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41. 发明公开

EP0152697A1 Heterocyclically substituted ethanes and their use in liquid crystal materials and devices 失效
标题翻译：杂环取代的乙烷以及它们在液晶材料和装置中使用。
公开(公告)号：EP0152697A1
公开(公告)日：1985-08-28
申请号：EP84308931.9
申请日：1984-12-31
申请人： Secretary of State for Defence in Her Britannic Majesty's Gov. of the United Kingdom of Great Britain and Northern Ireland
发明人： Gray, George William , Nicholas (nee Andrews) B. M.
IPC分类号： C07D319/06 , C07D239/26 , C09K19/34
CPC分类号： C07D239/26 , C07C31/1355 , C07C47/11 , C07C53/134 , C07C309/00 , C07D239/34 , C07D319/06 , C09K19/3402 , C09K19/3458 , C09K2019/3422
摘要： A heterocyclically substituted ethane having a formula:
wherein A represents a heterocyclic ring selected from a trans 2,5 disubstituted 1,3 dioxan ring and a 2,5 disubstituted 1,3-pyrimidine ring;
R, represents an alkyl group having from 1 to 15 carbon atoms and R 2 represents a group selected from hydrogen, alkyl having from 1 to 15 carbon atoms and alkoxy having from 1 to 15 carbon atoms provided that where A is a trans 2,5 disubstituted 1,3 dioxan ring R 2 is alkyl; and
Cy represents a trans-1,4 disubstituted cyclohexane ring.

42. 发明公开

EP0077550A2 1.4-Naphthoquinones, methods for their preparation and veterinary formulations thereof 失效
标题翻译： 1,4-萘醌，它们的制备方法，以及它们的兽医制剂。
公开(公告)号：EP0077550A2
公开(公告)日：1983-04-27
申请号：EP82109568.4
申请日：1982-10-15
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： Hudson, Alan Thomas , Randall, Anthony Winchester
IPC分类号： C07C50/32 , C07C46/00 , C07C46/06 , A61K31/12 , C07C69/14 , C07C69/78
CPC分类号： C07C61/22 , C07C50/32 , C07C51/08 , C07C51/36 , C07C51/487 , C07C53/134 , C07C61/08 , C07C61/15
摘要： 1,4-Naphthoquinones of formula (I), methods for their preparation veterinary formulations thereof, and the use thereof in animal therapy are disclosed.
Particularly preferred compounds of formula (I) are, 2-[trans-(4-t-butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone, and 2-[trans-(4-t-pentyl cyclohexyl)-methyl]-3-hydroxy-1,4-naphthoquinone. The compounds are of value as anti-protozoal agents, in particular as anti-theilerial agents.

43. 发明公开

EP0073771A1 NEUE RIECHSTOFFE 失效
标题翻译：新的香料。
公开(公告)号：EP0073771A1
公开(公告)日：1983-03-16
申请号：EP82900537.0
申请日：1982-02-25
申请人： L. GIVAUDAN & CIE Société Anonyme
发明人： BAUDIN, Josiane , GONZENBACH, Hans Ulrich
IPC分类号： A61K8 , A61Q13 , C07C45 , C07C49 , C07C53 , C07C57 , C07C61 , C07C67 , C11B9
CPC分类号： C11B9/0038 , C07C45/292 , C07C45/56 , C07C45/62 , C07C49/403 , C07C49/417 , C07C49/613 , C07C49/653 , C07C53/134 , C07C53/44 , C07C57/26 , C07C57/56 , C07C57/70 , C07C61/35 , C07C61/40 , C11B9/0034
摘要： Nouveaux composes odoriferants, en particulier les composes de formule (FORMULE) dans laquelle R est un reste aliphatique de formule (FORMULE) dans laquelle R1 est un alkyle en C1-4, un alkylidene en C1-4 ou un alkenyle en C2-4, la somme des atomes de carbone s'etablissant dans ces restes de 2 a 5, m et n etant zero ou a 1, p etant 1, 2 ou 3 et les lignes pointillees signifiant une ou deux doubles liaisons facultatives. L'invention concerne par ailleurs egalement un procede de preparation des nouvelles di-cetones I; ainsi que l'utilisation de I en tant que composes odoriferants dans des compositions parfumees, se distinguant par un certain taux en composes de formule I.

