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41. 发明公开

EP2408753A2 COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS 审中-公开
标题翻译：化合物和方法治疗微生物胃肠道感染哺乳动物
公开(公告)号：EP2408753A2
公开(公告)日：2012-01-25
申请号：EP10754239.1
申请日：2010-03-22
申请人： Brandeis University , The University Of Georgia Research Foundation, Inc
发明人： HEDSTROM, Lizbeth, K. , CUNY, Gregory, D. , GOLLAPALLI, Deviprasad, R. , KIRUBAKARAN, Sivapriya , STRIEPEN, Boris , GORLA, Suresh, Kumar , MAURYA, Sushi, K. , JOHNSON, Corey, Robert , KAVITHA, Mandapati , KHAN, JIHAN,
IPC分类号： C07D249/06 , C07D401/12 , C07D417/14 , C07D401/14 , A61K31/4192 , A61P37/00 , A61P19/02
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.

42. 发明授权

EP1453386B1 PREPARED FOODS CONTAINING TRIGLYCERIDE-RECRYSTALLIZED NON-ESTERIFIED PHYTOSTEROLS 有权
标题翻译：公式自甘油三酯重结晶的非酯化植物甾醇CONTAIN
公开(公告)号：EP1453386B1
公开(公告)日：2009-10-21
申请号：EP02789698.4
申请日：2002-11-14
申请人： BRANDEIS UNIVERSITY
发明人： PERLMAN, Daniel , HAYES, Kenneth , PRONCZUK, Andrzej
IPC分类号： A23D9/00
CPC分类号： A23D9/00 , A23D9/007 , A23L19/18 , A23L25/10 , A23L33/11 , C11B5/0021
摘要： A prepared food product for ingestion by mammals is described and methods for preparing such products. The food product includes an oxidation-resistant fat-based composition substantially free of exogenous solubilizing and dispersing agents for phytosterols. The fat-based composition includes between 75% and 98% by weight of at least one triglyceride-based edible oil or fat, and between 2% and 25% by weight of non-esterified phytosterols. Typically, approximately 1.5% by weight of phytosterols remain soluble at room temperature, and between 0.5% and 23.5% by weight are converted to triglyceride-recrystallized phytosterols (TRPs). The fat-based composition which has been partially oxidized in the prepared food by exposure to air (and typically heat), contains a reduced amount of oxidative by-products compared to a similar fat-based composition lacking these non-esterified phytosterols.

43. 发明公开

EP2046989A2 SPECIALIZED OLIGONUCLEOTIDES AND THEIR USE IN NUCLEIC ACID AMPLIFICATION AND DETECTION 有权
标题翻译： SPECIALIZED寡核苷酸及其USE IN核酸扩增和检测
公开(公告)号：EP2046989A2
公开(公告)日：2009-04-15
申请号：EP07796898.0
申请日：2007-07-17
申请人： BRANDEIS UNIVERSITY
发明人： WANGH, Lawrence, J.
IPC分类号： C12Q1/68 , C12P19/34 , C12N9/00 , C07H21/00
CPC分类号： C12Q1/686 , C12Q2531/107 , C12Q2527/143 , C12Q2525/125 , C12Q2561/101
摘要： Described herein are labeled probes and unlabeled oligonucleotides that are useful for use in nucleic acid amplification reactions. These probes and oligonucleotides are modified to alter their sensitivity to primer-independent 5' exonuclease activity of a thermostable DNA polymerase relative to its corresponding unmodified counterpart. Non-symmetric polymerase chain reaction (PCR) amplification and detection methods employing these labeled probes and unlabeled oligonucleotides are also described. Kits for nucleic acid amplification reactions including labeled probes and unlabeled oligonucleotides are also described.

44. 发明公开

EP1802774A1 REAGENTS AND METHODS FOR IMPROVING REPRODUCIBILITY AND REDUCING MISPRIMING IN PCR AMPLIFICATION 有权
标题翻译：试剂和一种提高再现性并减少PCR扩增的引导错误
公开(公告)号：EP1802774A1
公开(公告)日：2007-07-04
申请号：EP05813115.2
申请日：2005-10-17
申请人： BRANDEIS UNIVERSITY
发明人： WANGH, Lawrence J. , RICE, John , SANCHEZ, Aquiles J. , PIERCE, Kenneth , SALK, Jesse , REIS, Arthur
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6848 , C12Q1/686 , C12Q2527/125 , C12Q2525/301 , C12Q2525/186 , C12Q2531/107 , C12Q2527/137
摘要： An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be included in oligonucleotide sets and in kits for PCR amplification and assays.

