been induced from iPS cells derived from somatic cells of a patient with Alzheimer's disease.
摘要翻译：本发明提供了使用选自神经细胞等中的A 2低聚物，BiP，切割的半胱天冬酶4，PRDX4和ROS的水平的至少一种指标来筛选阿尔茨海默氏病的治疗和/或预防剂的方法其分化已经从源自阿尔茨海默氏病患者的体细胞的iPS细胞诱导。

48. 发明授权

EP2292736B1 Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue 有权
标题翻译：识别和多能细胞的分离从非骨软骨Mesenchymalgewebe
公开(公告)号：EP2292736B1
公开(公告)日：2015-01-21
申请号：EP10183073.5
申请日：2005-10-04
申请人： TiGenix, S.A.U. , Universidad Autónoma De Madrid
发明人： García Castro, Rosa Ana , Fernández Miguel, María Gema , García Arranz, Mariano , González De La Peña, Manuel Angel , García Olmo, Damián
IPC分类号： C12N5/074 , C12N5/0775
CPC分类号： A61K35/28 , C12N5/0607 , C12N5/0619 , C12N5/0654 , C12N5/0658 , C12N5/0667 , C12N2506/1384 , C12N2510/00 , G01N33/5008
摘要： Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. This invention relates to the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, it relates to an adult multipotent cell or a cell population or composition comprising said cell, isolated from non-osteochondral mesenchymal tissue, characterized in that it is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.

49. 发明公开

EP2798064A1 MAKING AND USING IN VITRO-SYNTHESIZED ssRNA FOR INTRODUCING INTO MAMMALIAN CELLS TO INDUCE A BIOLOGICAL OR BIOCHEMICAL EFFECT 有权
标题翻译：生产和应用体外合成的单链RNA引入哺乳动物细胞中诱导生物学或生物化学效应
公开(公告)号：EP2798064A1
公开(公告)日：2014-11-05
申请号：EP12815983.7
申请日：2012-12-31
申请人： CELLSCRIPT, LLC
发明人： MEIS, Judith , PERSON, Anthony , CHIN, Cynthia , JENDRISAK, Jerome , DAHL, Gary
IPC分类号： C12N15/10 , C12N15/08 , C12P19/34 , A61K31/7105
CPC分类号： A61K48/0066 , A61K31/7105 , A61K33/06 , A61K38/005 , A61K48/0041 , C12N5/0619 , C12N5/0658 , C12N5/0696 , C12N15/1003 , C12N15/1096 , C12N15/87 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/73 , C12N2506/1307 , C12N2510/00 , C12P19/34 , C12P19/38 , C12P21/02 , C12Y301/26003 , A61K2300/00
摘要： The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides mRNA and methods for reprogramming cells that exhibit a first differentiated state or phenotype to cells that exhibit a second differentiated state or phenotype, such as to reprogram human somatic cells to pluripotent stem cells.

50. 发明授权

EP2114433B1 USE OF SEMAPHORIN 6A FOR PROMOTING MYELINATION AND OLIGODENDROCYTE DIFFERENTIATION 有权转让
标题翻译：使用信号素6A促进和髓鞘少突胶质细胞分化
公开(公告)号：EP2114433B1
公开(公告)日：2014-04-09
申请号：EP08713389.8
申请日：2008-02-04
申请人： Biogen Idec MA Inc. , CNRS (Centre National De Recherche Scientifique) , University Pierre And Marie Curie
发明人： CHEDOTAL, Alain , MI, Sha , BERNARD, Frederic
IPC分类号： A61K38/17 , A61K48/00 , C07K14/705 , C12N5/00
CPC分类号： A61K38/1709 , A01K67/0276 , A01K2217/072 , A01K2227/105 , A61K35/12 , C07K14/705 , C12N5/0619 , C12N5/0622 , C12N2501/998 , C12N2502/08 , C12N2510/00
摘要： The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a Sema6A polypeptide.

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