44. 发明公开

EP2970089A4 SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS 有权转让
标题翻译：取代的芳香族化合物和相应的用于纤维化的治疗
公开(公告)号：EP2970089A4
公开(公告)日：2016-10-12
申请号：EP14764458
申请日：2014-03-14
申请人： PROMETIC PHARMA SMT LTD
发明人： ZACHARIE BOULOS , ABBOTT SHAUN , GAGNON LYNE , LAURIN PIERRE , GROUIX BRIGITTE
IPC分类号： C07C57/30 , A61K31/192 , A61P19/04 , C07C57/58 , C07C59/52
CPC分类号： C07C53/134 , A61K31/192 , C07C57/30 , C07C57/58 , C07C59/52
摘要： The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)—C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.

45. 发明授权

EP1931327B1 CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 有权
标题翻译：环丙基化合物和组合物输送剂
公开(公告)号：EP1931327B1
公开(公告)日：2016-08-17
申请号：EP06802048.6
申请日：2006-08-21
申请人： Emisphere Technologies, Inc.
发明人： TANG, Pingwah , DINH, Steven , LEE, Jongbin , LIU, Puchun , MUSTATA, Gabriela
IPC分类号： C07D213/78 , C07D213/69 , C07C53/134 , C07C57/26 , C07C59/13 , C07C233/05 , C07C233/09 , C07C233/58 , C07C233/65 , C07C235/14 , C07C323/60
CPC分类号： C07C233/05 , C07C53/134 , C07C57/26 , C07C59/13 , C07C233/06 , C07C233/09 , C07C233/58 , C07C233/65 , C07C235/14 , C07C323/60 , C07C2601/02 , C07C2601/14

46. 发明公开

EP2970089A1 SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS 有权转让
标题翻译：取代芳香族化合物及其治疗纤维化的相关方法
公开(公告)号：EP2970089A1
公开(公告)日：2016-01-20
申请号：EP14764458.7
申请日：2014-03-14
申请人： ProMetic BioSciences Inc.
发明人： ZACHARIE, Boulos , ABBOTT, Shaun , GAGNON, Lyne , LAURIN, Pierre , GROUIX, Brigitte
IPC分类号： C07C59/52 , A61K31/192 , A61P19/04 , C07C57/32
CPC分类号： C07C53/134 , A61K31/192 , C07C57/30 , C07C57/58 , C07C59/52 , Y02A50/423
摘要： The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)—C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.
摘要翻译：本发明涉及以下化合物或其药学上可接受的盐，其中A为C 5烷基，C 6烷基，C 5烯基，C 6烯基，C（O） - （CH 2）n -CH 3或CH（ OH） - （CH 2）n -CH 3其中n是3或4; R 1是H，F或OH; R 2是C 5烷基，C 6烷基，C 5烯基，C 6烯基，C（O） - （CH 2）n -CH 3或CH（OH） - （CH 2）n -CH 3，其中n是3 或4; R 3是H，F，OH或CH 2 Ph; R 4是H，F或OH; Q是1）（CH 2）mC（O）OH，其中m是1或2,2,2）CH（CH 3）C（O）OH，3）C（CH 3）2 C（O）OH，4）CH F）-C（O）OH，5）CF 2 -C（O）OH，或6）C（O）-C（O）OH; 和组合物，其包括相同的，并且使用用于各种纤维变性疾病和病症的受试者，包括肺纤维化，肝纤维化，皮肤纤维化，肾纤维化，胰纤维化，系统性硬化症，心脏纤维化或黄斑变性的预防或治疗的相同的方法。