45. 发明公开

EP1758899A1 ASYMMETRIC MICHAEL AND ALDOL ADDITION USING BIFUNCTIONAL CINCHONA-ALKALOID-BASED CATALYSTS 审中-公开
标题翻译：不公平的MICHAEL- UND ALDOLADDITION UNTER VERWENDUNG BIFUNKELLELLER KATALYSATOREN AUF CINCHONAALKALOIDBASIS
公开(公告)号：EP1758899A1
公开(公告)日：2007-03-07
申请号：EP05758837.8
申请日：2005-05-27
申请人： BRANDEIS UNIVERSITY
发明人： DENG, Li , LI, Hongming
IPC分类号： C07D453/04 , B01J31/02
CPC分类号： C07D453/04 , B01J31/0237 , B01J31/0244 , C07B2200/07 , C07C205/45 , C07C205/51 , C07C205/53 , C07C205/55 , C07C205/56 , C07C231/18 , C07C253/30 , C07C281/02 , C07C315/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C317/44 , C07C317/46 , C07C317/50 , C07C233/87 , C07C255/19 , C07C255/41
摘要： One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with 5 base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral 10 ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine.
摘要翻译：本发明的一个方面涉及基于奎宁和奎尼丁的催化剂。本发明的另一方面涉及一种制备衍生的基于奎宁或奎尼丁的催化剂的方法，其包括：1）将奎宁或奎尼丁与碱和具有合适离去基团的化合物反应，和2）将环甲氧基转化为羟基。本发明的另一方面涉及从前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮制备手性，非外消旋化合物的方法，其包括以下步骤：使前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮与亲核试剂在催化剂存在下反应; 从而产生手性，非外消旋化合物; 其中所述催化剂是衍生的奎宁或奎尼丁。本发明的另一方面涉及一种动力学拆分方法，其包括以下步骤：在衍生的奎宁或奎尼丁存在下使外消旋手性烯与亲核试剂反应。

46. 发明授权

EP1323346B1 Receptor specific transepithelial transport of immunogens 失效
标题翻译：免疫原的特异性受体Transepithelealer运输
公开(公告)号：EP1323346B1
公开(公告)日：2006-06-28
申请号：EP03004479.6
申请日：1996-01-17
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , BRANDEIS UNIVERSITY
发明人： Blumberg, Richard S. , Simister, Neil E. , Lencer, Wayne I.
IPC分类号： A01N63/00 , A61K39/385 , A61K39/00 , A61K47/48
CPC分类号： A61K39/385 , A61K47/646 , A61K47/68 , A61K2039/541 , A61K2039/543 , A61K2039/55516 , A61K2039/55522 , A61K2039/6056 , C07K2319/30

47. 发明授权

EP0686202B1 In vitro method for inducing nuclear swelling 失效
标题翻译：体外维生素Zur Induzierung dernukleärenSchwellung
公开(公告)号：EP0686202B1
公开(公告)日：2006-05-03
申请号：EP94909503.8
申请日：1994-02-01
申请人： BRANDEIS UNIVERSITY
发明人： WANGH, Lawrence J.
IPC分类号： C12Q1/68 , C12M1/40
CPC分类号： C12N15/873 , A01K2217/05 , C12N5/061 , C12N2500/80 , C12N2501/01 , C12N2501/70 , C12N2517/10 , C12Q1/6841 , C12Q1/70
摘要： The present invention concerns products and methods particularly useful for activating and analyzing non-dividing cell nuclei. The featured products include activating egg extracts, cytostatic factor (CSF) extracts, kits containing these extracts, and a microchamber microscope slide useful in analyzing nucleus activation.
摘要翻译：本发明涉及特别可用于激活和分析非分裂细胞核的产品和方法。特色产品包括活化卵提取物，细胞增殖因子（CSF）提取物，含有这些提取物的试剂盒和用于分析细胞核激活的微型显微镜载玻片。

48. 发明公开

EP1210358A2 DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：检测的NUCLEIC
公开(公告)号：EP1210358A2
公开(公告)日：2002-06-05
申请号：EP00955479.1
申请日：2000-08-14
申请人： BRANDEIS UNIVERSITY
发明人： WANGH, Lawrence , PIERCE, Kenneth , HARTSHORN, Cristina , RICE, John , SANCHEZ, J., Aquiles
IPC分类号： C07H21/02
CPC分类号： C12Q1/6876 , C12Q1/6806 , C12Q1/686 , C12Q2600/16 , C12Q2521/537 , C12Q2565/1015 , C12Q2547/107
摘要： Disclosed are compositions, methods, and kits useful for detection of the presence and/or quantity of one or more chromosomes from single cells, groups of cells, or subcellular compartments. Provided is a lysis buffer for the preparation of substantially accessible nucleic acid molecules from a single cell. Also provided are moderately-repeated highly-conserved nucleic acid sequences, and oligonucleotide primer and probe molecules which hybridize specifically thereto. Methods for the detection of the presence or quantity of one or more chromosomes from a single cell are included, as are methods for the assessment of the reliability of the results of the methods of the invention. Kits for the convenient practice of the invention are also included.

