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1. 发明授权

EP1480521B1 MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS 有权
标题翻译：维吾尔族维吾尔族维吾尔族维吾尔族
公开(公告)号：EP1480521B1
公开(公告)日：2015-02-25
申请号：EP03742750.7
申请日：2003-02-14
申请人： CORNELL RESEARCH FOUNDATION, INC.
发明人： GOLDMAN, Steven A. , ROY, Neeta , WINDREM, Martha
IPC分类号： A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method ofremyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. This further aspect of the present invention involves removing neurons and neuronal progenitor cells from the mixed population to produce a treated mixed population. Oligodendrocyte progenitor cells are then separated from the treated mixed population to form an enriched population of oligodendrocyte progenitor cells.
摘要翻译：本发明的一种形式涉及通过在允许轴突再髓鞘化的条件下用少突胶质祖细胞处理脱髓鞘化的轴突来再髓鞘化的轴突的方法。本发明的另一方面涉及通过在有效治疗由髓磷脂损失介导的病症的条件下给予少突胶质祖细胞的方法来治疗具有由髓磷脂损失或少突胶质细胞损失介导的病症的受试者的方法，或少突胶质细胞的丧失。本发明的另一方面涉及从含有其它哺乳动物脑或脊髓细胞类型的混合群体中鉴定和分离少突胶质祖细胞祖细胞的体外方法。本发明的另一方面涉及从混合群体中去除神经元和神经元祖细胞以产生经处理的混合群体。然后从处理的混合群体中分离少突胶质细胞祖细胞以形成少突胶质细胞祖细胞的富集群体。

2. 发明公开

EP1480521A2 MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS 有权
标题翻译：脑少突胶质细胞祖细胞的髓鞘形成先天性DYSMYELINISIERTEM FRONT
公开(公告)号：EP1480521A2
公开(公告)日：2004-12-01
申请号：EP03742750.7
申请日：2003-02-14
申请人： CORNELL RESEARCH FOUNDATION, INC.
发明人： GOLDMAN, Steven, A. , ROY, Neeta , WINDREM, Martha
IPC分类号： A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method ofremyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. This further aspect of the present invention involves removing neurons and neuronal progenitor cells from the mixed population to produce a treated mixed population. Oligodendrocyte progenitor cells are then separated from the treated mixed population to form an enriched population of oligodendrocyte progenitor cells.

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