47. 发明公开

EP2351729A4 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ORGANIC CARBOXYLIC ACID 有权
标题翻译：用于生产光学活性有机羧酸
公开(公告)号：EP2351729A4
公开(公告)日：2012-08-01
申请号：EP09823609
申请日：2009-10-28
申请人： MITSUBISHI GAS CHEMICAL CO
发明人： KYUUKO YOUICHI
IPC分类号： C07C51/43 , C07B57/00 , C07C51/487 , C07C53/134 , C07D311/66
CPC分类号： C07D311/66 , C07B57/00 , C07B2200/07 , C07C51/487 , C07C53/134

48. 发明公开

EP2351729A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ORGANIC CARBOXYLIC ACID 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON OPTISCH塞维尔组织机构CARBOXYLSÄURE
公开(公告)号：EP2351729A1
公开(公告)日：2011-08-03
申请号：EP09823609.4
申请日：2009-10-28
申请人： Mitsubishi Gas Chemical Company, Inc.
发明人： KYUUKO, Youichi
IPC分类号： C07C51/43 , C07B57/00 , C07C51/487 , C07C53/134 , C07D311/66
CPC分类号： C07D311/66 , C07B57/00 , C07B2200/07 , C07C51/487 , C07C53/134
摘要： The present invention is a simple method, in which a specific amount of alkali is added to an enantiomeric mixture of an optically active organic carboxylic acid where enantiomers are present in a non-equimolar ratio, or in which the enantiomeric mixture of an optically active organic carboxylic acid is neutralized with an alkali, and then a specific amount of acid is added thereto, thereby separating an organic carboxylic acid salt in the mother liquor and a crystallized organic carboxylic acid from each other. The method makes it possible to obtain an optically active organic carboxylic acid with improved enantiomeric excess. The present invention provides a simple production method for obtaining an optically active organic carboxylic acid with improved enantiomeric excess from an enantiomeric mixture of an optically active organic carboxylic acid where enantiomers are present in a non-equimolar ratio.
摘要翻译：本发明是一种简单的方法，其中将特定量的碱加入到对映体以非等摩尔比存在的光学活性有机羧酸的对映体混合物中，或其中光学活性有机物的对映体混合物羧酸用碱中和，然后加入特定量的酸，从而将母液中的有机羧酸盐和结晶的有机羧酸彼此分离。该方法可以获得具有改善的对映体过量的光学活性有机羧酸。本发明提供了一种简单的制备方法，用于从对映异构体以非等摩尔比存在的光学活性有机羧酸的对映体混合物中获得具有改进的对映体过量的光学活性有机羧酸。

49. 发明公开

EP2328572A1 PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权
标题翻译： PKC-AKTIVIERENDE VERBINDUNGEN ZUR BEHANDLUNG VON神经递质激素ERKRANKUNGEN
公开(公告)号：EP2328572A1
公开(公告)日：2011-06-08
申请号：EP09790874.3
申请日：2009-07-28
申请人： Blanchette Rockefeller Neurosciences Institute
发明人： NELSON, Thomas, J. , ALKON, Daniel, L.
IPC分类号： A61K31/215 , A61P25/28
CPC分类号： C07D303/42 , A61K31/045 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/335 , C07C31/13 , C07C31/1333 , C07C53/134 , C07C69/608 , C07D303/40 , C12N9/12 , C12Y207/11013
摘要： The present invention relates to methods of activating an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
摘要翻译：本发明涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物来激活蛋白激酶C（PKC）的同种型以治疗包括阿尔茨海默氏病和中风的神经疾病的方法。本发明还涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物减少神经变性的方法。

50. 发明公开

EP2303278A1 COMPOSITION FOR MODULATING STEM CELL GROWTH WITH PROSTAGLANDINS 审中-公开
标题翻译：成分调制与前列腺干细胞生长的
公开(公告)号：EP2303278A1
公开(公告)日：2011-04-06
申请号：EP09712320.2
申请日：2009-02-19
申请人： Sucampo AG
发明人： UENO, Ryuji , KUNO, Sachiko
IPC分类号： A61K31/5575 , A61P43/00 , A61P19/08 , A61P19/10 , A61P7/06 , A61P21/00
CPC分类号： C07C53/134 , A61K31/5575
摘要： In one embodiment, provided is a composition comprising a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is a composition comprising a prostaglandin compound for, which comprises a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.

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