49. 发明公开

EP0820307A1 INCREASING THE HDL LEVEL AND THE HDL/LDL RATIO IN HUMAN SERUM BY BALANCING SATURATED AND POLYUNSATURATED DIETARY FATTY ACIDS 无效
标题翻译：增加HDL镜子和HDL / LDL比率人血清中的平衡组合饱和与多不饱和脂肪酸的饮食
公开(公告)号：EP0820307A1
公开(公告)日：1998-01-28
申请号：EP96911560.0
申请日：1996-04-02
申请人： BRANDEIS UNIVERSITY
发明人： SUNDRAM, Kalyana , PERLMAN, Daniel , HAYES, Kenneth, C.
IPC分类号： A21D2 , A21D13 , A23C19 , A23D9 , A23L1 , A61K31
CPC分类号： A23D9/00 , A21D2/145 , A21D13/80 , A23C19/093 , A23L27/60 , A23L33/12 , A61K31/23 , A61K31/231 , A61K31/232
摘要： A method of increasing the HDL concentration and the HDL/LDL concentration ratio in human serum by providing a balance between a sufficient and required proportion of cholesterol-free saturated fatty acids in the daily dietary fat of the human and a sufficient and required, but not excessive, proportion of polyunsaturated fatty acids comprising linoleic acid in dietary fat, while the remaining proportion of fatty acids and energy from the dietary fat is provided by monounsaturated fatty acids comprising oleic acid. The saturated fatty acids must constitute between 20 % and 40 % by weight of the daily dietary fat based upon dietary fat accounting for 30 % of the total dietary energy consumption, and linoelic acid must constitute between 15 % and 40 % by weight of dietary fat. In this way, the required proportional intake of polyunsaturated fatty acids enhances the formation of HDL from VLDL and/or decreases the clearance of HDL, while an excessive proportional intake of polyunsaturated fatty acids and monounsaturated fatty acids is avoided to assure a sufficient dietary availability of saturated fatty acids which are required for sufficient VLDL synthesis and HDL production.
摘要翻译：增加HDL浓度，并通过在人的每日饮食中的脂肪和足够提供不含胆固醇的饱和脂肪酸的充足和所需比例之间的平衡人血清中HDL / LDL浓度比的方法和必需的，但不的多不饱和脂肪酸，包括在膳食脂肪亚油酸，而脂肪酸和能量从膳食脂肪的剩余比例由单不饱和脂肪酸包括油酸提供过多，比例。饱和脂肪酸必须按重量计基于膳食脂肪占总食物能量消耗的30％的日常饮食中的脂肪20％和40％之间构成，和亚油酸必须按重量计的饮食中的脂肪组成15和％之间％40 ，以这种方式，所需的比例摄取的多不饱和脂肪酸，从VLDL增强HDL的形成和/或降低HDL的间隙，而在过大的比例摄取的多不饱和脂肪酸和单不饱和脂肪酸被避免，以确保有足够的膳食可用性饱和脂肪酸是必需的哪个足够VLDL合成和HDL生产。

50. 发明公开

EP0805628A1 RECEPTOR SPECIFIC TRANSEPITHELIAL TRANSPORT OF IMMUNOGENS 失效
标题翻译：免疫原性受体特异性跨上皮转运
公开(公告)号：EP0805628A1
公开(公告)日：1997-11-12
申请号：EP96903522.0
申请日：1996-01-17
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , BRANDEIS UNIVERSITY
发明人： BLUMBERG, Richard, S. , SIMISTER, Neil, E. , LENCER, Wayne, I.
IPC分类号： A61K39 , A61K47 , A61P37
CPC分类号： A61K39/385 , A61K47/646 , A61K47/68 , A61K2039/541 , A61K2039/543 , A61K2039/55516 , A61K2039/55522 , A61K2039/6056 , C07K2319/30
摘要： Methods and products for modulating an immune response are provided. Pharmaceutical preparations contain a conjugate of an antigen and an FcRn binding partner. The conjugates are administered to mammals in effective amounts to modulate the immune system by stimulating the immune response against the antigen or tolerizing the immune system to the antigen. The antigen may be characteristic of a pathogen, of an autoimmune disease, of an allergen or of a tumor.

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